{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:22:57Z","timestamp":1790374977574,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304953"],"award-info":[{"award-number":["82304953"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103574"],"award-info":[{"award-number":["82103574"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82505215"],"award-info":[{"award-number":["82505215"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274233"],"award-info":[{"award-number":["82274233"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M783889"],"award-info":[{"award-number":["2025M783889"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["GZC20252575"],"award-info":[{"award-number":["GZC20252575"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013280","name":"Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013280","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","award":["BK20230744"],"award-info":[{"award-number":["BK20230744"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","award":["BK20240146"],"award-info":[{"award-number":["BK20240146"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017962","name":"Jiangsu Commission of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017962","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.phymed.2026.158366","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T16:07:53Z","timestamp":1779984473000},"page":"158366","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Dihydrotanshinone I inhibits PHGDH to suppress serine synthesis and remodel TME in NSCLC"],"prefix":"10.1016","volume":"158","author":[{"given":"Cheng","family":"Qian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongkuan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixiang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziye","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifei","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.phymed.2026.158366_bib0001","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s12943-022-01645-2","article-title":"The hypoxia-driven crosstalk between tumor and tumor-associated macrophages: mechanisms and clinical treatment strategies","volume":"21","author":"Bai","year":"2022","journal-title":"Mol. Cancer"},{"issue":"5","key":"10.1016\/j.phymed.2026.158366_bib0002","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/s41423-024-01134-0","article-title":"Targeting PHGDH reverses the immunosuppressive phenotype of tumor-associated macrophages through alpha-ketoglutarate and mTORC1 signaling","volume":"21","author":"Cai","year":"2024","journal-title":"Cell Mol. Immunol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158366_bib0003","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.apsb.2021.06.008","article-title":"Identification of a novel PHGDH covalent inhibitor by chemical proteomics and phenotypic profiling","volume":"12","author":"Chen","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"issue":"4","key":"10.1016\/j.phymed.2026.158366_bib0004","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/med.21304","article-title":"The anticancer properties of Salvia miltiorrhiza Bunge (Danshen): a systematic review","volume":"34","author":"Chen","year":"2014","journal-title":"Med. Res. Rev."},{"issue":"4","key":"10.1016\/j.phymed.2026.158366_bib0005","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1038\/s41596-020-0292-x","article-title":"CellPhoneDB: inferring cell-cell communication from combined expression of multi-subunit ligand-receptor complexes","volume":"15","author":"Efremova","year":"2020","journal-title":"Nat. Protoc."},{"issue":"2","key":"10.1016\/j.phymed.2026.158366_bib0006","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s42255-020-00329-9","article-title":"The ins and outs of serine and glycine metabolism in cancer","volume":"3","author":"Geeraerts","year":"2021","journal-title":"Nat. Metab."},{"issue":"1","key":"10.1016\/j.phymed.2026.158366_bib0007","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.cmet.2023.12.013","article-title":"Serine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD","volume":"36","author":"Ghrayeb","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.phymed.2026.158366_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115429","article-title":"Homoharringtonine as a PHGDH inhibitor: unraveling metabolic dependencies and developing a potent therapeutic strategy for high-risk neuroblastoma","volume":"166","author":"Hsieh","year":"2023","journal-title":"Biomed. PharmacOther"},{"issue":"3","key":"10.1016\/j.phymed.2026.158366_bib0009","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/s43018-023-00691-z","article-title":"Sirpalpha on tumor-associated myeloid cells restrains antitumor immunity in colorectal cancer independent of its interaction with CD47","volume":"5","author":"Huang","year":"2024","journal-title":"Nat. Cancer"},{"issue":"Pt B","key":"10.1016\/j.phymed.2026.158366_bib0010","article-title":"Adjuvant role of Salvia miltiorrhiza bunge in cancer chemotherapy: a review of its bioactive components, health-promotion effect and mechanisms","volume":"318","author":"Huang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158366_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107694","article-title":"Combination therapy with PD-1\/PD-L1 blockade in non-small cell lung cancer: strategies and mechanisms","volume":"219","author":"Huang","year":"2021","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.phymed.2026.158366_bib0012","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/s12964-025-02257-1","article-title":"FOLR2(+) macrophages in cancer: allies or enemies","volume":"23","author":"Jiang","year":"2025","journal-title":"Cell Commun. Signal."