{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T21:17:12Z","timestamp":1788988632605,"version":"build-2803163510"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073971"],"award-info":[{"award-number":["82073971"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2020071720300"],"award-info":[{"award-number":["2020071720300"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.phymed.2026.158270","type":"journal-article","created":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T05:27:36Z","timestamp":1777786056000},"page":"158270","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The purified extract of Cremastrae pseudobulbus pleiones pseudobulbus (EPC) induces mitochondrial apoptosis in hepatocellular carcinoma cells through inhibiting a key oncogenic signaling pathway"],"prefix":"10.1016","volume":"156","author":[{"given":"Jiayuan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renzhi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2797-1897","authenticated-orcid":false,"given":"Jinli","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158270_bib0001","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/hep.26323","article-title":"The mTOR pathway in hepatic malignancies","volume":"58","author":"Bhat","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2026.158270_bib0002","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.phymed.2026.158270_bib0003","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1544982","article-title":"Establishment of a new approach for quality evaluation of Pseudobulbus Cremastrae seu Pleiones (Shancigu) based on multicomponent analysis and anti-liver cancer pharmacological effects","volume":"16","author":"Cao","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158270_bib0004","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/s41571-020-0341-y","article-title":"Targeting apoptosis in cancer therapy","volume":"17","author":"Carneiro","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.phymed.2026.158270_bib0005","first-page":"2202","article-title":"Effect of Pseudobulbus Cremastrae seu Pleiones on apoptosis and epithelial-mesenchymal transition of Hepatoma carcinoma cell","volume":"36","author":"Cheng","year":"2021","journal-title":"Acta Chin. Med."},{"key":"10.1016\/j.phymed.2026.158270_bib0006","doi-asserted-by":"crossref","first-page":"36767","DOI":"10.18632\/oncotarget.9168","article-title":"Des-gamma-carboxy prothrombin antagonizes the effects of Sorafenib on human hepatocellular carcinoma through activation of the Raf\/MEK\/ERK and PI3K\/akt\/mTOR signaling pathways","volume":"7","author":"Cui","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.phymed.2026.158270_bib0007","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.7150\/thno.68804","article-title":"An update of label-free protein target identification methods for natural active products","volume":"12","author":"Cui","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.phymed.2026.158270_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156735","article-title":"Integrating thermal proteome profiling and virtual screening to reveal the mechanism of bletilla striata against osteoclast-driven osteoporosis","volume":"141","author":"Dai","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158270_bib0009","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1200\/JCO.19.01307","article-title":"Pembrolizumab as second-line therapy in patients with advanced hepatocellular carcinoma in KEYNOTE-240: a randomized, double-blind, phase III trial","volume":"38","author":"Finn","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.phymed.2026.158270_bib0010","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12943-023-01827-6","article-title":"PI3K\/AKT\/mTOR signaling transduction pathway and targeted therapies in cancer","volume":"22","author":"Glaviano","year":"2023","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.phymed.2026.158270_bib0011","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1080\/1061186X.2024.2309661","article-title":"Advances in herbal polysaccharides-based nano-drug delivery systems for cancer immunotherapy","volume":"32","author":"Han","year":"2024","journal-title":"J. Drug Target"},{"key":"10.1016\/j.phymed.2026.158270_bib0012","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2026.158270_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2025.108833","article-title":"Recent advances in target identification technology of natural products","volume":"269","author":"Liu","year":"2025","journal-title":"Pharmacol. Therapeut."},{"key":"10.1016\/j.phymed.2026.158270_bib0014","doi-asserted-by":"crossref","first-page":"572","DOI":"10.52586\/4968","article-title":"Current strategies and technologies for finding drug targets of active components from traditional Chinese medicine","volume":"26","author":"Lu","year":"2021","journal-title":"Front. Biosci."},{"key":"10.1016\/j.phymed.2026.158270_bib0015","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/hep.29913","article-title":"Diagnosis, staging, and management of hepatocellular carcinoma: 2018 practice guidance by the American association for the study of liver diseases","volume":"68","author":"Marrero","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2026.158270_bib0016","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1146\/annurev-pharmtox-052120-013205","article-title":"Drug target identification in tissues by thermal proteome profiling","volume":"62","author":"Mateus","year":"2022","journal-title":"Annu. Rev. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158270_bib0017","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/s12943-024-02157-x","article-title":"The PI3K-AKT-mTOR axis persists as a therapeutic dependency in KRAS(G12D)-driven non-small cell lung cancer","volume":"23","author":"McDaid","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.phymed.2026.158270_bib0018","article-title":"BAX, BAK, and BOK: a coming of age for the BCL-2 family effector proteins","volume":"12","author":"Moldoveanu","year":"2020","journal-title":"Csh. Perspect. Biol."},{"key":"10.1016\/j.phymed.2026.158270_bib0019","doi-asserted-by":"crossref","first-page":"448","DOI":"10.3390\/ijms19020448","article-title":"Apoptosis: a target for anticancer therapy","volume":"19","author":"Pfeffer","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158270_bib0020","doi-asserted-by":"crossref","DOI":"10.1126\/science.1255784","article-title":"Tracking cancer drugs in living cells by thermal profiling of the proteome","volume":"346","author":"Savitski","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.phymed.2026.158270_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156497","article-title":"Hua Zheng San Ji Fang suppresses liver cancer progression by inhibiting TYRO3 expression via the ERK signaling pathway","volume":"139","author":"Xiong","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158270_bib0022","doi-asserted-by":"crossref","DOI":"10.1002\/jgm.3658","article-title":"Single-cell RNA sequencing reveals the mechanism of PI3K\/AKT\/mTOR signaling pathway activation in lung adenocarcinoma by KRAS mutation","volume":"26","author":"Xu","year":"2024","journal-title":"J. Gene. Med."},{"key":"10.1016\/j.phymed.2026.158270_bib0023","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.fitote.2010.06.019","article-title":"Four new phenanthrenes from Lindl","volume":"81","author":"Yang","year":"2010","journal-title":"Fitoterapia"},{"key":"10.1016\/j.phymed.2026.158270_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155135","article-title":"Polyphyllin I induced ferroptosis to suppress the progression of hepatocellular carcinoma through activation of the mitochondrial dysfunction Nrf2\/HO-1\/GPX4 axis","volume":"122","author":"Yang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158270_bib0025","doi-asserted-by":"crossref","first-page":"5133","DOI":"10.1038\/onc.2013.468","article-title":"Synergistic function of Kras mutation and HBx in initiation and progression of hepatocellular carcinoma in mice","volume":"33","author":"Ye","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.phymed.2026.158270_bib0026","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1007\/s12094-020-02365-z","article-title":"FAM83H overexpression predicts worse prognosis and correlates with less CD8 T cells infiltration and Ras-PI3K-akt-mTOR signaling pathway in pancreatic cancer","volume":"22","author":"Zhuang","year":"2020","journal-title":"Clin. Transl. Oncol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326005040?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326005040?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:12:59Z","timestamp":1783116779000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326005040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":26,"alternative-id":["S0944711326005040"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158270","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The purified extract of Cremastrae pseudobulbus pleiones pseudobulbus (EPC) induces mitochondrial apoptosis in hepatocellular carcinoma cells through inhibiting a key oncogenic signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158270","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158270"}}