{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T13:55:30Z","timestamp":1784901330587,"version":"3.55.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074137"],"award-info":[{"award-number":["82074137"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574734"],"award-info":[{"award-number":["82574734"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374177"],"award-info":[{"award-number":["82374177"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010226","name":"Department of Education of Guangdong Province","doi-asserted-by":"publisher","award":["2022ZDZX2032"],"award-info":[{"award-number":["2022ZDZX2032"]}],"id":[{"id":"10.13039\/501100010226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515220068"],"award-info":[{"award-number":["2022A1515220068"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.phymed.2026.158204","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T08:54:03Z","timestamp":1776243243000},"page":"158204","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Lithocarpus litseifolius and trilobatin ameliorate diabetic nephropathy through alleviating carbonyl stress by inhibiting AGEs\/RAGE\/NF-\u03baB pathway"],"prefix":"10.1016","volume":"156","author":[{"given":"Xue-Min","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Mei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Xin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Yue","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Die-Yi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Qiang","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Tong","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Mei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0364-2220","authenticated-orcid":false,"given":"Dan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158204_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2022.110635","article-title":"The expanding impact of methylglyoxal on behavior-related disorders","volume":"120","author":"Almeida","year":"2023","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.phymed.2026.158204_bib0002","doi-asserted-by":"crossref","first-page":"10999","DOI":"10.1021\/acs.analchem.1c02225","article-title":"Sensitive measurement of drug-target engagement by a cellular thermal shift assay with multiplex proximity extension readout","volume":"93","author":"Al-Amin","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.phymed.2026.158204_bib0003","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s40520-025-03156-8","article-title":"The use of SGLT2 inhibitors in older people: what is important?","volume":"37","author":"Armentaro","year":"2025","journal-title":"Aging Clin. Exp. Res."},{"key":"10.1016\/j.phymed.2026.158204_bib0004","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.pharmthera.2017.02.030","article-title":"Advanced glycation end-products produced systemically and by macrophages: a common contributor to inflammation and degenerative diseases","volume":"177","author":"Byun","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2026.158204_bib0005","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.cmet.2018.08.014","article-title":"The role of advanced glycation end products in aging and metabolic diseases: bridging association and causality","volume":"28","author":"Chaudhuri","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.phymed.2026.158204_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115088","article-title":"Advances in the pharmacological study of Chinese herbal medicine to alleviate diabetic nephropathy by improving mitochondrial oxidative stress","volume":"165","author":"Chen","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2026.158204_bib0007","first-page":"900","article-title":"Advances in intelligent mass spectrometry data processing technology for in vivo analysis of natural medicines","volume":"22","author":"Chen","year":"2024","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.phymed.2026.158204_bib0008","doi-asserted-by":"crossref","first-page":"5899","DOI":"10.1039\/D2FO00245K","article-title":"Effects of natural dihydrochalcones in sweet tea (Lithocarpus polystachyus) on diabetes: a systematical review and meta-analysis of animal studies","volume":"13","author":"Chen","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2026.158204_bib0009","article-title":"Hepatoprotective effects of sweet tea and trilobatin against alcohol-induced acute liver injury in mice","volume":"3","author":"Chen","year":"2025","journal-title":"Food Med. Homol."},{"key":"10.1016\/j.phymed.2026.158204_bib0010","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bcp.2018.06.017","article-title":"MicroRNA: A new generation therapeutic target in diabetic nephropathy","volume":"155","author":"Dewanjee","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158204_bib0011","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.pharmthera.2016.11.013","article-title":"Cardiac oxidative stress in diabetes: mechanisms and therapeutic potential","volume":"172","author":"Faria","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2026.158204_bib0012","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1038\/s41401-022-00888-5","article-title":"Trilobatin rescues cognitive impairment of Alzheimer's disease by targeting HMGB1 through mediating SIRT3\/SOD2 signaling pathway","volume":"43","author":"Gao","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2026.158204_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.115927","article-title":"Ginsenoside Rh2 mitigates hepatic gluconeogenesis by regulating Akt\/FoxO1 pathway in type 2 diabetic mice","volume":"168","author":"Gao","year":"2026","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2026.158204_bib0014","article-title":"A review and a bibliometric analysis of tropical herbs and their bioactive compounds for modulating gut microbiota function and glucose regulation in type 2 diabetes","volume":"2","author":"Ghazaly","year":"2025","journal-title":"Food Med. Homol."