{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T16:04:08Z","timestamp":1780070648743,"version":"3.54.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001407","name":"India Ministry of Science & Technology Department of Biotechnology","doi-asserted-by":"publisher","award":["BT\/PR47609\/CMD\/150\/19\/2023"],"award-info":[{"award-number":["BT\/PR47609\/CMD\/150\/19\/2023"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014824","name":"Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014824","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.phymed.2026.158219","type":"journal-article","created":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T14:53:08Z","timestamp":1776610388000},"page":"158219","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Rhynchophylline inhibits cluster of differentiation 36 (CD36) on endothelial cells to reduce fibrotic scar formation and enhance functional recovery after spinal cord injury"],"prefix":"10.1016","volume":"156","author":[{"given":"Manjeet","family":"Chopra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhi","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenal","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Goyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saumya","family":"Kapoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Shard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6434-0245","authenticated-orcid":false,"given":"Hemant","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158219_bib0001","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3389\/fneur.2019.00282","article-title":"Traumatic spinal cord injury: an overview of pathophysiology, models and acute injury mechanisms","volume":"10","author":"Alizadeh","year":"2019","journal-title":"Front. Neurol."},{"key":"10.1016\/j.phymed.2026.158219_bib0002","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1089\/neu.2006.23.635","article-title":"Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains","volume":"23","author":"Basso","year":"2006","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.phymed.2026.158219_bib0003","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The Protein Data Bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic. Acids. Res."},{"key":"10.1016\/j.phymed.2026.158219_bib0004","first-page":"1","article-title":"Imperatorin, a natural furanocoumarin alleviates chronic neuropathic pain by targeting GABAergic tone in an animal model of spinal cord injury","volume":"0","author":"Butt","year":"2024","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.phymed.2026.158219_bib0005","article-title":"The beneficial pharmacological effects of Uncaria rhynchophylla in neurodegenerative diseases: focus on alkaloids","volume":"15","author":"Chen","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158219_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2025.104387","article-title":"Navigating the complexities of spinal cord injury: an overview of pathology, treatment strategies and clinical trials","volume":"30","author":"Chopra","year":"2025","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.phymed.2026.158219_bib0007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/neurosci3010001","article-title":"Blood-spinal cord barrier: its role in spinal disorders and emerging therapeutic strategies","volume":"3","author":"Chopra","year":"2022","journal-title":"NeuroSci."},{"key":"10.1016\/j.phymed.2026.158219_bib0008","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neuroscience.2021.12.038","article-title":"Ethamsylate attenuates mutilated secondary pathogenesis and exhibits a neuroprotective role in experimental model of spinal cord injury","volume":"484","author":"Dolma","year":"2022","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.phymed.2026.158219_bib0009","doi-asserted-by":"crossref","first-page":"512","DOI":"10.4103\/1673-5374.380821","article-title":"Role of CD36 in central nervous system diseases","volume":"19","author":"Feng","year":"2024","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.phymed.2026.158219_bib0010","doi-asserted-by":"crossref","first-page":"6177","DOI":"10.1021\/jm051256o","article-title":"Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes","volume":"49","author":"Friesner","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.phymed.2026.158219_bib0011","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13081170","article-title":"Recent advances in the anti-inflammatory activity of plant-derived alkaloid rhynchophylline in neurological and cardiovascular diseases","volume":"13","author":"Geetha","year":"2021","journal-title":"Pharmaceutics."},{"key":"10.1016\/j.phymed.2026.158219_bib0012","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s12264-022-00897-8","article-title":"Spatiotemporal dynamics of the molecular expression pattern and intercellular interactions in the glial scar response to spinal cord injury","volume":"39","author":"Gong","year":"2023","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.phymed.2026.158219_bib0013","article-title":"Inhibition of CD44 suppresses the formation of fibrotic scar after spinal cord injury via the JAK2\/STAT3 signaling pathway","volume":"27","author":"Guo","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.phymed.2026.158219_bib0014","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1021\/jm030644s","article-title":"Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening","volume":"47","author":"Halgren","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.phymed.2026.158219_bib0015","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1186\/s12974-021-02337-2","article-title":"Inflammation after spinal cord injury: a review of the critical timeline of signaling cues and cellular infiltration","volume":"18","author":"Hellenbrand","year":"2021","journal-title":"J. Neuroinflammation."},{"key":"10.1016\/j.phymed.2026.158219_bib0016","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12974-024-03143-2","article-title":"CD36 deletion prevents white matter injury by modulating microglia polarization through the Traf5-MAPK signal pathway","volume":"21","author":"Hou","year":"2024","journal-title":"J. Neuroinflammation."