{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:55:39Z","timestamp":1790618139646,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474379"],"award-info":[{"award-number":["82474379"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574907"],"award-info":[{"award-number":["82574907"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974520"],"award-info":[{"award-number":["81974520"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174266"],"award-info":[{"award-number":["82174266"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104504"],"award-info":[{"award-number":["82104504"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010618","name":"Guangzhou University of Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010618","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.phymed.2026.158365","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T15:33:58Z","timestamp":1780155238000},"page":"158365","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Liandan Xiaoyan Formula ameliorates DSS-induced ulcerative colitis through altering the metabolism of bile acids by regulating the FXR-FGF15 signaling pathway"],"prefix":"10.1016","volume":"157","author":[{"given":"Fangle","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzhu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baojun","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyu","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaozhan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenchen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.phymed.2026.158365_bib0001","article-title":"Honokiol antagonizes cadmium-induced ultrastructural nuclear variation and mitochondrial dysfunction of hepatocytes through targeting Bax protein","volume":"105","author":"Aftab Shaukat","year":"2026","journal-title":"Poult. Sci."},{"issue":"2","key":"10.1016\/j.phymed.2026.158365_bib0002","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.cell.2015.08.058","article-title":"Th17 cell induction by adhesion of microbes to intestinal epithelial cells","volume":"163","author":"Atarashi","year":"2015","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.phymed.2026.158365_bib0003","first-page":"367","article-title":"Mongolian medicine in treating type 2 diabetes mellitus combined with nonalcoholic fatty liver disease via FXR\/LXR-mediated P2X7R\/NLRP3\/NF-kappaB pathway activation","volume":"14","author":"Bao","year":"2022","journal-title":"Chin. Herb. Med."},{"issue":"5790","key":"10.1016\/j.phymed.2026.158365_bib0004","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1126\/science.1127119","article-title":"Symbiotic bacteria direct expression of an intestinal bactericidal lectin","volume":"313","author":"Cash","year":"2006","journal-title":"Science"},{"issue":"3\u20134","key":"10.1016\/j.phymed.2026.158365_bib0005","first-page":"162","article-title":"Serum bile acids in relation to disease activity and intake of dietary fibers in juvenile ulcerative colitis","volume":"50","author":"Ejderhamn","year":"1991","journal-title":"Digestion"},{"issue":"6","key":"10.1016\/j.phymed.2026.158365_bib0006","first-page":"579","article-title":"Counter-regulatory role of bile acid activated receptors in immunity and inflammation","volume":"10","author":"Fiorucci","year":"2010","journal-title":"Curr. Mol. Med."},{"issue":"12","key":"10.1016\/j.phymed.2026.158365_bib0007","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1139\/cjpp-2018-0017","article-title":"Bile acid malabsorption is associated with diarrhea in acute phase of colitis","volume":"96","author":"Hou","year":"2018","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"05","key":"10.1016\/j.phymed.2026.158365_bib0008","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1142\/S273741652550067X","article-title":"In silico screening of phytochemicals targeting the NF-\u03baB pathway: a novel approach for pancreatic cancer drug discovery","volume":"25","author":"Iqbal","year":"2026","journal-title":"J. Comput. Biophys. Chem."},{"issue":"5","key":"10.1016\/j.phymed.2026.158365_bib0009","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s11427-023-2353-0","article-title":"Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis","volume":"67","author":"Jia","year":"2024","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.phymed.2026.158365_bib0010","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1016\/j.csbj.2021.04.029","article-title":"Farnesoid X receptor (FXR): structures and ligands","volume":"19","author":"Jiang","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"issue":"43","key":"10.1016\/j.phymed.2026.158365_bib0011","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M306309200","article-title":"Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein","volume":"278","author":"Kok","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.phymed.2026.158365_bib0012","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.14456","article-title":"The secondary bile acids, ursodeoxycholic acid and lithocholic acid, protect against intestinal inflammation by inhibition of epithelial apoptosis","volume":"8","author":"Lajczak-McGinley","year":"2020","journal-title":"Physiol. rep."