{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:10:06Z","timestamp":1793286606553,"version":"4.5.0"},"reference-count":199,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.phymed.2026.158466","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T16:39:47Z","timestamp":1781800787000},"page":"158466","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Indirect pharmacology of phytopolyphenols: The role of intermediate substances in cross-organ regulation and phenotypic outcomes"],"prefix":"10.1016","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9068-8798","authenticated-orcid":false,"given":"Tran Chi","family":"Linh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4080-5140","authenticated-orcid":false,"given":"Chong Kim Thien","family":"Duc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158466_bib0001","doi-asserted-by":"crossref","first-page":"7117","DOI":"10.1038\/s41598-021-86514-6","article-title":"The gut microbiota metabolite urolithin A inhibits NF-\u03bab activation in LPS stimulated BMDMs","volume":"11","author":"Abdelazeem","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2026.158466_bib0002","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1515\/jtim-2017-0027","article-title":"Polyphenols treatment in patients with nonalcoholic fatty liver disease","volume":"5","author":"Abenavoli","year":"2017","journal-title":"J. Transl. Int. Med."},{"key":"10.1016\/j.phymed.2026.158466_bib0003","doi-asserted-by":"crossref","DOI":"10.1155\/mi\/6733477","article-title":"Unraveling the gut\u2013Liver\u2013Brain axis: microbiome, inflammation, and emerging therapeutic approaches","volume":"2025","author":"Aghara","year":"2025","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.phymed.2026.158466_bib0004","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3934\/microbiol.2024007","article-title":"What we need to know about the germ-free animal models","volume":"10","author":"Aghighi","year":"2024","journal-title":"AIMS Microbiol."},{"key":"10.1016\/j.phymed.2026.158466_bib0005","doi-asserted-by":"crossref","first-page":"11007","DOI":"10.1021\/acs.jafc.5c00916","article-title":"Bioaccessible (Poly)phenols of winery byproducts modulate pathogenic mediators of intestinal bowel disease: in vitro evidence","volume":"73","author":"Agull\u00f3","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2026.158466_bib0006","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2026.1767453","article-title":"Polyphenol metabolites in fermented foods: biotransformation, bioavailability, and functional roles","volume":"13","author":"Alharbi","year":"2026","journal-title":"Front. Nutr."},{"key":"10.1016\/j.phymed.2026.158466_bib0007","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/obr.12409","article-title":"Effects of dietary polyphenols on metabolic syndrome features in humans: a systematic review","volume":"17","author":"Amiot","year":"2016","journal-title":"Obes. Rev."},{"key":"10.1016\/j.phymed.2026.158466_bib0008","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40813-023-00316-y","article-title":"Acetate and propionate effects in response to LPS in a porcine intestinal co-culture model","volume":"9","author":"Andrani","year":"2023","journal-title":"Porc. Health Manag."},{"key":"10.1016\/j.phymed.2026.158466_bib0009","doi-asserted-by":"crossref","DOI":"10.1038\/srep34145","article-title":"Human and mouse monocytes display distinct signalling and cytokine profiles upon stimulation with FFAR2\/FFAR3 short-chain fatty acid receptor agonists","volume":"6","author":"Ang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2026.158466_bib0010","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28145415","article-title":"Polyphenols and neurodegenerative diseases: potential effects and mechanisms of neuroprotection","volume":"28","author":"Arias-S\u00e1nchez","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2026.158466_bib0011","doi-asserted-by":"crossref","DOI":"10.5493\/wjem.v15.i1.100275","article-title":"Impact of curcumin on gut microbiome","volume":"15","author":"Balaji","year":"2025","journal-title":"World J. Exp. Med."},{"key":"10.1016\/j.phymed.2026.158466_bib0012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2024\/3769933","article-title":"Assessment of acute and chronic toxicity in wistar rats (Rattus norvegicus) and New Zealand rabbits (Oryctolagus cuniculus) of an enriched polyphenol extract obtained from Caesalpinia spinosa","volume":"2024","author":"Ballesteros-Ram\u00edrez","year":"2024","journal-title":"J. Toxicol."