},{"key":"10.1016\/j.phymed.2026.158204_bib0015","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/MNH.0000000000000465","article-title":"Methylglyoxal stress, the glyoxalase system, and diabetic chronic kidney disease","volume":"28","author":"Hanssen","year":"2019","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.phymed.2026.158204_bib0016","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41398-021-01392-w","article-title":"Glyoxalase I disruption and external carbonyl stress impair mitochondrial function in human induced pluripotent stem cells and derived neurons","volume":"11","author":"Hara","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.phymed.2026.158204_bib0017","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1039\/D1FO03636J","article-title":"Inhibition of alpha-glucosidase by trilobatin and its mechanism: kinetics, interaction mechanism and molecular docking","volume":"13","author":"He","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2026.158204_bib0018","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/jpp\/rgae035","article-title":"Trilobatin regulates glucose metabolism by ameliorating oxidative stress and insulin resistance in vivo and in vitro","volume":"77","author":"He","year":"2025","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158204_bib0019","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/cr.2015.139","article-title":"Gasdermin D is an executor of pyroptosis and required for interleukin-1beta secretion","volume":"25","author":"He","year":"2015","journal-title":"Cell Res."},{"key":"10.1016\/j.phymed.2026.158204_bib0020","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252111432","article-title":"Effect of buddleja cordata leaf extract on diabetic nephropathy in rats","volume":"25","author":"Hern\u00e1ndez","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158204_bib0021","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1007\/s12272-018-1061-z","article-title":"D-ribose induces nephropathy through RAGE-dependent NF-kappaB inflammation","volume":"41","author":"Hong","year":"2018","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.phymed.2026.158204_bib0022","article-title":"Lithocarpus litseifolius (Hance) Chun, widely known as sweet tea, promotes neuronal differentiation and maturation of neural stem\/progenitor cells","volume":"355","author":"Jiang","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158204_bib0023","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s00125-024-06108-5","article-title":"Circulating metabolomic markers linking diabetic kidney disease and incident cardiovascular disease in type 2 diabetes: analyses from the Hong Kong Diabetes Biobank","volume":"67","author":"Jin","year":"2024","journal-title":"Diabetologia"},{"key":"10.1016\/j.phymed.2026.158204_bib0024","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1185317","article-title":"Oxidative stress and inflammation in diabetic nephropathy: role of polyphenols","volume":"14","author":"Jin","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2026.158204_bib0025","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5511881","article-title":"Cudrania tricuspidata root extract prevents methylglyoxal-induced inflammation and oxidative stress via regulation of the PKC-NOX4 pathway in Human kidney cells","volume":"2021","author":"Kim","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.phymed.2026.158204_bib0026","doi-asserted-by":"crossref","first-page":"9800","DOI":"10.3390\/ijms22189800","article-title":"Treatment response to SGLT2 inhibitors: from clinical characteristics to genetic variations","volume":"22","author":"Klen","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158204_bib0027","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1016\/j.cell.2024.03.006","article-title":"A glycolytic metabolite bypasses \"two-hit\" tumor suppression by BRCA2","volume":"187","author":"Kong","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2026.158204_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111369","article-title":"The protective effects of moscatilin against methylglyoxal-induced neurotoxicity via the regulation of p38\/JNK MAPK pathways in PC12 neuron-like cells","volume":"140","author":"Lai","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2026.158204_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.146142","article-title":"Role of gasotransmitters in pyroptosis","volume":"322","author":"Li","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2026.158204_bib0030","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.yrtph.2017.07.006","article-title":"Evaluation of toxicity studies of flavonoid fraction of lithocarpus polystachyus Rehd in rodents","volume":"88","author":"Liang","year":"2017","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158204_bib0031","article-title":"Relevance of the pyroptosis-related inflammasome pathway in the pathogenesis of diabetic kidney disease","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2026.158204_bib0032","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/s41419-023-06005-6","article-title":"Pyroptosis in renal inflammation and fibrosis: current knowledge and clinical significance","volume":"14","author":"Liu","year":"2023","journal-title":"Cell Death. Dis."