{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:15:37Z","timestamp":1787314537951,"version":"build-2736575974"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","award":["SJCX24_1046"],"award-info":[{"award-number":["SJCX24_1046"]}],"id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274469"],"award-info":[{"award-number":["82274469"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204995"],"award-info":[{"award-number":["82204995"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.phymed.2026.158192","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T07:22:27Z","timestamp":1776237747000},"page":"158192","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Hongqi Shenmai Yin attenuates adverse cardiac remodeling following myocardial infarction via inhibition of STING-dependent PANoptosis"],"prefix":"10.1016","volume":"156","author":[{"given":"Meng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0554-7702","authenticated-orcid":false,"given":"Zhaoyang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehui","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2555-1885","authenticated-orcid":false,"given":"Haohao","family":"Bo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenhan","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juexiao","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xindong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158192_bib0001","doi-asserted-by":"crossref","first-page":"4919","DOI":"10.1038\/s41467-025-60226-1","article-title":"Ferroptosis-activating metabolite acrolein antagonizes necroptosis and anti-cancer therapeutics","volume":"16","author":"Bae","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.158192_bib0002","doi-asserted-by":"crossref","DOI":"10.1002\/pro.4213","article-title":"RCSB protein data bank: tools for visualizing and understanding biological macromolecules in 3D","volume":"31","author":"Burley","year":"2022","journal-title":"Protein Sci."},{"key":"10.1016\/j.phymed.2026.158192_bib0003","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1161\/CIRCULATIONAHA.117.031046","article-title":"Cytosolic DNA sensing promotes macrophage transformation and governs myocardial ischemic injury","volume":"137","author":"Cao","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.phymed.2026.158192_bib0004","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1042\/BJ20090598","article-title":"Polyamine catabolism and disease","volume":"421","author":"Casero","year":"2009","journal-title":"Biochem. J."},{"key":"10.1016\/j.phymed.2026.158192_bib0005","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1252942","article-title":"Tanshinone IIA inhibits cardiomyocyte pyroptosis through TLR4\/NF-\u03bab p65 pathway after acute myocardial infarction","volume":"11","author":"Chai","year":"2023","journal-title":"Front Cell Dev. Biol."},{"key":"10.1016\/j.phymed.2026.158192_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156252","article-title":"Bushen Huoxue Yiqi formula alleviates cardiac fibrosis in ischemic heart failure through SIRT1\/Notch1 pathway-mediated EndMT","volume":"135","author":"Chen","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158192_bib0007","doi-asserted-by":"crossref","first-page":"45","DOI":"10.31083\/j.fbl2803045","article-title":"Astragaloside IV inhibits NLRP3 inflammasome-mediated pyroptosis via activation of nrf-2\/HO-1 signaling pathway and protects against doxorubicin-induced cardiac dysfunction","volume":"28","author":"Chen","year":"2023","journal-title":"Front Biosci. (Landmark Ed)"},{"key":"10.1016\/j.phymed.2026.158192_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156187","article-title":"Huangqi-Danshen decoction improves heart failure by regulating pericardial adipose tissue derived extracellular vesicular miR-27a-3p to activate AMPK\u03b12 mediated mitophagy","volume":"135","author":"Chen","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158192_bib0009","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1186\/s12974-024-03302-5","article-title":"Synergistic effects of repeated transcranial magnetic stimulation and mesenchymal stem cells transplantation on alleviating neuroinflammation and PANoptosis in cerebral ischemia","volume":"21","author":"Cheng","year":"2024","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.phymed.2026.158192_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112373","article-title":"ZBP1-mediated PANoptosis: a possible novel mechanism underlying the therapeutic effects of penehyclidine hydrochloride on myocardial ischemia-reperfusion injury","volume":"137","author":"Cui","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2026.158192_bib0011","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1152\/physrev.00022.2018","article-title":"Fundamental mechanisms of regulated cell death and implications for heart disease","volume":"99","author":"Del Re","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.phymed.2026.158192_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115614","article-title":"IRG1 prevents excessive inflammatory responses and cardiac dysfunction after myocardial injury","volume":"213","author":"Duan","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158192_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2022.04.006","article-title":"The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis","volume":"55","author":"Erttmann","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.phymed.2026.158192_bib0014","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3892\/ijmm.2021.4991","article-title":"Tanshinone\u2011IIA