},{"key":"10.1016\/j.phymed.2026.158466_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2025.110119","article-title":"Mass spectrometry imaging to evaluate (poly)phenol distribution in animal tissues","volume":"147","author":"Berzaghi","year":"2026","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.phymed.2026.158466_bib0014","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.3390\/antiox11091700","article-title":"Polyphenols\u2013Gut\u2013Heart: an impactful relationship to improve cardiovascular diseases","volume":"11","author":"Bianchi","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2026.158466_bib0015","doi-asserted-by":"crossref","first-page":"900","DOI":"10.3389\/fphys.2018.00900","article-title":"The gut-brain axis, the human gut microbiota and their integration in the development of obesity","volume":"9","author":"Bliss","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.phymed.2026.158466_bib0016","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1007\/s00394-020-02386-y","article-title":"Comparative studies of urolithins and their phase II metabolites on macrophage and neutrophil functions","volume":"60","author":"Bobowska","year":"2021","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.phymed.2026.158466_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2025.110195","article-title":"Fermented foods and brain health: gut\u2013brain axis mechanisms and clinical insights","volume":"149","author":"Bodur","year":"2026","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.phymed.2026.158466_bib0018","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1002\/mnfr.201400745","article-title":"Mind the gap\u2014deficits in our knowledge of aspects impacting the bioavailability of phytochemicals and their metabolites\u2014a position paper focusing on carotenoids and polyphenols","volume":"59","author":"Bohn","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.phymed.2026.158466_bib0019","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1124\/mol.115.102301","article-title":"The pharmacology and function of receptors for short-chain fatty acids","volume":"89","author":"Bolognini","year":"2016","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158466_bib0020","doi-asserted-by":"crossref","first-page":"424","DOI":"10.3390\/cimb47060424","article-title":"Gut\u2013Adipose tissue axis and metabolic health","volume":"47","author":"Borozan","year":"2025","journal-title":"Curr Issues Mol Biol"},{"key":"10.1016\/j.phymed.2026.158466_bib0021","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26115188","article-title":"Hazardous interactions between food, herbs, and drugs in the first stage of biotransformation: case reports of adverse drug interactions in humans","volume":"26","author":"Bukowska","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158466_bib0022","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.3390\/nu16101514","article-title":"Effects of saponins on lipid metabolism: the gut\u2013Liver axis plays a key role","volume":"16","author":"Cao","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.158466_bib0023","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.662739","article-title":"Participation of short-chain fatty acids and their receptors in gut inflammation and colon cancer","volume":"12","author":"Carretta","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.phymed.2026.158466_bib0024","doi-asserted-by":"crossref","first-page":"5942","DOI":"10.1039\/D3FO05579E","article-title":"Bound polyphenols in insoluble dietary fiber of navel orange peel modulate LPS-induced intestinal-like co-culture inflammation through CSF2-mediated NF-\u03bab\/JAK-STAT pathway","volume":"15","author":"Chang","year":"2024","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2026.158466_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2025.107091","article-title":"Dietary polyphenols and gut\u2013brain axis modulation: the neuroprotective role of quercetin, allicin, and ferulic acid in traumatic brain injury and neurodegeneration","volume":"135","author":"Chelliah","year":"2025","journal-title":"J Funct Foods"},{"key":"10.1016\/j.phymed.2026.158466_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118922","article-title":"Bisphenol A increases fat mass in adipose tissue by disturbing gut microbiota-dependent bile acid metabolism and TGR5\/UCP1 signaling pathways in CD-1 mice","volume":"303","author":"Chen","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.phymed.2026.158466_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154979","article-title":"Interactions between gut microbiota and polyphenols: a mechanistic and metabolomic review","volume":"119","author":"Cheng","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158466_bib0028","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3390\/publications11010002","article-title":"The science of literature reviews: searching, identifying, selecting, and synthesising","volume":"11","author":"Chigbu","year":"2023","journal-title":"Publications"},{"key":"10.1016\/j.phymed.2026.158466_bib0029","doi-asserted-by":"crossref","unstructured":"Choi, S.R., Lee, H., Singh, D., Cho, D., Chung, J.-O., Roh, J.-H., Kim, W.