{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:12:24Z","timestamp":1785510744560,"version":"3.56.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.phymed.2026.158453","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:35:51Z","timestamp":1781678151000},"page":"158453","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Icariin ameliorates sarcopenia via activation of the estrogen receptor \u03b1\/fatty acid transport protein 1 pathway"],"prefix":"10.1016","volume":"159","author":[{"given":"Li","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingfeng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhen","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feida","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingli","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0748-0222","authenticated-orcid":false,"given":"Nani","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158453_bib0001","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.3390\/biom13111670","article-title":"AI-based homology modelling of fatty acid transport protein 1 using AlphaFold: structural elucidation and molecular dynamics exploration","volume":"13","author":"Acharya","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.phymed.2026.158453_bib0002","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.3390\/ijms19102959","article-title":"Ectopic overexpression of porcine Myh1 increased in slow muscle fibers and enhanced endurance exercise in transgenic mice","volume":"19","author":"Ahn","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158453_bib0003","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s10522-019-09837-y","article-title":"D-galactose-induced accelerated aging model: an overview","volume":"20","author":"Azman","year":"2019","journal-title":"Biogerontology"},{"key":"10.1016\/j.phymed.2026.158453_bib0004","doi-asserted-by":"crossref","first-page":"E203","DOI":"10.1152\/ajpendo.2001.280.2.E203","article-title":"Age effect on transcript levels and synthesis rate of muscle MHC and response to resistance exercise","volume":"280","author":"Balagopal","year":"2001","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.phymed.2026.158453_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2023.108383","article-title":"Pharmaceutical treatment of bone loss: from animal models and drug development to future treatment strategies","volume":"244","author":"Brent","year":"2023","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2026.158453_bib0006","doi-asserted-by":"crossref","DOI":"10.1002\/jcsm.70081","article-title":"ARC-18 improved motor performance through inhibiting ACLY-mediated smad2\/3 acetylation in a model of duchenne muscular dystrophy","volume":"16","author":"Chen","year":"2025","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.phymed.2026.158453_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.maturitas.2023.107844","article-title":"The role of estrogen in female skeletal muscle aging: a systematic review","volume":"178","author":"Critchlow","year":"2023","journal-title":"Maturitas"},{"key":"10.1016\/j.phymed.2026.158453_bib0008","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3390\/molecules28020517","article-title":"Icariin alleviates nonalcoholic fatty liver disease in polycystic ovary syndrome by improving liver fatty acid oxidation and inhibiting lipid accumulation","volume":"28","author":"Hai","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2026.158453_bib0009","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ejphar.2015.03.059","article-title":"Effects of Icariin on insulin resistance via the activation of AMPK pathway in C2C12 mouse muscle cells","volume":"758","author":"Han","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158453_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122838","article-title":"Repositioning of baricitinib for management of memory impairment in ovariectomized\/D-galactose treated rats: a potential role of JAK2\/STAT3-PI3K\/AKT\/mTOR signaling pathway","volume":"351","author":"Hindam","year":"2024","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2026.158453_bib0011","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1021\/acs.jproteome.9b00637","article-title":"Untargeted lipidomics reveals specific lipid abnormalities in nonfunctioning human pituitary adenomas","volume":"19","author":"Hu","year":"2020","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.phymed.2026.158453_bib0012","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1007\/s10787-022-00973-5","article-title":"Dapagliflozin as an autophagic enhancer via LKB1\/AMPK\/SIRT1 pathway in ovariectomized\/D-galactose Alzheimer's rat model","volume":"30","author":"Ibrahim","year":"2022","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.phymed.2026.158453_bib0013","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/jbmr.4441","article-title":"Vitamin D\/vitamin D receptor signaling attenuates skeletal muscle atrophy by suppressing renin-angiotensin system","volume":"37","author":"Li","year":"2020","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.phymed.2026.158453_bib0014","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/jcsm.12144","article-title":"Lipid modulation of skeletal muscle mass and function","volume":"8","author":"Lipina","year":"2017","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.phymed.2026.158453_bib0015","article-title":"Icariin as a potential anticancer agent: a review of its biological effects on various cancers","volume":"14","author":"Liu","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158453_bib0016","first-page":"1","article-title":"PDE5A suppresses proteasome activity leading to insulin resistance in C2C12 myotubes","volume":"2019","author":"Liu","year":"2019","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.phymed.2026.158453_bib0017","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202200524","article-title":"Icariin ameliorates spermatogenesis disorder in obese mice induced by high-fat diet through regulating the glycolytic pathway","volume":"67","author":"Luo","year":"2023","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.phymed.2026.158453_bib0018","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s41999-025-01181-4","article-title":"Fndc5\/irisin mediates the benefits of aerobic exercise intervention on aging-associated sarcopenia in mice","volume":"16","author":"Ma","year":"2025","journal-title":"Eur. Geriatr. Med."