inhibits myocardial infarct via decreasing of the mitochondrial apoptotic signaling pathway in myocardiocytes","volume":"48","author":"Fang","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.phymed.2026.158192_bib0015","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.phrs.2017.05.020","article-title":"Renin angiotensin aldosterone inhibition in the treatment of cardiovascular disease","volume":"125","author":"Ferrario","year":"2017","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2026.158192_bib0016","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nrcardio.2014.28","article-title":"The inflammatory response in myocardial injury, repair, and remodelling","volume":"11","author":"Frangogiannis","year":"2014","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.phymed.2026.158192_bib0017","doi-asserted-by":"crossref","first-page":"10L","DOI":"10.1016\/j.amjcard.2005.09.060","article-title":"Drugs for left ventricular remodeling in heart failure","volume":"96","author":"Frigerio","year":"2005","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.phymed.2026.158192_bib0018","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s10741-010-9181-7","article-title":"Left ventricular remodeling in the post-infarction heart: a review of cellular, molecular mechanisms, and therapeutic modalities","volume":"16","author":"Gajarsa","year":"2011","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.phymed.2026.158192_bib0019","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/3087469","article-title":"Caspase-3 deletion promotes necrosis in atherosclerotic plaques of ApoE knockout mice","volume":"2016","author":"Grootaert","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.phymed.2026.158192_bib0020","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.7150\/thno.84049","article-title":"iNOS aggravates pressure overload-induced cardiac dysfunction via activation of the cytosolic-mtDNA-mediated cGAS-STING pathway","volume":"13","author":"Guo","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.phymed.2026.158192_bib0021","doi-asserted-by":"crossref","first-page":"60","DOI":"10.21010\/ajtcam.v13i4.10","article-title":"In vivo and IN vitro immunomodulatory and anti-inflammatory effects of total flavonoids of Astragalus","volume":"13","author":"Guo","year":"2016","journal-title":"Afric. J. Tradition., Complement. Alternat. Med."},{"key":"10.1016\/j.phymed.2026.158192_bib0022","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ijcard.2007.07.163","article-title":"Polyamine metabolism in rat myocardial ischemia-reperfusion injury","volume":"132","author":"Han","year":"2009","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.phymed.2026.158192_bib0023","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232112906","article-title":"The role of inflammation in cardiovascular disease","volume":"23","author":"Henein","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158192_bib0024","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s42003-018-0237-x","article-title":"Z-DNA and Z-RNA in human disease","volume":"2","author":"Herbert","year":"2019","journal-title":"Commun. Biol."},{"key":"10.1016\/j.phymed.2026.158192_bib0025","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1161\/CIRCRESAHA.124.323658","article-title":"Repair of the infarcted heart: cellular effectors, molecular mechanisms and therapeutic opportunities","volume":"134","author":"Hilgendorf","year":"2024","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2026.158192_bib0026","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.csbj.2023.11.049","article-title":"PANoptosis signaling enables broad immune response in psoriasis: from pathogenesis to new therapeutic strategies","volume":"23","author":"Hu","year":"2024","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.phymed.2026.158192_bib0027","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1093\/eurheartj\/ehac661","article-title":"Late outcomes of ST-elevation myocardial infarction treated by pharmaco-invasive or primary percutaneous coronary intervention","volume":"44","author":"Jamal","year":"2023","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.phymed.2026.158192_bib0028","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1161\/CIRCULATIONAHA.121.057549","article-title":"Cardiac resident macrophage-derived legumain improves Cardiac repair by promoting clearance and degradation of apoptotic cardiomyocytes after myocardial infarction","volume":"145","author":"Jia","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.phymed.2026.158192_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.11.025","article-title":"Synergism of TNF-\u03b1 and IFN-\u03b3 triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and Cytokine shock syndromes","volume":"184","author":"Karki","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2026.158192_bib0030","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1084\/jem.20170550","article-title":"ZBP1\/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death","volume":"214","author":"Kesavardhana","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.phymed.2026.158192_bib0031","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1126\/science.aav4011","article-title":"VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease","volume":"366","author":"Kim","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.phymed.2026.158192_bib0032","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/s12276-023-00965-7","article-title":"Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway","volume":"55","author":"Kim","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.phymed.2026.158192_bib0033","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1038\/nm.4428","article-title":"IRF3 