{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:16:29Z","timestamp":1793063789514,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.phymed.2026.158390","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T01:02:58Z","timestamp":1781312578000},"page":"158390","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Elucidating the NETs-BNIP3-pyroptosis axis in cerebral ischemia-reperfusion injury and the intervention of Bu Yang Huan Wu decoction"],"prefix":"10.1016","volume":"159","author":[{"given":"Tianci","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu han","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiangang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohan","family":"chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuorui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijuan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.phymed.2026.158390_bib0001","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuint.2005.12.008","article-title":"Expression of the gene encoding the pro-apoptotic BNIP3 protein and stimulation of hypoxia-inducible factor-1alpha (HIF-1alpha) protein following focal cerebral ischemia in rats","volume":"48","author":"Althaus","year":"2006","journal-title":"Neurochem. Int."},{"issue":"6","key":"10.1016\/j.phymed.2026.158390_bib0002","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1007\/s11239-024-03004-y","article-title":"Assessment of associations between neutrophil extracellular trap biomarkers in blood and thrombi in acute ischemic stroke patients","volume":"57","author":"Baumann","year":"2024","journal-title":"J. Thromb. Thrombolysis."},{"issue":"5","key":"10.1016\/j.phymed.2026.158390_bib0003","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1161\/STROKEAHA.122.036946","article-title":"Neuroinflammation, stroke, blood-brain barrier dysfunction, and imaging modalities","volume":"53","author":"Candelario-Jalil","year":"2022","journal-title":"Stroke"},{"key":"10.1016\/j.phymed.2026.158390_bib0004","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12964-015-0115-9","article-title":"Autophagy capacity and sub-mitochondrial heterogeneity shape Bnip3-induced mitophagy regulation of apoptosis","volume":"13","author":"Choe","year":"2015","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.phymed.2026.158390_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102906","article-title":"Neutrophil extracellular traps drive intestinal microvascular endothelial ferroptosis by impairing Fundc1-dependent mitophagy","volume":"67","author":"Chu","year":"2023","journal-title":"Redox. Biol."},{"issue":"10","key":"10.1016\/j.phymed.2026.158390_bib0006","doi-asserted-by":"crossref","DOI":"10.1172\/JCI154225","article-title":"Neutrophil extracellular traps regulate ischemic stroke brain injury","volume":"132","author":"Denorme","year":"2022","journal-title":"J. Clin. Invest."},{"issue":"10","key":"10.1016\/j.phymed.2026.158390_bib0007","doi-asserted-by":"crossref","DOI":"10.26599\/FSHW.2024.9250250","article-title":"Isodon Szuhoensis extract interferes with miRNA expression profile for prevention and treatment of chronic obstructive pneumonia disease","volume":"14","author":"Duan","year":"2025","journal-title":"Food Sci. Hum. Wellness"},{"key":"10.1016\/j.phymed.2026.158390_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103244","article-title":"A detrimental role of endothelial S1PR2 in cardiac ischemia-reperfusion injury via modulating mitochondrial dysfunction, NLRP3 inflammasome activation, and pyroptosis","volume":"75","author":"Duan","year":"2024","journal-title":"Redox. Biol."},{"issue":"4","key":"10.1016\/j.phymed.2026.158390_bib0009","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1161\/STROKEAHA.124.048085","article-title":"Spatial transcriptomics and proteomics profiling after ischemic stroke reperfusion: insights into vascular alterations","volume":"56","author":"Hansen","year":"2025","journal-title":"Stroke"},{"key":"10.1016\/j.phymed.2026.158390_bib0010","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2025.1641985","article-title":"Neutrophil extracellular traps in ischemic stroke: mechanisms, clinical implications, and therapeutic potential","volume":"16","author":"He","year":"2025","journal-title":"Front. Neurol."},{"issue":"11","key":"10.1016\/j.phymed.2026.158390_bib0011","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/s41419-022-05418-z","article-title":"BNIP3 phosphorylation by JNK1\/2 promotes mitophagy via enhancing its stability under hypoxia","volume":"13","author":"He","year":"2022","journal-title":"Cell Death. Dis."