},{"key":"10.1016\/j.phymed.2026.158219_bib0017","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.31500","article-title":"Physiological insights into the role of pericytes in spinal cord injury","volume":"240","author":"Jin","year":"2025","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.phymed.2026.158219_bib0018","doi-asserted-by":"crossref","DOI":"10.1111\/ejn.70389","article-title":"Molecular changes in cspg and glial scar markers in response to subpial chondroitinase abc treatment following spinal cord injury","volume":"63","author":"Kisuck\u00e1","year":"2026","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.phymed.2026.158219_bib0019","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1523\/JNEUROSCI.2035-19.2020","article-title":"Elevated TRPV4 levels contribute to endothelial damage and scarring in experimental spinal cord injury","volume":"40","author":"Kumar","year":"2020","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phymed.2026.158219_bib0020","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1093\/brain\/aws171","article-title":"Fluoxetine inhibits matrix metalloprotease activation and prevents disruption of blood\u2013spinal cord barrier after spinal cord injury","volume":"135","author":"Lee","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.phymed.2026.158219_bib0021","article-title":"Fibrotic scar after spinal cord injury: crosstalk with other cells, cellular origin, function, and mechanism","volume":"15","author":"Li","year":"2021","journal-title":"Front. Cell Neurosci."},{"key":"10.1016\/j.phymed.2026.158219_bib0022","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1186\/s12967-025-06973-7","article-title":"Quercetin promotes angiogenesis and protects the blood-spinal cord barrier structure after spinal cord injury by targeting the PI3K\/Akt signaling pathway","volume":"23","author":"Liu","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.phymed.2026.158219_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117521","article-title":"Disruption of blood-brain barrier and endothelial-to-mesenchymal transition are attenuated by Astragalus polysaccharides mediated through upregulation of ETS1 expression in experimental autoimmune encephalomyelitis","volume":"180","author":"Lu","year":"2024","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.phymed.2026.158219_bib0024","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.expneurol.2014.03.016","article-title":"CD36 deletion improves recovery from spinal cord injury","volume":"256","author":"Myers","year":"2014","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.phymed.2026.158219_bib0025","article-title":"Maresin-1 prevents blood-spinal cord barrier disruption associated with TRPV4 elevation in the experimental model of spinal cord injury","author":"Pathak","year":"2023","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1868"},{"key":"10.1016\/j.phymed.2026.158219_bib0026","doi-asserted-by":"crossref","first-page":"4555","DOI":"10.1002\/ptr.8294","article-title":"Tangeretin alleviates inflammation and oxidative response induced by spinal cord injury by activating the Sesn2\/Keap1\/Nrf2 pathway","volume":"38","author":"Peng","year":"2024","journal-title":"PhytOther Res."},{"key":"10.1016\/j.phymed.2026.158219_bib0027","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1021\/acsptsci.3c00272","article-title":"Investigating lim (lin-11, isl-1, and mec-3) kinases and their correlation with pathological events and microtubule dynamics in an experimental model of spinal cord injury in rats","volume":"7","author":"Roy","year":"2024","journal-title":"ACS. Pharmacol. Transl. Sci."},{"key":"10.1016\/j.phymed.2026.158219_bib0028","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s10822-013-9644-8","article-title":"Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments","volume":"27","author":"Sastry","year":"2013","journal-title":"J. Comput. Aided. Mol. Des."},{"key":"10.1016\/j.phymed.2026.158219_bib0029","unstructured":"Schr\u00f6dinger Release 2023, 1, n.d. Schr\u00f6dinger Release 2023-1: Maestro, S. (LLC, 2023)., (n.d.)."},{"key":"10.1016\/j.phymed.2026.158219_bib0030","unstructured":"Schr\u00f6dinger Release 2023, 1, n.d. Schr\u00f6dinger Release 2023-1: LigPrep, S (LLC, 2023), (n.d.)."},{"key":"10.1016\/j.phymed.2026.158219_bib0031","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s11064-025-04332-y","article-title":"Exploring ubiquitination in spinal cord injury therapy: multifaceted targets and promising strategies","volume":"50","author":"Shi","year":"2025","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.phymed.2026.158219_bib0032","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.272re3","article-title":"CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior","volume":"2","author":"Silverstein","year":"2009","journal-title":"Sci. Signal."},{"key":"10.1016\/j.phymed.2026.158219_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2025.214357","article-title":"Rab27a-mediated extracellular vesicle release drives astrocytic CSPG secretion and glial scarring in spinal cord injury","volume":"176","author":"Singh","year":"2025","journal-title":"Biomater. Adv."},{"key":"10.1016\/j.phymed.2026.158219_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113276","article-title":"Regulation of autophagy by inhibitory CSPG interactions with receptor ptp\u03c3 and its impact on plasticity and regeneration after spinal cord injury","volume":"328","author":"Tran","year":"2020","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.phymed.2026.158219_bib0035","article-title":"Inhibition of CD36 ameliorates mouse spinal cord injury by accelerating microglial lipophagy","author":"Wang","year":"2025","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2026.158219_bib0036","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s12035-025-05410-6","article-title":"Salidroside-pretreated small extracellular vesicles derived from human umbilical cord mesenchymal stem cells promote blood-spinal cord barrier repair after spinal cord injury in mice","volume":"63","author":"Wang","year":"2025","journal-title":"Mol. Neurobiol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326004538?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326004538?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:20:14Z","timestamp":1780068014000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326004538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":36,"alternative-id":["S0944711326004538"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158219","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rhynchophylline inhibits cluster of differentiation 36 (CD36) on endothelial cells to reduce fibrotic scar formation and enhance functional recovery after spinal cord injury","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158219","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158219"}}