{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:02:54Z","timestamp":1790190174613,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong Province","doi-asserted-by":"publisher","award":["2022TZXD0018"],"award-info":[{"award-number":["2022TZXD0018"]}],"id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["RS-2025-00521523"],"award-info":[{"award-number":["RS-2025-00521523"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["2020R1A2C2004144"],"award-info":[{"award-number":["2020R1A2C2004144"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["RS-2024-00334577"],"award-info":[{"award-number":["RS-2024-00334577"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2026-RISE-17-001"],"award-info":[{"award-number":["2026-RISE-17-001"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.phymed.2026.158423","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:41:20Z","timestamp":1781278880000},"page":"158423","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Medium-chain inulin reshapes the gut microbiome-metabolome axis to counteract high-fat diet-induced obesity"],"prefix":"10.1016","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0190-4146","authenticated-orcid":false,"given":"Yunpeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9018-1797","authenticated-orcid":false,"given":"Eunyoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9126-9667","authenticated-orcid":false,"given":"Jiamei","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6453-769X","authenticated-orcid":false,"given":"Yunkyoung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiguo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158423_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.cdnut.2023.102026","article-title":"Role of Bifidobacterium in modulating the intestinal epithelial tight junction barrier: current knowledge and perspectives","volume":"7","author":"Abdulqadir","year":"2023","journal-title":"Curr. Dev. Nutr"},{"key":"10.1016\/j.phymed.2026.158423_bib0002","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.3390\/nu16172935","article-title":"Health effects and mechanisms of inulin action in human metabolism","volume":"16","author":"Alonso-Allende","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.158423_bib0003","article-title":"Therapeutic potential of inulin-coated MCT microcapsules in modulating the gut microbiome for effective treatment of diet-induced obesity","volume":"8","author":"Ariaee","year":"2025","journal-title":"Adv. Ther"},{"key":"10.1016\/j.phymed.2026.158423_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2024.155932","article-title":"The evolutionary conserved miR-137\/325 tandem mediates obesity-induced hypogonadism and metabolic comorbidities by repressing hypothalamic kisspeptin","volume":"157","author":"Avenda\u00f1o","year":"2024","journal-title":"Metabolism"},{"key":"10.1016\/j.phymed.2026.158423_bib0005","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.3390\/nu11081943","article-title":"The short-chain fatty acid acetate in body weight control and insulin sensitivity","volume":"11","author":"Gonz\u00e1lez Hern\u00e1ndez","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.158423_bib0006","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1017\/S0007114508894378","article-title":"Dietary long-chain inulin reduces abdominal fat but has no effect on bone density in growing female rats","volume":"100","author":"Jamieson","year":"2008","journal-title":"Br. J. Nutr"},{"key":"10.1016\/j.phymed.2026.158423_bib0007","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2026.158423_bib0008","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/4441022a","article-title":"Human gut microbes associated with obesity","volume":"444","author":"Ley","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2026.158423_bib0009","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/s41598-020-58048-w","article-title":"Inulin with different degrees of polymerization protects against diet-induced endotoxemia and inflammation in association with gut microbiota regulation in mice","volume":"10","author":"Li","year":"2020","journal-title":"Sci. Rep"},{"key":"10.1016\/j.phymed.2026.158423_bib0010","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2377576","article-title":"Gut microbiota metabolite indole-3-acetic acid maintains intestinal epithelial homeostasis through mucin sulfation","volume":"16","author":"Li","year":"2024","journal-title":"Gut. Microbes."