{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:57:31Z","timestamp":1781107051385,"version":"3.54.1"},"reference-count":138,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013137","name":"Guangdong Province Higher Vocational Colleges and Schools Pearl River Scholar Funded Scheme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013137","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019005","name":"Young Elite Scientists Sponsorship Program by Tianjin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.phymed.2026.158294","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T11:18:14Z","timestamp":1778757494000},"page":"158294","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Bridging traditional knowledge and modern discovery: The role of zebrafish in anti-aging research of medicinal and edible traditional Chinese medicine"],"prefix":"10.1016","volume":"157","author":[{"given":"Jiamin","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenye","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9326-6312","authenticated-orcid":false,"given":"Junshan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158294_bib0001","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1002\/fsn3.2313","article-title":"Lotus seeds (Nelumbinis semen) as an emerging therapeutic seed: a comprehensive review","volume":"9","author":"Arooj","year":"2021","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.phymed.2026.158294_bib0002","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s10522-019-09837-y","article-title":"d-galactose-induced accelerated aging model: an overview","volume":"20","author":"Azman","year":"2019","journal-title":"Biogerontology"},{"key":"10.1016\/j.phymed.2026.158294_bib0003","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.foodchem.2016.02.047","article-title":"Phytochemistry and pharmacological activities of the genus Prunella","volume":"204","author":"Bai","year":"2016","journal-title":"Food Chem."},{"key":"10.1016\/j.phymed.2026.158294_bib0004","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2025.1542930","article-title":"The role of telomere and telomerase in cancer and novel therapeutic target: narrative review","volume":"15","author":"Baylie","year":"2025","journal-title":"Front. Oncol."},{"key":"10.1016\/j.phymed.2026.158294_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.141665","article-title":"Extraction and purification, structural characteristics, pharmacological activities, structure-activity relationships, applications, and quality assessments of Prunella vulgaris L. polysaccharides: a review","volume":"306","author":"Bi","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2026.158294_bib0006","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrg1656","article-title":"Telomeres and human disease: ageing, cancer and beyond","volume":"6","author":"Blasco","year":"2005","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.phymed.2026.158294_bib0007","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.3390\/pharmaceutics13081106","article-title":"Nanoparticles-based oligonucleotides delivery in cancer: role of zebrafish as animal model","volume":"13","author":"Bozzer","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.phymed.2026.158294_bib0008","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.arr.2017.08.003","article-title":"Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: a systematic review and meta-analysis","volume":"40","author":"Campbell","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.phymed.2026.158294_bib0009","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41586-019-1365-2","article-title":"From discoveries in ageing research to therapeutics for healthy ageing","volume":"571","author":"Campisi","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2026.158294_bib0010","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1242\/dmm.025130","article-title":"Telomeres in aging and disease: lessons from zebrafish","volume":"9","author":"Carneiro","year":"2016","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.phymed.2026.158294_bib0011","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3389\/fcell.2018.00178","article-title":"The zebrafish as an emerging model to study DNA damage in aging, cancer and other diseases","volume":"6","author":"Cayuela","year":"2018","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.phymed.2026.158294_bib0012","doi-asserted-by":"crossref","first-page":"5958","DOI":"10.1080\/10408398.2022.2160961","article-title":"Anti-aging effects of dietary phytochemicals: from Caenorhabditis elegans, Drosophila melanogaster, rodents to clinical studies","volume":"64","author":"Chen","year":"2024","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.phymed.2026.158294_bib0013","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s10522-020-09857-z","article-title":"Coix seed oil prolongs lifespan and enhances stress resistance in Caenorhabditis elegans","volume":"21","author":"Chen","year":"2020","journal-title":"Biogerontology"},{"key":"10.1016\/j.phymed.2026.158294_bib0014","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/agm2.12077","article-title":"Traditional Chinese medicine and aging: integration and collaboration promote healthy aging","volume":"2","author":"Cong","year":"2019","journal-title":"Aging Med."