and type I interferons fuel a fatal response to myocardial infarction","volume":"23","author":"King","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.phymed.2026.158192_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122474","article-title":"Cardiac injury activates STING signaling via upregulating SIRT6 in macrophages after myocardial infarction","volume":"341","author":"Kong","year":"2024","journal-title":"Life Sci"},{"key":"10.1016\/j.phymed.2026.158192_bib0035","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00540-013-1716-3","article-title":"Combination of necroptosis and apoptosis inhibition enhances cardioprotection against myocardial ischemia-reperfusion injury","volume":"28","author":"Koshinuma","year":"2014","journal-title":"J. Anesth."},{"key":"10.1016\/j.phymed.2026.158192_bib0036","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41586-021-03875-8","article-title":"AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence","volume":"597","author":"Lee","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2026.158192_bib0037","article-title":"Landscape of RNA-binding proteins in diagnostic utility, immune cell infiltration and PANoptosis features of heart failure","volume":"13","author":"Li","year":"2022","journal-title":"Front Genet."},{"key":"10.1016\/j.phymed.2026.158192_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113874","article-title":"Conductive bioadhesive hydrogel with controlled astragaloside IV release for ferroptosis-mediated cardiac repair","volume":"384","author":"Li","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.phymed.2026.158192_bib0039","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/s41419-020-03120-6","article-title":"GDF11 inhibits cardiomyocyte pyroptosis and exerts cardioprotection in acute myocardial infarction mice by upregulation of transcription factor HOXA3","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.phymed.2026.158192_bib0040","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1097\/WNR.0000000000001998","article-title":"Alpha-lipoic acid (ALA) ameliorates early brain injury after subarachnoid hemorrhage in Sprague-Dawley (SD) rats via inhibiting STING-NLRP3 inflammatory signaling","volume":"35","author":"Lin","year":"2024","journal-title":"Neuroreport"},{"key":"10.1016\/j.phymed.2026.158192_bib0041","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.122.321587","article-title":"Critical role of the cGAS-STING pathway in doxorubicin-induced cardiotoxicity","volume":"132","author":"Luo","year":"2023","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2026.158192_bib0042","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1084\/jem.20171922","article-title":"TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation","volume":"215","author":"Malireddi","year":"2018","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.phymed.2026.158192_bib0043","doi-asserted-by":"crossref","DOI":"10.1161\/CIR.0000000000001209","article-title":"2024 heart disease and stroke statistics: a report of US and global data from the American heart association","volume":"149","author":"Martin","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.phymed.2026.158192_bib0044","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/eurheartj\/ehad486","article-title":"Inflammation in acute myocardial infarction: the good, the bad and the ugly","volume":"45","author":"Matter","year":"2024","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.phymed.2026.158192_bib0045","doi-asserted-by":"crossref","DOI":"10.1126\/science.aao6047","article-title":"BAK\/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis","volume":"359","author":"McArthur","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.phymed.2026.158192_bib0046","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41419-022-04664-5","article-title":"STING agonist diABZI induces PANoptosis and DNA mediated acute respiratory distress syndrome (ARDS)","volume":"13","author":"Messaoud-Nacer","year":"2022","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.phymed.2026.158192_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.coi.2024.102489","article-title":"Inflammasomes and their role in PANoptosomes","volume":"91","author":"Nadella","year":"2024","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.phymed.2026.158192_bib0048","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1038\/s41423-023-01107-9","article-title":"Integrated NLRP3, AIM2, NLRC4, pyrin inflammasome activation and assembly drive PANoptosis","volume":"20","author":"Oh","year":"2023","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.phymed.2026.158192_bib0049","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.molmed.2023.10.001","article-title":"Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes","volume":"30","author":"Pandeya","year":"2024","journal-title":"Trend. Mol. Med."