},{"key":"10.1016\/j.phymed.2026.158390_bib0012","doi-asserted-by":"crossref","DOI":"10.1093\/burnst\/tkad018","article-title":"Targeting neuronal mitophagy in ischemic stroke: an update","volume":"11","author":"Li","year":"2023","journal-title":"Burns. Trauma"},{"issue":"Pt 3","key":"10.1016\/j.phymed.2026.158390_bib0013","article-title":"HSYA ameliorates venous thromboembolism by depleting the formation of TLR4\/NF-\u03bab pathway-dependent neutrophil extracellular traps","volume":"143","author":"Li","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"Pt 3","key":"10.1016\/j.phymed.2026.158390_bib0014","article-title":"Drug pairs of Huangqi and Danggui alleviates pyroptosis by promoting autophagy activity via AMPK\/mTOR signaling pathway in middle-cerebral artery occlusion\/reperfusion in rats","volume":"337","author":"Liu","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158390_bib0015","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.mvr.2013.08.004","article-title":"A simple method for isolating and culturing the rat brain microvascular endothelial cells","volume":"90","author":"Liu","year":"2013","journal-title":"Microvasc. Res."},{"issue":"Pt 3","key":"10.1016\/j.phymed.2026.158390_bib0016","article-title":"Buyang Huanwu decoction restores the balance of mitochondrial dynamics after cerebral ischemia-reperfusion through calcium overload reduction by the PKC\u03b5-Nampt-Sirt5 axis","volume":"338","author":"Liu","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"10","key":"10.1016\/j.phymed.2026.158390_bib0017","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.2174\/1570159X21666230308090351","article-title":"Neutrophil extracellular traps in cerebral ischemia\/reperfusion injury: friend and foe","volume":"21","author":"Luo","year":"2023","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.phymed.2026.158390_bib0018","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2025.1649533","article-title":"Dynamic mechanisms and targeted interventions in cerebral ischemia-reperfusion injury: pathological cascade from ischemia to reperfusion and promising therapeutic strategies","volume":"19","author":"Meng","year":"2025","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.phymed.2026.158390_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2025.111200","article-title":"Electroacupuncture combined with trigonelline inhibits pyroptosis in cerebral ischemia-reperfusion by suppressing autophagy via the PI3K\/AKT\/mTOR signaling pathway","volume":"221","author":"Qiu","year":"2025","journal-title":"Brain Res. Bull."},{"issue":"1","key":"10.1016\/j.phymed.2026.158390_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2024.108107","article-title":"Hydroxysafflor Yellow A promotes angiogenesis of brain microvascular endothelial cells from ischemia\/reperfusion injury via glycolysis pathway in vitro","volume":"34","author":"Ruan","year":"2025","journal-title":"J. Stroke Cerebrovasc. Dis."},{"issue":"8","key":"10.1016\/j.phymed.2026.158390_bib0022","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1182\/blood.2020005861","article-title":"Neutrophil extracellular traps promote fibrous vascular occlusions in chronic thrombosis","volume":"137","author":"Sharma","year":"2021","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.phymed.2026.158390_bib0023","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1111\/cns.12325","article-title":"BNIP3 interacting with LC3 triggers excessive mitophagy in delayed neuronal death in stroke","volume":"20","author":"Shi","year":"2014","journal-title":"CNS. Neurosci. Ther."},{"issue":"6","key":"10.1016\/j.phymed.2026.158390_bib0024","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.4103\/1673-5374.385313","article-title":"Mitochondrial transplantation confers protection against the effects of ischemic stroke by repressing microglial pyroptosis and promoting neurogenesis","volume":"19","author":"Sun","year":"2024","journal-title":"Neural Regener. Res."},{"key":"10.1016\/j.phymed.2026.158390_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107695","article-title":"Natural medicine in neuroprotection for ischemic stroke: challenges and prospective","volume":"216","author":"Tao","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2026.158390_bib0026","first-page":"109","article-title":"Neutrophil extracellular traps aggravate placental injury in OAPS by facilitating activation of BNIP3 mediated mitophagy. Free radic","volume":"235","author":"Wang","year":"2025","journal-title":"Biol. Med."},{"key":"10.1016\/j.phymed.2026.158390_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155139","article-title":"Targeted intervention of natural medicinal active ingredients and traditional Chinese medicine on epigenetic modification: possible strategies for prevention and treatment of atherosclerosis","volume":"122","author":"Wang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158390_bib0028","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41401-024-01365-x","article-title":"BNIP3-mediated mitophagy attenuates hypoxic-ischemic brain damage in neonatal rats by inhibiting ferroptosis through P62-KEAP1-NRF2 pathway activation to maintain iron and redox homeostasis","volume":"46","author":"Wang","year":"2025","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2026.158390_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2025.110642","article-title":"Ligustilide ameliorates cerebral ischemia-reperfusion injury by inhibiting NLRP3 inflammasome-dependent pyroptosis through enhancing Nrf2 signaling","volume":"279","author":"Wang","year":"2025","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phymed.2026.158390_bib0030","first-page":"1","article-title":"Three ingredients of safflower alleviate acute lung injury and inhibit NET release induced by lipopolysaccharide","volume":"2020","author":"Wang","year":"2020","journal-title":"Mediators. Inflamm."