},{"key":"10.1016\/j.phymed.2026.158453_bib0019","doi-asserted-by":"crossref","first-page":"799","DOI":"10.3390\/biom15060799","article-title":"Increased [18F]DPA-714 uptake in the skeletal muscle of SOD1G93A mice: a new potential of translocator protein 18 kDa imaging in amyotrophic lateral sclerosis","volume":"15","author":"Marini","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.phymed.2026.158453_bib0020","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1126\/science.1233606","article-title":"Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay","volume":"341","author":"Martinez","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.phymed.2026.158453_bib0021","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2024.1415398","article-title":"The prevalence of sarcopenia and risk factors in the older adult in China: a systematic review and meta-analysis","volume":"12","author":"Meng","year":"2024","journal-title":"Front Public Health"},{"key":"10.1016\/j.phymed.2026.158453_bib0022","doi-asserted-by":"crossref","first-page":"5808","DOI":"10.1038\/s41467-019-13694-1","article-title":"Mitochondrial oxidative capacity and NAD+ biosynthesis are reduced in human sarcopenia across ethnicities","volume":"10","author":"Migliavacca","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.158453_bib0023","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s10555-022-10059-x","article-title":"The adipocyte microenvironment and cancer","volume":"41","author":"Mukherjee","year":"2022","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.phymed.2026.158453_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155695","article-title":"Exercise-induced signaling activation by Chrysanthemum zawadskii and its active compound, linarin, ameliorates age-related sarcopenia through Sestrin 1 regulation","volume":"129","author":"Nirmala","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158453_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2024.112327","article-title":"Effect of ovariectomy and high-fat diet on the expression of estrogen receptors and adipose tissue metabolism in wistar rats","volume":"592","author":"Oliveira","year":"2024","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.phymed.2026.158453_bib0026","doi-asserted-by":"crossref","DOI":"10.1126\/science.abc8059","article-title":"Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength","volume":"371","author":"Palla","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.phymed.2026.158453_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.117453","article-title":"Research progress and perspectives of dual-target inhibitors","volume":"289","author":"Pang","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.phymed.2026.158453_bib0028","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1016\/j.cmet.2023.10.010","article-title":"Impact of biological sex and sex hormones on molecular signatures of skeletal muscle at rest and in response to distinct exercise training modes","volume":"35","author":"Pataky","year":"2023","journal-title":"Cell Metab."},{"key":"10.1016\/j.phymed.2026.158453_bib0029","first-page":"9393","article-title":"Single nuclei profiling identifies cell specific markers of skeletal muscle aging, frailty, and senescence","volume":"14","author":"Perez","year":"2022","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.phymed.2026.158453_bib0030","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/jcsm.12783","article-title":"Global prevalence of sarcopenia and severe sarcopenia: a systematic review and meta-analysis","volume":"13","author":"Petermann-Rocha","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.phymed.2026.158453_bib0031","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3389\/fphys.2017.00449","article-title":"Lower expression of SLC27A1 enhances intramuscular fat deposition in chicken via down-regulated fatty acid oxidation mediated by CPT1A","volume":"8","author":"Qiu","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.phymed.2026.158453_bib0032","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.3390\/cells11152391","article-title":"A\u00e7a\u00ec (Euterpe oleracea) extract protects human erythrocytes from age-related oxidative stress","volume":"11","author":"Remigante","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.phymed.2026.158453_bib0033","doi-asserted-by":"crossref","first-page":"7781","DOI":"10.3390\/ijms23147781","article-title":"Oxidation stress as a mechanism of aging in human erythrocytes: protective effect of quercetin","volume":"23","author":"Remigante","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158453_bib0034","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/jcb.25369","article-title":"Intracellular distribution and involvement of GPR30 in the actions of E2 on C2C12 cells","volume":"117","author":"Ronda","year":"2016","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.phymed.2026.158453_bib0035","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/s41467-020-14734-x","article-title":"Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors","volume":"11","author":"Saito","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.158453_bib0036","doi-asserted-by":"crossref","DOI":"10.1093\/ageing\/afac220","article-title":"Sarcopenia definition, diagnosis and treatment: consensus is growing","volume":"51","author":"Sayer","year":"2022","journal-title":"Age Ageing"},{"key":"10.1016\/j.phymed.2026.158453_bib0037","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1194\/jlr.M800535-JLR200","article-title":"Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells","volume":"50","author":"Sebasti\u00e1n","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.phymed.2026.158453_bib0038","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3945\/ajcn.114.105833","article-title":"Fish oil-derived n-3 PUFA therapy increases muscle mass and function in healthy older adults","volume":"102","author":"Smith","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.phymed.2026.158453_bib0039","doi-asserted-by":"crossref","first-page":"0158","DOI":"10.34133\/research.0158","article-title":"Protein arginine methyltransferase 1 ablation in motor neurons causes mitochondrial dysfunction leading to age-related motor neuron degeneration with muscle loss","volume":"6","author":"So","year":"2023","journal-title":"Research"},{"key":"10.1016\/j.phymed.2026.158453_bib0040","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s11899-019-00533-9","article-title":"Immunohistochemistry innovations for diagnosis and tissue-based biomarker detection","volume":"14","author":"Sukswai","year":"2019","journal-title":"Curr. Hematol. Malig. Rep."