{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T02:49:17Z","timestamp":1788058157215,"version":"build-2784847793"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010203","name":"Agriculture Research System of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010203","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012453","name":"China Agricultural Research System","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011798","name":"Ministry of Agriculture and Rural Affairs of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011798","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.phymed.2026.158357","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:04:53Z","timestamp":1780013093000},"page":"158357","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Targeting the virulence factor suilysin: a structure-guided discovery of chebulinic acid as a potent antivirulence agent"],"prefix":"10.1016","volume":"157","author":[{"given":"Chenchen","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoran","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renhang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangru","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanchun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158357_bib0001","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s43188-021-00092-3","article-title":"Non-toxic nature of chebulinic acid on biochemical, hematological and histopathological analysis in normal sprague dawley rats","volume":"38","author":"Aamir","year":"2022","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.phymed.2026.158357_bib0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/07391102.2023.2245470","article-title":"A chemoinformatic-biophysics based approach to identify novel anti-virulent compounds against Pseudomonas aeruginosa disulfide-bond protein A1","author":"Al-Harbi","year":"2023","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.phymed.2026.158357_bib0003","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3390\/antibiotics11020178","article-title":"Repurposing \u03b1-adrenoreceptor blockers as promising anti-virulence agents in gram-negative bacteria","volume":"11","author":"Almalki","year":"2022","journal-title":"Antibiotics"},{"key":"10.1016\/j.phymed.2026.158357_bib0004","doi-asserted-by":"crossref","first-page":"746","DOI":"10.3390\/antibiotics13080746","article-title":"Plant-derived antimicrobials and their crucial role in combating antimicrobial resistance","volume":"13","author":"Angelini","year":"2024","journal-title":"Antibiotics"},{"key":"10.1016\/j.phymed.2026.158357_bib0005","doi-asserted-by":"crossref","first-page":"919","DOI":"10.3390\/antibiotics13100919","article-title":"Beyond antibiotics: what the future holds","volume":"13","author":"Benyamini","year":"2024","journal-title":"Antibiotics"},{"key":"10.1016\/j.phymed.2026.158357_bib0006","doi-asserted-by":"crossref","first-page":"587","DOI":"10.2174\/1389200224666230817101950","article-title":"Preclinical pharmacokinetics and CYP modulation activity of chebulinic acid: a potent molecule against metabolic disease","volume":"24","author":"Biswas","year":"2023","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.phymed.2026.158357_bib0007","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/jvp.12482","article-title":"Amoxicillin\u2014current use in swine medicine","volume":"41","author":"Burch","year":"2018","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2026.158357_bib0008","doi-asserted-by":"crossref","first-page":"e2517","DOI":"10.1002\/rmv.2517","article-title":"Human-virus protein-protein interactions maps assist in revealing the pathogenesis of viral infection","volume":"34","author":"Chen","year":"2024","journal-title":"Rev. Med. Virol."},{"key":"10.1016\/j.phymed.2026.158357_bib0009","series-title":"CLSI Supplement M100","article-title":"Performance Standards for Antimicrobial Susceptibility Testing","year":"2007"},{"key":"10.1016\/j.phymed.2026.158357_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.prmcm.2022.100163","article-title":"Pharmacological properties of chebulinic acid and related ellagitannins from nature: an emerging contemporary bioactive entity","volume":"5","author":"Dhingra","year":"2022","journal-title":"Pharmacol. Res. - Mod. Chin. Med"},{"key":"10.1016\/j.phymed.2026.158357_bib0011","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s44259-023-00011-6","article-title":"Using next generation antimicrobials to target the mechanisms of infection","volume":"1","author":"Gadar","year":"2023","journal-title":"NPJ Antimicrob Resist"},{"key":"10.1016\/j.phymed.2026.158357_bib0012","doi-asserted-by":"crossref","first-page":"570","DOI":"10.3389\/fimmu.2015.00570","article-title":"Bacterial exotoxins and the inflammasome","volume":"6","author":"Greaney","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2026.158357_bib0013","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1021\/ct700301q","article-title":"GROMACS 4: algorithms for highly efficient, load-balanced, and scalable molecular simulation","volume":"4","author":"Hess","year":"2008","journal-title":"J. Chem. Theory. Comput."},{"key":"10.1016\/j.phymed.2026.158357_bib0014","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.cmi.2019.11.028","article-title":"Mouton JW. Oral amoxicillin and amoxicillin-clavulanic acid: properties, indications and usage","volume":"26","author":"Huttner","year":"2020","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.phymed.2026.158357_bib0015","series-title":"Bacterial Virulence factors, Bacterial pathogens and Their Virulence Factors","first-page":"1","author":"Johnson","year":"2017"},{"key":"10.1016\/j.phymed.2026.158357_bib0016","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/S0140-6736(24)01885-3","article-title":"Global burden of antimicrobial resistance and forecasts to 2050","volume":"404","author":"Kariuki","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2026.158357_bib0017","doi-asserted-by":"crossref","first-page":"9447","DOI":"10.1007\/s00253-014-5903-4","article-title":"Anti-biofilm, anti-hemolysis, and anti-virulence activities of black pepper, cananga, myrrh oils, and nerolidol against Staphylococcus aureus","volume":"98","author":"Lee","year":"2014","journal-title":"Appl Microbiol