{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T08:18:36Z","timestamp":1783153116919,"version":"3.54.6"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204719"],"award-info":[{"award-number":["82204719"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFE0213800"],"award-info":[{"award-number":["2024YFE0213800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.phymed.2026.158265","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:22:10Z","timestamp":1777674130000},"page":"158265","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Fucoidan attenuates alcohol-induced liver injury via PON1\/HDL\/NF-\u03baB axis"],"prefix":"10.1016","volume":"156","author":[{"given":"Xindan","family":"Ai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongchuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujie","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiongchao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongkang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoming","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9208-586X","authenticated-orcid":false,"given":"Yulin","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158265_bib0001","doi-asserted-by":"crossref","first-page":"42817","DOI":"10.18632\/oncotarget.17069","article-title":"Paraoxonase-1 (PON1) induces metastatic potential and apoptosis escape via its antioxidative function in lung cancer cells","volume":"8","author":"Aldonza","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.phymed.2026.158265_bib0002","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3389\/fnagi.2020.00068","article-title":"Nuclear factor-\u03bab dysregulation and \u03b1-synuclein pathology: critical interplay in the pathogenesis of Parkinson's Disease","volume":"12","author":"Bellucci","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.phymed.2026.158265_bib0003","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1001\/jama.299.11.1265","article-title":"Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk","volume":"299","author":"Bhattacharyya","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.phymed.2026.158265_bib0004","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1194\/jlr.M300431-JLR200","article-title":"Apolipoprotein A-II regulates HDL stability and affects hepatic lipase association and activity","volume":"45","author":"Boucher","year":"2004","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.phymed.2026.158265_bib0005","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/s41586-019-1670-9","article-title":"Somatic mutations and clonal dynamics in healthy and cirrhotic human liver","volume":"574","author":"Brunner","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2026.158265_bib0006","doi-asserted-by":"crossref","first-page":"113422","DOI":"10.1016\/j.jep.2020.113422","article-title":"The effects of Gentiana dahurica Fisch on alcoholic liver disease revealed by RNA sequencing","volume":"279","author":"Cao","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158265_bib0007","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.apsb.2022.06.015","article-title":"Melatonin alleviates alcoholic liver disease via EGFR-BRG1-TERT axis regulation","volume":"13","author":"Che","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"issue":"5","key":"10.1016\/j.phymed.2026.158265_bib0008","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3390\/antiox13050529","article-title":"Oral supplementation of ozonated sunflower oil augments plasma antioxidant and anti-inflammatory abilities with enhancement of high-density lipoproteins functionality in rats","volume":"13","author":"Cho","year":"2024","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.phymed.2026.158265_bib0009","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ijbiomac.2019.07.119","article-title":"Characterization and screening of anti-tumor activity of fucoidan from acid-processed hijiki (Hizikia fusiforme)","volume":"139","author":"Dai","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2026.158265_bib0010","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.ijbiomac.2020.05.143","article-title":"Fucoidan from acid-processed Hizikia fusiforme attenuates oxidative damage and regulate apoptosis","volume":"160","author":"Dai","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2026.158265_bib0011","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.3390\/ijms21113858","article-title":"Relevance of SIRT1-NF-\u03bab axis as therapeutic target to ameliorate inflammation in liver disease","volume":"21","author":"de Gregorio","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158265_bib0012","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adt6195","article-title":"Hepatic NMNAT1 is required to defend against alcohol-associated fatty liver disease","volume":"11","author":"Ding","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.phymed.2026.158265_bib0013","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.biocel.2005.07.010","article-title":"Recombinant hep G2 cells that express alcohol dehydrogenase and cytochrome P450 2E1 as a model of ethanol-elicited cytotoxicity","volume":"38","author":"Donohue","year":"2006","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"4","key":"10.1016\/j.phymed.2026.158265_bib0014","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3390\/antiox14040430","article-title":"How