},{"key":"10.1016\/j.phymed.2026.158192_bib0050","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12967-023-03873-6","article-title":"GSDMD-mediated pyroptosis dominantly promotes left ventricular remodeling and dysfunction in post-myocardial infarction: a comparison across modes of programmed cell death and mitochondrial involvement","volume":"21","author":"Piamsiri","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.phymed.2026.158192_bib0051","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.3390\/biomedicines10051016","article-title":"The impact of RIPK1 kinase inhibition on atherogenesis: a genetic and a pharmacological approach","volume":"10","author":"Puylaert","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.phymed.2026.158192_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156784","article-title":"The extract of chrysanthemum flos mitigates post-stroke sarcopenia by inhibiting PANoptosis and restoring muscle homeostasis","volume":"142","author":"Qi","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158192_bib0053","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3389\/fcimb.2020.00238","article-title":"The PANoptosome: a deadly protein complex driving pyroptosis, apoptosis, and necroptosis (PANoptosis)","volume":"10","author":"Samir","year":"2020","journal-title":"Front Cell Infect Microbiol."},{"key":"10.1016\/j.phymed.2026.158192_bib0054","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20220809","article-title":"Innate immune signaling drives late cardiac toxicity following DNA-damaging cancer therapies","volume":"220","author":"Shamseddine","year":"2023","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.phymed.2026.158192_bib0055","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/7580731","article-title":"Kaempferol attenuates myocardial ischemic injury via inhibition of MAPK signaling pathway in experimental model of myocardial ischemia-reperfusion injury","volume":"2016","author":"Suchal","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.phymed.2026.158192_bib0056","article-title":"Astragaloside IV ameliorates myocardial infarction induced apoptosis and restores cardiac function","volume":"9","author":"Sun","year":"2021","journal-title":"Front Cell Dev. Biol."},{"key":"10.1016\/j.phymed.2026.158192_bib0057","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/imr.13279","article-title":"PANoptosis: mechanisms, biology, and role in disease","volume":"321","author":"Sun","year":"2024","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.phymed.2026.158192_bib0058","article-title":"Activation of the cGAS-STING-IRF3 axis by type I and II interferons contributes to host defense","volume":"11","author":"Tong","year":"2024","journal-title":"Adv. Sci. (Weinheim, Baden-Wurttemberg, Germany)"},{"key":"10.1016\/j.phymed.2026.158192_bib0059","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jchf.2019.08.014","article-title":"Left ventricular post-infarct remodeling: implications for systolic function improvement and outcomes in the modern era","volume":"8","author":"Van der Bijl","year":"2020","journal-title":"JACC Heart Fail."},{"key":"10.1016\/j.phymed.2026.158192_bib0060","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.4103\/NRR.NRR-D-24-00674","article-title":"Voltage-dependent anion channel 1 oligomerization regulates PANoptosis in retinal ischemia-reperfusion injury","volume":"21","author":"Wan","year":"2026","journal-title":"Neural Regen Res."},{"key":"10.1016\/j.phymed.2026.158192_bib0061","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.phymed.2008.07.013","article-title":"The in vitro and in vivo antiviral effects of salidroside from Rhodiola rosea L. against coxsackievirus B3","volume":"16","author":"Wang","year":"2009","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158192_bib0062","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.carbpol.2014.04.061","article-title":"A polysaccharide from Salvia miltiorrhiza Bunge improves immune function in gastric cancer rats","volume":"111","author":"Wang","year":"2014","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.phymed.2026.158192_bib0063","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.tips.2024.06.002","article-title":"PANoptosis: a novel target for cardiovascular diseases","volume":"45","author":"Xiang","year":"2024","journal-title":"Trend. Pharmacol. Sci."},{"key":"10.1016\/j.phymed.2026.158192_bib0064","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.tem.2023.10.010","article-title":"Regulated cell death in myocardial ischemia-reperfusion injury","volume":"35","author":"Xiang","year":"2024","journal-title":"Trend. Endocrinol. Metab."},{"key":"10.1016\/j.phymed.2026.158192_bib0065","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s12964-023-01216-y","article-title":"Decreased MFN2 activates the cGAS-STING pathway in diabetic myocardial ischaemia-reperfusion by triggering the release of mitochondrial DNA","volume":"21","author":"Xiong","year":"2023","journal-title":"Cell Communicat. Signal."},{"key":"10.1016\/j.phymed.2026.158192_bib0066","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1447546","article-title":"Combination decoction of Astragalus mongholicus and Salvia miltiorrhiza mitigates pressure-overload cardiac dysfunction by inhibiting multiple ferroptosis pathways","volume":"15","author":"Xu","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158192_bib0067","doi-asserted-by":"crossref","first-page":"357","DOI":"10.4103\/1673-5374.346545","article-title":"PANoptosis-like cell death in ischemia\/reperfusion injury of retinal neurons","volume":"18","author":"Yan","year":"2023","journal-title":"Neural Regen Res."