{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:09:22Z","timestamp":1790114962660,"version":"4.0.1"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai Municipality","doi-asserted-by":"publisher","award":["25ZR1402577"],"award-info":[{"award-number":["25ZR1402577"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372434"],"award-info":[{"award-number":["82372434"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82502955"],"award-info":[{"award-number":["82502955"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.phymed.2026.158197","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T20:32:12Z","timestamp":1776285132000},"page":"158197","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Friedelin suppresses osteoclastogenesis via sequential dual-targeting of p105 processing and STAT3-mediated metabolic reprogramming"],"prefix":"10.1016","volume":"155","author":[{"given":"Xuanrui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1518-125X","authenticated-orcid":false,"given":"Xiaoyu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunpei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoqin","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanrong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuhui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7201-221X","authenticated-orcid":false,"given":"Zheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengbo","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.phymed.2026.158197_bib0001","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1111\/j.2042-7158.2011.01300.x","article-title":"Anti-inflammatory, analgesic and antipyretic effects of friedelin isolated from Azima tetracantha Lam. in mouse and rat models","volume":"63","author":"Antonisamy","year":"2011","journal-title":"J. Pharm. Pharmacol."},{"issue":"2","key":"10.1016\/j.phymed.2026.158197_bib0002","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.abb.2008.03.018","article-title":"Functions of RANKL\/RANK\/OPG in bone modeling and remodeling","volume":"473","author":"Boyce","year":"2008","journal-title":"Arch. Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.phymed.2026.158197_bib0003","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1136\/ard-2022-223626","article-title":"L-arginine metabolism inhibits arthritis and inflammatory bone loss","volume":"83","author":"Cao","year":"2024","journal-title":"Ann. Rheum. Dis."},{"issue":"104)","key":"10.1016\/j.phymed.2026.158197_bib0004","article-title":"A mechanistic overview of triptolide and celastrol, natural products from tripterygium wilfordii Hook F","volume":"9","author":"Chen","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158197_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153254","article-title":"An herbal formula inhibits STAT3 signaling and attenuates bone erosion in collagen-induced arthritis rats","volume":"76","author":"Chen","year":"2020","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.phymed.2026.158197_bib0006","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1002\/art.23417","article-title":"Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: a twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial","volume":"58","author":"Cohen","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.phymed.2026.158197_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155054","article-title":"Celastrol as an intestinal FXR inhibitor triggers tripolide-induced intestinal bleeding: underlying mechanism of gastrointestinal injury induced by Tripterygium wilfordii","volume":"121","author":"Dai","year":"2023","journal-title":"Phytomedicine"},{"issue":"10416","key":"10.1016\/j.phymed.2026.158197_bib0008","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/S0140-6736(23)01525-8","article-title":"Rheumatoid arthritis","volume":"402","author":"Di Matteo","year":"2023","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.phymed.2026.158197_bib0009","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1136\/ard.2009.112920","article-title":"Effects of denosumab on bone mineral density and bone turnover in patients with rheumatoid arthritis receiving concurrent glucocorticoids or bisphosphonates","volume":"69","author":"Dore","year":"2010","journal-title":"Ann. Rheum. Dis."},{"issue":"4","key":"10.1016\/j.phymed.2026.158197_bib0010","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nrrheum.2011.23","article-title":"Advances in osteoclast biology: old findings and new insights from mouse models","volume":"7","author":"Edwards","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.phymed.2026.158197_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106405","article-title":"Efficacy of tripterygium glycosides (TG) in rheumatoid arthritis as a disease-modifying anti-rheumatic drug (DMARD) in combination with conventional DMARDs: a systematic review and meta-analysis of randomized controlled trials","volume":"184","author":"Feng","year":"2022","journal-title":"Pharmacol. Res."