},{"key":"10.1016\/j.phymed.2026.158294_bib0015","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.3390\/molecules23051170","article-title":"A review: the bioactivities and pharmacological applications of polygonatum sibiricum polysaccharides","volume":"23","author":"Cui","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2026.158294_bib0016","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.3390\/nu16111681","article-title":"A lombard variety of sweet pepper regulating senescence and proliferation: the Voghera pepper","volume":"16","author":"De Luca","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.158294_bib0017","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s40120-018-0093-0","article-title":"Correction to: risk of adverse outcomes for older people with dementia prescribed antipsychotic medication: a population based e-cohort study","volume":"7","author":"Dennis","year":"2018","journal-title":"Neurol. Ther."},{"key":"10.1016\/j.phymed.2026.158294_bib0018","doi-asserted-by":"crossref","first-page":"681","DOI":"10.2147\/CIA.S447514","article-title":"Potential effects of traditional Chinese medicine in anti-aging and aging-related diseases: current evidence and perspectives","volume":"19","author":"Ding","year":"2024","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.phymed.2026.158294_bib0019","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev-publhealth-052620-091107","article-title":"Active Aging and Public health: evidence, implications, and opportunities","volume":"43","author":"Dogra","year":"2022","journal-title":"Annu. Rev. Publ. Health"},{"key":"10.1016\/j.phymed.2026.158294_bib0020","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s00394-019-01919-4","article-title":"Acute nicotinamide riboside supplementation improves redox homeostasis and exercise performance in old individuals: a double-blind cross-over study","volume":"59","author":"Dolopikou","year":"2020","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.phymed.2026.158294_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112706","article-title":"Neuroprotective effects of Tongtian oral liquid, a Traditional Chinese Medicine in the Parkinson's disease-induced zebrafish model","volume":"148","author":"Dongjie","year":"2022","journal-title":"Biomed. PharmacOther"},{"issue":"Suppl 10","key":"10.1016\/j.phymed.2026.158294_bib0022","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1289\/ehp.94102s1017","article-title":"Mechanisms of cell injury by activated oxygen species","volume":"102","author":"Farber","year":"1994","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.phymed.2026.158294_bib0023","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.tem.2024.01.004","article-title":"A perspective on muscle phenotyping in musculoskeletal research","volume":"35","author":"Foessl","year":"2024","journal-title":"Trends. Endocrinol. Metab."},{"key":"10.1016\/j.phymed.2026.158294_bib0024","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.expneurol.2017.10.004","article-title":"The developing utility of zebrafish models of neurological and neuropsychiatric disorders: a critical review","volume":"299","author":"Fontana","year":"2018","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.phymed.2026.158294_bib0025","doi-asserted-by":"crossref","first-page":"15320","DOI":"10.18632\/aging.203090","article-title":"Cistanche deserticola polysaccharides alleviate cognitive decline in aging model mice by restoring the gut microbiota-brain axis","volume":"13","author":"Gao","year":"2021","journal-title":"Aging (Albany. NY)"},{"key":"10.1016\/j.phymed.2026.158294_bib0026","doi-asserted-by":"crossref","first-page":"778","DOI":"10.14336\/AD.2017.0725","article-title":"Lycium barbarum: a traditional Chinese herb and A promising anti-aging agent","volume":"8","author":"Gao","year":"2017","journal-title":"Aging Dis."},{"key":"10.1016\/j.phymed.2026.158294_bib0027","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/2075444","article-title":"Phytochemical characteristics and anti-inflammatory, immunoregulatory, and antioxidant effects of portulaca oleracea L.: a comprehensive review","volume":"2023","author":"Ghorani","year":"2023","journal-title":"Evid. Based. Complement. Alternat. Med."},{"key":"10.1016\/j.phymed.2026.158294_bib0028","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1038\/s41591-023-02543-w","article-title":"Senolytic therapy in mild Alzheimer's disease: a phase 1 feasibility trial","volume":"29","author":"Gonzales","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.phymed.2026.158294_bib0029","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1089\/jmf.2015.0075","article-title":"Effects of the intake of Sesame seeds (Sesamum indicum L.) and derivatives on oxidative stress: a systematic review","volume":"19","author":"Gouveia","year":"2016","journal-title":"J. Med. Food"},{"key":"10.1016\/j.phymed.2026.158294_bib0030","article-title":"Literature analysis on asparagus roots and review of its functional characterizations","volume":"9","author":"Guo","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.phymed.2026.158294_bib0031","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5582\/ddt.2015.01007","article-title":"Anti-tumor effects and cellular mechanisms of resveratrol","volume":"9","author":"Han","year":"2015","journal-title":"Drug Discov. Ther."},{"key":"10.1016\/j.phymed.2026.158294_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2020.111111","article-title":"Resveratrol and exercise combined to treat functional limitations in late life: a pilot randomized controlled trial","volume":"143","author":"Harper","year":"2021","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.phymed.2026.158294_bib0033","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.foodchem.2017.11.084","article-title":"Structures, bioactivities and future prospective of polysaccharides from Morus alba (white mulberry): a review","volume":"245","author":"He","year":"2018","journal-title":"Food Chem."