{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T21:44:38Z","timestamp":1785879878258,"version":"3.56.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LMS25H310004"],"award-info":[{"award-number":["LMS25H310004"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.phymed.2026.158456","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:34:17Z","timestamp":1782257657000},"page":"158456","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Apigenin ameliorates methionine-choline deficient diet-induced metabolic-associated fatty liver disease through modulation of gut microbiota-liver axis"],"prefix":"10.1016","volume":"159","author":[{"given":"Fen","family":"Xiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingruo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyuan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruguang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huarui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongchang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158456_bib0001","doi-asserted-by":"crossref","first-page":"4304","DOI":"10.3390\/molecules27134304","article-title":"Pharmacological properties of 4', 5, 7-trihydroxyflavone (apigenin) and its impact on cell signaling pathways","volume":"27","author":"Abid","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2026.158456_bib0002","doi-asserted-by":"crossref","first-page":"346","DOI":"10.3390\/nu9040346","article-title":"Homocysteine induces hepatic steatosis involving ER stress response in high methionine diet-fed mice","volume":"9","author":"Ai","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.158456_bib0003","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/s41575-020-0269-9","article-title":"Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders","volume":"17","author":"Aron-Wisnewsky","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2026.158456_bib0004","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1072376","article-title":"Gut microbiota: the key to the treatment of metabolic syndrome in traditional Chinese medicine - a case study of diabetes and nonalcoholic fatty liver disease","volume":"13","author":"Bao","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2026.158456_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e15609","article-title":"Insights into the pharmacological and therapeutic effects of apigenin in liver injuries and diseases","volume":"9","author":"Bi","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.phymed.2026.158456_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.plaphy.2023.108272","article-title":"Unraveling lipid peroxidation-mediated regulation of redox homeostasis for sustaining plant health","volume":"206","author":"Chakraborty","year":"2024","journal-title":"Plant Physiol. Biochem."},{"key":"10.1016\/j.phymed.2026.158456_bib0007","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.clnu.2019.05.020","article-title":"Resveratrol attenuates high-fat diet-induced non-alcoholic steatohepatitis by maintaining gut barrier integrity and inhibiting gut inflammation through regulation of the endocannabinoid system","volume":"39","author":"Chen","year":"2020","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.phymed.2026.158456_bib0008","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41522-023-00419-y","article-title":"Bacteroides ovatus accelerates metformin-induced vitamin B12 deficiency in type 2 diabetes patients by accumulating cobalamin","volume":"9","author":"Chen","year":"2023","journal-title":"NPJ Biofilms Microbiomes"},{"key":"10.1016\/j.phymed.2026.158456_bib0009","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.chembiol.2019.03.001","article-title":"Saturated fatty acids, Mufas and Pufas regulate ferroptosis","volume":"26","author":"Das","year":"2019","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.phymed.2026.158456_bib0010","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/s41591-019-0495-2","article-title":"Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study","volume":"25","author":"Depommier","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.phymed.2026.158456_bib0011","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1190602","article-title":"Fucose ameliorates the proinflammatory property of Fusobacterium nucleatum in colitis via altering its metabolism","volume":"13","author":"Duan","year":"2023","journal-title":"Front. Cell Infect. Microbiol."},{"key":"10.1016\/j.phymed.2026.158456_bib0012","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1097\/MOL.0000000000000933","article-title":"Altered lipid metabolism and the development of metabolic-associated fatty liver disease","volume":"35","author":"Foster","year":"2024","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.phymed.2026.158456_bib0013","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.phymed.2026.158456_bib0014","doi-asserted-by":"crossref","DOI":"10.1111\/eci.13895","article-title":"Association between homocysteine and nonalcoholic fatty liver disease: mendelian randomisation study","volume":"53","author":"Fu","year":"2023","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.phymed.2026.158456_bib0015","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.1062961","article-title":"Apigenin remodels the gut microbiota to ameliorate ulcerative colitis","volume":"9","author":"Fu","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.phymed.2026.158456_bib0016","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3945\/an.116.012948","article-title":"Flavones: food sources, bioavailability, metabolism, and