},{"issue":"2","key":"10.1016\/j.phymed.2026.158197_bib0012","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00198-010-1326-y","article-title":"Do RANKL inhibitors (denosumab) affect inflammation and immunity?","volume":"22","author":"Ferrari-Lacraz","year":"2011","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.phymed.2026.158197_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154813","article-title":"Toxic effects of Tripterygium glycoside tablets on the reproductive system of male rats by metabolomics, cytotoxicity, and molecular docking","volume":"114","author":"Ge","year":"2023","journal-title":"Phytomedicine"},{"issue":"6","key":"10.1016\/j.phymed.2026.158197_bib0014","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1056\/NEJMra2103726","article-title":"Rheumatoid arthritis - common origins, divergent mechanisms","volume":"388","author":"Gravallese","year":"2023","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.phymed.2026.158197_bib0015","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12964-022-00924-1","article-title":"STAT3-mediated osteogenesis and osteoclastogenesis in osteoporosis","volume":"20","author":"Hou","year":"2022","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.phymed.2026.158197_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157110","article-title":"Celastrol derivatives ameliorate arthritis in AIA rats via modulating calcium signaling","volume":"146","author":"Huang","year":"2025","journal-title":"Phytomedicine"},{"issue":"11","key":"10.1016\/j.phymed.2026.158197_bib0017","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/nm1197-1285","article-title":"Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2","volume":"3","author":"Iotsova","year":"1997","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.phymed.2026.158197_bib0018","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1002\/art.21824","article-title":"Preliminary evidence for a structural benefit of the new bisphosphonate zoledronic acid in early rheumatoid arthritis","volume":"54","author":"Jarrett","year":"2006","journal-title":"Arthritis Rheum."},{"issue":"8","key":"10.1016\/j.phymed.2026.158197_bib0019","doi-asserted-by":"crossref","DOI":"10.3390\/nu14081673","article-title":"Friedelin alleviates the pathogenesis of collagenase-induced tendinopathy in mice by promoting the selective autophagic degradation of p65","volume":"14","author":"Jiang","year":"2022","journal-title":"Nutrients"},{"issue":"11","key":"10.1016\/j.phymed.2026.158197_bib0020","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1136\/ard-2023-224898","article-title":"Itaconate is a metabolic regulator of bone formation in homeostasis and arthritis","volume":"83","author":"Kieler","year":"2024","journal-title":"Ann. Rheum. Dis."},{"issue":"5","key":"10.1016\/j.phymed.2026.158197_bib0021","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1136\/annrheumdis-2012-202958","article-title":"Bone loss before the clinical onset of rheumatoid arthritis in subjects with anticitrullinated protein antibodies","volume":"73","author":"Kleyer","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.phymed.2026.158197_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156232","article-title":"Jinwu Jiangu capsule attenuates rheumatoid arthritis via the SLC7A11\/GSH\/GPX4 pathway in M1 macrophages","volume":"135","author":"Ling","year":"2024","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.phymed.2026.158197_bib0023","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.cell.2015.05.011","article-title":"Treatment of obesity with celastrol","volume":"161","author":"Liu","year":"2015","journal-title":"Cell"},{"issue":"10086","key":"10.1016\/j.phymed.2026.158197_bib0024","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1016\/S0140-6736(17)31472-1","article-title":"Pathogenetic insights from the treatment of rheumatoid arthritis","volume":"389","author":"McInnes","year":"2017","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.phymed.2026.158197_bib0025","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1093\/rheumatology\/41.7.741","article-title":"Methotrexate in the treatment of rheumatoid arthritis. II. In vivo effects on bone mineral density","volume":"41","author":"Minaur","year":"2002","journal-title":"Rheumatol. (Oxf.)"