-G., Lee, C.H., 2023. Bidirectional interactions between green tea (GT) polyphenols and human gut bacteria 33, 1317\u20131328. https:\/\/doi.org\/10.4014\/jmb.2306.06014.","DOI":"10.4014\/jmb.2306.06014"},{"key":"10.1016\/j.phymed.2026.158466_bib0030","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.3390\/cancers12082147","article-title":"Stable isotope tracing metabolomics to investigate the metabolic activity of bioactive compounds for cancer prevention and treatment","volume":"12","author":"Choudhury","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.phymed.2026.158466_bib0031","doi-asserted-by":"crossref","first-page":"31","DOI":"10.20517\/mrr.2025.25","article-title":"Recent advances in gut microbiota-mediated regulation of fat deposition and metabolic disorders","volume":"4","author":"Cui","year":"2025","journal-title":"Microbiome Res. Rep."},{"key":"10.1016\/j.phymed.2026.158466_bib0032","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25073694","article-title":"Underlying mechanisms behind the brain\u2013gut\u2013liver axis and metabolic-associated fatty liver disease (MAFLD): an update","volume":"25","author":"De C\u00f3l","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158466_bib0033","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.947240","article-title":"Gut microbes and food reward: from the gut to the brain","volume":"16","author":"de Wouters d\u2019Oplinter","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.phymed.2026.158466_bib0034","doi-asserted-by":"crossref","first-page":"7231","DOI":"10.1021\/jacs.4c09892","article-title":"Enantiocomplementary gut bacterial enzymes metabolize dietary polyphenols","volume":"147","author":"Dong","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.phymed.2026.158466_bib0035","doi-asserted-by":"crossref","DOI":"10.1161\/circ.147.suppl_1.22","article-title":"Abstract 22: the effects of randomized cocoa extract and multivitamins on the gut microbiome: a pilot study in COSMOS","volume":"147","author":"Dong","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.phymed.2026.158466_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107511","article-title":"Effect of anthocyanins on metabolic syndrome through interacting with gut microbiota","volume":"210","author":"Du","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2026.158466_bib0037","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25137379","article-title":"The role of short chain fatty acids in inflammation and body health","volume":"25","author":"Du","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158466_bib0038","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.22146\/ijc.94762","article-title":"Isolation and evaluation of the antioxidant capacity of compounds from Ehretia asperula Zoll. & Moritzi","volume":"24","author":"Duc","year":"2024","journal-title":"Indones. J. Chem."},{"key":"10.1016\/j.phymed.2026.158466_bib0039","article-title":"Optimization of ultrasound-assisted extraction of Ehretia asperula leaves with antioxidant and anti-diabetic activities and assessment of the process environmental impacts","volume":"45","author":"Duc","year":"2025","journal-title":"Sustain. Chem. Pharm."},{"key":"10.1016\/j.phymed.2026.158466_bib0040","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28062536","article-title":"Possible side effects of polyphenols and their interactions with medicines","volume":"28","author":"Duda-Chodak","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2026.158466_bib0041","doi-asserted-by":"crossref","first-page":"8627","DOI":"10.3390\/app14198627","article-title":"Applications of artificial intelligence in microbiome analysis and probiotic interventions\u2014an overview and perspective based on the current state of the art","volume":"14","author":"D\u2019Urso","year":"2024","journal-title":"Appl. Sci."},{"key":"10.1016\/j.phymed.2026.158466_bib0042","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/8100195","article-title":"Effects of polyphenols on oxidative stress, inflammation, and interconnected pathways during spinal cord injury","volume":"2022","author":"Fakhri","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.phymed.2026.158466_bib0043","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1111\/1750-3841.14128","article-title":"Interactions of dihydromyricetin, a flavonoid from vine tea (Ampelopsis grossedentata) with gut microbiota","volume":"83","author":"Fan","year":"2018","journal-title":"J. Food Sci."},{"key":"10.1016\/j.phymed.2026.158466_bib0044","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1038\/s44318-025-00450-z","article-title":"Approaches to stable isotope tracing and in vivo metabolomics in the cancer clinic","volume":"44","author":"Faubert","year":"2025","journal-title":"EMBO J."