{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:54:00Z","timestamp":1785887640227,"version":"3.56.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404639"],"award-info":[{"award-number":["82404639"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U24A20794"],"award-info":[{"award-number":["U24A20794"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2024KY1205"],"award-info":[{"award-number":["2024KY1205"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017599","name":"Science and Technology Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2024ZL219"],"award-info":[{"award-number":["2024ZL219"]}],"id":[{"id":"10.13039\/501100017599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","award":["BK20241249"],"award-info":[{"award-number":["BK20241249"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LYY22H310004"],"award-info":[{"award-number":["LYY22H310004"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.phymed.2026.158386","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T06:36:18Z","timestamp":1780727778000},"page":"158386","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Shegan Mahuang Decoction ameliorates pulmonary fibrosis progression by inhibiting CCL3-mediated NETosis"],"prefix":"10.1016","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6160-4551","authenticated-orcid":false,"given":"Wencheng","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhisen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojie","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanjun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengcheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1425-0089","authenticated-orcid":false,"given":"Yang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6409","key":"10.1016\/j.phymed.2026.158386_bib0001","article-title":"Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice","volume":"361","author":"Albrengues","year":"2018","journal-title":"Science (1979)"},{"key":"10.1016\/j.phymed.2026.158386_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116229","article-title":"Advances in traditional Chinese medicine for the treatment of chronic obstructive pulmonary disease","volume":"307","author":"Cao","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158386_bib0003","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41392-024-01881-6","article-title":"DNA of neutrophil extracellular traps promote NF-kappaB-dependent autoimmunity via cGAS\/TLR9 in chronic obstructive pulmonary disease","volume":"9","author":"Chen","year":"2024","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"3","key":"10.1016\/j.phymed.2026.158386_bib0004","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/path.4359","article-title":"Neutrophil extracellular traps promote differentiation and function of fibroblasts","volume":"233","author":"Chrysanthopoulou","year":"2014","journal-title":"J. Pathol."},{"issue":"174","key":"10.1016\/j.phymed.2026.158386_bib0005","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0139-2024","article-title":"Neutrophil dynamics in pulmonary fibrosis: pathophysiological and therapeutic perspectives","volume":"33","author":"Crowley","year":"2024","journal-title":"Eur. Respir. Rev."},{"issue":"10","key":"10.1016\/j.phymed.2026.158386_bib0006","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1039\/D2MO00216G","article-title":"LC-MS-based metabolomics reveals the in vivo effect of Shegan Mahuang Decoction in an OVA-induced rat model of airway hyperresponsiveness","volume":"18","author":"Han","year":"2022","journal-title":"Mol. Omics."},{"issue":"3","key":"10.1016\/j.phymed.2026.158386_bib0007","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.ccell.2024.01.013","article-title":"Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment","volume":"42","author":"He","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.phymed.2026.158386_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107843","article-title":"Traditional Chinese Medicine (TCM) in the treatment of COVID-19 and other viral infections: efficacies and mechanisms","volume":"225","author":"Huang","year":"2021","journal-title":"Pharmacol. Ther."},{"issue":"5","key":"10.1016\/j.phymed.2026.158386_bib0009","doi-asserted-by":"crossref","first-page":"5034","DOI":"10.3390\/ijms24055034","article-title":"Neutrophil extracellular traps in airway diseases: pathological roles and therapeutic implications","volume":"24","author":"Jo","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158386_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104766","article-title":"Precision medicine advances in idiopathic pulmonary fibrosis","volume":"95","author":"Karampitsakos","year":"2023","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.phymed.2026.158386_bib0011","doi-asserted-by":"crossref","first-page":"5766","DOI":"10.1038\/s41467-024-50197-0","article-title":"Neutrophil extracellular traps promote immunopathogenesis of virus-induced COPD exacerbations","volume":"15","author":"Katsoulis","year":"2024","journal-title":"Nat. Commun."