},{"issue":"2","key":"10.1016\/j.phymed.2026.158365_bib0013","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.taap.2013.01.022","article-title":"Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease","volume":"268","author":"Lake","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"12","key":"10.1016\/j.phymed.2026.158365_bib0014","doi-asserted-by":"crossref","first-page":"6468","DOI":"10.3390\/ijms22126468","article-title":"Atorvastatin modulates bile acid homeostasis in mice with diet-induced nonalcoholic steatohepatitis","volume":"22","author":"Lastuvkova","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158365_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153438","article-title":"5-Hydroxy-4-methoxycanthin-6-one alleviates dextran sodium sulfate-induced colitis in rats via regulation of metabolic profiling and suppression of NF-kappaB\/p65 signaling pathway","volume":"82","author":"Liu","year":"2021","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.phymed.2026.158365_bib0016","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/ptr.7588","article-title":"Nigakinone alleviates DSS-induced experimental colitis via regulating bile acid profile and FXR\/NLRP3 signaling pathways","volume":"37","author":"Liu","year":"2023","journal-title":"PhytOther Res."},{"issue":"8","key":"10.1016\/j.phymed.2026.158365_bib0017","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1111\/jgh.16279","article-title":"Farnesoid X receptor is an important target for the treatment of disorders of bile acid and fatty acid metabolism in mice with nonalcoholic fatty liver disease combined with cholestasis","volume":"38","author":"Liu","year":"2023","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"5","key":"10.1016\/j.phymed.2026.158365_bib0018","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/ni.3400","article-title":"Gut microbiome-derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease","volume":"17","author":"Mathewson","year":"2016","journal-title":"Nat. Immunol."},{"issue":"5","key":"10.1016\/j.phymed.2026.158365_bib0019","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1136\/gutjnl-2023-329963","article-title":"Fibrosis in IBD: from pathogenesis to therapeutic targets","volume":"73","author":"Rieder","year":"2024","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.phymed.2026.158365_bib0020","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/cts.12468","article-title":"Metabolic profile of obeticholic acid and endogenous bile acids in rats with decompensated liver cirrhosis","volume":"10","author":"Roda","year":"2017","journal-title":"Clin. Transl. Sci."},{"issue":"2","key":"10.1016\/j.phymed.2026.158365_bib0021","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1124\/jpet.121.000828","article-title":"Novel bile acid-dependent mechanisms of hepatotoxicity associated with tyrosine kinase inhibitors","volume":"380","author":"Saran","year":"2022","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1","key":"10.1016\/j.phymed.2026.158365_bib0022","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/s12944-023-01971-4","article-title":"Altered fecal bile acid composition in active ulcerative colitis","volume":"22","author":"Sommersberger","year":"2023","journal-title":"Lipids Health Dis."},{"issue":"1","key":"10.1016\/j.phymed.2026.158365_bib0023","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.cmet.2024.09.008","article-title":"Hepatic FXR-FGF4 is required for bile acid homeostasis via an FGFR4-LRH-1 signal node under cholestatic stress","volume":"37","author":"Song","year":"2025","journal-title":"Cell Metab."},{"issue":"2","key":"10.1016\/j.phymed.2026.158365_bib0024","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1055\/s-0030-1253226","article-title":"Organic solute transporter, OSTalpha-OSTbeta: its role in bile acid transport and cholestasis","volume":"30","author":"Soroka","year":"2010","journal-title":"Semin. Liver. Dis."