},{"issue":"1","key":"10.1016\/j.phymed.2026.158197_bib0026","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/cr.2010.159","article-title":"Role of NF-\u03baB in the skeleton","volume":"21","author":"Novack","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.phymed.2026.158197_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104354","article-title":"Effects of biological and targeted synthetic DMARDs on bone loss in rheumatoid arthritis","volume":"147","author":"Orsolini","year":"2019","journal-title":"Pharmacol. Res."},{"issue":"5","key":"10.1016\/j.phymed.2026.158197_bib0028","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00281-019-00757-0","article-title":"Metabolic reprogramming in osteoclasts","volume":"41","author":"Park-Min","year":"2019","journal-title":"Semin. Immunopathol."},{"issue":"10","key":"10.1016\/j.phymed.2026.158197_bib0029","doi-asserted-by":"crossref","first-page":"706","DOI":"10.14348\/molcells.2017.0225","article-title":"Current understanding of RANK signaling in osteoclast differentiation and maturation","volume":"40","author":"Park","year":"2017","journal-title":"Mol. Cells"},{"issue":"9773","key":"10.1016\/j.phymed.2026.158197_bib0030","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/S0140-6736(10)62349-5","article-title":"Osteoporosis: now and the future","volume":"377","author":"Rachner","year":"2011","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.phymed.2026.158197_bib0031","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/s41584-025-01323-9","article-title":"Mechanisms of osteoclast activation in inflammatory bone loss in rheumatoid arthritis","volume":"22","author":"Rauner","year":"2026","journal-title":"Nat. Rev. Rheumatol."},{"issue":"2","key":"10.1016\/j.phymed.2026.158197_bib0032","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0092-8674(92)90353-E","article-title":"The precursor of NF-kappa B p50 has I kappa B-like functions","volume":"71","author":"Rice","year":"1992","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.phymed.2026.158197_bib0033","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00198-020-05664-x","article-title":"Methotrexate osteopathy: five cases and systematic literature review","volume":"32","author":"Robin","year":"2021","journal-title":"Osteoporos. Int."},{"issue":"1","key":"10.1016\/j.phymed.2026.158197_bib0034","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/s41413-025-00437-w","article-title":"Inflammatory macrophage-derived itaconate inhibits DNA demethylase TET2 to prevent excessive osteoclast activation in rheumatoid arthritis","volume":"13","author":"Rong","year":"2025","journal-title":"Bone Res."},{"issue":"10","key":"10.1016\/j.phymed.2026.158197_bib0035","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1084\/jem.20042081","article-title":"I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss","volume":"201","author":"Ruocco","year":"2005","journal-title":"J. Exp. Med."},{"issue":"4","key":"10.1016\/j.phymed.2026.158197_bib0036","article-title":"STAT3 signaling pathway in health and disease","volume":"6","author":"Samad","year":"2025","journal-title":"MedComm (2020)"},{"issue":"23","key":"10.1016\/j.phymed.2026.158197_bib0037","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28237760","article-title":"Friedelin: structure, biosynthesis, extraction, and its potential health impact","volume":"28","author":"Singh","year":"2023","journal-title":"Molecules"},{"issue":"10055","key":"10.1016\/j.phymed.2026.158197_bib0038","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2026.158197_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114705","article-title":"A comprehensive review on celastrol, triptolide and triptonide: insights on their pharmacological activity, toxicity, combination therapy, new dosage form and novel drug delivery routes","volume":"162","author":"Song","year":"2023","journal-title":"Biomed. PharmacOther"},{"issue":"7","key":"10.1016\/j.phymed.2026.158197_bib0040","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41574-024-00969-x","article-title":"Metabolic regulation of skeletal cell fate and function","volume":"20","author":"Stegen","year":"2024","journal-title":"Nat. Rev. Endocrinol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158197_bib0041","article-title":"Rheumatoid arthritis, disease-modifying antirheumatic drugs and risk of major osteoporotic fracture: prospective data from the HUNT Study","volume":"10","author":"Tronstad","year":"2024","journal-title":"Nor. RMD Open"},{"issue":"1","key":"10.1016\/j.phymed.2026.158197_bib0042","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00774-020-01162-6","article-title":"Osteoclast differentiation by RANKL and OPG signaling pathways","volume":"39","author":"Udagawa","year":"2021","journal-title":"J. Bone Min. Metab."