does HDL participate in atherogenesis? Antioxidant activity versus role in reverse cholesterol transport","volume":"14","author":"Durrington","year":"2025","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.phymed.2026.158265_bib0015","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.biochi.2004.09.018","article-title":"SREBP transcription factors: master regulators of lipid homeostasis","volume":"86","author":"Eberl\u00e9","year":"2004","journal-title":"Biochimie"},{"key":"10.1016\/j.phymed.2026.158265_bib0016","first-page":"1126","article-title":"The human serum paraoxonase\/arylesterase polymorphism","volume":"35","author":"Eckerson","year":"1983","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.phymed.2026.158265_bib0017","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.semcdb.2017.07.011","article-title":"Developmental and extrahepatic physiological functions of SREBP pathway genes in mice","volume":"81","author":"Engelking","year":"2018","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.phymed.2026.158265_bib0018","doi-asserted-by":"crossref","first-page":"49","DOI":"10.5114\/ceh.2020.93057","article-title":"The effect of curcumin and exercise rehabilitation on liver paraoxonase-1 and NF-k\u03b2 gene expression in the rat induced by forced drinking of ethanol","volume":"6","author":"Fatolahi","year":"2020","journal-title":"Clin. Exp. Hepatol."},{"key":"10.1016\/j.phymed.2026.158265_bib0019","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70086","article-title":"Therapeutic potential of nicotinamide and ABT263 in alcohol-associated liver disease through targeting cellular senescence","volume":"6","author":"Gold","year":"2025","journal-title":"MedComm"},{"issue":"10","key":"10.1016\/j.phymed.2026.158265_bib0020","first-page":"1319","article-title":"The pathophysiology of alcohol-associated liver disease: focusing on superoxide dismutase 1 as a therapeutic target","volume":"14","author":"Gopal","year":"2025","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.phymed.2026.158265_bib0021","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.immuni.2018.08.021","article-title":"Cholesterol homeostatic regulator SCAP-SREBP2 integrates NLRP3 inflammasome activation and Cholesterol biosynthetic signaling in macrophages","volume":"49","author":"Guo","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.phymed.2026.158265_bib0022","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.14500","article-title":"Laminarin ameliorates alcohol-induced liver damage and its molecular mechanism in mice","volume":"46","author":"Guo","year":"2022","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.phymed.2026.158265_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.148202","article-title":"Water-soluble Poria cocos polysaccharide improves alcoholic liver disease via modulation of gut microbiota-mediated intestinal bile acids-farnesoid X receptor","volume":"330","author":"Huang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2026.158265_bib0024","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/ng0193-73","article-title":"The molecular basis of the human serum paraoxonase activity polymorphism","volume":"3","author":"Humbert","year":"1993","journal-title":"Nat. Genet."},{"key":"10.1016\/j.phymed.2026.158265_bib0025","doi-asserted-by":"crossref","first-page":"7764","DOI":"10.3390\/ijms24097764","article-title":"Proteomic exploration of paraoxonase 1 function in health and disease","volume":"24","author":"Jakubowski","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158265_bib0026","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/216450","article-title":"Mechanisms of alcohol-induced endoplasmic reticulum stress and organ injuries","volume":"2012","author":"Ji","year":"2012","journal-title":"Biochem. Res. Int."},{"key":"10.1016\/j.phymed.2026.158265_bib0027","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1093\/nar\/27.4.1104","article-title":"DNA binding specificity and transactivation properties of SREBP-2 bound to multiple sites on the human apoA-II promoter","volume":"27","author":"Kan","year":"1999","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.phymed.2026.158265_bib0028","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4103\/1319-3767.61232","article-title":"Serum paraoxonase 1 activity status in patients with liver disorders","volume":"16","author":"Kedage","year":"2010","journal-title":"Saudi J. Gastroenterol."},{"issue":"9","key":"10.1016\/j.phymed.2026.158265_bib0029","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.3390\/antiox13091137","article-title":"Comparative study on hepatoprotective effects of traditional herbs, roots of Angelica gigas Nakai, Glycyrrhiza uralensis Fischer, Zizyphus jujuba Mill., and fruits of Paeonia lactiflora Pall., on ethanol-induced liver injury in mice","volume":"13","author":"Kim","year":"2024","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.phymed.2026.158265_bib0030","doi-asserted-by":"crossref","first-page":"4547","DOI":"10.3390\/ijms22094547","article-title":"HDL cholesterol and non-cardiovascular disease: a narrative review","volume":"22","author":"Kjeldsen","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158265_bib0031","doi-asserted-by":"crossref","DOI":"10.1002\/eji.202451273","article-title":"Regulation and function of the Atypical i\u03babs-bcl-3, i\u03bab(NS), and i\u03bab\u03b6-in lymphocytes and autoimmunity","volume":"55","author":"K\u00fcbelbeck","year":"2025","journal-title":"Eur. J. Immunol."