},{"key":"10.1016\/j.phymed.2026.158365_bib0025","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.mam.2013.05.001","article-title":"Biosynthesis and trafficking of the bile salt export pump, BSEP: therapeutic implications of BSEP mutations","volume":"37","author":"Soroka","year":"2014","journal-title":"Mol Asp. Med"},{"key":"10.1016\/j.phymed.2026.158365_bib0026","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.829525","article-title":"The emerging role of bile acids in the pathogenesis of inflammatory bowel disease","volume":"13","author":"Thomas","year":"2022","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.phymed.2026.158365_bib0027","first-page":"266","article-title":"Role of bile acids in inflammatory bowel disease","volume":"31","author":"Tiratterra","year":"2018","journal-title":"Ann. Gastroenterol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158365_bib0028","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cmet.2016.05.005","article-title":"Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism","volume":"24","author":"Wahlstr\u00f6m","year":"2016","journal-title":"Cell Metab."},{"issue":"2","key":"10.1016\/j.phymed.2026.158365_bib0029","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.chom.2016.01.003","article-title":"Intestinal REG3 lectins protect against alcoholic steatohepatitis by reducing mucosa-associated microbiota and preventing bacterial translocation","volume":"19","author":"Wang","year":"2016","journal-title":"Cell Host. Microbe"},{"key":"10.1016\/j.phymed.2026.158365_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2022.115115","article-title":"A comparative study of Liandan Xiaoyan Formula metabolic profiles in control and colitis rats by UPLC-Q-TOF-MS combined with chemometrics","volume":"223","author":"Wang","year":"2023","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"5","key":"10.1016\/j.phymed.2026.158365_bib0031","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1128\/IAI.01578-14","article-title":"Toll-like receptor stimulation induces nondefensin protein expression and reverses antibiotic-induced gut defense impairment","volume":"82","author":"Wu","year":"2014","journal-title":"Infect. Immun."},{"issue":"1","key":"10.1016\/j.phymed.2026.158365_bib0032","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2025.2489070","article-title":"Fusobacterium nucleatum exacerbates colitis via STAT3 activation induced by Acetyl-CoA accumulation","volume":"17","author":"Xiang","year":"2025","journal-title":"Gut. Microbes."},{"key":"10.1016\/j.phymed.2026.158365_bib0033","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1399829","article-title":"Pulsatilla decoction alleviates DSS-induced UC by activating FXR-ASBT pathways to ameliorate disordered bile acids homeostasis","volume":"15","author":"Xiao","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.phymed.2026.158365_bib0034","doi-asserted-by":"crossref","DOI":"10.3390\/nu15051255","article-title":"Gamma-muricholic acid inhibits nonalcoholic steatohepatitis: abolishment of steatosis-dependent peroxidative impairment by FXR\/SHP\/LXR\u03b1\/FASN signaling","volume":"15","author":"Xie","year":"2023","journal-title":"Nutrients."},{"issue":"1","key":"10.1016\/j.phymed.2026.158365_bib0035","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/s12951-023-01965-5","article-title":"Eucommia ulmoides polysaccharide modified nano-selenium effectively alleviated DSS-induced colitis through enhancing intestinal mucosal barrier function and antioxidant capacity","volume":"21","author":"Ye","year":"2023","journal-title":"J. Nanobiotechnology."},{"issue":"1","key":"10.1016\/j.phymed.2026.158365_bib0036","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s40249-021-00918-0","article-title":"Infection with severe fever with thrombocytopenia virus in healthy population: a cohort study in a high endemic region, China","volume":"10","author":"Ye","year":"2021","journal-title":"Infect. Dis. Poverty."},{"issue":"4","key":"10.1016\/j.phymed.2026.158365_bib0037","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/ame2.12255","article-title":"Association between intestinal microbiota and inflammatory bowel disease","volume":"5","author":"Zhang","year":"2022","journal-title":"Anim. Model Exp Med"},{"key":"10.1016\/j.phymed.2026.158365_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155571","article-title":"Zhilining Formula alleviates DSS-induced colitis through suppressing inflammation and gut barrier dysfunction via the AHR\/NF-kappaBp65 axis","volume":"129","author":"Zhou","year":"2024","journal-title":"Phytomedicine"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326005970?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326005970?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:51:14Z","timestamp":1783111874000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326005970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":38,"alternative-id":["S0944711326005970"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158365","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Liandan Xiaoyan Formula ameliorates DSS-induced ulcerative colitis through altering the metabolism of bile acids by regulating the FXR-FGF15 signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158365","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158365"}}