{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T10:32:12Z","timestamp":1789122732613,"version":"build-2803163510"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019034","name":"Hubei Provincial Central Guidance Local Science and Technology Development Project","doi-asserted-by":"publisher","award":["254Z7707G"],"award-info":[{"award-number":["254Z7707G"]}],"id":[{"id":"10.13039\/501100019034","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012505","name":"Hebei Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974184"],"award-info":[{"award-number":["81974184"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271366"],"award-info":[{"award-number":["82271366"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.phymed.2026.158247","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:52:05Z","timestamp":1777567925000},"page":"158247","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Rhodiosin promotes cerebral angiogenesis in mice with ischemic stroke via PI3K\/Akt pathway activation"],"prefix":"10.1016","volume":"156","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8823-9846","authenticated-orcid":false,"given":"Chaohui","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianya","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhisen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjia","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renhao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangjian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158247_bib0001","doi-asserted-by":"crossref","first-page":"4644","DOI":"10.1111\/j.1742-4658.2009.07176.x","article-title":"Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke","volume":"276","author":"Arai","year":"2009","journal-title":"FEBS. J."},{"key":"10.1016\/j.phymed.2026.158247_bib0002","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nature09522","article-title":"Pericytes regulate the blood\u2013brain barrier","volume":"468","author":"Armulik","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2026.158247_bib0003","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s00401-009-0483-6","article-title":"Angiogenesis after cerebral ischemia","volume":"117","author":"Beck","year":"2009","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.phymed.2026.158247_bib0004","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s10456-021-09818-1","article-title":"Chemerin regulates normal angiogenesis and hypoxia-driven neovascularization","volume":"25","author":"Ben Dhaou","year":"2022","journal-title":"Angiogenesis."},{"key":"10.1016\/j.phymed.2026.158247_bib0005","doi-asserted-by":"crossref","first-page":"8251","DOI":"10.1038\/s41467-023-43900-0","article-title":"Suppression of angiopoietin-like 4 reprograms endothelial cell metabolism and inhibits angiogenesis","volume":"14","author":"Chaube","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.158247_bib0006","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1001\/jamaneurol.2024.2500","article-title":"Endovascular stroke thrombectomy for patients with large ischemic core","volume":"81","author":"Chen","year":"2024","journal-title":"JAMa Neurol."},{"key":"10.1016\/j.phymed.2026.158247_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118418","article-title":"Neuroprotection of benzoinum in cerebral ischemia model rats via the ACE-AngI-VEGF pathway","volume":"260","author":"Chen","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2026.158247_bib0008","first-page":"12","article-title":"3-HKA promotes vascular remodeling after stroke by modulating the activation of A1\/A2 reactive astrocytes","author":"Chen","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.phymed.2026.158247_bib0009","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jfda.2015.04.007","article-title":"Rhodiola plants: chemistry and biological activity","volume":"23","author":"Chiang","year":"2015","journal-title":"J. Food Drug Anal."},{"key":"10.1016\/j.phymed.2026.158247_bib0010","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1161\/STROKEAHA.121.034620","article-title":"Thomas Willis Lecture: targeting brain arterioles for acute stroke treatment","volume":"52","author":"Cipolla","year":"2021","journal-title":"Stroke"},{"key":"10.1016\/j.phymed.2026.158247_bib0011","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1146\/annurev-neuro-091922-031205","article-title":"Astrocyte endfeet in brain function and pathology: open questions","volume":"46","author":"D\u00edaz-Castro","year":"2023","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.phymed.2026.158247_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102803","article-title":"Traditional Chinese herbal medicines for the treatment of ischemic stroke in China","volume":"110","author":"Dong","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.phymed.2026.158247_bib0013","doi-asserted-by":"crossref","first-page":"172","DOI":"10.4103\/bc.bc_52_22","article-title":"Neuroprotective approach in acute ischemic stroke","volume":"8","author":"Eren","year":"2022","journal-title":"Brain Circ."