},{"key":"10.1016\/j.phymed.2026.158294_bib0034","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jep.2013.11.023","article-title":"Eucommia ulmoides Oliv.: ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine","volume":"151","author":"He","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158294_bib0035","first-page":"3","article-title":"Food and medicine continuum' - why we should promote cross-cultural communication between the global East and West","volume":"14","author":"Heinrich","year":"2021","journal-title":"Chin. Herb. Med."},{"key":"10.1016\/j.phymed.2026.158294_bib0036","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003214","article-title":"Telomerase is required for zebrafish lifespan","volume":"9","author":"Henriques","year":"2013","journal-title":"PLoS. Genet."},{"key":"10.1016\/j.phymed.2026.158294_bib0037","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature12111","article-title":"The zebrafish reference genome sequence and its relationship to the human genome","volume":"496","author":"Howe","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2026.158294_bib0038","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0300227","article-title":"Aging in zebrafish is associated with reduced locomotor activity and strain dependent changes in bottom dwelling and thigmotaxis","volume":"19","author":"Hudock","year":"2024","journal-title":"PLoS. One"},{"key":"10.1016\/j.phymed.2026.158294_bib0039","doi-asserted-by":"crossref","DOI":"10.1017\/erm.2022.33","article-title":"Preclinical activities of Cassia tora Linn against aging-related diseases","volume":"24","author":"Hwang","year":"2022","journal-title":"Expert. Rev. Mol. Med."},{"key":"10.1016\/j.phymed.2026.158294_bib0040","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1007\/s11357-024-01092-5","article-title":"Longevity and anti-aging effects of curcumin supplementation","volume":"46","author":"Izadi","year":"2024","journal-title":"Geroscience"},{"key":"10.1016\/j.phymed.2026.158294_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115809","article-title":"Progress of research into the pharmacological effect and clinical application of the traditional Chinese medicine Rehmanniae Radix","volume":"168","author":"Jia","year":"2023","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.phymed.2026.158294_bib0042","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.3389\/fphar.2020.01031","article-title":"Clinical and preclinical systematic review of Panax ginseng C. A. Mey and its compounds for fatigue","volume":"11","author":"Jin","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158294_bib0043","article-title":"Polyphenolic spectrum of cornelian cherry fruits and their health-promoting effect","volume":"20","author":"Jurikova","year":"2025","journal-title":"Open. Life Sci."},{"key":"10.1016\/j.phymed.2026.158294_bib0044","first-page":"335","article-title":"The use of mature zebrafish (Danio rerio) as a model for human aging and disease","volume":"138","author":"Keller","year":"2004","journal-title":"Comp Biochem Physiol C"},{"key":"10.1016\/j.phymed.2026.158294_bib0045","doi-asserted-by":"crossref","first-page":"51","DOI":"10.5455\/jice.20140120103320","article-title":"The investigation of some bioactive compounds and antioxidant properties of hawthorn (Crataegus monogyna subsp. monogyna Jacq)","volume":"3","author":"Keser","year":"2014","journal-title":"J. Intercult. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158294_bib0046","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.3390\/foods13101426","article-title":"A frontier review of nutraceutical Chinese yam","volume":"13","author":"Khol","year":"2024","journal-title":"Foods"},{"key":"10.1016\/j.phymed.2026.158294_bib0047","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.21873\/invivo.11661","article-title":"Understanding the role of ztor in aging-related diseases using the Zebrafish model","volume":"33","author":"Khor","year":"2019","journal-title":"In. Vivo (Brooklyn)"},{"key":"10.1016\/j.phymed.2026.158294_bib0048","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/bdrc.20217","article-title":"The search for evolutionary developmental origins of aging in zebrafish: a novel intersection of developmental and senescence biology in the zebrafish model system","volume":"93","author":"Kishi","year":"2011","journal-title":"Birth Defects Res. C Embryo Today"},{"key":"10.1016\/j.phymed.2026.158294_bib0049","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1016\/j.cell.2025.03.011","article-title":"From geroscience to precision geromedicine: understanding and managing aging","volume":"188","author":"Kroemer","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2026.158294_bib0050","doi-asserted-by":"crossref","first-page":"239","DOI":"10.4103\/2225-4110.139109","article-title":"Induction of angiogenesis in zebrafish embryos and proliferation of endothelial cells by an active fraction isolated from the root of astragalus membranaceus using bioassay-guided fractionation","volume":"4","author":"Lai","year":"2014","journal-title":"J. Tradit. Compl. Med."