Biot"},{"key":"10.1016\/j.phymed.2026.158357_bib0018","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.intimp.2019.01.017","article-title":"Quercetin reduces Streptococcus suis virulence by inhibiting suilysin activity and inflammation","volume":"69","author":"Li","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2026.158357_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156616","article-title":"Brazilin reduces methicillin-resistant Staphylococcus aureus virulence and pathogenicity by decreasing the secretion of the \u03b1-hemolysin","volume":"140","author":"Li","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158357_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157362","article-title":"Chebulinic acid from chebulae fructus alleviates influenza virus-induced acute lung injury by inhibiting IDO1-Kyn axis activation","volume":"148","author":"Li","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158357_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157278","article-title":"Daphnetin as a novel polyphosphate kinase inhibitor to combat Salmonella infection","volume":"148","author":"Li","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158357_bib0022","article-title":"Canagliflozin inhibited the activity of hemolysin and reduced the inflammatory response caused by Streptococcus suis","volume":"24","author":"Li","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158357_bib0023","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007795","article-title":"An NLRP3 inflammasome-triggered cytokine storm contributes to Streptococcal toxic shock-like syndrome (STSLS)","volume":"15","author":"Lin","year":"2019","journal-title":"PLoS. Pathog."},{"key":"10.1016\/j.phymed.2026.158357_bib0024","doi-asserted-by":"crossref","DOI":"10.1128\/aac.00611-24","article-title":"Elucidating the potential of isorhapontigenin in targeting the MgrA regulatory network: a paradigm shift for attenuating MRSA virulence","volume":"68","author":"Liu","year":"2024","journal-title":"Antimicrob Agents Ch"},{"key":"10.1016\/j.phymed.2026.158357_bib0025","article-title":"Metformin restores tetracyclines susceptibility against multidrug resistant bacteria","volume":"7","author":"Liu","year":"2020","journal-title":"Adv. Sci."},{"key":"10.1016\/j.phymed.2026.158357_bib0026","doi-asserted-by":"crossref","first-page":"5829","DOI":"10.3390\/ijms22115829","article-title":"Baicalein ameliorates Streptococcus suis-induced infection in vitro and in vivo","volume":"22","author":"Lu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158357_bib0027","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.3390\/molecules26071980","article-title":"Apigenin and ampicillin as combined strategy to treat severe Streptococcus suis infection","volume":"7","author":"Lu","year":"2021","journal-title":"Molecules."},{"key":"10.1016\/j.phymed.2026.158357_bib0028","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s10989-014-9424-x","article-title":"Inhibition of pore formation by blocking the assembly of Staphylococcus aureus \u03b1-Hemolysin through a novel peptide inhibitor: an in Silco approach","volume":"20","author":"Rani","year":"2014","journal-title":"Int. J. Pept. Res. Ther."},{"key":"10.1016\/j.phymed.2026.158357_bib0029","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nrd3013","article-title":"Anti-virulence strategies to combat bacteria-mediated disease","volume":"9","author":"Rasko","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.phymed.2026.158357_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.153946","article-title":"Nordihydroguaiaretic acid reverses the antibacterial activity of colistin against MCR-1-positive bacteria in vivo\/in vitro by inhibiting MCR-1 activity and injuring the bacterial cell membrane","volume":"98","author":"Song","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158357_bib0031","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13567-022-01111-3","article-title":"How Streptococcus suis escapes antibiotic treatments","volume":"53","author":"Uru\u00e9n","year":"2022","journal-title":"Vet. Res."},{"key":"10.1016\/j.phymed.2026.158357_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2025.117018","article-title":"Surface plasmon resonance biosensor chips: fabrications and pharmaceutical applications","volume":"265","author":"Wan","year":"2025","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.phymed.2026.158357_bib0033","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.03165-20","article-title":"Effective antibacterial and antihemolysin activities of ellipticine hydrochloride against Streptococcus suis in a mouse model","volume":"87","author":"Wang","year":"2021","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.phymed.2026.158357_bib0034","doi-asserted-by":"crossref","DOI":"10.1002\/bies.202300007","article-title":"Molecules interact. But how strong and how much?","volume":"45","author":"Weimer","year":"2023","journal-title":"BioEssays"},{"key":"10.1016\/j.phymed.2026.158357_bib0035","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1080\/22221751.2021.1908098","article-title":"Acquiring high expression of suilysin enable non-epidemic Streptococccus suis to cause streptococcal toxic shock-like syndrome (STSLS) through NLRP3 inflammasome hyperactivation","volume":"10","author":"Xu","year":"2021","journal-title":"Emerg. Microbes. Infect."},{"key":"10.1016\/j.phymed.2026.158357_bib0036","doi-asserted-by":"crossref","first-page":"8359","DOI":"10.3390\/ijerph19148359","article-title":"Sub-inhibitory concentrations of amoxicillin and tylosin affect the biofilm formation and virulence of Streptococcus suis","volume":"19","author":"Zuo","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326005891?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326005891?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:00:33Z","timestamp":1781103633000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326005891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":36,"alternative-id":["S0944711326005891"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158357","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting the virulence factor suilysin: a structure-guided discovery of chebulinic acid as a potent antivirulence agent","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158357","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158357"}}