{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:15:08Z","timestamp":1792815308292,"version":"4.5.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["20050006"],"award-info":[{"award-number":["20050006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["ydhx202201"],"award-info":[{"award-number":["ydhx202201"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["ydhx202402"],"award-info":[{"award-number":["ydhx202402"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["20050005"],"award-info":[{"award-number":["20050005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304834"],"award-info":[{"award-number":["82304834"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460713"],"award-info":[{"award-number":["82460713"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013061","name":"Jilin Provincial Scientific and Technological Development Program","doi-asserted-by":"publisher","award":["YDZJ202501ZYTS17"],"award-info":[{"award-number":["YDZJ202501ZYTS17"]}],"id":[{"id":"10.13039\/501100013061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.phymed.2026.158187","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T05:03:02Z","timestamp":1776142982000},"page":"158187","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Jingfang granules alleviate atopic dermatitis by restoring skin barrier function and inhibiting NF-\u03baB\/NLRP3 axis and JAK\/STAT3 axis"],"prefix":"10.1016","volume":"155","author":[{"given":"Yi","family":"Tai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinzhe","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shufeng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiqin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqian","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming Yue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Xiang","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guimin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158187_bib0001","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12986-016-0080-3","article-title":"Hydroxycinnamic acid derivatives: a potential class of natural compounds for the management of lipid metabolism and obesity","volume":"13","author":"Alam","year":"2016","journal-title":"Nutr. Metab. (Lond)"},{"key":"10.1016\/j.phymed.2026.158187_bib0002","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1007\/s40265-024-02095-4","article-title":"Emerging biologic therapies for the treatment of atopic dermatitis","volume":"84","author":"Alvarenga","year":"2024","journal-title":"Drugs"},{"key":"10.1016\/j.phymed.2026.158187_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2015.03.051","article-title":"The Janus kinase inhibitor JTE-052 improves skin barrier function through suppressing signal transducer and activator of transcription 3 signaling","volume":"136","author":"Amano","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.phymed.2026.158187_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116344","article-title":"A homogeneous Lonicera japonica polysaccharide alleviates atopic dermatitis by promoting Nrf2 activation and NLRP3 inflammasome degradation via p62","volume":"309","author":"Bai","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158187_bib0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00424-016-1903-9","article-title":"Tight junctions in skin inflammation","volume":"469","author":"B\u00e4sler","year":"2017","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.phymed.2026.158187_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.xjidi.2022.100131","article-title":"Type 2 inflammation contributes to skin barrier dysfunction in atopic dermatitis","volume":"2","author":"Beck","year":"2022","journal-title":"JID Innov."},{"key":"10.1016\/j.phymed.2026.158187_bib0007","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1111\/all.16092","article-title":"Skin, gut, and lung barrier: physiological interface and target of intervention for preventing and treating allergic diseases","volume":"79","author":"Berni Canani","year":"2024","journal-title":"Allergy"},{"key":"10.1016\/j.phymed.2026.158187_bib0008","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1016\/j.jaci.2017.01.011","article-title":"The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies","volume":"139","author":"Brunner","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.phymed.2026.158187_bib0009","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11882-020-00959-9","article-title":"Traditional Chinese medicine (TCM) and allergic diseases","volume":"20","author":"Chan","year":"2020","journal-title":"Curr. Allergy Asthma Rep."},{"key":"10.1016\/j.phymed.2026.158187_bib0010","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.jep.2015.04.002","article-title":"Chinese herbal medicine network and core treatments for allergic skin diseases: implications from a nationwide database","volume":"168","author":"Chen","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158187_bib0011","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.alit.2017.10.002","article-title":"Barrier dysfunction in the skin allergy","volume":"67","author":"Egawa","year":"2018","journal-title":"Allergol. Int."