{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T16:04:45Z","timestamp":1780070685266,"version":"3.54.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["D18007"],"award-info":[{"award-number":["D18007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32172921"],"award-info":[{"award-number":["32172921"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32302935"],"award-info":[{"award-number":["32302935"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD1801100"],"award-info":[{"award-number":["2023YFD1801100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012222","name":"Jiangsu Institute of Educational Science Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012222","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.phymed.2026.158218","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T14:53:19Z","timestamp":1776523999000},"page":"158218","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Narciclasine alleviates zearalenone-induced focal adhesion damage and anoikis in rat Sertoli cells through PI3K signaling pathway"],"prefix":"10.1016","volume":"156","author":[{"given":"Peirong","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nannan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhong","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuezhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8023-0751","authenticated-orcid":false,"given":"Jianchun","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158218_bib0001","first-page":"1163","article-title":"Focal adhesion kinase: protein interactions and cellular functions","volume":"17","author":"Abbi","year":"2002","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.phymed.2026.158218_bib0002","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24021578","article-title":"Estrogenic and non-Estrogenic disruptor effect of zearalenone on male reproduction: a review","volume":"24","author":"Ball\u00f3","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158218_bib0003","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/tox.23694","article-title":"Zearalenone damages the male reproductive system of rats by destroying testicular focal adhesion","volume":"38","author":"Cai","year":"2023","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.phymed.2026.158218_bib0004","doi-asserted-by":"crossref","first-page":"60276","DOI":"10.1007\/s11356-021-14052-9","article-title":"N-acetylcysteine ameliorate cytotoxic injury in piglets sertoli cells induced by zearalenone and deoxynivalenol","volume":"28","author":"Cao","year":"2021","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.phymed.2026.158218_bib0005","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/1873-3468.14291","article-title":"Lysophosphatidylcholine disrupts cell adhesion and induces anoikis in hepatocytes","volume":"596","author":"Chen","year":"2022","journal-title":"FEBS Lett."},{"key":"10.1016\/j.phymed.2026.158218_bib0006","first-page":"621","article-title":"The PI3K\/AKT signaling pathway: how does it regulate development of sertoli cells and spermatogenic cells?","volume":"37","author":"Chen","year":"2022","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.phymed.2026.158218_bib0007","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.bcp.2008.07.023","article-title":"Anoikis: a necessary death program for anchorage-dependent cells","volume":"76","author":"Chiarugi","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158218_bib0008","doi-asserted-by":"crossref","first-page":"35622","DOI":"10.1074\/jbc.M804036200","article-title":"Focal adhesion kinase as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protection","volume":"283","author":"Del Re","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2026.158218_bib0009","first-page":"539","article-title":"The Role of the PI3K\/AKT\/mTOR Signalling Pathway in Male Reproduction","volume":"21","author":"Deng","year":"2021","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.phymed.2026.158218_bib0010","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1080\/21655979.2020.1795424","article-title":"Narciclasine attenuates LPS-induced acute lung injury in neonatal rats through suppressing inflammation and oxidative stress","volume":"11","author":"Duan","year":"2020","journal-title":"Bioengineered"},{"key":"10.1016\/j.phymed.2026.158218_bib0011","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/andr.12165","article-title":"The Sertoli cell: one hundred fifty years of beauty and plasticity","volume":"4","author":"Fran\u00e7a","year":"2016","journal-title":"Andrology."},{"key":"10.1016\/j.phymed.2026.158218_bib0012","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1083\/jcb.124.4.619","article-title":"Disruption of epithelial cell-matrix interactions induces apoptosis","volume":"124","author":"Frisch","year":"1994","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.phymed.2026.158218_bib0013","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0955-0674(97)80124-X","article-title":"Integrins and anoikis","volume":"9","author":"Frisch","year":"1997","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.phymed.2026.158218_bib0014","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1055\/s-0042-115034","article-title":"Narciclasine - an amaryllidaceae alkaloid with potent antitumor and anti-Inflammatory properties","volume":"82","author":"F\u00fcrst","year":"2016","journal-title":"Planta Med."