},{"key":"10.1016\/j.phymed.2026.158294_bib0051","doi-asserted-by":"crossref","first-page":"6071","DOI":"10.3390\/molecules28166071","article-title":"Yellow Himalayan Raspberry (Rubus ellipticus Sm.): ethnomedicinal, nutraceutical, and pharmacological aspects","volume":"28","author":"Lamichhane","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2026.158294_bib0052","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0960-9822(02)01319-2","article-title":"Zebrafish as a model organism for the identification and characterization of drugs and genes affecting p53 signaling","volume":"12","author":"Langheinrich","year":"2002","journal-title":"Curr. Biol."},{"key":"10.1016\/j.phymed.2026.158294_bib0053","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1021\/nn700048y","article-title":"In vivo imaging of transport and biocompatibility of single silver nanoparticles in early development of zebrafish embryos","volume":"1","author":"Lee","year":"2007","journal-title":"ACS Nano"},{"key":"10.1016\/j.phymed.2026.158294_bib0054","doi-asserted-by":"crossref","first-page":"963","DOI":"10.2147\/CIA.S414714","article-title":"Gut microbiota and aging: traditional Chinese medicine and modern medicine","volume":"18","author":"Li","year":"2023","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.phymed.2026.158294_bib0055","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/jcmm.13564","article-title":"Molecular basis for Poria cocos mushroom polysaccharide used as an antitumour drug in China","volume":"23","author":"Li","year":"2019","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.phymed.2026.158294_bib0056","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.3390\/ijms13021747","article-title":"Mitochondrial protection and anti-aging activity of Astragalus polysaccharides and their potential mechanism","volume":"13","author":"Li","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158294_bib0057","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ijbiomac.2014.04.038","article-title":"Evaluation of antioxidant and immuno-enhancing activities of Purslane polysaccharides in gastric cancer rats","volume":"68","author":"Li","year":"2014","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2026.158294_bib0058","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s10522-021-09910-5","article-title":"Aging and age-related diseases: from mechanisms to therapeutic strategies","volume":"22","author":"Li","year":"2021","journal-title":"Biogerontology"},{"key":"10.1016\/j.phymed.2026.158294_bib0059","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.127647","article-title":"Anti-aging activities of Rehmannia glutinosa Libosch. Crude polysaccharide in Caenorhabditis elegans based on gut microbiota and metabonomic analysis","volume":"253","author":"Liang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2026.158294_bib0060","doi-asserted-by":"crossref","first-page":"453","DOI":"10.3390\/cells8050453","article-title":"Zebrafish carrying pycr1 gene deficiency display aging and multiple behavioral abnormalities","volume":"8","author":"Liang","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.phymed.2026.158294_bib0061","article-title":"Exploring the antimicrobial, anti-inflammatory, antioxidant, and immunomodulatory properties of Chrysanthemum morifolium and chrysanthemum indicum: a narrow review","volume":"16","author":"Liang","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158294_bib0062","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2025.1601490","article-title":"Polygonatum sibiricum polysaccharides enhance pancreatic \u03b2-cell function in diabetic zebrafish by mitigating mitochondrial oxidative damage via the AMPK-SIRT1 pathway","volume":"12","author":"Lin","year":"2025","journal-title":"Front. Nutr."},{"key":"10.1016\/j.phymed.2026.158294_bib0063","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jep.2014.11.009","article-title":"Traditional usages, botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Thunb.: a review","volume":"159","author":"Lin","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158294_bib0064","first-page":"1144","article-title":"[Anti-aging traditional Chinese medicine: potential mechanisms involving AMPK pathway and calorie restriction based on \"medicine-food homology\" theory]","volume":"41","author":"Liu","year":"2016","journal-title":"Zhongguo Zhong. Yao Za Zhi."},{"key":"10.1016\/j.phymed.2026.158294_bib0065","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1504009","article-title":"Phytochemical, pharmacological, pharmacokinetic and toxicological characteristics of Ziziphi Spinosae Semen: a review","volume":"15","author":"Liu","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158294_bib0066","article-title":"Immunomodulatory and antioxidant activities of a polysaccharide from Ligustrum vicaryi L","volume":"2020","author":"Liu","year":"2020","journal-title":"Fruit Evid. Based Complement Alternat. Med."},{"key":"10.1016\/j.phymed.2026.158294_bib0067","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.3390\/molecules30071476","article-title":"Purification and oxidative scavenging of total alkaloids of piperis longi fructus based on adsorption kinetics and thermodynamic theory","volume":"30","author":"Lu","year":"2025","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2026.158294_bib0068","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrd4627","article-title":"Zebrafish as tools for drug discovery","volume":"14","author":"MacRae","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.phymed.2026.158294_bib0069","doi-asserted-by":"crossref","first-page":"7324","DOI":"10.3390\/ijms22147324","article-title":"Licochalcone D ameliorates oxidative stress-induced senescence via AMPK activation","volume":"22","author":"Maharajan","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158294_bib0070","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2025.1548242","article-title":"Cerebrovascular ageing: how zebrafish can contribute to solving the puzzle","volume":"16","author":"Malkinson","year":"2025","journal-title":"Front. Physiol."