},{"key":"10.1016\/j.phymed.2026.158466_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103095","article-title":"Factors driving the inter-individual variability in the metabolism and bioavailability of (poly)phenolic metabolites: a systematic review of human studies","volume":"71","author":"Favari","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.phymed.2026.158466_bib0046","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12986-019-0410-3","article-title":"Curcumin prevents high-fat diet-induced hepatic steatosis in ApoE\u2212\/\u2212 mice by improving intestinal barrier function and reducing endotoxin and liver TLR4\/NF-\u03bab inflammation","volume":"16","author":"Feng","year":"2019","journal-title":"Nutr. Metab. (Lond)"},{"key":"10.1016\/j.phymed.2026.158466_bib0047","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1556\/1886.2016.00036","article-title":"Dissecting the interplay between intestinal microbiota and host immunity in health and disease: lessons learned from germfree and gnotobiotic animal models","volume":"6","author":"Fiebiger","year":"2016","journal-title":"Eur. J. Microbiol. Immunol. (Bp)"},{"key":"10.1016\/j.phymed.2026.158466_bib0048","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.4103\/1673-5374.241429","article-title":"Polyphenols-gut microbiota interplay and brain neuromodulation","volume":"13","author":"Filosa","year":"2018","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.phymed.2026.158466_bib0049","doi-asserted-by":"crossref","DOI":"10.1017\/S0029665123001271","article-title":"Polyphenols and depression: exploring the potential mechanisms of action","volume":"82","author":"Gamage","year":"2023","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.phymed.2026.158466_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.crfs.2023.100448","article-title":"Conversion of (poly)phenolic compounds in food fermentations by lactic acid bacteria: novel insights into metabolic pathways and functional metabolites","volume":"6","author":"Gaur","year":"2023","journal-title":"Curr. Res. Food Sci."},{"key":"10.1016\/j.phymed.2026.158466_bib0051","first-page":"1262","article-title":"Molecular mechanisms underlying the neuroprotective effects of polyphenols: implications for cognitive function","volume":"24","author":"Godos","year":"2025","journal-title":"EXCLI J."},{"key":"10.1016\/j.phymed.2026.158466_bib0052","doi-asserted-by":"crossref","DOI":"10.3390\/nu17152468","article-title":"Effect of polyphenol-rich interventions on gut microbiota and inflammatory or oxidative stress markers in adults who are overweight or obese: a systematic review and meta-analysis","volume":"17","author":"Gonz\u00e1lez-G\u00f3mez","year":"2025","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.158466_bib0053","article-title":"Genomics and physiology of Catenibacillus, human gut bacteria capable of polyphenol C-deglycosylation and flavonoid degradation","volume":"10","author":"Goris","year":"2024","journal-title":"Microb. Genom."},{"key":"10.1016\/j.phymed.2026.158466_bib0054","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.3390\/nu15153454","article-title":"Polyphenols and their impact on the prevention of neurodegenerative diseases and development","volume":"15","author":"Grabska-Koby\u0142ecka","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.158466_bib0055","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/cld.1254","article-title":"Green tea extract\u2013associated acute liver injury: case report and review","volume":"20","author":"Grajecki","year":"2022","journal-title":"Clin. Liver Dis. (Hoboken)"},{"key":"10.1016\/j.phymed.2026.158466_bib0056","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118231","article-title":"Ganoderma lucidum polysaccharide modulates gut microbiota and immune cell function to inhibit inflammation and tumorigenesis in colon","volume":"267","author":"Guo","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.phymed.2026.158466_bib0057","doi-asserted-by":"crossref","DOI":"10.3390\/nu17162708","article-title":"Type 2 diabetes and the multifaceted gut-X axes","volume":"17","author":"Guo","year":"2025","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.158466_bib0058","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2015.122","article-title":"Regulation of glucose metabolism from a liver-centric perspective","volume":"48","author":"Han","year":"2016","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.phymed.2026.158466_bib0059","doi-asserted-by":"crossref","first-page":"950","DOI":"10.3390\/i8090950","article-title":"Dietary polyphenols and their biological significance","volume":"8","author":"Han","year":"2007","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158466_bib0060","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21176356","article-title":"Short-chain fatty acids and their association with signalling pathways in inflammation, glucose and lipid metabolism","volume":"21","author":"He","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158466_bib0061","doi-asserted-by":"crossref","first-page":"6678","DOI":"10.1039\/D3FO01358H","article-title":"Apple peel polyphenol alleviates antibiotic-induced intestinal dysbiosis by modulating tight junction proteins, the TLR4\/NF-\u03bab pathway and intestinal flora","volume":"14","author":"He","year":"2023","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2026.158466_bib0062","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1039\/D3FO04338J","article-title":"(Poly)phenol-related gut metabotypes