},{"key":"10.1016\/j.phymed.2026.158218_bib0015","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.fct.2018.04.011","article-title":"Prenatal exposure to zearalenone disrupts reproductive potential and development via hormone-related genes in male rats","volume":"116","author":"Gao","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2026.158218_bib0016","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1038\/sj.cdd.4401723","article-title":"Anoikis","volume":"12","author":"Gilmore","year":"2005","journal-title":"Cell death differ."},{"key":"10.1016\/j.phymed.2026.158218_bib0017","first-page":"189","article-title":"Metabolism: narciclasine boosts energy metabolism","volume":"13","author":"Greenhill","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"issue":"3","key":"10.1016\/j.phymed.2026.158218_bib0018","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1023\/A:1015312119693","article-title":"Molecular mechanisms of \"detachment-induced apoptosis\u2013Anoikis\"","volume":"7","author":"Grossmann","year":"2002","journal-title":"Apoptosis"},{"key":"10.1016\/j.phymed.2026.158218_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynpai.2019.100037","article-title":"Alleviation of paclitaxel-induced mechanical hypersensitivity and hyperalgesic priming with AMPK activators in male and female mice","volume":"6","author":"Inyang","year":"2019","journal-title":"Neurobiol. Pain."},{"key":"10.1016\/j.phymed.2026.158218_bib0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1002597","article-title":"Narciclasine attenuates diet-induced obesity by promoting oxidative metabolism in skeletal muscle","volume":"15","author":"Julien","year":"2017","journal-title":"PLoS. Biol."},{"key":"10.1016\/j.phymed.2026.158218_bib0021","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.2741\/2168","article-title":"Junction interaction in the seminiferous epithelium: regulatory roles of connexin-based gap junction","volume":"12","author":"Lee","year":"2007","journal-title":"Front. Biosci."},{"key":"10.1016\/j.phymed.2026.158218_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112457","article-title":"Male reproductive toxicity of zearalenone-meta-analysis with mechanism review","volume":"221","author":"Li","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.phymed.2026.158218_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112457","article-title":"Male reproductive toxicity of zearalenone-meta-analysis with mechanism review","volume":"221","author":"Li","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.phymed.2026.158218_bib0024","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/135608","article-title":"Angiopoietin-like 3 induces podocyte F-actin rearrangement through integrin \u03b1(V)\u03b2\u2083\/FAK\/PI3K pathway-mediated Rac1 activation","volume":"2013","author":"Lin","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.phymed.2026.158218_bib0025","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.mvr.2011.05.003","article-title":"Focal adhesion kinase and endothelial cell apoptosis","volume":"83","author":"Lu","year":"2012","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.phymed.2026.158218_bib0026","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1007\/s00204-016-1704-0","article-title":"Biomonitoring of the mycotoxin Zearalenone: current state-of-the art and application to human exposure assessment","volume":"90","author":"Mally","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.phymed.2026.158218_bib0027","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.bbamcr.2004.02.008","article-title":"Regulation of Bcl-2 proteins during anoikis and amorphosis","volume":"1692","author":"Martin","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.phymed.2026.158218_bib0028","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.toxicon.2012.04.333","article-title":"Brown spider (Loxosceles intermedia) venom triggers endothelial cells death by anoikis","volume":"60","author":"Nowatzki","year":"2012","journal-title":"Toxicon."},{"key":"10.1016\/j.phymed.2026.158218_bib0029","first-page":"1034","article-title":"Impact of zearalenone on male fertility: an update","volume":"22","author":"Pang","year":"2016","journal-title":"Zhonghua Nan. Ke Xue"},{"key":"10.1016\/j.phymed.2026.158218_bib0030","first-page":"153","article-title":"The sertoli cell\u2013a hormonal target and 'super' nurse for germ cells that determines testicular size","volume":"66","author":"Petersen","year":"2006","journal-title":"Horm. Res."},{"key":"10.1016\/j.phymed.2026.158218_bib0031","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1177\/0192623314547279","article-title":"Postnatal development of the testis in the rat: morphologic study and correlation of morphology to neuroendocrine parameters","volume":"43","author":"Picut","year":"2015","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.phymed.2026.158218_bib0032","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1080\/10408398.2019.1655388","article-title":"Occurrence and toxicity of a fusarium mycotoxin, zearalenone","volume":"60","author":"Rai","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.phymed.2026.158218_bib0033","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.toxicon.2019.03.004","article-title":"Zearalenone and its metabolites: effect on human health, metabolism and neutralisation methods","volume":"162","author":"Rogowska","year":"2019","journal-title":"Toxicon"},{"key":"10.1016\/j.phymed.2026.158218_bib0034","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3390\/toxins13010035","article-title":"Zearalenone and its metabolites-General overview, occurrence, and toxicity","volume":"13","author":"Ropejko","year":"2021","journal-title":"Toxins"},{"key":"10.1016\/j.phymed.2026.158218_bib0035","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/aja.1001880104","article-title":"A comparative study in twelve mammalian species of volume densities, volumes, and numerical densities of selected testis components, emphasizing those related to the Sertoli cell","volume":"188","author":"Russell","year":"1990","journal-title":"Am. J. Anat."