},{"issue":"163","key":"10.1016\/j.phymed.2026.158386_bib0012","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0241-2021","article-title":"Neutrophil extracellular traps in chronic lung disease: implications for pathogenesis and therapy","volume":"31","author":"Keir","year":"2022","journal-title":"Eur. Respir. Rev."},{"issue":"8","key":"10.1016\/j.phymed.2026.158386_bib0013","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.3390\/jcm13082390","article-title":"Neutrophil extracellular traps and Respiratory disease","volume":"13","author":"King","year":"2024","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.phymed.2026.158386_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118504","article-title":"Shegan-Mahuang decoction ameliorates cold-induced asthma via regulating the proliferation and apoptosis of airway smooth muscle cells through TAS2R10: an in vivo and in vitro study","volume":"334","author":"Li","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"23","key":"10.1016\/j.phymed.2026.158386_bib0015","first-page":"6414","article-title":"Improvement effect of Shegan Mahuang Decoction on rats with cold-induced asthma based on TRPV1\/NRF-1\/mtTFA pathway]","volume":"48","author":"Li","year":"2023","journal-title":"Zhongguo Zhong. Yao Za Zhi."},{"key":"10.1016\/j.phymed.2026.158386_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112656","article-title":"Shegan-Mahuang decoction ameliorates asthmatic airway hyperresponsiveness by downregulating Th2\/Th17 cells but upregulating CD4+FoxP3+ tregs","volume":"253","author":"Lin","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158386_bib0017","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1186\/s12964-024-01966-3","article-title":"Biological and pharmacological roles of pyroptosis in pulmonary inflammation and fibrosis: recent advances and future directions","volume":"22","author":"Liu","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.phymed.2026.158386_bib0018","first-page":"1","article-title":"Shegan Mahuang decoction may reduce airway inflammation in neutrophilic asthmatic mice by improving the mitochondrial function of bronchoalveolar lavage fluid exosomes","volume":"2022","author":"Lu","year":"2022","journal-title":"Evid. Based. Complement. Alternat. Med."},{"key":"10.1016\/j.phymed.2026.158386_bib0019","article-title":"Research progress in the molecular mechanisms, therapeutic targets, and drug development of idiopathic pulmonary fibrosis","volume":"13","author":"Ma","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158386_bib0020","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cytogfr.2024.12.001","article-title":"Cytokine signalling in formation of neutrophil extracellular traps: implications for health and diseases","volume":"81","author":"Manoj","year":"2025","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.phymed.2026.158386_bib0021","article-title":"Neutrophil extracellular traps linked to idiopathic pulmonary fibrosis severity and survival","author":"Matson","year":"2024","journal-title":"medRxiv."},{"issue":"2","key":"10.1016\/j.phymed.2026.158386_bib0022","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1007\/s12016-020-08804-7","article-title":"A review of neutrophil extracellular traps (NETs) in disease: potential anti-NETs therapeutics","volume":"61","author":"Mutua","year":"2021","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.phymed.2026.158386_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112861","article-title":"Peptidyl arginine deiminase-4 inhibitor ameliorates pulmonary fibrosis through positive regulation of developmental endothelial locus-1","volume":"140","author":"Panda","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"11","key":"10.1016\/j.phymed.2026.158386_bib0024","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1161\/ATVBAHA.109.193268","article-title":"Ccl2 and Ccl3 mediate neutrophil recruitment via induction of protein synthesis and generation of lipid mediators","volume":"29","author":"Reichel","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"3","key":"10.1016\/j.phymed.2026.158386_bib0025","doi-asserted-by":"crossref","DOI":"10.1128\/iai.00491-21","article-title":"Neutrophil extracellular traps as an exacerbating factor in bacterial pneumonia","volume":"90","author":"Sanders","year":"2022","journal-title":"Infect. Immun."},{"key":"10.1016\/j.phymed.2026.158386_bib0026","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.953195","article-title":"The role of neutrophil extracellular traps in acute lung injury","volume":"13","author":"Scozzi","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2026.158386_bib0027","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1580750","article-title":"Establishment of prognostic signature based on neutrophil extracellular traps-related genes in acute myeloid leukemia: a bioinformatics analysis","volume":"16","author":"Shen","year":"2025","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.phymed.2026.158386_bib0028","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-003793","article-title":"Ccl3 enhances docetaxel chemosensitivity in breast cancer by triggering proinflammatory macrophage polarization","volume":"10","author":"Sheng","year":"2022","journal-title":"J. ImmunOther Cancer"},{"issue":"2","key":"10.1016\/j.phymed.2026.158386_bib0029","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.iac.2023.01.010","article-title":"Idiopathic pulmonary fibrosis and Progressive Pulmonary Fibrosis","volume":"43","author":"Strykowski","year":"2023","journal-title":"Immunol. Allergy Clin. North Am."