and human health: an update","volume":"15","author":"Hu","year":"2024","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2026.158466_bib0063","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1021\/acs.jafc.0c07407","article-title":"Lychee (Litchi chinensis Sonn.) pulp phenolics activate the short-chain fatty acid-free fatty acid receptor anti-inflammatory pathway by regulating microbiota and mitigate intestinal barrier damage in dextran sulfate sodium-induced colitis in mice","volume":"69","author":"Huang","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2026.158466_bib0064","first-page":"205","article-title":"Butyrate alleviates cytokine-induced barrier dysfunction by modifying claudin-2 levels","volume":"10","author":"Huang","year":"2021","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.phymed.2026.158466_bib0065","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1186\/s12967-023-04259-4","article-title":"Sodium butyrate ameliorates diabetic retinopathy in mice via the regulation of gut microbiota and related short-chain fatty acids","volume":"21","author":"Huang","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.phymed.2026.158466_bib0066","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1017\/S0007114599000537","article-title":"Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages","volume":"81","author":"Hurrell","year":"1999","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.phymed.2026.158466_bib0067","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.freeradbiomed.2020.01.022","article-title":"Ellagic acid protects caco-2 cell monolayers against inflammation-induced permeabilization","volume":"152","author":"Iglesias","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2026.158466_bib0068","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jff.2019.04.025","article-title":"Metabolism of ellagitannins from jabuticaba (Myrciaria jaboticaba) in normoweight, overweight and obese Brazilians: unexpected laxative effects influence urolithins urinary excretion and metabotype distribution","volume":"57","author":"Inada","year":"2019","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.phymed.2026.158466_bib0069","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28176403","article-title":"Plant polyphenols and their potential benefits on cardiovascular health: a review","volume":"28","author":"Iqbal","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2026.158466_bib0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2022.109242","article-title":"Anti-inflammatory mechanisms of polyphenols in adipose tissue: role of gut microbiota, intestinal barrier integrity and zinc homeostasis","volume":"115","author":"Islam","year":"2023","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.phymed.2026.158466_bib0071","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22073715","article-title":"Beneficial effects of phenolic compounds on gut microbiota and metabolic syndrome","volume":"22","author":"Kasprzak-Drozd","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158466_bib0072","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.3390\/nu7042839","article-title":"Dietary gut microbial metabolites, short-chain fatty acids, and host metabolic regulation","volume":"7","author":"Kasubuchi","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.158466_bib0073","doi-asserted-by":"crossref","first-page":"370","DOI":"10.3390\/molecules24020370","article-title":"Role of intestinal microbiota in the bioavailability and physiological functions of dietary polyphenols","volume":"24","author":"Kawabata","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2026.158466_bib0074","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1152\/physrev.00041.2018","article-title":"Free fatty acid receptors in health and disease","volume":"100","author":"Kimura","year":"2020","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.phymed.2026.158466_bib0075","doi-asserted-by":"crossref","first-page":"982","DOI":"10.3390\/antiox9100982","article-title":"Insight into polyphenol and gut microbiota crosstalk: are their metabolites the key to understand protective effects against metabolic disorders?","volume":"9","author":"Koudoufio","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2026.158466_bib0076","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.3390\/nu17132164","article-title":"Twelve-week curcumin supplementation improves glucose homeostasis and gut health in prediabetic older adults: a pilot, double-blind, placebo-controlled trial","volume":"17","author":"Lamichhane","year":"2025","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.158466_bib0077","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.1039\/D0FO00713G","article-title":"Synergic interactions between polyphenols and gut microbiota in mitigating inflammatory bowel diseases","volume":"11","author":"Li","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2026.158466_bib0078","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jare.2024.03.004","article-title":"Polyphenols