{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:20:26Z","timestamp":1783128026612,"version":"3.54.6"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.phymed.2026.158264","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:24:27Z","timestamp":1777875867000},"page":"158264","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Targeting the mitochondrial-associated endoplasmic reticulum membrane to regulate calcium homeostasis: ShenfuYixin Granules counteract myocardial ischemia-reperfusion injury through the sGC\/PKG pathway"],"prefix":"10.1016","volume":"156","author":[{"given":"Xiaoyu","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaibing","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangcao","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.phymed.2026.158264_bib0001","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.tcm.2022.02.005","article-title":"Myocardial ischemia-reperfusion injury and the influence of inflammation","volume":"33","author":"Algoet","year":"2023","journal-title":"Trends. Cardiovasc. Med."},{"key":"10.1016\/j.phymed.2026.158264_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2020.102343","article-title":"Mitochondria associated membranes (MAMs): architecture and physiopathological role","volume":"94","author":"Barazzuol","year":"2021","journal-title":"Cell. Calcium."},{"issue":"1","key":"10.1016\/j.phymed.2026.158264_bib0003","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/1471-2105-15-293","article-title":"Jvenn: an interactive Venn diagram viewer","volume":"15","author":"Bardou","year":"2014","journal-title":"BMC. Bioinformatics."},{"issue":"11","key":"10.1016\/j.phymed.2026.158264_bib0004","first-page":"1319","article-title":"Regulation of mitochondria-associated membranes (MAMs) by NO\/sGC\/PKG participates in the control of","volume":"8","author":"Bassot","year":"2019","journal-title":"Hepatic Insulin Response. Cells."},{"issue":"4","key":"10.1016\/j.phymed.2026.158264_bib0005","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s00395-024-01060-2","article-title":"Mitochondrial calcium in cardiac ischemia\/reperfusion injury and cardioprotection","volume":"119","author":"Bertero","year":"2024","journal-title":"Basic. Res. Cardiol."},{"issue":"2","key":"10.1016\/j.phymed.2026.158264_bib0006","doi-asserted-by":"crossref","first-page":"F322","DOI":"10.1152\/ajprenal.00533.2019","article-title":"Elucidation of cGMP-dependent induction of mitochondrial biogenesis through PKG and p38 MAPK in the kidney","volume":"318","author":"Bhargava","year":"2020","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.1016\/j.phymed.2026.158264_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.120958","article-title":"Mechanism of Shenzhu components in alleviating chemotherapy-induced diarrhea via mitochondria-associated endoplasmic reticulum membranes (MAMs) regulation","volume":"358","author":"Cao","year":"2026","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158264_bib0008","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.peptides.2018.04.016","article-title":"B-type natriuretic peptide attenuates endoplasmic reticulum stress in H9c2 cardiomyocytes underwent hypoxia\/reoxygenation injury under high glucose\/high fat conditions","volume":"111","author":"Chang","year":"2019","journal-title":"Peptides"},{"issue":"7","key":"10.1016\/j.phymed.2026.158264_bib0009","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1002\/jat.4719","article-title":"Oxidative stress and inflammation in myocardial ischemia-reperfusion I njury: protective effects of plant-derived natural active compounds","volume":"45","author":"Chen","year":"2025","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.phymed.2026.158264_bib0010","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.peptides.2017.02.008","article-title":"Exendin-4 inhibits structural remodeling and improves Ca2+ homeostasis in rats with heart failure via the GLP-1 receptor through the eNOS\/cGMP\/PKG pathway","volume":"90","author":"Chen","year":"2017","journal-title":"Peptides"},{"issue":"5","key":"10.1016\/j.phymed.2026.158264_bib0011","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1016\/j.apsb.2023.02.005","article-title":"The traditional Chinese medicines treat chronic heart failure and their main bioactive constituents and mechanisms","volume":"13","author":"Chen","year":"2023","journal-title":"Acta. Pharm. Sin. B."},{"key":"10.1016\/j.phymed.2026.158264_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115705","article-title":"Zhenwu decoction ameliorates cardiac hypertrophy through activating sGC (soluble guanylate cyclase) - cGMP (cyclic guanosine monophosphate) - PKG (protein kinase G) pathway","volume":"300","author":"Chen","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158264_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122184","article-title":"Vericiguat alleviates ventricular remodeling and arrhythmias in mouse models of myocardial infarction via CaMKII signaling","volume":"334","author":"Chen","year":"2023","journal-title":"Life. Sci."