},{"key":"10.1016\/j.phymed.2026.158192_bib0068","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.1016\/j.apsb.2025.06.014","article-title":"Targeted inhibition of macrophage STING signaling alleviates inflammatory injury and ventricular remodeling in acute myocardial infarction","volume":"15","author":"Yao","year":"2025","journal-title":"Acta. Pharm Sin B"},{"key":"10.1016\/j.phymed.2026.158192_bib0069","article-title":"The role of RIPK3-regulated cell death pathways and necroptosis in the pathogenesis of cardiac ischaemia-reperfusion injury","volume":"231","author":"Ying","year":"2021","journal-title":"Acta. Physiol. (Oxf. Engl.)"},{"key":"10.1016\/j.phymed.2026.158192_bib0070","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41401-024-01376-8","article-title":"Baicalin inhibits PANoptosis by blocking mitochondrial Z-DNA formation and ZBP1-PANoptosome assembly in macrophages","volume":"46","author":"You","year":"2025","journal-title":"Acta. Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2026.158192_bib0071","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13020-024-00908-y","article-title":"The combination of Tanshinone IIA and Astragaloside IV attenuates myocardial ischemia-reperfusion injury by inhibiting the STING pathway","volume":"19","author":"Zhai","year":"2024","journal-title":"Chin. Med."},{"key":"10.1016\/j.phymed.2026.158192_bib0072","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115751","article-title":"Uncovering the molecular mechanisms of Curcumae Rhizoma against myocardial fibrosis using network pharmacology and experimental validation","volume":"300","author":"Zhang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158192_bib0073","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1161\/CIRCULATIONAHA.123.068595","article-title":"Extracellular RIPK3 acts as a damage-associated molecular pattern to exaggerate cardiac ischemia\/reperfusion injury","volume":"150","author":"Zhang","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.phymed.2026.158192_bib0074","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1080\/15384101.2022.2093598","article-title":"Astragaloside IV attenuate MI-induced myocardial fibrosis and cardiac remodeling by inhibiting ROS\/caspase-1\/GSDMD signaling pathway","volume":"21","author":"Zhang","year":"2022","journal-title":"Cell Cycle"},{"key":"10.1016\/j.phymed.2026.158192_bib0075","doi-asserted-by":"crossref","first-page":"4053","DOI":"10.2147\/DDDT.S326024","article-title":"The synergistic effects of Astragalus mongholicus and salvia miltiorrhiza on coronary heart disease identified by network pharmacology and experiment","volume":"15","author":"Zhang","year":"2021","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.phymed.2026.158192_bib0076","article-title":"Inhibition of GSDMD activates poly(ADP-ribosyl)ation and promotes myocardial ischemia-reperfusion injury","volume":"2022","author":"Zhang","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.phymed.2026.158192_bib0077","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1089\/ars.2019.7796","article-title":"Dihydrotanshinone I attenuates plaque vulnerability in apolipoprotein E-deficient mice: role of receptor-interacting protein 3","volume":"34","author":"Zhao","year":"2021","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.phymed.2026.158192_bib0078","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8815349","article-title":"Pharmacological modulation of cardiac remodeling after myocardial infarction","volume":"2020","author":"Zhao","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.phymed.2026.158192_bib0079","first-page":"556","article-title":"Schisandrin B protects against myocardial ischemia\/reperfusion injury via the PI3K\/akt pathway in rats","volume":"17","author":"Zhao","year":"2018","journal-title":"Mol. Med. Report."},{"key":"10.1016\/j.phymed.2026.158192_bib0080","article-title":"Mitophagy deficiency activates stimulator of interferon genes activation and aggravates pathogenetic cardiac remodeling","volume":"11","author":"Zhou","year":"2024","journal-title":"Genes Dis"},{"key":"10.1016\/j.phymed.2026.158192_bib0081","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s40360-025-00908-0","article-title":"Kaempferol inhibits cardiomyocyte pyroptosis via promoting O-GlcNAcylation of GSDME and improved acute myocardial infarction","volume":"26","author":"Zhou","year":"2025","journal-title":"BMC Pharmacol. Toxicol."},{"key":"10.1016\/j.phymed.2026.158192_bib0082","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s12964-025-02145-8","article-title":"Neutrophil extracellular trap-derived double-stranded RNA aggravates PANoptosis in renal ischemia reperfusion injury","volume":"23","author":"Zhuang","year":"2025","journal-title":"Cell Communicat. Signal."},{"key":"10.1016\/j.phymed.2026.158192_bib0083","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.tcb.2020.05.006","article-title":"Regulation and consequences of cGAS activation by self-DNA","volume":"30","author":"Zierhut","year":"2020","journal-title":"Trend. Cell Biol"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326004265?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326004265?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:29:15Z","timestamp":1780068555000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326004265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":83,"alternative-id":["S0944711326004265"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158192","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hongqi Shenmai Yin attenuates adverse cardiac remodeling following myocardial infarction via inhibition of STING-dependent PANoptosis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158192","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158192"}}