synergistic drugs to ameliorate non-alcoholic fatty liver disease via signal pathway and gut microbiota: a review","volume":"68","author":"Li","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.phymed.2026.158466_bib0079","article-title":"The anti-inflammatory effects of short chain fatty acids on lipopolysaccharide- or tumor necrosis factor \u03b1-stimulated endothelial cells via activation of GPR41\/43 and inhibition of HDACs","volume":"9","author":"Li","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158466_bib0080","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejphar.2018.05.003","article-title":"Pro- and anti-inflammatory effects of short chain fatty acids on immune and endothelial cells","volume":"831","author":"Li","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158466_bib0081","article-title":"Short-chain fatty acids in nonalcoholic fatty liver disease: new prospects for short-chain fatty acids as therapeutic targets","volume":"10","author":"Li","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.phymed.2026.158466_bib0082","doi-asserted-by":"crossref","first-page":"9816","DOI":"10.1080\/10408398.2022.2076064","article-title":"Dietary polyphenols: regulate the advanced glycation end products-RAGE axis and the microbiota-gut-brain axis to prevent neurodegenerative diseases","volume":"63","author":"Li","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.phymed.2026.158466_bib0083","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.3390\/microorganisms11082059","article-title":"The crosstalk between gut microbiota and bile acids promotes the development of non-alcoholic fatty liver disease","volume":"11","author":"Li","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.phymed.2026.158466_bib0084","article-title":"The gut\u2013adipose\/pancreas axis: a novel perspective on glycolipid metabolism dysregulation in MAFLD and T2DM pathogenesis","volume":"16","author":"Liang","year":"2025","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.phymed.2026.158466_bib0085","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.3390\/ph16091224","article-title":"Effect of betanin, the major pigment of red beetroot (Beta vulgaris L.), on the activity of recombinant human cytochrome P450 enzymes","volume":"16","author":"Lim","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.phymed.2026.158466_bib0086","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.3390\/molecules27082507","article-title":"Curcumin facilitates aryl hydrocarbon receptor activation to ameliorate inflammatory astrogliosis","volume":"27","author":"Lin","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2026.158466_bib0087","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1021\/acs.jafc.9b06817","article-title":"Beneficial effects of dietary polyphenols on high-fat diet-induced obesity linking with modulation of gut microbiota","volume":"68","author":"Liu","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2026.158466_bib0088","first-page":"1","article-title":"The bioprotective effects of polyphenols on metabolic syndrome against oxidative stress: evidences and perspectives","volume":"2019","author":"Liu","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.phymed.2026.158466_bib0089","doi-asserted-by":"crossref","first-page":"9486","DOI":"10.1039\/D3FO02471G","article-title":"Dietary polyphenols maintain homeostasis via regulating bile acid metabolism: a review of possible mechanisms","volume":"14","author":"Liu","year":"2023","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2026.158466_bib0090","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1111\/1541-4337.12563","article-title":"Modulation of the human gut microbiota by phenolics and phenolic fiber-rich foods","volume":"19","author":"Loo","year":"2020","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"10.1016\/j.phymed.2026.158466_bib0091","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12906-021-03220-6","article-title":"Efficacy of a curcumin extract (Curcugen\u2122) on gastrointestinal symptoms and intestinal microbiota in adults with self-reported digestive complaints: a randomised, double-blind, placebo-controlled study","volume":"21","author":"Lopresti","year":"2021","journal-title":"BMC Complement Med. Ther."},{"key":"10.1016\/j.phymed.2026.158466_bib0092","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3390\/nu13010273","article-title":"Polyphenols and Human health: the role of bioavailability","volume":"13","author":"Lorenzo","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.158466_bib0093","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1080\/10408398.2018.1546669","article-title":"Bioactivity of dietary polyphenols: the role of metabolites","volume":"60","author":"Luca","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.phymed.2026.158466_bib0094","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.apsb.2023.11.011","article-title":"Mechanism of action of the bile acid receptor TGR5 in obesity","volume":"14","author":"Lun","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2026.158466_bib0095","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13099-024-00625-9","article-title":"Equol: a metabolite of gut microbiota with potential antitumor effects","volume":"16","author":"Lv","year":"2024","journal-title":"Gut Pathog."