bioactivity","volume":"8","author":"Hostetler","year":"2017","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.phymed.2026.158456_bib0017","doi-asserted-by":"crossref","first-page":"4146","DOI":"10.12659\/MSM.897924","article-title":"Clinical study of serum homocysteine and non-alcoholic fatty liver disease in euglycemic patients","volume":"22","author":"Hu","year":"2016","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.phymed.2026.158456_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.106020","article-title":"Lactobacillus acidophilus ameliorates obesity in mice through modulation of gut microbiota dysbiosis and intestinal permeability","volume":"175","author":"Kang","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2026.158456_bib0019","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1080\/15548627.2020.1712108","article-title":"SQSTM1\/p62 activates NFE2L2\/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity","volume":"16","author":"Lee","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2026.158456_bib0020","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nrgastro.2016.85","article-title":"The role of the gut microbiota in NAFLD","volume":"13","author":"Leung","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2026.158456_bib0021","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.freeradbiomed.2022.12.087","article-title":"Gut microbiota and bile acids partially mediate the improvement of fibroblast growth factor 21 on methionine-choline-deficient diet-induced non-alcoholic fatty liver disease mice","volume":"195","author":"Lin","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2026.158456_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113409","article-title":"Apigenin alleviates Sjogren's syndrome-induced salivary gland epithelial cell ferroptosis via ERalpha signaling-mediated regulation of the ATF3\/SLC7A1l axis","volume":"143","author":"Liu","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2026.158456_bib0023","doi-asserted-by":"crossref","first-page":"7996","DOI":"10.1038\/s41598-023-34654-2","article-title":"Apigenin attenuates atherosclerosis and non-alcoholic fatty liver disease through inhibition of NLRP3 inflammasome in mice","volume":"13","author":"Lu","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2026.158456_bib0024","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jnutbio.2019.05.015","article-title":"Apigenin ameliorates HFD-induced NAFLD through regulation of the XO\/NLRP3 pathways","volume":"71","author":"Lv","year":"2019","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.phymed.2026.158456_bib0025","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.redox.2018.01.010","article-title":"Homocysteine causes dysfunction of chondrocytes and oxidative stress through repression of SIRT1\/AMPK pathway: a possible link between hyperhomocysteinemia and osteoarthritis","volume":"15","author":"Ma","year":"2018","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2026.158456_bib0026","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.3390\/ijms25063236","article-title":"Gut microbiota and inflammation modulation in a rat model for ulcerative colitis after the intraperitoneal administration of apigenin, luteolin, and xanthohumol","volume":"25","author":"Magadan-Corpas","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158456_bib0027","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jhep.2017.11.014","article-title":"Lipotoxicity and the gut-liver axis in NASH pathogenesis","volume":"68","author":"Marra","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2026.158456_bib0028","doi-asserted-by":"crossref","first-page":"7032","DOI":"10.1021\/acs.jafc.2c07581","article-title":"Apigenin alleviated high-fat-diet-induced hepatic pyroptosis by mitophagy-ros-ctsb-nlrp3 pathway in mice and aml12 cells","volume":"71","author":"Meng","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2026.158456_bib0029","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.cell.2018.06.051","article-title":"The gut microbiota mediates the anti-seizure effects of the ketogenic diet","volume":"174","author":"Olson","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2026.158456_bib0030","doi-asserted-by":"crossref","DOI":"10.1002\/alz.70223","article-title":"Apigenin mitigates oxidative stress, neuroinflammation, and cognitive impairment but enhances learning and memory in aluminum chloride-induced neurotoxicity in rats","volume":"21","author":"Oyagbemi","year":"2025","journal-title":"Alzheimers. Dement."},{"key":"10.1016\/j.phymed.2026.158456_bib0031","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jare.2025.08.015","article-title":"Refining antibiotic cocktail regimens for pseudo-germ-free mice and their impact on gut microbiome and pancreatic tumor proteomics","volume":"83","author":"Panyod","year":"2026","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.phymed.2026.158456_bib0032","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.cgh.2014.08.039","article-title":"Effect of weight loss on magnetic resonance imaging estimation of liver fat and volume in patients with nonalcoholic steatohepatitis","volume":"13","author":"Patel","year":"2015","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2026.158456_bib0033","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/S0140-6736(20)32511-3","article-title":"Non-alcoholic fatty liver disease","volume":"397","author":"Powell","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2026.158456_bib0034","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1002\/hep.21763","article-title":"A lipidomic analysis of nonalcoholic fatty liver disease","volume":"46","author":"Puri","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2026.158456_bib0035","article-title":"Apigenin alleviates obesity-associated metabolic syndrome