{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:12:45Z","timestamp":1785510765792,"version":"3.56.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.phymed.2026.158464","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T23:27:02Z","timestamp":1781911622000},"page":"158464","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Stachydrine alleviates thoracic aortic aneurysm via regulating lactate dehydrogenase A in Marfan syndrome mice"],"prefix":"10.1016","volume":"159","author":[{"given":"Yufan","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhao","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanxun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7836-4177","authenticated-orcid":false,"given":"Hang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiwen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2144-7525","authenticated-orcid":false,"given":"Jiahong","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.phymed.2026.158464_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167096","article-title":"Functional and metabolomic analysis of urinary extracellular vesicles from juvenile mice with renal compensatory hypertrophy","volume":"1870","author":"Aly","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"issue":"4","key":"10.1016\/j.phymed.2026.158464_bib0002","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/s10555-022-10067-x","article-title":"Physicochemical aspects of the tumour microenvironment as drivers of vasculogenic mimicry","volume":"41","author":"Andreucci","year":"2022","journal-title":"Cancer Metastasis Rev."},{"issue":"5","key":"10.1016\/j.phymed.2026.158464_bib0003","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41569-020-00472-6","article-title":"Epidemiology and management of aortic disease: aortic aneurysms and acute aortic syndromes","volume":"18","author":"Bossone","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"issue":"17","key":"10.1016\/j.phymed.2026.158464_bib0004","doi-asserted-by":"crossref","first-page":"9610","DOI":"10.3390\/ijms25179610","article-title":"Left ventricular systolic dysfunction in NBCe1-B\/C-Knockout mice","volume":"25","author":"Brady","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158464_bib0005","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.freeradbiomed.2024.11.054","article-title":"GATAD1 is involved in sphingosylphosphorylcholine-attenuated myocardial ischemia-reperfusion injury by modulating myocardial fatty acid oxidation and glucose oxidation","volume":"227","author":"Cai","year":"2025","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.phymed.2026.158464_bib0006","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1159\/000477119","article-title":"Stachydrine protects against pressure overload-induced cardiac hypertrophy by suppressing autophagy","volume":"42","author":"Cao","year":"2017","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.phymed.2026.158464_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102446","article-title":"LDHA-mediated metabolic reprogramming promoted cardiomyocyte proliferation by alleviating ROS and inducing M2 macrophage polarization","volume":"56","author":"Chen","year":"2022","journal-title":"Redox Biol."},{"issue":"5","key":"10.1016\/j.phymed.2026.158464_bib0008","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.124.036377","article-title":"Lactate dehydrogenase a crotonylation and mono-ubiquitination maintains vascular smooth muscle cell growth and migration and promotes neointima hyperplasia","volume":"14","author":"Chen","year":"2025","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.phymed.2026.158464_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104755","article-title":"A review of pharmacological and pharmacokinetic properties of stachydrine","volume":"155","author":"Cheng","year":"2020","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.phymed.2026.158464_bib0010","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/sj.bjp.0707391","article-title":"Imbalanced synthesis of cyclooxygenase-derived thromboxane A2 and prostacyclin compromises vasomotor function of the thoracic aorta in Marfan syndrome","volume":"152","author":"Chung","year":"2007","journal-title":"Br. J. Pharmacol."},{"issue":"12","key":"10.1016\/j.phymed.2026.158464_bib0011","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.3390\/nu17122015","article-title":"Stachydrine showing metabolic changes in mice exposed to house dust mites ameliorates allergen-induced inflammation","volume":"17","author":"Do","year":"2025","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.158464_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156621","article-title":"Stachydrine hydrochloride reduces NOX2 activity to suppress oxidative stress levels to improve cardiac insufficiency","volume":"140","author":"Fu","year":"2025","journal-title":"Phytomedicine"},{"issue":"14","key":"10.1016\/j.phymed.2026.158464_bib0013","doi-asserted-by":"crossref","first-page":"5256","DOI":"10.1073\/pnas.0408624102","article-title":"Discovery of the ergothioneine transporter","volume":"102","author":"Gr\u00fcndemann","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phymed.2026.158464_bib0014","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2024.1442879","article-title":"Exploring stachydrine: from natural occurrence to biological activities and metabolic pathways","volume":"15","author":"He","year":"2024","journal-title":"Front. Plant Sci."