},{"key":"10.1016\/j.phymed.2026.158294_bib0071","doi-asserted-by":"crossref","first-page":"142","DOI":"10.14283\/jfa.2018.6","article-title":"Effects of fermented Papaya preparation (FPP) on safety outcomes in older adults - A short report of a placebo-controlled clinical trial","volume":"7","author":"Mankowski","year":"2018","journal-title":"J. Frailty. Aging"},{"key":"10.1016\/j.phymed.2026.158294_bib0072","article-title":"Integration of lncRNA and mRNA profiles to reveal the protective effects of Codonopsis pilosula extract on the gastrointestinal tract of mice subjected to D\u2011galactose\u2011induced aging","volume":"47","author":"Meng","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.phymed.2026.158294_bib0073","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.819767","article-title":"In vivo evaluation of non-viral NICD plasmid-loaded PLGA nanoparticles in developing zebrafish to improve cardiac functions","volume":"13","author":"Messerschmidt","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.phymed.2026.158294_bib0074","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13835","article-title":"A p21-GFP zebrafish model of senescence for rapid testing of senolytics in vivo","volume":"22","author":"Morsli","year":"2023","journal-title":"Aging Cell"},{"key":"10.1016\/j.phymed.2026.158294_bib0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.sjbs.2023.103872","article-title":"Antioxidant and anti-aging role of silk sericin in d-galactose induced mice model","volume":"30","author":"Mumtaz","year":"2023","journal-title":"Saudi. J. Biol. Sci."},{"key":"10.1016\/j.phymed.2026.158294_bib0076","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1016\/j.ijbiomac.2021.05.213","article-title":"Extraction, structure, pharmacological activities and drug carrier applications of Angelica sinensis polysaccharide","volume":"183","author":"Nai","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2026.158294_bib0077","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1234307","article-title":"TCM \"medicine and food homology\" in the management of post-COVID disorders","volume":"14","author":"Ng","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2026.158294_bib0078","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.136280","article-title":"Extraction, purification, structural characterization, and bioactivities of Ginkgo biloba leave polysaccharides: a review","volume":"281","author":"Nie","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2026.158294_bib0079","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13020","article-title":"Rag1 immunodeficiency-induced early aging and senescence in zebrafish are dependent on chronic inflammation and oxidative stress","volume":"18","author":"Novoa","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.phymed.2026.158294_bib0080","article-title":"Loss of alphaklotho causes reduced motor ability and short lifespan in zebrafish","volume":"11","author":"Ogura","year":"2021","journal-title":"Sci Rep-UK"},{"key":"10.1016\/j.phymed.2026.158294_bib0081","doi-asserted-by":"crossref","first-page":"7323","DOI":"10.3390\/molecules26237323","article-title":"Bioactive phytochemicals with anti-aging and lifespan extending potentials in Caenorhabditis elegans","volume":"26","author":"Okoro","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2026.158294_bib0082","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/978-981-32-9421-9_13","article-title":"Anti-aging effect of ganoderma (Lingzhi) with health and fitness","volume":"1182","author":"Pan","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.phymed.2026.158294_bib0083","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1007\/s00204-016-1789-5","article-title":"Humanizing the zebrafish liver shifts drug metabolic profiles and improves pharmacokinetics of CYP3A4 substrates","volume":"91","author":"Poon","year":"2017","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.phymed.2026.158294_bib0084","first-page":"50","article-title":"Anti-aging effect and mechanisms of perilla seed oil","author":"Rong","year":"2025","journal-title":"China Oils & Fats"},{"key":"10.1016\/j.phymed.2026.158294_bib0085","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1159\/000433534","article-title":"Oxidation and cognitive impairment in the aging zebrafish","volume":"62","author":"Ruhl","year":"2016","journal-title":"Gerontology"},{"key":"10.1016\/j.phymed.2026.158294_bib0086","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114570","article-title":"Traditional uses, bioactive composition, pharmacology, and toxicology of Phyllanthus emblica fruits: a comprehensive review","volume":"282","author":"Saini","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158294_bib0087","article-title":"Oxidative stress induced by hydrogen peroxide disrupts zebrafish visual development by altering apoptosis, antioxidant and estrogen related genes","volume":"14","author":"Saputra","year":"2024","journal-title":"Sci. Rep-UK"},{"key":"10.1016\/j.phymed.2026.158294_bib142","doi-asserted-by":"crossref","first-page":"977","DOI":"10.3233\/JAD-2010-1296","article-title":"Ginsenoside Rg1 attenuates