},{"issue":"4","key":"10.1016\/j.phymed.2026.158366_bib0013","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.cell.2020.06.032","article-title":"Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer","volume":"182","author":"Katzenelenbogen","year":"2020","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.phymed.2026.158366_bib0014","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1038\/s12276-024-01268-1","article-title":"PHGDH: a novel therapeutic target in cancer","volume":"56","author":"Lee","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.phymed.2026.158366_bib0015","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.molimm.2019.11.014","article-title":"Chemokines and their receptors promoting the recruitment of myeloid-derived suppressor cells into the tumor","volume":"117","author":"Li","year":"2020","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.phymed.2026.158366_bib0016","article-title":"Targeting the noncanonical function of metabolic enzyme PHGDH in driving PD-L1 expression and cancer immune evasion","author":"Liu","year":"2026","journal-title":"Cell Rep. Med."},{"issue":"6","key":"10.1016\/j.phymed.2026.158366_bib0017","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1172\/JCI132876","article-title":"Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progression","volume":"130","author":"Liu","year":"2020","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.phymed.2026.158366_bib0018","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s13046-025-03361-3","article-title":"PHGDH activation fuels glioblastoma progression and radioresistance via serine synthesis pathway","volume":"44","author":"Liu","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"10","key":"10.1016\/j.phymed.2026.158366_bib0019","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/s42255-021-00456-x","article-title":"The alternative activity of nuclear PHGDH contributes to tumour growth under nutrient stress","volume":"3","author":"Ma","year":"2021","journal-title":"Nat. Metab."},{"issue":"2","key":"10.1016\/j.phymed.2026.158366_bib0020","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.cmet.2016.12.011","article-title":"Serine Is an Essential Metabolite for Effector T Cell Expansion","volume":"25","author":"Ma","year":"2017","journal-title":"Cell Metab."},{"issue":"5","key":"10.1016\/j.phymed.2026.158366_bib0021","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.immuni.2019.09.003","article-title":"Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8(+) T Cells","volume":"51","author":"Ma","year":"2019","journal-title":"Immunity."},{"issue":"7433","key":"10.1016\/j.phymed.2026.158366_bib0022","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nature11743","article-title":"Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells","volume":"493","author":"Maddocks","year":"2013","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.phymed.2026.158366_bib0023","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41568-021-00378-6","article-title":"Cancer metabolism: looking forward","volume":"21","author":"Martinez-Reyes","year":"2021","journal-title":"Nat. Rev. Cancer"},{"issue":"7831","key":"10.1016\/j.phymed.2026.158366_bib0024","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/s41586-020-2609-x","article-title":"Serine restriction alters sphingolipid diversity to constrain tumour growth","volume":"586","author":"Muthusamy","year":"2020","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.phymed.2026.158366_bib0025","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nchembio.2070","article-title":"A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate","volume":"12","author":"Pacold","year":"2016","journal-title":"Nat. Chem. Biol."},{"issue":"7360","key":"10.1016\/j.phymed.2026.158366_bib0026","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nature10350","article-title":"Functional genomics reveal that the serine synthesis pathway is essential in breast cancer","volume":"476","author":"Possemato","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2026.158366_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156427","article-title":"Integrated identification and mechanism exploration of bioactive ingredients from Salvia miltiorrhiza to induce vascular normalization","volume":"138","author":"Qian","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158366_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106333","article-title":"Pharmacological manipulation of Ezh2 with salvianolic acid B results in tumor vascular normalization and synergizes with cisplatin and T cell-mediated immunotherapy","volume":"182","author":"Qian","year":"2022","journal-title":"Pharmacol. Res."},{"issue":"5","key":"10.1016\/j.phymed.2026.158366_bib0029","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1016\/j.apsb.2024.02.003","article-title":"Targeting PKM2 signaling cascade with salvianic acid A normalizes tumor blood vessels to facilitate chemotherapeutic drug delivery","volume":"14","author":"Qian","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"issue":"11","key":"10.1016\/j.phymed.2026.158366_bib0030","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1038\/s41423-022-00925-7","article-title":"Serine metabolism orchestrates macrophage polarization by regulating the IGF1-p38 axis","volume":"19","author":"Shan","year":"2022","journal-title":"Cell Mol. Immunol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158366_bib0031","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s12964-024-01506-z","article-title":"PRMT1 in human neoplasm: cancer biology and potential therapeutic target","volume":"22","author":"Shen","year":"2024","journal-title":"Cell Commun. Signal."