},{"issue":"18","key":"10.1016\/j.phymed.2026.158265_bib0032","doi-asserted-by":"crossref","first-page":"9145","DOI":"10.3390\/ijms26189145","article-title":"Exploring the anti-inflammatory activity of the heat-processed gynostemma pentaphyllum extract (Actiponin(\u00ae)) in RAW264.7 cells and carrageenan-induced rat models","volume":"26","author":"Lee","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"23","key":"10.1016\/j.phymed.2026.158265_bib0033","doi-asserted-by":"crossref","first-page":"13129","DOI":"10.3390\/ijms252313129","article-title":"Molecular structure of paraoxonase-1 and its modifications in relation to enzyme activity and biological functions-A comprehensive review","volume":"25","author":"Lewo\u0144-Mrozek","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158265_bib0034","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.ijbiomac.2019.11.061","article-title":"Antioxidant and antihyperlipidemic activities of high sulfate content purified polysaccharide from Ulva pertusa","volume":"146","author":"Li","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2026.158265_bib0035","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1097\/HEP.0000000000000433","article-title":"Targeting hepatic serine-arginine protein kinase 2 ameliorates alcohol-associated liver disease by alternative splicing control of lipogenesis","volume":"78","author":"Li","year":"2023","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.phymed.2026.158265_bib0036","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.3390\/foods10071660","article-title":"Hizikia fusiformis: pharmacological and nutritional properties","volume":"10","author":"Meinita","year":"2021","journal-title":"Foods"},{"key":"10.1016\/j.phymed.2026.158265_bib0037","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000480313","article-title":"Ethanol decreases inflammatory response in Human lung epithelial cells by inhibiting the canonical NF-kB-pathway","volume":"43","author":"M\u00f6rs","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.phymed.2026.158265_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.gim.2024.101174","article-title":"Dominant missense variants in SREBF2 are associated with complex dermatological, neurological, and skeletal abnormalities","volume":"26","author":"Moulton","year":"2024","journal-title":"Genet. Med."},{"key":"10.1016\/j.phymed.2026.158265_bib0039","doi-asserted-by":"crossref","first-page":"9793","DOI":"10.3390\/ijms25189793","article-title":"NF-\u03baB transcription factors: their distribution, Family expansion, structural conservation, and evolution in animals","volume":"25","author":"Msweli","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158265_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.aohep.2024.101499","article-title":"Alcohol-related liver disease: a global perspective","volume":"29","author":"Narro","year":"2024","journal-title":"Ann. Hepatol."},{"key":"10.1016\/j.phymed.2026.158265_bib0041","doi-asserted-by":"crossref","first-page":"9407","DOI":"10.3390\/ijms21249407","article-title":"The impact of acute or chronic alcohol intake on the NF-\u03bab signaling pathway in alcohol-related liver disease","volume":"21","author":"Nowak","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158265_bib0042","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.3390\/nu14142842","article-title":"Effect of carotenoids on paraoxonase-1 activity and gene expression","volume":"14","author":"Otocka-Kmiecik","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.158265_bib0043","doi-asserted-by":"crossref","first-page":"7752","DOI":"10.1038\/s41598-025-91139-0","article-title":"Oxidative stress in a cellular model of alcohol-related liver disease: protection using curcumin nanoformulations","volume":"15","author":"Petagine","year":"2025","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.phymed.2026.158265_bib0044","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3390\/antiox14020209","article-title":"PON-1 and PON-2 polymorphisms and PON-1 paraoxonase activity in people living with HIV-1","volume":"14","author":"Reichert","year":"2025","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.phymed.2026.158265_bib0045","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/s12029-021-00699-7","article-title":"The activity and polymorphism of the PON1 in patients with chronic liver disease: a systematic review and meta-analysis","volume":"53","author":"Salari","year":"2022","journal-title":"J. Gastrointest. Cancer"},{"key":"10.1016\/j.phymed.2026.158265_bib0046","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s10072-020-04842-3","article-title":"Association between serum paraoxonase 1 activity and its polymorphisms with multiple sclerosis: a systematic review","volume":"42","author":"Salari","year":"2021","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.phymed.2026.158265_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103674","article-title":"In vivo protein half-life analysis identifies the SREBF1-SLC27a5 axis governs antioxidant response in preclinical alcoholic rat