},{"key":"10.1016\/j.phymed.2026.158204_bib0034","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/med.21410","article-title":"Methylglyoxal in metabolic disorders: facts, myths, and promises","volume":"37","author":"Matafome","year":"2017","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.phymed.2026.158204_bib0035","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1038\/s41467-021-23625-8","article-title":"Synergistic sequence contributions bias glycation outcomes","volume":"12","author":"McEwen","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.158204_bib0036","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1681\/ASN.0000000531","article-title":"Damage-associated molecular patterns and pattern recognition receptors in the podocyte","volume":"36","author":"Myette","year":"2025","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phymed.2026.158204_bib0037","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.3390\/antiox10081327","article-title":"Enzymatic production of 3-OH phlorizin, a possible bioactive polyphenol from apples, by Bacillus megaterium CYP102A1 via regioselective hydroxylation","volume":"10","author":"Nguyen","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2026.158204_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2021.109118","article-title":"IDF diabetes Atlas: global estimates of undiagnosed diabetes in adults for 2021","volume":"183","author":"Ogurtsova","year":"2022","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.phymed.2026.158204_bib0039","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.redox.2013.12.016","article-title":"Role of advanced glycation end products in cellular signaling","volume":"2","author":"Ott","year":"2014","journal-title":"Redox Biol."},{"key":"10.1016\/j.phymed.2026.158204_bib0040","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.26599\/FSHW.2022.9250094","article-title":"Effects of Maillard reaction and its product AGEs on aging and age-related diseases","volume":"13","author":"Peng","year":"2024","journal-title":"Food Sci. Hum. Wellness"},{"key":"10.1016\/j.phymed.2026.158204_bib0041","article-title":"Formation of advanced glycation end products by novel food processing technologies: a review","volume":"393","author":"Prestes","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.phymed.2026.158204_bib0042","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1042\/CS20160025","article-title":"Methylglyoxal-induced dicarbonyl stress in aging and disease: first steps towards glyoxalase 1-based treatments","volume":"130","author":"Rabbani","year":"2016","journal-title":"Clin. Sci."},{"key":"10.1016\/j.phymed.2026.158204_bib0043","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.148109","article-title":"Twist1 in podocytes ameliorates podocyte injury and proteinuria by limiting CCL2-dependent macrophage infiltration","volume":"6","author":"Ren","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.phymed.2026.158204_bib0044","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1152\/physrev.00001.2019","article-title":"Methylglyoxal, a highly reactive dicarbonyl compound, in diabetes, its vascular complications, and other age-related diseases","volume":"100","author":"Schalkwijk","year":"2020","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.phymed.2026.158204_bib0045","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1080\/10408398.2020.1830363","article-title":"Sweet tea (Lithocarpus polystachyus rehd.) as a new natural source of bioactive dihydrochalcones with multiple health benefits","volume":"62","author":"Shang","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.phymed.2026.158204_bib0046","doi-asserted-by":"crossref","first-page":"891","DOI":"10.3390\/nu13030891","article-title":"Effect of trilobatin from lithocarpus polystachyus rehd on gut microbiota of obese rats induced by a high-fat diet","volume":"13","author":"Shen","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.158204_bib0047","article-title":"Trilobatin, a natural food additive, exerts anti-type 2 diabetes effect mediated by Nrf2\/ARE and IRS-1\/GLUT2 signaling pathways","volume":"13","author":"Shi","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158204_bib0048","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.freeradbiomed.2017.02.003","article-title":"Chemistry and analysis of HNE and other prominent carbonyl-containing lipid oxidation compounds","volume":"111","author":"Sousa","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2026.158204_bib0049","article-title":"Transformation from traditional medicine-food homology to modern food-medicine homology","volume":"1","author":"Sun-Waterhouse","year":"2024","journal-title":"Food Med. Homol."},{"key":"10.1016\/j.phymed.2026.158204_bib0050","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/cvr\/cvae079","article-title":"NLRP3 inflammasome-mediated premature immunosenescence drives diabetic vascular aging dependent on the induction of perivascular adipose tissue dysfunction","volume":"121","author":"Tai","year":"2025","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.phymed.2026.158204_bib0051","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1016\/j.apsb.2020.12.020","article-title":"Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management","volume":"11","author":"Tang","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2026.158204_bib0052","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1021\/acs.jafc.0c07748","article-title":"Simultaneous determination of multiple reactive carbonyl species in high fat diet-induced metabolic disordered mice and the inhibitory effects of rosemary on carbonyl stress","volume":"69","author":"Tang","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2026.158204_bib0053","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1681\/ASN.2005040393","article-title":"Linking metabolism and immunology: diabetic nephropathy is an inflammatory disease","volume":"16","author":"Tuttle","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phymed.2026.158204_bib0054","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3390\/antiox14020212","article-title":"Methylglyoxal