},{"key":"10.1016\/j.phymed.2026.158423_bib0011","article-title":"Diet type impacts production performance of fattening lambs by manipulating the ruminal microbiota and metabolome","volume":"13","author":"Li","year":"2022","journal-title":"Front. Microbiol"},{"key":"10.1016\/j.phymed.2026.158423_bib0012","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.aninu.2025.07.003","article-title":"Effects of inulin on growth performance and intestinal health of broilers by modulating intestinal microbiota and metabolome","volume":"23","author":"Li","year":"2025","journal-title":"Anim. Nutr"},{"key":"10.1016\/j.phymed.2026.158423_bib0013","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.micpath.2018.08.036","article-title":"Gut microbiome: microflora association with obesity and obesity-related comorbidities","volume":"124","author":"Lone","year":"2018","journal-title":"Microb. Pathog"},{"key":"10.1016\/j.phymed.2026.158423_bib0014","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s40168-021-01061-6","article-title":"Gut microbiome variation modulates the effects of dietary fiber on host metabolism","volume":"9","author":"Murga-Garrido","year":"2021","journal-title":"Microbiome"},{"key":"10.1016\/j.phymed.2026.158423_bib0015","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cmet.2009.02.002","article-title":"A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance","volume":"9","author":"Newgard","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.phymed.2026.158423_bib0016","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s12944-022-01711-0","article-title":"Potential novel biomarkers in small intestine for obesity\/obesity resistance revealed by multi-omics analysis","volume":"21","author":"Pang","year":"2022","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.phymed.2026.158423_bib0017","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2178796","article-title":"Inulin increases the beneficial effects of rhubarb supplementation on high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota","volume":"15","author":"R\u00e9gnier","year":"2023","journal-title":"Gut. Microbes."},{"key":"10.1016\/j.phymed.2026.158423_bib0018","article-title":"Inulin as a multifunctional prebiotic: from gut modulation to systemic health benefits","volume":"10","author":"Sanlier","year":"2026","journal-title":"Food Qual. Saf"},{"key":"10.1016\/j.phymed.2026.158423_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2024.106367","article-title":"HP inulin-MCT dietary fiber improves lipid metabolism and prevents non-alcoholic steatohepatitis in obese mice","volume":"120","author":"Tjahjono","year":"2024","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.phymed.2026.158423_bib0020","doi-asserted-by":"crossref","unstructured":"Wang, Y., Kim, E., Cui, J., Zhang, C., Guo, C., Lee, Y., Zhang, G., 2023. Medium-chain inulin alleviates the obesity and improves systemic health in diet-induced obese mice via mediating the gut microbiome and metabolome. Pre-Print. https:\/\/doi.org\/10.21203\/rs.3.rs-3440303\/v1.","DOI":"10.21203\/rs.3.rs-3440303\/v1"},{"key":"10.1016\/j.phymed.2026.158423_bib0022","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jnutbio.2017.10.003","article-title":"Cholesterol-lowering effects of dietary pomegranate extract and inulin in mice fed an obesogenic diet","volume":"52","author":"Yang","year":"2018","journal-title":"J. Nutr. Biochem"},{"key":"10.1016\/j.phymed.2026.158423_bib0023","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/s41580-018-0044-8","article-title":"Metabolites as regulators of insulin sensitivity and metabolism","volume":"19","author":"Yang","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2026.158423_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2022.112309","article-title":"Inulin intervention attenuates hepatic steatosis in rats via modulating gut microbiota and maintaining intestinal barrier function","volume":"163","author":"Yang","year":"2023","journal-title":"Food Res. Int"},{"key":"10.1016\/j.phymed.2026.158423_bib0025","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.3390\/nu11051181","article-title":"Extract methods, molecular characteristics, and bioactivities of polysaccharide from alfalfa (Medicago sativa L.)","volume":"11","author":"Zhang","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.158423_bib0026","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.ijbiomac.2022.11.151","article-title":"Response of gut microbiota and ileal transcriptome to inulin intervention in HFD induced obese mice","volume":"225","author":"Zhang","year":"2023","journal-title":"Int. J. Biol. Macromol"},{"key":"10.1016\/j.phymed.2026.158423_bib0027","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1126\/science.aao5774","article-title":"Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes","volume":"359","author":"Zhao","year":"2018","journal-title":"Science"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326006549?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326006549?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:39:08Z","timestamp":1786480748000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326006549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":26,"alternative-id":["S0944711326006549"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158423","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Medium-chain inulin reshapes the gut microbiome-metabolome axis to counteract high-fat diet-induced obesity","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158423","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"158423"}}