},{"key":"10.1016\/j.phymed.2026.158453_bib0041","doi-asserted-by":"crossref","first-page":"6317","DOI":"10.1039\/D1FO03612B","article-title":"Hydroxysafflor yellow A triggered a fast-to-slow muscle fiber-type conversion via regulating FoxO1 in myocytes","volume":"13","author":"Sun","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2026.158453_bib0042","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1042\/CS20210519","article-title":"Hormonal regulation of metabolism-recent lessons learned from insulin and estrogen","volume":"137","author":"Tao","year":"2023","journal-title":"Clin. Sci."},{"key":"10.1016\/j.phymed.2026.158453_bib0043","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.3390\/nu15163579","article-title":"The effect of long chain n-3 fatty acid supplementation on muscle strength in older adults: a systematic review and meta-analysis","volume":"15","author":"Timraz","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.158453_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102297","article-title":"Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1\/M2 phenotypic polarization","volume":"52","author":"Wang","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.phymed.2026.158453_bib0045","doi-asserted-by":"crossref","first-page":"0612","DOI":"10.34133\/research.0612","article-title":"The common hallmarks and interconnected pathways of aging, circadian rhythms, and cancer: implications for therapeutic strategies","volume":"8","author":"Wang","year":"2025","journal-title":"Research"},{"key":"10.1016\/j.phymed.2026.158453_bib0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.120116","article-title":"Anemarrhena asphodeloides fructan attenuates cigarette smoke-induced muscle atrophy by activating the Akt\/mTOR pathway and inhibiting the ubiquitin-proteasome pathway","volume":"351","author":"Wang","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158453_bib0047","article-title":"Effects of icariin on modulating gut microbiota and regulating metabolite alterations to prevent bone loss in ovariectomized rat model","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.phymed.2026.158453_bib0048","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1039\/D4FO04341C","article-title":"Differential effects of EPA and DHA on aging-related sarcopenia in mice and possible mechanisms involved","volume":"16","author":"Wu","year":"2025","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2026.158453_bib0049","doi-asserted-by":"crossref","first-page":"8846","DOI":"10.3390\/nu7105435","article-title":"Antioxidant and anti-fatigue constituents of Okra","volume":"7","author":"Xia","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.158453_bib0050","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.895916","article-title":"Estrogen mediates an atherosclerotic-protective action via estrogen receptor alpha\/SREBP-1 signaling","volume":"9","author":"Xie","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.phymed.2026.158453_bib0051","first-page":"720","article-title":"VDR activation attenuates osteoblastic ferroptosis and senescence by stimulating the Nrf2\/GPX4 pathway in age-related osteoporosis. Free radic","volume":"193","author":"Xu","year":"2022","journal-title":"Biol. Med."},{"key":"10.1016\/j.phymed.2026.158453_bib0052","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1099143","article-title":"Mechanism of skeletal muscle atrophy after spinal cord injury: a narrative review","volume":"10","author":"Xu","year":"2023","journal-title":"Front. Nutr."},{"key":"10.1016\/j.phymed.2026.158453_bib0053","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153607","article-title":"Cardioprotective effect of icariin against myocardial fibrosis and its molecular mechanism in diabetic cardiomyopathy based on network pharmacology: role of ICA in DCM","volume":"91","author":"Zhang","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158453_bib0054","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2022.986388","article-title":"Effect of n-6\/n-3 PUFA ratio on body fat deposition, tissues fatty acid composition and key genes expression of liver lipid metabolism in silver foxes (Vulpes vulpes fulva) during the winter fur-growth period","volume":"9","author":"Zhong","year":"2022","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.phymed.2026.158453_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153413","article-title":"Icariin ameliorates estrogen-deficiency induced bone loss by enhancing IGF-I signaling via its crosstalk with non-genomic er\u03b1 signaling","volume":"82","author":"Zhou","year":"2021","journal-title":"Phytomedicine"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326006847?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326006847?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T14:43:44Z","timestamp":1785509024000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326006847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":55,"alternative-id":["S0944711326006847"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158453","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Icariin ameliorates sarcopenia via activation of the estrogen receptor \u03b1\/fatty acid transport protein 1 pathway","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158453","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158453"}}