},{"key":"10.1016\/j.phymed.2026.158247_bib0014","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1038\/s41401-023-01061-2","article-title":"Angiogenesis after ischemic stroke","volume":"44","author":"Fang","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2026.158247_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119234","article-title":"XQ-1H promotes cerebral angiogenesis via activating PI3K\/akt\/GSK3\u03b2\/\u03b2-catenin\/VEGF signal in mice exposed to cerebral ischemic injury","volume":"272","author":"Fei","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2026.158247_bib0016","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1042\/BJ20061489","article-title":"Exploring the specificity of the PI3K family inhibitor LY294002","volume":"404","author":"Gharbi","year":"2007","journal-title":"Biochem. J."},{"key":"10.1016\/j.phymed.2026.158247_bib0017","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.cmet.2020.03.005","article-title":"Mitochondria-endoplasmic reticulum contacts in reactive astrocytes promote vascular remodeling","volume":"31","author":"G\u04e7bel","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.phymed.2026.158247_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117506","article-title":"APMCG-1 attenuates ischemic stroke injury by reducing oxidative stress and apoptosis and promoting angiogenesis via activating PI3K\/AKT pathway","volume":"180","author":"He","year":"2024","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.phymed.2026.158247_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2023.106080","article-title":"Circular RNA CircPDS5B impairs angiogenesis following ischemic stroke through its interaction with hnRNPL to inactivate VEGF-A","volume":"181","author":"Jiang","year":"2023","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.phymed.2026.158247_bib0020","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00380-011-0197-2","article-title":"Effects of erythropoietin on angiogenesis after myocardial infarction in porcine","volume":"27","author":"Kawachi","year":"2012","journal-title":"Heart Vessels"},{"key":"10.1016\/j.phymed.2026.158247_bib0021","first-page":"202","article-title":"Induction of acute ischemic stroke in mice using the distal middle cerebral artery occlusion technique","volume":"15","author":"Leng","year":"2023","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.phymed.2026.158247_bib0022","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1515\/revneuro-2022-0127","article-title":"Two-photon microscopy: application advantages and latest progress for in vivo imaging of neurons and blood vessels after ischemic stroke","volume":"34","author":"Li","year":"2023","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.phymed.2026.158247_bib0023","doi-asserted-by":"crossref","first-page":"11362","DOI":"10.1007\/s12035-025-04969-4","article-title":"Melatonin promotes cerebral angiogenesis in ischemic mice via BMP6\/Smad1\/5\/9 pathway","volume":"62","author":"Li","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phymed.2026.158247_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2024.102758","article-title":"Global, regional, and national burden of ischemic stroke, 1990\u20132021: an analysis of data from the global burden of disease study 2021","volume":"75","author":"Li","year":"2024","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.phymed.2026.158247_bib0025","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12974-023-02738-5","article-title":"Human umbilical cord-derived mesenchymal stem cell transplantation supplemented with curcumin improves the outcomes of ischemic stroke via AKT\/GSK-3\u03b2\/\u03b2-TrCP\/Nrf2 axis","volume":"20","author":"Li","year":"2023","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.phymed.2026.158247_bib0026","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12951-023-01828-z","article-title":"Comparative study of extracellular vesicles derived from mesenchymal stem cells and brain endothelial cells attenuating blood-brain barrier permeability via regulating Caveolin-1-dependent ZO-1 and Claudin-5 endocytosis in acute ischemic stroke","volume":"21","author":"Li","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.phymed.2026.158247_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116625","article-title":"Salidroside promotes angiogenesis after cerebral ischemia in mice through Shh signaling pathway","volume":"174","author":"Li","year":"2024","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.phymed.2026.158247_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157354","article-title":"Mechanism and potential targets of kaempferol alleviating photothrombotic stroke via integrating experimental validation, network pharmacology, and molecular docking","volume":"148","author":"Liu","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158247_bib0029","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s12974-022-02540-9","article-title":"A cannabidiol aminoquinone derivative activates the