},{"issue":"1","key":"10.1016\/j.phymed.2026.158366_bib0032","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1186\/s12964-025-02327-4","article-title":"Protein post-translational modifications in serine synthetic pathway: functions and molecular mechanisms","volume":"23","author":"Shu","year":"2025","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.phymed.2026.158366_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116735","article-title":"Salvia mitiorrhiza Bunge aqueous extract attenuates infiltration of tumor-associated macrophages and potentiates anti-PD-L1 immunotherapy in colorectal cancer through modulating Cox2\/PGE2 cascade","volume":"316","author":"Song","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.phymed.2026.158366_bib0034","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41573-021-00339-6","article-title":"Targeting cancer metabolism in the era of precision oncology","volume":"21","author":"Stine","year":"2022","journal-title":"Nat. Rev. Drug Discovery"},{"issue":"12","key":"10.1016\/j.phymed.2026.158366_bib0035","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/s41422-023-00883-3","article-title":"An idle PHGDH takes control of cell fate","volume":"33","author":"Sun","year":"2023","journal-title":"Cell Res."},{"issue":"1","key":"10.1016\/j.phymed.2026.158366_bib0036","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1136\/gutjnl-2020-322744","article-title":"Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism","volume":"71","author":"Sun","year":"2022","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.phymed.2026.158366_bib0037","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/s41467-020-20223-y","article-title":"Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy","volume":"12","author":"Tajan","year":"2021","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.phymed.2026.158366_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108021","article-title":"Acetylation Stabilizes Phosphoglycerate Dehydrogenase by Disrupting the Interaction of E3 Ligase RNF5 to Promote Breast Tumorigenesis","volume":"32","author":"Wang","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.phymed.2026.158366_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2023.100985","article-title":"Inhibition of phosphoglycerate dehydrogenase induces ferroptosis and overcomes enzalutamide resistance in castration-resistant prostate cancer cells","volume":"70","author":"Wang","year":"2023","journal-title":"Drug Resist. Updat."},{"issue":"1","key":"10.1016\/j.phymed.2026.158366_bib0040","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/s41467-023-36708-5","article-title":"PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma","volume":"14","author":"Wang","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.phymed.2026.158366_bib0041","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.apsb.2022.07.006","article-title":"Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS","volume":"13","author":"Wu","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"issue":"1","key":"10.1016\/j.phymed.2026.158366_bib0042","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12943-021-01316-8","article-title":"The cancer metabolic reprogramming and immune response","volume":"20","author":"Xia","year":"2021","journal-title":"Mol. Cancer"},{"issue":"7","key":"10.1016\/j.phymed.2026.158366_bib0043","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1158\/0008-5472.CAN-23-2266","article-title":"PRMT1 Sustains De Novo Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer","volume":"84","author":"Yamamoto","year":"2024","journal-title":"Cancer Res."},{"key":"10.1016\/j.phymed.2026.158366_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116635","article-title":"The multifaceted mechanisms of Dihydrotanshinone I in the treatment of tumors","volume":"175","author":"Yue","year":"2024","journal-title":"Biomed. PharmacOther"},{"issue":"3","key":"10.1016\/j.phymed.2026.158366_bib0045","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.cmet.2023.01.010","article-title":"PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy","volume":"35","author":"Zhang","year":"2023","journal-title":"Cell Metab."},{"issue":"4","key":"10.1016\/j.phymed.2026.158366_bib0046","article-title":"Chronic Stress-Induced and Tumor Derived SP1(+) Exosomes Polarizing IL-1beta(+) Neutrophils to Increase Lung Metastasis of Breast Cancer","volume":"12","author":"Zhang","year":"2025","journal-title":"Adv. Sci. (Weinh)"},{"issue":"1","key":"10.1016\/j.phymed.2026.158366_bib0047","doi-asserted-by":"crossref","first-page":"6119","DOI":"10.1038\/s41467-020-19973-6","article-title":"CCL7 recruits cDC1 to promote antitumor immunity and facilitate checkpoint immunotherapy to non-small cell lung cancer","volume":"11","author":"Zhang","year":"2020","journal-title":"Nat. Commun."},{"issue":"21","key":"10.1016\/j.phymed.2026.158366_bib0048","doi-asserted-by":"crossref","DOI":"10.1172\/JCI146187","article-title":"Cul4A-DDB1-mediated monoubiquitination of phosphoglycerate dehydrogenase promotes colorectal cancer metastasis via increased S-adenosylmethionine","volume":"131","author":"Zhang","year":"2021","journal-title":"J. Clin. Invest."},{"issue":"17","key":"10.1016\/j.phymed.2026.158366_bib0049","article-title":"Elevated nuclear PHGDH synergistically functions with cMyc to reshape the immune microenvironment of liver cancer","volume":"10","author":"Zhu","year":"2023","journal-title":"Adv. Sci. (Weinh)"},{"issue":"6","key":"10.1016\/j.phymed.2026.158366_bib0050","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.ccell.2025.03.015","article-title":"Cancer cell-derived arginine fuels polyamine biosynthesis in tumor-associated macrophages to promote immune evasion","volume":"43","author":"Zhu","year":"2025","journal-title":"Cancer Cell"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326005982?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326005982?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T03:22:25Z","timestamp":1783135345000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326005982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":50,"alternative-id":["S0944711326005982"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158366","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dihydrotanshinone I inhibits PHGDH to suppress serine synthesis and remodel TME in NSCLC","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158366","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158366"}}