},{"issue":"5","key":"10.1016\/j.phymed.2026.158390_bib0031","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1136\/svn-2024-003977","article-title":"Chinese stroke association guidelines on reperfusion therapy for acute ischaemic stroke 2024","volume":"10","author":"Xiong","year":"2025","journal-title":"Stroke Vasc. Neurol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158390_bib0032","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10985549.2024.2426282","article-title":"SIRT3 deficiency promotes lung endothelial pyroptosis through impairing mitophagy to activate NLRP3 inflammasome during sepsis-induced acute lung injury","volume":"45","author":"Yan","year":"2025","journal-title":"Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.phymed.2026.158390_bib0033","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3892\/mmr.2025.13436","article-title":"Calycosin-7-O-\u03b2-d-glucoside downregulates mitophagy by mitigating mitochondrial fission to protect HT22 cells from oxygen-glucose deprivation\/reperfusion-induced injury","volume":"31","author":"Yan","year":"2025","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.phymed.2026.158390_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115953","article-title":"Buyang Huanwu decoction alleviates oxidative injury of cerebral ischemia-reperfusion through pkc\u03b5\/Nrf2 signaling pathway","volume":"303","author":"Yin","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158390_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122272","article-title":"Trigonelline mitigates bleomycin-induced pulmonary inflammation and fibrosis: insight into NLRP3 inflammasome and SPHK1\/S1P\/Hippo signaling modulation","volume":"336","author":"Zeyada","year":"2024","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2026.158390_bib0036","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.jare.2024.08.012","article-title":"Extracellular vesicle-derived miR-146a as a novel crosstalk mechanism for high-fat induced atherosclerosis by targeting SMAD4","volume":"73","author":"Zhai","year":"2025","journal-title":"J. Adv. Res."},{"issue":"11","key":"10.1016\/j.phymed.2026.158390_bib0037","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1016\/j.apsb.2021.03.032","article-title":"Ginsenoside Rg1 ameliorates blood-brain barrier disruption and traumatic brain injury via attenuating macrophages derived exosomes miR-21 release","volume":"11","author":"Zhai","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2026.158390_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.116122","article-title":"Paeoniflorin suppresses cardiomyocyte pyroptosis and ameliorates diabetic cardiomyopathy by AMPK\/Nrf2\/NLRP3 pathway","volume":"171","author":"Zhang","year":"2026","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2026.158390_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.120832","article-title":"Traditional Chinese medicine regulate mitochondrial dysfunction in cerebral ischemia-reperfusion injury","volume":"356","author":"Zhao","year":"2026","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158390_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108328","article-title":"Neutrophil extracellular traps: a novel target for the treatment of stroke","volume":"241","author":"Zhao","year":"2023","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2026.158390_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111032","article-title":"Paeoniflorin attenuates particulate matter-induced acute lung injury by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis through activation of the Nrf2 signaling pathway","volume":"395","author":"Zhou","year":"2024","journal-title":"Chem. Biol. Interact."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326006227?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326006227?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T14:36:57Z","timestamp":1785508617000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326006227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":40,"alternative-id":["S0944711326006227"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158390","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elucidating the NETs-BNIP3-pyroptosis axis in cerebral ischemia-reperfusion injury and the intervention of Bu Yang Huan Wu decoction","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158390","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158390"}}