},{"key":"10.1016\/j.phymed.2026.158187_bib0012","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.2147\/CCID.S479632","article-title":"Research trend and future perspectives of traditional Chinese medicine for atopic dermatitis from 2004 to 2023: a bibliometric analysis","volume":"17","author":"Feng","year":"2024","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"10.1016\/j.phymed.2026.158187_bib0013","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/glia.24123","article-title":"Lithium inhibits tryptophan catabolism via the inflammation-induced kynurenine pathway in human microglia","volume":"70","author":"Gottert","year":"2022","journal-title":"Glia"},{"key":"10.1016\/j.phymed.2026.158187_bib0014","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/s41419-017-0147-8","article-title":"Game-changing restraint of Ros-damaged phenylalanine, upon tumor metastasis","volume":"9","author":"Gueron","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2026.158187_bib0015","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jaci.2018.08.022","article-title":"Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitis","volume":"143","author":"Guttman-Yassky","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.phymed.2026.158187_bib0016","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.jaci.2019.11.025","article-title":"Upadacitinib in adults with moderate to severe atopic dermatitis: 16-week results from a randomized, placebo-controlled trial","volume":"145","author":"Guttman-Yassky","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.phymed.2026.158187_bib0017","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23084470","article-title":"Dendrobium nobile Lindley administration attenuates atopic dermatitis-like lesions by modulating immune cells","volume":"23","author":"Hong","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158187_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122560","article-title":"Ursodeoxycholic acid alleviates atopic dermatitis-associated inflammatory responses in HaCaT and RBL-2H3 cells and DNCB\/DFE-treated mice","volume":"344","author":"Kim","year":"2024","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2026.158187_bib0019","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0140-6736(20)31286-1","article-title":"Atopic dermatitis","volume":"396","author":"Langan","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2026.158187_bib0020","article-title":"Oral administration of p-hydroxycinnamic acid attenuates atopic dermatitis by downregulating Th1 and Th2 cytokine production and keratinocyte activation","volume":"11","author":"Lee","year":"2016","journal-title":"PLoS One."},{"key":"10.1016\/j.phymed.2026.158187_bib0021","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1021\/acs.jafc.3c06015","article-title":"Ginsenoside F2-mediated intestinal microbiota and its metabolite propionic acid positively impact the gut-skin axis in atopic dermatitis mice","volume":"72","author":"Li","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2026.158187_bib0022","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s11684-011-0126-x","article-title":"The fundamental theory of traditional Chinese medicine and the consideration in its research strategy","volume":"5","author":"Li","year":"2011","journal-title":"Front Med."},{"key":"10.1016\/j.phymed.2026.158187_bib0023","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.ctim.2015.07.006","article-title":"Efficacy of a Chinese herbal medicine for the treatment of atopic dermatitis: a randomised controlled study","volume":"23","author":"Liu","year":"2015","journal-title":"Complement Ther. Med."},{"key":"10.1016\/j.phymed.2026.158187_bib0024","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nature18629","article-title":"Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores","volume":"535","author":"Liu","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2026.158187_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110958","article-title":"Inhibition of gasdermin D (GSDMD) as a promising therapeutic approach for atopic dermatitis","volume":"124","author":"Lu","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2026.158187_bib0026","article-title":"Integrated plasma metabolomic and cytokine analysis reveals a distinct immunometabolic signature in atopic dermatitis","volume":"15","author":"Ma","year":"2024","journal-title":"Front Immunol."