PP2A\/B55\u03b1\/HIF pathway and shows protective effects in a murine model of traumatic brain injury","volume":"19","author":"Navarrete","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.phymed.2026.158247_bib0030","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/biof.1499","article-title":"The inhibition of hypoxia-induced angiogenesis and metastasis by cinnamaldehyde is mediated by decreasing HIF-1\u03b1 protein synthesis via PI3K\/akt pathway","volume":"45","author":"Patra","year":"2019","journal-title":"Biofactors"},{"key":"10.1016\/j.phymed.2026.158247_bib0031","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12974-024-03026-6","article-title":"SRGN amplifies microglia-mediated neuroinflammation and exacerbates ischemic brain injury","volume":"21","author":"Qian","year":"2024","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.phymed.2026.158247_bib0032","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41392-022-01064-1","article-title":"Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions","volume":"7","author":"Qin","year":"2022","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2026.158247_bib0033","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41586-020-03116-4","article-title":"Gut-licensed ifn\u03b3+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes","volume":"590","author":"Sanmarco","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2026.158247_bib0034","first-page":"25","article-title":"Targeting the Zbp1-Ripk3 axis attenuates ischemic neuronal injury by suppressing PANoptosis","author":"Shu","year":"2025","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.phymed.2026.158247_bib0035","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1182\/blood.2021012787","article-title":"Robust thrombolytic and anti-inflammatory action of a constitutively active ADAMTS13 variant in murine stroke models","volume":"139","author":"South","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.phymed.2026.158247_bib0036","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1002\/bies.20092","article-title":"VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection","volume":"26","author":"Storkebaum","year":"2004","journal-title":"Bioessays"},{"key":"10.1016\/j.phymed.2026.158247_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurot.2025.e00735","article-title":"The GPR120 agonist TUG-891 mitigates ischemic brain injury by attenuating endoplasmic reticulum stress and apoptosis via the PI3K\/AKT signaling pathway","volume":"22","author":"Sun","year":"2025","journal-title":"Neurotherapeutics."},{"key":"10.1016\/j.phymed.2026.158247_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102852","article-title":"Remote ischemic conditioning attenuates oxidative stress and inflammation via the Nrf2\/HO-1 pathway in MCAO mice","volume":"66","author":"Sun","year":"2023","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2026.158247_bib0039","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.semcancer.2019.12.008","article-title":"Natural products targeting the PI3K-akt-mTOR signaling pathway in cancer: a novel therapeutic strategy","volume":"80","author":"Tewari","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.phymed.2026.158247_bib0040","doi-asserted-by":"crossref","first-page":"896","DOI":"10.7150\/thno.80307","article-title":"TCR\u03b1\u03b2+NK1.1-CD4-CD8-double-negative T cells inhibit central and peripheral inflammation and ameliorate ischemic stroke in mice","volume":"13","author":"Tian","year":"2023","journal-title":"Theranostics."},{"key":"10.1016\/j.phymed.2026.158247_bib0041","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/S1474-4422(22)00519-1","article-title":"Thrombolysis for acute ischaemic stroke: current status and future perspectives","volume":"22","author":"Tsivgoulis","year":"2023","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.phymed.2026.158247_bib0042","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jare.2024.02.019","article-title":"Salidroside promotes pro-angiogenesis and repair of blood brain barrier via Notch\/ITGB1 signal path in CSVD Model","volume":"68","author":"Tu","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.phymed.2026.158247_bib0043","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1038\/s41401-021-00803-4","article-title":"Catalpol improves impaired neurovascular unit in ischemic stroke rats via enhancing VEGF-PI3K\/AKT and VEGF-MEK1\/2\/ERK1\/2 signaling","volume":"43","author":"Wang","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2026.158247_bib0044","first-page":"0676","article-title":"Low-intensity pulsed ultrasound promotes oligodendrocyte maturation and remyelination by down-regulating the interleukin-17A\/Notch1 signaling pathway in mice with ischemic stroke","volume":"8","author":"Wang","year":"2025","journal-title":"Research. (Wash. D. C)"},{"key":"10.1016\/j.phymed.2026.158247_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155836","article-title":"Rhodiosin from Rhodiola crenulata effectively alleviate postprandial hyperglycemia by inhibiting both the activity and production of \u03b1glucosidase","volume":"132","author":"Wang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158247_bib0046","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s00018-023-04801-z","article-title":"The role of blood flow in vessel remodeling and its regulatory mechanism during developmental angiogenesis","volume":"80","author":"Wen","year":"2023","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.phymed.2026.158247_bib0047","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12987-025-00706-0","article-title":"Eppur si muove: the dynamic brain pericyte","volume":"22","author":"Wilhelm","year":"2025","journal-title":"Fluids. Barriers. CNS."