},{"key":"10.1016\/j.phymed.2026.158218_bib0036","doi-asserted-by":"crossref","first-page":"17638","DOI":"10.1074\/jbc.M111575200","article-title":"Distinct role of phosphatidylinositol 3-kinase and Rho family GTPases in Vav3-induced cell transformation, cell motility, and morphological changes","volume":"277","author":"Sachdev","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2026.158218_bib0037","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/1541-4337.12657","article-title":"The fate of mycotoxins during secondary food processing of maize for human consumption","volume":"20","author":"Schaarschmidt","year":"2021","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"10.1016\/j.phymed.2026.158218_bib0038","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1095\/biolreprod.104.028225","article-title":"Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis","volume":"71","author":"Siu","year":"2004","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.phymed.2026.158218_bib0039","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.ecoenv.2018.04.046","article-title":"The detoxification effect of vitamin C on zearalenone toxicity in piglets","volume":"158","author":"Su","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.phymed.2026.158218_bib0040","article-title":"Does probiotic Kefir reduce dyslipidemia, hematological disorders and oxidative stress induced by zearalenone toxicity in wistar rats?","volume":"14","author":"Taheur","year":"2022","journal-title":"Toxicon. X."},{"key":"10.1016\/j.phymed.2026.158218_bib0041","article-title":"Kefir mitigates renal damage caused by zearalenone in female wistar rats by reducing oxidative stress","volume":"243","author":"Taheur","year":"2024","journal-title":"Toxicon"},{"key":"10.1016\/j.phymed.2026.158218_bib0042","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3390\/toxins12080495","article-title":"Individual and combined in vitro effects of deoxynivalenol and zearalenone on boar semen","volume":"12","author":"Tassis","year":"2026","journal-title":"Toxins"},{"key":"10.1016\/j.phymed.2026.158218_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellimm.2022.104631","article-title":"Narciclasine ameliorated T cell mediated acute liver injury through activating AMPK pathway","volume":"382","author":"Tian","year":"2022","journal-title":"Cell Immunol."},{"key":"10.1016\/j.phymed.2026.158218_bib0044","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/med.21253","article-title":"Narciclasine as well as other amaryllidaceae isocarbostyrils are promising GTP-ase targeting agents against brain cancers","volume":"33","author":"Van Goietsenoven","year":"2013","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.phymed.2026.158218_bib0045","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3390\/toxins10100398","article-title":"The effects of autophagy and PI3K\/AKT\/m-TOR signaling pathway on the cell-cycle arrest of rats primary sertoli cells Induced by zearalenone","volume":"10","author":"Wang","year":"2018","journal-title":"Toxins"},{"key":"10.1016\/j.phymed.2026.158218_bib0046","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3390\/toxins10110477","article-title":"Occurrence and quantitative risk assessment of twelve mycotoxins in eggs and chicken tissues in China","volume":"10","author":"Wang","year":"2018","journal-title":"Toxins"},{"key":"10.1016\/j.phymed.2026.158218_bib0047","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1016\/j.yexcr.2007.05.010","article-title":"RhoG regulates anoikis through a phosphatidylinositol 3-kinase-dependent mechanism","volume":"313","author":"Yamaki","year":"2007","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.phymed.2026.158218_bib0048","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.fct.2019.02.031","article-title":"Effects of zearalenone and its derivatives on the synthesis and secretion of mammalian sex steroid hormones: a review","volume":"126","author":"Zheng","year":"2019","journal-title":"Food Chem. Toxicol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326004526?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326004526?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:23:51Z","timestamp":1780068231000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326004526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":48,"alternative-id":["S0944711326004526"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158218","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Narciclasine alleviates zearalenone-induced focal adhesion damage and anoikis in rat Sertoli cells through PI3K signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158218","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158218"}}