amyloid-beta content, regulates PKA\/CREB activity, and improves cognitive performance in SAMP8 mice","volume":"19","author":"Shi","year":"2010","journal-title":"Journal of Alzheimer\u2019s disease\u202f: JAD"},{"key":"10.1016\/j.phymed.2026.158294_bib0088","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1007\/s10787-024-01511-1","article-title":"The potential of zebrafish as drug discovery research tool in immune-mediated inflammatory disease","volume":"32","author":"Smith","year":"2024","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.phymed.2026.158294_bib0089","doi-asserted-by":"crossref","first-page":"9737","DOI":"10.1007\/s11033-022-07459-1","article-title":"The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions","volume":"49","author":"Soma","year":"2022","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.phymed.2026.158294_bib0090","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.2147\/IJN.S510352","article-title":"Aloe vera gel and rind-derived nanoparticles mitigate skin photoaging via activation of Nrf2\/ARE pathway","volume":"20","author":"Sun","year":"2025","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.phymed.2026.158294_bib0091","doi-asserted-by":"crossref","first-page":"835","DOI":"10.3390\/molecules23040835","article-title":"Therapeutic potential and recent advances of curcumin in the treatment of aging-associated diseases","volume":"23","author":"Sundar","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2026.158294_bib0092","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113015","article-title":"Extraction, structure, and activity of polysaccharide from Radix astragali","volume":"150","author":"Tang","year":"2022","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.phymed.2026.158294_bib0093","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117809","article-title":"Extraction, purification, structural characterization and pharmacological activities of polysaccharides from sea buckthorn (Hippophae rhamnoides L.): a review","volume":"324","author":"Teng","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158294_bib0094","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/nrc2012","article-title":"Regulating the p53 pathway: in vitro hypotheses, in vivo veritas","volume":"6","author":"Toledo","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.phymed.2026.158294_bib0095","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3390\/life10060080","article-title":"Almond skin extracts and chlorogenic acid delay chronological aging and enhanced oxidative stress response in yeast","volume":"10","author":"Tungmunnithum","year":"2020","journal-title":"Life"},{"key":"10.1016\/j.phymed.2026.158294_bib0096","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1126\/science.280.5365.855","article-title":"Biodemographic trajectories of longevity","volume":"280","author":"Vaupel","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.phymed.2026.158294_bib0097","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3390\/antiox11020248","article-title":"Health benefits and applications of Goji berries in functional food products development: a review","volume":"11","author":"Vidovic","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2026.158294_bib0098","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.3390\/antiox11112146","article-title":"Bifidobacterium animalis MSMC83 improves oxidative stress and gut microbiota in d-galactose-induced rats","volume":"11","author":"Vitheejongjaroen","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2026.158294_bib0099","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.3390\/antiox11112121","article-title":"Pharmacological activity, pharmacokinetics, and clinical research progress of Puerarin","volume":"11","author":"Wang","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2026.158294_bib0100","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1248\/bpb.b12-00238","article-title":"Effect of colla corii asini (E'jiao) on d-galactose induced aging mice","volume":"35","author":"Wang","year":"2012","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.phymed.2026.158294_bib0101","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.3390\/molecules24162886","article-title":"Ophiopogon polysaccharide promotes the In vitro metabolism of ophiopogonins by Human gut microbiota","volume":"24","author":"Wang","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2026.158294_bib0102","doi-asserted-by":"crossref","first-page":"740","DOI":"10.14336\/AD.2017.0720","article-title":"Herba Cistanches: anti-aging","volume":"8","author":"Wang","year":"2017","journal-title":"Aging Dis."},{"key":"10.1016\/j.phymed.2026.158294_bib0104","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.3390\/molecules28031350","article-title":"Health-promoting activities and associated mechanisms of polygonati rhizoma polysaccharides","volume":"28","author":"Wang","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2026.158294_bib0105","doi-asserted-by":"crossref","first-page":"888","DOI":"10.3390\/antiox13080888","article-title":"Investigation of antioxidant mechanisms of novel peptides derived from Asian swamp eel hydrolysate in chemical systems and AAPH-induced Human erythrocytes","volume":"13","author":"Wang","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2026.158294_bib0106","doi-asserted-by":"crossref","first-page":"10680","DOI":"10.1039\/D2FO01657E","article-title":"Hawthorn fruit extract ameliorates H(2)O(2)-induced oxidative damage in neuronal PC12 cells and