},{"key":"10.1016\/j.phymed.2026.158187_bib0027","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1600-065X.2012.01149.x","article-title":"Amino acid catabolism: a pivotal regulator of innate and adaptive immunity","volume":"249","author":"McGaha","year":"2012","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.phymed.2026.158187_bib0028","doi-asserted-by":"crossref","DOI":"10.1111\/jdv.19153","article-title":"IL-1\u03b1\/\u03b2 and IL-18 profiles and their impact on claudin-1, loricrin and filaggrin expression in patients with atopic dermatitis","volume":"37","author":"Michaelidou","year":"2023","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.phymed.2026.158187_bib0029","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1111\/all.16009","article-title":"Treatment of atopic dermatitis: recently approved drugs and advanced clinical development programs","volume":"79","author":"Muller","year":"2024","journal-title":"Allergy"},{"key":"10.1016\/j.phymed.2026.158187_bib0030","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1002\/ptr.8409","article-title":"Chinese herbal medicine and their active ingredients involved in the treatment of atopic dermatitis related signaling pathways","volume":"39","author":"Nie","year":"2025","journal-title":"Phytother Res."},{"key":"10.1016\/j.phymed.2026.158187_bib0031","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s13059-019-1758-4","article-title":"Cytoscape Automation: empowering workflow-based network analysis","volume":"20","author":"Otasek","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.phymed.2026.158187_bib0032","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.1111\/bph.15193","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"177","author":"Percie du Sert","year":"2020","journal-title":"Br J. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158187_bib0033","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1111\/j.1600-0625.2008.00786.x","article-title":"The skin: an indispensable barrier","volume":"17","author":"Proksch","year":"2008","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.phymed.2026.158187_bib0034","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.jaip.2020.11.034","article-title":"Biologics for treatment of atopic dermatitis: current status and future prospect","volume":"9","author":"Ratchataswan","year":"2021","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"10.1016\/j.phymed.2026.158187_bib0035","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.jaci.2022.10.023","article-title":"Novel insights into atopic dermatitis","volume":"151","author":"Schuler","year":"2023","journal-title":"J. Allergy Clin. Immun."},{"key":"10.1016\/j.phymed.2026.158187_bib0036","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1002\/eji.201646421","article-title":"Increased Th2 activity and diminished skin barrier function cooperate in allergic skin inflammation","volume":"46","author":"Sehra","year":"2016","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.phymed.2026.158187_bib0037","first-page":"907","article-title":"[Bioactive compounds of Jingfang Granules against SARS-CoV-2 virus proteases 3CL(pro) and PL(pro)]","volume":"54","author":"Shang","year":"2022","journal-title":"Beijing Da Xue Xue Bao Yi Xue Ban."},{"key":"10.1016\/j.phymed.2026.158187_bib0038","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1254150","article-title":"The gasdermins: a pore-forming protein family expressed in the epidermis","volume":"14","author":"Slaufova","year":"2023","journal-title":"Front Immunol."},{"key":"10.1016\/j.phymed.2026.158187_bib0039","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22084130","article-title":"Molecular mechanisms of atopic dermatitis pathogenesis","volume":"22","author":"Sroka-Tomaszewska","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158187_bib0040","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1056\/NEJMra2023911","article-title":"Atopic dermatitis","volume":"384","author":"St\u00e4nder","year":"2021","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.phymed.2026.158187_bib0041","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s13020-021-00506-2","article-title":"Integrated Chinese and western medicine interventions for atopic dermatitis: a systematic review and meta-analysis","volume":"16","author":"Sum","year":"2021","journal-title":"Chin. Med."},{"key":"10.1016\/j.phymed.2026.158187_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115913","article-title":"Jingfang granules improve glucose metabolism disturbance and inflammation in mice with urticaria by up-regulating LKB1\/AMPK\/SIRT1 axis","volume":"302","author":"Sun","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158187_bib0043","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.jaad.2013.01.019","article-title":"Chinese herbal medicine for atopic dermatitis: a systematic review","volume":"69","author":"Tan","year":"2013","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.phymed.2026.158187_bib0044","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0294236","article-title":"SRplot: a free online platform for data visualization and graphing","volume":"18","author":"Tang","year":"2023","journal-title":"PLoS One."},{"key":"10.1016\/j.phymed.2026.158187_bib0045","article-title":"Time- and dose-dependent claudin contribution to biological functions: lessons from claudin-1 in skin","volume":"5","author":"Tokumasu","year":"2017","journal-title":"Tissue Barrier."