},{"key":"10.1016\/j.phymed.2026.158197_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102643","article-title":"The role and mechanism of triptolide, a potential new DMARD, in the treatment of rheumatoid arthritis","volume":"104","author":"Wang","year":"2025","journal-title":"Ageing Res. Rev."},{"issue":"9","key":"10.1016\/j.phymed.2026.158197_bib0044","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.tips.2024.07.003","article-title":"Targeting the STAT3 pathway with STAT3 degraders","volume":"45","author":"Wang","year":"2024","journal-title":"Trends. Pharmacol. Sci."},{"issue":"3","key":"10.1016\/j.phymed.2026.158197_bib0045","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/s41423-021-00791-9","article-title":"Metabolism of tissue macrophages in homeostasis and pathology","volume":"19","author":"Wculek","year":"2022","journal-title":"Cell Mol. Immunol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158197_bib0046","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1186\/s13018-019-1492-3","article-title":"Zoledronic acid ameliorates the effects of secondary osteoporosis in rheumatoid arthritis patients","volume":"14","author":"Xie","year":"2019","journal-title":"J. Orthop. Surg. Res."},{"issue":"2","key":"10.1016\/j.phymed.2026.158197_bib0047","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1359\/jbmr.2003.18.2.260","article-title":"Expression of either NF-kappaB p50 or p52 in osteoclast precursors is required for IL-1-induced bone resorption","volume":"18","author":"Xing","year":"2003","journal-title":"J. Bone Min. Res."},{"key":"10.1016\/j.phymed.2026.158197_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155311","article-title":"Jolkinolide B ameliorates rheumatoid arthritis by regulating the JAK2\/STAT3 signaling pathway","volume":"124","author":"Yan","year":"2024","journal-title":"Phytomedicine"},{"issue":"42","key":"10.1016\/j.phymed.2026.158197_bib0049","doi-asserted-by":"crossref","first-page":"15395","DOI":"10.1074\/jbc.RA119.010139","article-title":"STAT3 controls osteoclast differentiation and bone homeostasis by regulating NFATc1 transcription","volume":"294","author":"Yang","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2026.158197_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154875","article-title":"Tubson-2 decoction ameliorates rheumatoid arthritis complicated with osteoporosis in CIA rats involving isochlorogenic acid A regulating IL-17\/MAPK pathway","volume":"116","author":"Yang","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158197_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156254","article-title":"Guizhi Shaoyao Zhimu decoction inhibits neutrophil extracellular traps formation to relieve rheumatoid arthritis via gut microbial outer membrane vesicles","volume":"136","author":"Ye","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158197_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154048","article-title":"Lactate metabolism in rheumatoid arthritis: pathogenic mechanisms and therapeutic intervention with natural compounds","volume":"100","author":"Yi","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158197_bib0053","first-page":"0784","article-title":"Visomitin attenuates pathological bone loss by reprogramming osteoclast metabolism via the STAT3\/LDHB Axis","volume":"8","author":"Yuan","year":"2025","journal-title":"Res. (Wash DC)"},{"issue":"3","key":"10.1016\/j.phymed.2026.158197_bib0054","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1002\/med.21762","article-title":"Tripterygium wilfordii: an inspiring resource for rheumatoid arthritis treatment","volume":"41","author":"Zhang","year":"2021","journal-title":"Med. Res. Rev."},{"issue":"12","key":"10.1016\/j.phymed.2026.158197_bib0055","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1038\/s12276-025-01591-1","article-title":"A novel DCSTAMP antagonist impedes preosteoclast fusion via modulation of RAP1B-RAC1-mediated cytoskeletal remodeling","volume":"57","author":"Zhang","year":"2025","journal-title":"Exp. Mol. Med."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326004320?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326004320?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:56:52Z","timestamp":1790114212000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326004320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":55,"alternative-id":["S0944711326004320"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158197","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Friedelin suppresses osteoclastogenesis via sequential dual-targeting of p105 processing and STAT3-mediated metabolic reprogramming","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158197","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158197"}}