prolongs the lifespan of Caenorhabditis elegans via the IIS signaling pathway","volume":"13","author":"Wang","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2026.158294_bib0107","doi-asserted-by":"crossref","first-page":"4962","DOI":"10.3390\/molecules29204962","article-title":"A comparative study of the chemical composition and skincare activities of red and yellow ginseng berries","volume":"29","author":"Wang","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2026.158294_bib0108","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.3390\/nu14194079","article-title":"Sesame (Sesamum indicum L.): a comprehensive review of nutritional value, phytochemical composition, health benefits, development of food, and industrial applications","volume":"14","author":"Wei","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.158294_bib0109","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.2147\/IJGM.S253177","article-title":"Deprescribing in the older patient: a narrative review of challenges and solutions","volume":"14","author":"Wu","year":"2021","journal-title":"Int. J. Gen. Med."},{"key":"10.1016\/j.phymed.2026.158294_bib0110","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.3892\/mmr.2014.1964","article-title":"Inhibitory effect of Lycium barbarum polysaccharides on cell apoptosis and senescence is potentially mediated by the p53 signaling pathway","volume":"9","author":"Xia","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.phymed.2026.158294_bib0111","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4236\/ajmb.2012.22011","article-title":"The effects of astragalus polysaccharide on zebrafish cell apoptosis and senescence","volume":"02","author":"Xia","year":"2012","journal-title":"Am. J. Mol. Biol."},{"key":"10.1016\/j.phymed.2026.158294_bib0112","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1007\/s13577-020-00405-y","article-title":"Enzyme-digested Colla Corii Asini (E'jiao) accelerates wound healing and prevents ultraviolet A-induced collagen synthesis decline and wrinkle formation in three-dimensional skin equivalents","volume":"33","author":"Xiao","year":"2020","journal-title":"Hum. Cell"},{"key":"10.1016\/j.phymed.2026.158294_bib0113","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1034515","article-title":"Alpiniae oxyphylla fructus extract promotes longevity and stress resistance of C. elegans via DAF-16 and SKN-1","volume":"13","author":"Xiao","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158294_bib0114","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/6293355","article-title":"Bioactivities and mechanism of actions of dendrobium officinale: a comprehensive review","volume":"2022","author":"Xu","year":"2022","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.phymed.2026.158294_bib0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156217","article-title":"Mulberry leaf benefits the intestinal epithelial barrier via direct anti-oxidation and indirect modulation of microbiota in pigs","volume":"135","author":"Yan","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158294_bib0116","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1055\/s-0035-1557893","article-title":"The pharmacological activities of licorice","volume":"81","author":"Yang","year":"2015","journal-title":"Planta Med."},{"key":"10.1016\/j.phymed.2026.158294_bib0117","first-page":"6","article-title":"Food and medicine continuum' in the East and West: old tradition and current regulation","volume":"15","author":"Yao","year":"2022","journal-title":"Chin. Herb. Med."},{"key":"10.1016\/j.phymed.2026.158294_bib0118","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2025.1574182","article-title":"Flavonoids from the genus Polygonatum: biological activities and biosynthesis mechanism","volume":"12","author":"Ye","year":"2025","journal-title":"Front. Nutr."},{"key":"10.1016\/j.phymed.2026.158294_bib0119","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156213","article-title":"Xiyangshen Sanqi Danshen granules attenuated d-gal-induced C57BL\/6J mouse aging through the AMPK\/SIRT1 signaling pathway","volume":"136","author":"Yin","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158294_bib0120","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1093\/nar\/gkac065","article-title":"The non-telomeric evolutionary trajectory of TRF2 in zebrafish reveals its specific roles in neurodevelopment and aging","volume":"50","author":"Ying","year":"2022","journal-title":"Nucleic. Acids Res."},{"key":"10.1016\/j.phymed.2026.158294_bib0121","doi-asserted-by":"crossref","first-page":"160","DOI":"10.5142\/jgr.2010.34.3.160","article-title":"Chemical and pharmacological studies of saponins with a focus on American ginseng","volume":"34","author":"Yuan","year":"2010","journal-title":"J. Ginseng. Res."},{"key":"10.1016\/j.phymed.2026.158294_bib0122","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/s12877-022-02956-1","article-title":"Change of vitamin D status and all-cause mortality among Chinese older adults: a population-based cohort study","volume":"22","author":"Zeng","year":"2022","journal-title":"BMC Geriatr."