formation-metabolic routes and consequences","volume":"14","author":"Vaskova","year":"2025","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2026.158204_bib0055","doi-asserted-by":"crossref","first-page":"925","DOI":"10.3390\/antiox9100925","article-title":"Oxidative stress markers in chronic kidney disease with emphasis on diabetic nephropathy","volume":"9","author":"Vodosek","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2026.158204_bib0056","article-title":"Phytochemicals and bioactive analysis of different sweet tea (Lithocarpus litseifolius [Hance] Chun) varieties","volume":"45","author":"Wang","year":"2021","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.phymed.2026.158204_bib0057","doi-asserted-by":"crossref","first-page":"20496","DOI":"10.1021\/acs.jafc.4c05185","article-title":"Ocotillol-type pseudoginsenoside-F11 alleviates lipopolysaccharide-induced acute kidney injury through regulation of macrophage function by suppressing the NF-\u03baB\/NLRP3\/IL-1\u03b2 signaling pathway","volume":"72","author":"Wang","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2026.158204_bib0058","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1016\/j.apsb.2021.12.023","article-title":"Gentiopicroside targets PAQR3 to activate the PI3K\/AKT signaling pathway and ameliorate disordered glucose and lipid metabolism","volume":"12","author":"Xiao","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2026.158204_bib0059","article-title":"Trilobatin, a naturally occurring food additive, ameliorates exhaustive exercise-induced fatigue in mice: involvement of Nrf2\/ARE\/ferroptosis signaling pathway","volume":"13","author":"Xiao","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158204_bib0060","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9570616","article-title":"Advanced glycation end products: potential mechanism and therapeutic target in cardiovascular complications under diabetes","volume":"2019","author":"Yang","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.phymed.2026.158204_bib0062","first-page":"254","article-title":"Protective role of the curcumin derivative, FM0807, in regulating JAK2\/STAT3 and TGF-\u03b21\/SMAD2\/3 signaling pathways in glomerular mesangial cells and renal function in db\/db mice","volume":"3","author":"Zhang","year":"2024","journal-title":"Acta Mater. Med."},{"key":"10.1016\/j.phymed.2026.158204_bib0064","doi-asserted-by":"crossref","first-page":"13948","DOI":"10.1021\/acs.jafc.9b05910","article-title":"A new possible mechanism by which Punicalagin protects against liver injury induced by type 2 diabetes mellitus: upregulation of autophagy via the Akt\/FoxO3a signaling pathway","volume":"67","author":"Zhang","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2026.158204_bib0063","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1002\/fsn3.2165","article-title":"Hypoglycemic and hypolipidemic activities of phlorizin from Lithocarpus polystachyus Rehd in diabetes rats","volume":"9","author":"Zhang","year":"2021","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.phymed.2026.158204_bib0065","doi-asserted-by":"crossref","first-page":"10943","DOI":"10.1021\/acs.jafc.1c03582","article-title":"Metabolic profiling of carbonyl compounds for unveiling protective mechanisms of pueraria lobata against diabetic nephropathy by UPLC-Q-Orbitrap HRMS\/MS analysis","volume":"69","author":"Zhang","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2026.158204_bib0066","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175291","article-title":"Trilobatin alleviates non-alcoholic fatty liver disease in high-fat diet plus streptozotocin-induced diabetic mice by suppressing NLRP3 inflammasome activation","volume":"933","author":"Zhang","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158204_bib0067","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155743","article-title":"Phlorizin from Lithocarpus litseifolius [Hance] Chun ameliorates FFA-induced insulin resistance by regulating AMPK\/PI3K\/AKT signaling pathway","volume":"130","author":"Zhao","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158204_bib0068","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2025.344091","article-title":"Cell-based surface plasmon resonance approach for monitoring the inhibitory effect of Evasin-3 on Interleukin-8","volume":"1359","author":"Zhao","year":"2025","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.phymed.2026.158204_bib0069","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1039\/c3ay41288a","article-title":"Characterization of phenolic constituents in lithocarpus polystachyus","volume":"6","author":"Zhao","year":"2014","journal-title":"Anal. Methods"},{"key":"10.1016\/j.phymed.2026.158204_bib0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118787","article-title":"Huang-Lian-Jie-Du decoction alleviates diabetic encephalopathy by regulating inflammation and pyroptosis via suppression of AGEs\/RAGE\/NF-kappaB pathways","volume":"337","author":"Zhuang","year":"2025","journal-title":"J. Ethnopharmacol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326004393?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326004393?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:24:12Z","timestamp":1780068252000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326004393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":68,"alternative-id":["S0944711326004393"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158204","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lithocarpus litseifolius and trilobatin ameliorate diabetic nephropathy through alleviating carbonyl stress by inhibiting AGEs\/RAGE\/NF-\u03baB pathway","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158204","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158204"}}