},{"key":"10.1016\/j.phymed.2026.158386_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117650","article-title":"Multi-omics analysis of lung tissue metabolome and proteome reveals the therapeutic effect of Shegan Mahuang Decoction against asthma in rats","volume":"322","author":"Sun","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.phymed.2026.158386_bib0031","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1165\/rcmb.2019-0433OC","article-title":"PAD4 Deficiency improves bleomycin-induced neutrophil extracellular traps and fibrosis in mouse lung","volume":"63","author":"Suzuki","year":"2020","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158386_bib0032","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s12964-024-01627-5","article-title":"Helicobacter pylori disrupts gastric mucosal homeostasis by stimulating macrophages to secrete CCL3","volume":"22","author":"Wei","year":"2024","journal-title":"Cell Commun. Signal."},{"issue":"5","key":"10.1016\/j.phymed.2026.158386_bib0033","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/s41577-022-00787-0","article-title":"Neutrophil extracellular traps in systemic autoimmune and autoinflammatory diseases","volume":"23","author":"Wigerblad","year":"2023","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.phymed.2026.158386_bib0034","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.ccell.2020.12.012","article-title":"Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation","volume":"39","author":"Xiao","year":"2021","journal-title":"Cancer Cell"},{"issue":"7814","key":"10.1016\/j.phymed.2026.158386_bib0035","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41586-020-2394-6","article-title":"DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25","volume":"583","author":"Yang","year":"2020","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.phymed.2026.158386_bib0036","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1080\/08820139.2024.2364796","article-title":"The therapeutic potential of neutrophil extracellular traps and NLRP3 inflammasomes in Mycoplasma pneumoniae pneumonia","volume":"53","author":"Yang","year":"2024","journal-title":"Immunol. Invest."},{"issue":"1","key":"10.1016\/j.phymed.2026.158386_bib0037","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41390-022-02409-w","article-title":"CCL3 aggravates intestinal damage in NEC by promoting macrophage chemotaxis and M1 macrophage polarization","volume":"94","author":"Yuan","year":"2023","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.phymed.2026.158386_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115051","article-title":"The analgesic properties of Yu-Xue-Bi tablets in the inflammatory pain mice: by the inhibition of CCL3-mediated macrophage transmigration into the spinal cord","volume":"289","author":"Zhang","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158386_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112923","article-title":"Timing, initiation and function: an in-depth exploration of the interaction network among neutrophil extracellular traps related genes in acute pancreatitis","volume":"141","author":"Zhang","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"6","key":"10.1016\/j.phymed.2026.158386_bib0040","doi-asserted-by":"crossref","first-page":"5125","DOI":"10.3390\/ijms24065125","article-title":"NETs promote inflammatory injury by activating cGAS-STING pathway in acute lung injury","volume":"24","author":"Zhao","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158386_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156543","article-title":"Jinkui Shenqi decoction targets PAD4 to restrain NETosis and ameliorates psoriasis progression","volume":"139","author":"Zhao","year":"2025","journal-title":"Phytomedicine"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326006185?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326006185?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:35:06Z","timestamp":1785886506000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326006185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":41,"alternative-id":["S0944711326006185"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158386","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Shegan Mahuang Decoction ameliorates pulmonary fibrosis progression by inhibiting CCL3-mediated NETosis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158386","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158386"}}