},{"key":"10.1016\/j.phymed.2026.158294_bib143","doi-asserted-by":"crossref","first-page":"109871","DOI":"10.1016\/j.carres.2026.109871","article-title":"Extraction, structural characteristics, bioactivities, structural-activity relationships, and application prospects of the polysaccharides from Ophiopogon japonicus: a review","volume":"565","author":"Zhang","year":"2026","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.phymed.2026.158294_bib0123","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2024.114099","article-title":"Production and pharmaceutical research of minor saponins in Panax notoginseng (Sanqi): current status and future prospects","volume":"223","author":"Zhang","year":"2024","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phymed.2026.158294_bib0124","article-title":"Preliminary investigation of anti-fatigue effects and potential mechanisms of meiju oral liquid in mouse and zebrafish models","volume":"20","author":"Zhang","year":"2025","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2026.158294_bib0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113559","article-title":"Peppermint essential oil: its phytochemistry, biological activity, pharmacological effect and application","volume":"154","author":"Zhao","year":"2022","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.phymed.2026.158294_bib0126","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3390\/antiox13070763","article-title":"Antioxidant and stress resistance properties of flavonoids from Chinese sea buckthorn leaves from the Qinghai-Tibet plateau","volume":"13","author":"Zhao","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2026.158294_bib0127","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jep.2017.12.006","article-title":"The genus polygonatum: a review of ethnopharmacology, phytochemistry and pharmacology","volume":"214","author":"Zhao","year":"2018","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.phymed.2026.158294_bib0128","first-page":"2554","article-title":"Targeting cellular senescence in aging and age-related diseases: challenges, considerations, and the emerging role of senolytic and senomorphic therapies","volume":"15","author":"Zheng","year":"2024","journal-title":"Aging Dis."},{"key":"10.1016\/j.phymed.2026.158294_bib0129","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/ptr.2276","article-title":"Effects of icariin combined with Panax notoginseng saponins on ischemia reperfusion-induced cognitive impairments related with oxidative stress and CA1 of hippocampal neurons in rat","volume":"22","author":"Zheng","year":"2008","journal-title":"PhytOther Res."},{"key":"10.1016\/j.phymed.2026.158294_bib0130","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.3390\/molecules21111465","article-title":"Cytotoxic, antitumor and immunomodulatory effects of the water-soluble polysaccharides from Lotus (Nelumbo nucifera Gaertn.) seeds","volume":"21","author":"Zheng","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2026.158294_bib0131","first-page":"1","article-title":"Panax Notoginseng Saponins ameliorate abeta-mediated neurotoxicity in C. elegans through antioxidant activities","volume":"2019","author":"Zhou","year":"2019","journal-title":"Evid. Based. Complement. Alternat. Med."},{"key":"10.1016\/j.phymed.2026.158294_bib0132","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.3390\/ijms26073381","article-title":"2,3,5,4\u2032-Tetrahydroxystilbene-2-O-beta-d-glucoside (TSG) from polygonum multiflorum thunb.: a systematic review on Anti-aging","volume":"26","author":"Zhu","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158294_bib0133","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.3390\/molecules24132436","article-title":"Gastrodia elata blume polysaccharides: a review of their acquisition, analysis, modification, and pharmacological activities","volume":"24","author":"Zhu","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2026.158294_bib0134","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10522-018-9769-1","article-title":"Telomere and its role in the aging pathways: telomere shortening, cell senescence and mitochondria dysfunction","volume":"20","author":"Zhu","year":"2019","journal-title":"Biogerontology"},{"issue":"6","key":"10.1016\/j.phymed.2026.158294_bib141","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0101291","article-title":"Ginsenoside Rg1 prevents cognitive impairment and hippocampus senescence in a rat model of D-galactose-induced aging","volume":"9","author":"Zhu","year":"2014","journal-title":"PloS one"},{"key":"10.1016\/j.phymed.2026.158294_bib140","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.neuroscience.2015.02.031","article-title":"Chronic treatment with ginsenoside Rg1 promotes memory and hippocampal long-term potentiation in middle-aged mice","volume":"292","author":"Zhu","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.phymed.2026.158294_bib0135","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.3390\/antiox13121449","article-title":"Research updates and advances on flavonoids derived from dandelion and their antioxidant activities","volume":"13","author":"Zhuang","year":"2024","journal-title":"Antioxidants"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326005283?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326005283?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:02:33Z","timestamp":1781103753000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326005283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":138,"alternative-id":["S0944711326005283"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158294","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bridging traditional knowledge and modern discovery: The role of zebrafish in anti-aging research of medicinal and edible traditional Chinese medicine","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158294","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158294"}}