},{"issue":"24","key":"10.1016\/j.phymed.2026.158464_bib0015","doi-asserted-by":"crossref","first-page":"e334","DOI":"10.1161\/CIR.0000000000001106","article-title":"2022 ACC\/AHA guideline for the diagnosis and management of aortic disease: a report of the American heart association\/american college of cardiology joint committee on clinical practice guidelines","volume":"146","author":"Isselbacher","year":"2022","journal-title":"Circulation."},{"issue":"4","key":"10.1016\/j.phymed.2026.158464_bib0016","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1096\/fj.14-258947","article-title":"The endogenous zinc finger transcription factor, ZNF24, modulates the angiogenic potential of human microvascular endothelial cells","volume":"29","author":"Jia","year":"2015","journal-title":"FASEB J."},{"key":"10.1016\/j.phymed.2026.158464_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2021.111490","article-title":"Age-associated proinflammatory elastic fiber remodeling in large arteries","volume":"196","author":"Kim","year":"2021","journal-title":"Mech. Ageing Dev."},{"issue":"25","key":"10.1016\/j.phymed.2026.158464_bib0018","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1016\/j.jacc.2025.11.014","article-title":"Heart failure and hypertension in the metabolic era: 2 Atlases, 1 Message","volume":"86","author":"Krumholz","year":"2025","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.phymed.2026.158464_bib0019","doi-asserted-by":"crossref","first-page":"538","DOI":"10.3389\/fphar.2019.00538","article-title":"Stachydrine ameliorates cardiac fibrosis through inhibition of angiotensin II\/transformation growth factor \u03b21 fibrogenic axis","volume":"10","author":"Liu","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158464_bib0020","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41572-021-00298-7","article-title":"Marfan syndrome","volume":"7","author":"Milewicz","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"21","key":"10.1016\/j.phymed.2026.158464_bib0021","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1161\/CIRCULATIONAHA.120.051171","article-title":"Extracellular tuning of mitochondrial respiration leads to aortic aneurysm","volume":"143","author":"Oller","year":"2021","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.phymed.2026.158464_bib0022","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1093\/cvr\/cvaf077","article-title":"Proteomic profiling reveals a higher presence of glycolytic enzymes in human atherosclerotic lesions with unfavourable histological characteristics","volume":"121","author":"Palm","year":"2025","journal-title":"Cardiovasc. Res."},{"issue":"37","key":"10.1016\/j.phymed.2026.158464_bib0023","doi-asserted-by":"crossref","first-page":"13697","DOI":"10.1074\/jbc.RA119.009886","article-title":"MtpB, a member of the MttB superfamily from the human intestinal acetogen Eubacterium limosum, catalyzes proline betaine demethylation","volume":"294","author":"Picking","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"45","key":"10.1016\/j.phymed.2026.158464_bib0024","doi-asserted-by":"crossref","first-page":"4988","DOI":"10.1093\/eurheartj\/ehaf556","article-title":"Excessive glycosylation drives thoracic aortic aneurysm formation through integrated stress response","volume":"46","author":"Rochano-Ortiz","year":"2025","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.phymed.2026.158464_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.pmatsci.2024.101363","article-title":"Mechanisms of aortic dissection: From pathological changes to experimental and in silico models","volume":"150","author":"Rolf-Pissarczyk","year":"2025","journal-title":"Prog. Mater. Sci."},{"issue":"8","key":"10.1016\/j.phymed.2026.158464_bib0026","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.7150\/thno.30714","article-title":"Soluble EMMPRIN levels discriminate aortic ectasia in Marfan syndrome patients","volume":"9","author":"Rurali","year":"2019","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.phymed.2026.158464_bib0027","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-44629-y","article-title":"Untargeted metabolomics analysis on kidney tissues from mice reveals potential hypoxia biomarkers","volume":"13","author":"Sajid","year":"2023","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.phymed.2026.158464_bib0028","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.tjnut.2023.10.031","article-title":"Prognostic performance of hematological and serum iron and metabolite indices for detection of early iron deficiency induced metabolic brain dysfunction in infant rhesus monkeys","volume":"154","author":"Sandri","year":"2024","journal-title":"J. Nutr."