},{"key":"10.1016\/j.phymed.2026.158247_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109048","article-title":"Reactive astrocytes facilitate vascular repair and remodeling after stroke","volume":"35","author":"Williamson","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.phymed.2026.158247_bib0049","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1158\/0008-5472.CAN-09-4355","article-title":"Drugging the PI3 kinome: from chemical tools to drugs in the clinic","volume":"70","author":"Workman","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.phymed.2026.158247_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157094","article-title":"Puerarin alleviates cerebral ischemia\/reperfusion (CIR)-induced neurocyte oxidative stress and apoptosis via DNA demethylation-mediated PI3K\/akt activation","volume":"145","author":"Xu","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158247_bib0051","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1080\/13880209.2021.1992449","article-title":"Salidroside orchestrates metabolic reprogramming by regulating the hif-1\u03b1 signalling pathway in acute mountain sickness","volume":"59","author":"Yan","year":"2021","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.phymed.2026.158247_bib0052","first-page":"16","article-title":"Bioactive compound combinations from Rhodiola tangutica alleviate pulmonary vascular remodeling in high-altitude pulmonary hypertension rats through the PI3K\u2013AKT pathway","author":"Yang","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158247_bib0053","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.105091","article-title":"The three-phase enriched environment paradigm promotes neurovascular restorative and prevents learning impairment after ischemic stroke in rats","volume":"146","author":"Zhan","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.phymed.2026.158247_bib0054","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jare.2024.07.003","article-title":"Targeting MAD2B as a strategy for ischemic stroke therapy","volume":"72","author":"Zhang","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.phymed.2026.158247_bib0055","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/s41419-021-04363-7","article-title":"Extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the TGF-\u03b2\/Smad2\/3 pathway","volume":"12","author":"Zhang","year":"2021","journal-title":"Cell Death. Dis."},{"key":"10.1016\/j.phymed.2026.158247_bib0056","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41392-023-01688-x","article-title":"Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2026.158247_bib0057","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1021\/acscentsci.3c00377","article-title":"A triple-targeted rutin-based self-assembled delivery vector for treating ischemic stroke by vascular normalization and anti-inflammation via ACE2\/Ang1-7 signaling","volume":"9","author":"Zhao","year":"2023","journal-title":"ACS. Cent. Sci."},{"key":"10.1016\/j.phymed.2026.158247_bib0058","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112719","article-title":"Therapeutic targets of neuroprotection and neurorestoration in ischemic stroke: applications for natural compounds from medicinal herbs","volume":"148","author":"Zhu","year":"2022","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.phymed.2026.158247_bib0059","first-page":"541","article-title":"Hypoxia preconditioned MSC exosomes attenuate high-altitude cerebral edema via the miR-125a-5p\/RTEF-1 axis to protect vascular endothelial cells","volume":"52","author":"Zuo","year":"2025","journal-title":"Bioact. Mater."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326004812?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326004812?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T12:30:00Z","timestamp":1783168200000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326004812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":59,"alternative-id":["S0944711326004812"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158247","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rhodiosin promotes cerebral angiogenesis in mice with ischemic stroke via PI3K\/Akt pathway activation","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158247","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"158247"}}