},{"issue":"1","key":"10.1016\/j.phymed.2026.158264_bib0014","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.drudis.2021.09.007","article-title":"Machine-learning methods for ligand-protein molecular docking","volume":"27","author":"Crampon","year":"2022","journal-title":"Drug. Discov. Today."},{"issue":"9","key":"10.1016\/j.phymed.2026.158264_bib0015","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.3390\/biom13091409","article-title":"Mitochondrial calcium overload playsa causal role in oxidative stress in the failing heart","volume":"13","author":"Dridi","year":"2023","journal-title":"Biomolecules"},{"issue":"8","key":"10.1016\/j.phymed.2026.158264_bib0016","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1021\/acs.jcim.8b00312","article-title":"Evaluation of AutoDock and AutoDock vina on the CASF-2013 benchmark","volume":"58","author":"Gaillard","year":"2018","journal-title":"J. Chem. Inf. Model."},{"issue":"5","key":"10.1016\/j.phymed.2026.158264_bib0017","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.3390\/ijms25052667","article-title":"Mitochondrial dysfunction in heart failure: from pathophysiological me chanisms to therapeutic opportunities","volume":"25","author":"Gallo","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158264_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2025.111629","article-title":"Zn2+ protects H9C2 cardiomyocytes by alleviating MAMs-assoc iated apoptosis and calcium signaling dysregulation","volume":"127","author":"Guo","year":"2025","journal-title":"Cell. Signal."},{"issue":"15","key":"10.1016\/j.phymed.2026.158264_bib0019","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.7150\/ijms.103986","article-title":"Enhancement of mitochondrial homeostasis: a novel approach to attenuate hypoxic myocardial injury","volume":"21","author":"Guo","year":"2024","journal-title":"Int. J. Med. Sci."},{"issue":"1\u20133","key":"10.1016\/j.phymed.2026.158264_bib0020","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ejphar.2012.07.053","article-title":"Atrial natriuretic peptide prevents the mitochondrial permeability transition pore opening by inactivating glycogen synthase kinase 3\u03b2 via P","volume":"695","author":"Hong","year":"2012","journal-title":"Eur. J. Pharmacol."},{"issue":"14","key":"10.1016\/j.phymed.2026.158264_bib0021","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.jacc.2015.02.032","article-title":"Evolving therapies for myocardial ischemia\/reperfusion injury","volume":"65","author":"Ib\u00e1\u00f1ez","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.phymed.2026.158264_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2022.110266","article-title":"Nrf2 participates in the protective effect of exogenous mitochondria against mitochondrial dysfunction in myocardial ischaemic and hypoxic injury","volume":"92","author":"Jia","year":"2022","journal-title":"Cell. Signal."},{"issue":"D1","key":"10.1016\/j.phymed.2026.158264_bib0023","doi-asserted-by":"crossref","first-page":"D1388","DOI":"10.1093\/nar\/gkaa971","article-title":"PubChem in 2021: new data content and improved web interfaces","volume":"49","author":"Kim","year":"2021","journal-title":"Nucleic. Acids. Res."},{"issue":"7","key":"10.1016\/j.phymed.2026.158264_bib0024","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0180207","article-title":"Cardioprotective effects of PKG activation by soluble GC activator, BAY 60-2770, in ischemia-reperfusion-injured rat hearts","volume":"12","author":"Lee","year":"2017","journal-title":"PLoS. One."},{"key":"10.1016\/j.phymed.2026.158264_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156503","article-title":"Shenfuyixin granules enhance mitochondrial autophagy after myocardial infarction by regulating protein deacetylation via the SIRT3\/FOXO1 signaling axis","volume":"139","author":"Li","year":"2025","journal-title":"Phytomedicine"},{"issue":"10","key":"10.1016\/j.phymed.2026.158264_bib0027","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.3390\/antiox13101158","article-title":"Signaling paradigms of H2S-induced vasodilation: a comprehe nsive review","volume":"13","author":"Munteanu","year":"2024","journal-title":"Antioxidants"},{"issue":"1","key":"10.1016\/j.phymed.2026.158264_bib0028","doi-asserted-by":"crossref","DOI":"10.1085\/jgp.202313520","article-title":"How does mitochondrial Ca2+ change during ischemia and reperfusion? Im plications for activation of the permeability transition pore","volume":"157","author":"Murphy","year":"2025","journal-title":"J. Gen. Physiol."},{"issue":"11","key":"10.1016\/j.phymed.2026.158264_bib0029","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1016\/j.cmet.2022.10.008","article-title":"Mitochondrial signal transduction","volume":"34","author":"Picard","year":"2022","journal-title":"Cell. Metab."