},{"issue":"11","key":"10.1016\/j.phymed.2026.158464_bib0029","doi-asserted-by":"crossref","first-page":"H1583","DOI":"10.1152\/ajpheart.00875.2015","article-title":"Dysfunction of the \u03b22-spectrin-based pathway in human heart failure","volume":"310","author":"Smith","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.phymed.2026.158464_bib0030","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/fphys.2018.00077","article-title":"Participation of arachidonic acid metabolism in the aortic aneurysm formation in patients with Marfan Syndrome","volume":"9","author":"Soto","year":"2018","journal-title":"Front. Physiol."},{"issue":"19","key":"10.1016\/j.phymed.2026.158464_bib0031","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.184329","article-title":"Perivascular inflammation in the progression of aortic aneurysms in Marfan syndrome","volume":"10","author":"Sowa","year":"2025","journal-title":"JCI Insight"},{"key":"10.1016\/j.phymed.2026.158464_bib0032","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.849973","article-title":"Metabolomic profiling of respiratory muscles and lung in response to long-term controlled mechanical ventilation","volume":"10","author":"Wen","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.phymed.2026.158464_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.106051","article-title":"LDHA mediated degradation of extracellular matrix is a potential target for the treatment of aortic dissection","volume":"176","author":"Wu","year":"2022","journal-title":"Pharmacol. Res."},{"issue":"11","key":"10.1016\/j.phymed.2026.158464_bib0034","doi-asserted-by":"crossref","first-page":"4297","DOI":"10.7150\/thno.96375","article-title":"Astrocyte-derived lactate aggravates brain injury of ischemic stroke in mice by promoting the formation of protein lactylation","volume":"14","author":"Xiong","year":"2024","journal-title":"Theranostics"},{"issue":"19","key":"10.1016\/j.phymed.2026.158464_bib0035","first-page":"4063","article-title":"miR-143 is involved in endothelial cell dysfunction through suppression of glycolysis and correlated with atherosclerotic plaques formation","volume":"20","author":"Xu","year":"2016","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"2","key":"10.1016\/j.phymed.2026.158464_bib0036","doi-asserted-by":"crossref","DOI":"10.1111\/cbdd.70066","article-title":"Multiomics analyses demonstrate the attenuation of metabolic cardiac disorders associated with type 2 diabetes by stachydrine in relation with the transition of gastrointestinal microbiota","volume":"105","author":"Yang","year":"2025","journal-title":"Chem. Biol. Drug Des."},{"issue":"3","key":"10.1016\/j.phymed.2026.158464_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2025.168107","article-title":"High-fat diet does not exacerbate aortic pathology and enhances metabolic function in Marfan syndrome Fbn1 mice","volume":"1872","author":"Yap","year":"2026","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.phymed.2026.158464_bib0038","article-title":"Associations of gut microbiota and fatty metabolism with immune thrombocytopenia","volume":"9","author":"Yu","year":"2022","journal-title":"Front. Med. (Lausanne)"},{"key":"10.1016\/j.phymed.2026.158464_bib0039","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.intimp.2017.05.002","article-title":"Stachydrine ameliorates isoproterenol-induced cardiac hypertrophy and fibrosis by suppressing inflammation and oxidative stress through inhibiting NF-\u03baB and JAK\/STAT signaling pathways in rats","volume":"48","author":"Zhao","year":"2017","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158464_bib0040","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/s13019-023-02363-6","article-title":"Stachydrine ameliorates hypoxia reoxygenation injury of cardiomyocyte via enhancing SIRT1-Nrf2 pathway","volume":"18","author":"Zhu","year":"2023","journal-title":"J. Cardiothorac. Surg."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326006951?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326006951?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T14:45:47Z","timestamp":1785509147000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326006951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":40,"alternative-id":["S0944711326006951"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158464","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stachydrine alleviates thoracic aortic aneurysm via regulating lactate dehydrogenase A in Marfan syndrome mice","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158464","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158464"}}