},{"key":"10.1016\/j.phymed.2026.158466_bib0096","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.107949","article-title":"Bisphenol P exposure in C57BL\/6 mice caused gut microbiota dysbiosis and induced intestinal barrier disruption via LPS\/TLR4\/NF-\u03bab signaling pathway","volume":"175","author":"Ma","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.phymed.2026.158466_bib0097","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12986-022-00694-0","article-title":"Browning of the white adipose tissue regulation: new insights into nutritional and metabolic relevance in health and diseases","volume":"19","author":"Machado","year":"2022","journal-title":"Nutr. Metab. (Lond)"},{"key":"10.1016\/j.phymed.2026.158466_bib0098","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.3390\/nu17172793","article-title":"Unlocking polyphenol efficacy: the role of gut microbiota in modulating bioavailability and health effects","volume":"17","author":"Mahdi","year":"2025","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.158466_bib0099","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12906-019-2487-7","article-title":"Tannin profile, antioxidant properties, and antimicrobial activity of extracts from two Mediterranean species of parasitic plant Cytinus","volume":"19","author":"Maisetta","year":"2019","journal-title":"BMC Complement Altern. Med."},{"key":"10.1016\/j.phymed.2026.158466_bib0100","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25136971","article-title":"The postbiotic properties of butyrate in the modulation of the gut microbiota: the potential of its combination with polyphenols and dietary fibers","volume":"25","author":"Maiuolo","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158466_bib0101","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3390\/antiox10020188","article-title":"The interactions between polyphenols and microorganisms, Especially Gut Microbiota","volume":"10","author":"Makarewicz","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2026.158466_bib0102","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3138\/canlivj-2023-0022","article-title":"Effects of curcumin in patients with non-alcoholic fatty liver disease: a systematic review and meta-analysis","volume":"7","author":"Malik","year":"2024","journal-title":"Can. Liver J."},{"key":"10.1016\/j.phymed.2026.158466_bib0103","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/ajcn\/79.5.727","article-title":"Polyphenols: food sources and bioavailability","volume":"79","author":"Manach","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.phymed.2026.158466_bib0104","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1016\/j.bcp.2010.08.008","article-title":"Influence of the flavonoids apigenin, kaempferol, and quercetin on the function of organic anion transporting polypeptides 1A2 and 2B1","volume":"80","author":"Mandery","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158466_bib0105","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.3390\/molecules28052117","article-title":"Impact of pomegranate juice on the pharmacokinetics of CYP3A4- and CYP2C9-mediated drugs metabolism: a preclinical and clinical review","volume":"28","author":"Mansoor","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2026.158466_bib0106","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2025.107055","article-title":"Curcumin supplementation increases butyrogenic bacteria in the gut of obese individuals following a weight-loss diet: a randomized controlled trial","volume":"135","author":"Mansouri","year":"2025","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.phymed.2026.158466_bib0107","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1039\/C5FO00202H","article-title":"A review of the efficacy of dietary polyphenols in experimental models of inflammatory bowel diseases","volume":"6","author":"Martin","year":"2015","journal-title":"Food Funct"},{"key":"10.1016\/j.phymed.2026.158466_bib0108","doi-asserted-by":"crossref","first-page":"850","DOI":"10.3390\/nu13030850","article-title":"Impact of dietary flavanols on microbiota, immunity and inflammation in metabolic diseases","volume":"13","author":"Mart\u00edn","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.158466_bib0109","doi-asserted-by":"crossref","first-page":"12666","DOI":"10.1021\/acs.jafc.8b04138","article-title":"Resveratrol ameliorates intestinal barrier defects and inflammation in colitic mice and intestinal cells","volume":"66","author":"Mayangsari","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2026.158466_bib0110","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/s00204-015-1521-x","article-title":"Hepatotoxicity