by regulating the composition of the gut microbiome","volume":"12","author":"Qiao","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.phymed.2026.158456_bib0036","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S2468-1253(22)00165-0","article-title":"The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis","volume":"7","author":"Riazi","year":"2022","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2026.158456_bib0037","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.jhep.2017.05.016","article-title":"Treatment of NAFLD with diet, physical activity and exercise","volume":"67","author":"Romero-Gomez","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2026.158456_bib0038","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3390\/ijms20020308","article-title":"Intestinal microbiota protects against mcd diet-induced steatohepatitis","volume":"20","author":"Schneider","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158456_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105484","article-title":"Epigenetics in NAFLD\/NASH: targets and therapy","volume":"167","author":"Sodum","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2026.158456_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2025.167670","article-title":"Apigenin enhancing oxidative resistance and proteostasis to extend lifespan via PTEN-mediated AKT signalling pathway","volume":"1871","author":"Sun","year":"2025","journal-title":"Biochim. Biophys. Acta Mol. Basis. Dis."},{"key":"10.1016\/j.phymed.2026.158456_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154208","article-title":"The improvement of nonalcoholic steatohepatitis by Poria cocos polysaccharides associated with gut microbiota and NF-kappaB\/CCL3\/CCR1 axis","volume":"103","author":"Tan","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158456_bib0042","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.3390\/antiox13101225","article-title":"Lactobacillus eats amyloid plaque and post-biotically attenuates senescence due to repeat expansion disorder and alzheimer's disease","volume":"13","author":"Tyagi","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2026.158456_bib0043","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1111\/bph.14938","article-title":"Naringenin attenuates non-alcoholic fatty liver disease by down-regulating the NLRP3\/NF-kappaB pathway in mice","volume":"177","author":"Wang","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158456_bib0044","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1172\/JCI11596","article-title":"Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways","volume":"107","author":"Werstuck","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2026.158456_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2023.166725","article-title":"Intermittent fasting alleviates type 1 diabetes-induced cognitive dysfunction by improving the frontal cortical metabolic disorder","volume":"1869","author":"Xiong","year":"2023","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.phymed.2026.158456_bib0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101742","article-title":"Homocysteine promotes hepatic steatosis by activating the adipocyte lipolysis in a HIF1alpha-ERO1alpha-dependent oxidative stress manner","volume":"37","author":"Yan","year":"2020","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2026.158456_bib0047","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.00532-24","article-title":"Prevotella copri alleviates hyperglycemia and regulates gut microbiota and metabolic profiles in mice","volume":"9","author":"Yang","year":"2024","journal-title":"mSystems"},{"key":"10.1016\/j.phymed.2026.158456_bib0048","doi-asserted-by":"crossref","first-page":"E4966","DOI":"10.1073\/pnas.1603244113","article-title":"Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis","volume":"113","author":"Yang","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phymed.2026.158456_bib0049","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.3748\/wjg.v24.i23.2468","article-title":"Dynamic alterations in the gut microbiota and metabolome during the development of methionine-choline-deficient diet-induced nonalcoholic steatohepatitis","volume":"24","author":"Ye","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.phymed.2026.158456_bib0050","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s40168-024-01872-3","article-title":"BCAA mediated microbiota-liver-heart crosstalk regulates diabetic cardiomyopathy via FGF21","volume":"12","author":"Zheng","year":"2024","journal-title":"Microbiome"},{"key":"10.1016\/j.phymed.2026.158456_bib0051","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1038\/s41380-019-0475-4","article-title":"Transplantation of microbiota from drug-free patients with schizophrenia causes schizophrenia-like abnormal behaviors and dysregulated kynurenine metabolism in mice","volume":"25","author":"Zhu","year":"2020","journal-title":"Mol. Psychiatry"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326006872?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326006872?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:49:45Z","timestamp":1785876585000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326006872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":51,"alternative-id":["S0944711326006872"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158456","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Apigenin ameliorates methionine-choline deficient diet-induced metabolic-associated fatty liver disease through modulation of gut microbiota-liver axis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158456","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"158456"}}