},{"key":"10.1016\/j.phymed.2026.158187_bib0046","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jid.2020.05.095","article-title":"Granzyme B contributes to barrier dysfunction in oxazolone-induced skin inflammation through E-cadherin and FLG cleavage","volume":"141","author":"Turner","year":"2021","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.phymed.2026.158187_bib0047","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.coi.2014.09.009","article-title":"I-l-C-2 it: type 2 immunity and group 2 innate lymphoid cells in homeostasis","volume":"31","author":"von Moltke","year":"2014","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.phymed.2026.158187_bib0048","article-title":"Jingfang Granules alleviates OVA-induced allergic rhinitis through regulating endoplasmic reticulum stress signaling pathway","volume":"338","author":"Wang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158187_bib0049","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.anai.2020.12.002","article-title":"Traditional Chinese medicine for food allergy and eczema","volume":"126","author":"Wang","year":"2021","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"10.1016\/j.phymed.2026.158187_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41572-018-0001-z","article-title":"Atopic dermatitis","volume":"4","author":"Weidinger","year":"2018","journal-title":"Nat. Rev. Dis. Primer."},{"key":"10.1016\/j.phymed.2026.158187_bib0051","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/3164105","article-title":"Traditional Chinese medicine use among patients with psoriasis in Taiwan: a nationwide population-based study","author":"Weng","year":"2016","journal-title":"Evid-Based Compl Alt"},{"key":"10.1016\/j.phymed.2026.158187_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154925","article-title":"Jingfang granules exert anti-psoriasis effect by targeting MAPK-mediated dendritic cell maturation and PPARgamma-mediated keratinocytes cell cycle progression in vitro and in vivo","volume":"117","author":"Xu","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158187_bib0053","doi-asserted-by":"crossref","DOI":"10.1080\/08916934.2024.2310269","article-title":"The role of NLRP3 inflammasome in type 2 inflammation related diseases","volume":"57","author":"Xu","year":"2024","journal-title":"Autoimmunity"},{"key":"10.1016\/j.phymed.2026.158187_bib0054","doi-asserted-by":"crossref","DOI":"10.1111\/exd.70148","article-title":"Advances in the study of pyroptosis in dermatological disorders","volume":"34","author":"Xue","year":"2025","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.phymed.2026.158187_bib0055","first-page":"2819","article-title":"[Randomized double-blind placebo-controlled trial of Jingfang Granules in treatment of common cold(wind-cold syndrome)]","volume":"47","author":"Yang","year":"2022","journal-title":"Zhongguo Zhong Yao Za Zhi."},{"key":"10.1016\/j.phymed.2026.158187_bib0056","article-title":"Skin barrier abnormalities and immune dysfunction in atopic dermatitis","volume":"21","author":"Yang","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.phymed.2026.158187_bib0057","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1007\/s00210-023-02464-y","article-title":"Integrating network pharmacology and experimental validation to decipher the mechanism of action of Jingfang Granule in the treatment of viral myocarditis","volume":"396","author":"Yao","year":"2023","journal-title":"Naunyn Schmiedebergs Arch Pharmacol."},{"key":"10.1016\/j.phymed.2026.158187_bib0058","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcmgh.2025.101558","article-title":"Exercise-induced metabolite N-lactoyl-phenylalanine ameliorates colitis by inhibiting M1 macrophage polarization via the suppression of the NF-kappaB signaling pathway","volume":"19","author":"Yu","year":"2025","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2026.158187_bib0059","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1186\/s12967-022-03566-6","article-title":"Evidence of pyroptosis and ferroptosis extensively involved in autoimmune diseases at the single-cell transcriptome level","volume":"20","author":"Zhang","year":"2022","journal-title":"J. Transl. Med."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326004216?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326004216?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:53:31Z","timestamp":1790114011000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326004216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":59,"alternative-id":["S0944711326004216"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158187","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Jingfang granules alleviate atopic dermatitis by restoring skin barrier function and inhibiting NF-\u03baB\/NLRP3 axis and JAK\/STAT3 axis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158187","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158187"}}