},{"issue":"18","key":"10.1016\/j.phymed.2026.158264_bib0030","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.3390\/ijms20184331","article-title":"Molecular docking: shifting paradigms in drug discovery","volume":"20","author":"Pinzi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.phymed.2026.158264_bib0031","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.3390\/biom12121764","article-title":"Boosting the full potential of PyMOL with structural biology plugins","volume":"12","author":"Rosignoli","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.phymed.2026.158264_bib0032","doi-asserted-by":"crossref","DOI":"10.1113\/JP287770","article-title":"Mitochondrial oxidative stress, calcium and dynamics in cardiac ischae mia-reperfusion injury","author":"Rozich","year":"2025","journal-title":"J. Physiol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158264_bib0033","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12872-023-03231-w","article-title":"The global prevalence of myocardial infarction: a systematic review and meta-analysis","volume":"23","author":"Salari","year":"2023","journal-title":"BMC. Cardiovasc. Disord."},{"issue":"7","key":"10.1016\/j.phymed.2026.158264_bib0034","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1515\/hsz-2018-0155","article-title":"From molecules to patients: exploring the therapeutic role of soluble guanylate cyclase stimulators","volume":"399","author":"Sandner","year":"2018","journal-title":"Biol. Chem."},{"key":"10.1016\/j.phymed.2026.158264_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104758","article-title":"ER membranes associated with mitochondria: possible therapeutic targets in heart-associated diseases","volume":"156","author":"Silva-Palacios","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2026.158264_bib0036","article-title":"Identification of the potential biomarkers associated with circadian rhythms in heart failure","volume":"11","author":"Sun","year":"2023","journal-title":"PeerJ"},{"issue":"D1","key":"10.1016\/j.phymed.2026.158264_bib0037","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic. Acids. Res."},{"issue":"1","key":"10.1016\/j.phymed.2026.158264_bib0038","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1186\/s12967-023-04715-1","article-title":"WGX50 mitigates doxorubicin-induced cardiotoxicity through inhibition of mitochondrial ROS and ferroptosis","volume":"21","author":"Tai","year":"2023","journal-title":"J. Transl. Med."},{"issue":"7","key":"10.1016\/j.phymed.2026.158264_bib0039","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.3390\/ijms21072350","article-title":"Burn-induced cardiac mitochondrial dysfunction via interruption of the PDE5A-cGMP-PKG pathway","volume":"21","author":"Wen","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158264_bib0040","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1055248","article-title":"Research progress on effects of traditional Chinese medicine on myocardial ischemia-reperfusion injury: a review","volume":"13","author":"Xing","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158264_bib0041","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1558484","article-title":"Immune in myocardial ischemia\/reperfusion injury: potential mechanisms and therapeutic strategies","volume":"16","author":"Xuan","year":"2025","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.phymed.2026.158264_bib0042","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s11655-023-3650-z","article-title":"Shuxuening injection inhibits apoptosis and reduces myocardial ischemia-reperfusion injury in rats through PI3K\/AKT pathway","volume":"30","author":"Yue","year":"2024","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.phymed.2026.158264_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155649","article-title":"The pathological mechanisms and potential therapeutic drugs for myocardial ischemia reperfusion injury","volume":"129","author":"Zhang","year":"2024","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.phymed.2026.158264_bib0044","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41401-024-01359-9","article-title":"The correlation between mitochondria-associated endoplasmic reticulum membranes (MAMs) and Ca2+ transport in the pathogenesis of diseases","volume":"46","author":"Zhao","year":"2025","journal-title":"Acta. Pharmacol. Sin."},{"issue":"1","key":"10.1016\/j.phymed.2026.158264_bib0045","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326004988?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326004988?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:57:19Z","timestamp":1783126639000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326004988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":44,"alternative-id":["S0944711326004988"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158264","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting the mitochondrial-associated endoplasmic reticulum membrane to regulate calcium homeostasis: ShenfuYixin Granules counteract myocardial ischemia-reperfusion injury through the sGC\/PKG pathway","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158264","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"158264"}}