model","volume":"85","author":"Sharma","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.phymed.2026.158265_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2020.108067","article-title":"Importance of paraoxonase 1 (PON1) as an antioxidant and antiatherogenic enzyme in the cardiovascular complications of type 2 diabetes: genotypic and phenotypic evaluation","volume":"161","author":"Shokri","year":"2020","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"12","key":"10.1016\/j.phymed.2026.158265_bib0049","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.3390\/antiox9121198","article-title":"Genetic attenuation of paraoxonase 1 activity induces proatherogenic changes in plasma proteomes of mice and humans","volume":"9","author":"Sikora","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.phymed.2026.158265_bib0050","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1080\/09629350400003035","article-title":"Differential activation of NF kappa B\/RelA-p50 and NF kappa B\/p50-p50 in control and alcohol-drinking rats subjected to carrageenin-induced pleurisy","volume":"13","author":"Singh","year":"2004","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.phymed.2026.158265_bib0051","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3389\/fphar.2015.00222","article-title":"Antioxidant properties of HDL","volume":"6","author":"Soran","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158265_bib0052","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.clinbiochem.2017.08.001","article-title":"Paraoxonase 1 (PON1) and stroke; the dilemma of genetic variation","volume":"50","author":"Tajbakhsh","year":"2017","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.phymed.2026.158265_bib0053","doi-asserted-by":"crossref","unstructured":"Wang, H., Wang, X., Mao, M., Chen, X., Han, Z., Xun, Z., Wang, Q., Qi, Y., Zhao, W., Li, T., Yan, X., Liu, J., Gao, L., Xue, X., 2025a. Oral iron sulfide prevents acute alcohol intoxication by initiating the endogenous multienzymatic antioxidant defense system. 11, eadr4231.","DOI":"10.1126\/sciadv.adr4231"},{"key":"10.1016\/j.phymed.2026.158265_bib0054","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1002\/hep.31197","article-title":"Elevated fructose and uric acid through aldose reductase contribute to experimental and Human alcoholic liver disease","volume":"72","author":"Wang","year":"2020","journal-title":"Hepatology"},{"issue":"9","key":"10.1016\/j.phymed.2026.158265_bib0055","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.3390\/nu17091589","article-title":"Sugarcane molasses polyphenol extract attenuates alcohol-induced chronic liver damage via antioxidant, anti-inflammatory, and CYP2E1\/Keap1\/NF-\u03bab pathway modulation","volume":"17","author":"Wang","year":"2025","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.158265_bib0056","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/MOL.0000000000000840","article-title":"Resolution of apolipoprotein A1 and A2 proteoforms: their cardiometabolic correlates and implications for future research","volume":"33","author":"Wilkins","year":"2022","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.phymed.2026.158265_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106125","article-title":"DNMT3a-mediated methylation of PSTPIP2 enhances inflammation in alcohol-induced liver injury via regulating STAT1 and NF-\u03bab pathway","volume":"177","author":"Xu","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2026.158265_bib0058","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2025.107505","article-title":"Structural characteristics of brassica rapa L. Polysaccharide and its bioactivity on alcoholic liver injury","volume":"120","author":"Xu","year":"2025","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.phymed.2026.158265_bib0059","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41392-020-00312-6","article-title":"Targeting NF-\u03bab pathway for the therapy of diseases: mechanism and clinical study","volume":"5","author":"Yu","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2026.158265_bib0060","doi-asserted-by":"crossref","unstructured":"Yu, J.-s., Huang, T., Zhang, Y., Mao, X.-T., Huang, L.-J., Li, Y.-N., Wu, T.-T., Zhong, J.-Y., Cao, Q., Li, Y.-Y., Jin, J., 2021. Substrate-specific recognition of IKKs mediated by USP16 facilitates autoimmune inflammation. 7, eabc4009.","DOI":"10.1126\/sciadv.abc4009"},{"key":"10.1016\/j.phymed.2026.158265_bib0061","doi-asserted-by":"crossref","first-page":"196","DOI":"10.21053\/ceo.2019.00094","article-title":"Antiallergic effect of Hizikia fusiformis in an ovalbumin-induced allergic rhinitis mouse model","volume":"12","author":"Zhang","year":"2019","journal-title":"Clin. Exp. Otorhinolaryngol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132600499X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132600499X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T07:47:59Z","timestamp":1783151279000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S094471132600499X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":61,"alternative-id":["S094471132600499X"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158265","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fucoidan attenuates alcohol-induced liver injury via PON1\/HDL\/NF-\u03baB axis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158265","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158265"}}