of green tea: an update","volume":"89","author":"Mazzanti","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.phymed.2026.158466_bib0111","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00228-008-0610-7","article-title":"Hepatotoxicity from green tea: a review of the literature and two unpublished cases","volume":"65","author":"Mazzanti","year":"2009","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158466_bib0112","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1038\/s41467-021-22765-1","article-title":"Decrypting bacterial polyphenol metabolism in an anoxic wetland soil","volume":"12","author":"McGivern","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.158466_bib0113","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.871080","article-title":"Cranberry polyphenols and agave agavins impact gut immune response and microbiota composition while improving gut barrier function, inflammation, and glucose metabolism in mice fed an obesogenic diet","volume":"13","author":"Medina-Larqu\u00e9","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2026.158466_bib0114","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1007\/s11130-023-01121-2","article-title":"Catechin composition, phenolic content, and antioxidant properties of commercially-available bagged, gunpowder, and matcha green teas","volume":"78","author":"Meyer","year":"2023","journal-title":"Plant Foods Hum. Nutr."},{"key":"10.1016\/j.phymed.2026.158466_bib0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2021.110189","article-title":"Role of dietary polyphenols on gut microbiota, their metabolites and health benefits","volume":"142","author":"Mithul Aravind","year":"2021","journal-title":"Food Res. Int."},{"key":"10.1016\/j.phymed.2026.158466_bib0116","doi-asserted-by":"crossref","first-page":"5341","DOI":"10.1002\/fsn3.4178","article-title":"Polyphenols improve non-alcoholic fatty liver disease via gut microbiota: a comprehensive review","volume":"12","author":"Mohammadhasani","year":"2024","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.phymed.2026.158466_bib0117","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1038\/ejcn.2017.89","article-title":"Gut microbiota composition in relation to the metabolic response to 12-week combined polyphenol supplementation in overweight men and women","volume":"71","author":"Most","year":"2017","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.phymed.2026.158466_bib0118","doi-asserted-by":"crossref","DOI":"10.1080\/14756366.2025.2472817","article-title":"Discovery of lignans as the effective inhibitors of CES1A alleviate lipid droplets formation","volume":"40","author":"Mu","year":"2025","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.phymed.2026.158466_bib0119","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3390\/life15010003","article-title":"The microbiota\u2013Gut\u2013Brain axis: key mechanisms driving glymphopathy and cerebral small vessel disease","volume":"15","author":"Nassir","year":"2024","journal-title":"Life"},{"key":"10.1016\/j.phymed.2026.158466_bib0120","doi-asserted-by":"crossref","DOI":"10.3390\/foods14223976","article-title":"Polyphenols bioactive metabolites, and their anti-biofilm and neuroprotective potential","volume":"14","author":"Nazzaro","year":"2025","journal-title":"Foods"},{"key":"10.1016\/j.phymed.2026.158466_bib0121","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.230014","article-title":"Short chain fatty acids: key regulators of the local and systemic immune response in inflammatory diseases and infections","volume":"13","author":"Ney","year":"2023","journal-title":"Open Biol."},{"key":"10.1016\/j.phymed.2026.158466_bib0122","doi-asserted-by":"crossref","DOI":"10.3390\/nu17213468","article-title":"Peptide YY in type 2 diabetes: a complementary gut hormone with therapeutic potential beyond GLP-1","volume":"17","author":"Nguyen","year":"2025","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.158466_bib0123","article-title":"Short chain fatty acids: microbial metabolites for gut-brain axis signalling","volume":"546","author":"O\u2019Riordan","year":"2022","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.phymed.2026.158466_bib0124","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1679286","article-title":"Microbial orchestration of neuroimmune crosstalk: from homeostasis to disease","volume":"16","author":"Ouyang","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2026.158466_bib0125","doi-asserted-by":"crossref","first-page":"11","DOI":"10.7762\/cnr.2020.9.1.11","article-title":"Effects of quercetin supplementation on hematological parameters in non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled pilot study","volume":"9","author":"Pasdar","year":"2020","journal-title":"Clin. Nutr. Res."},{"key":"10.1016\/j.phymed.2026.158466_bib0126","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.650313","article-title":"Use of short-chain fatty acids for the recovery of the intestinal epithelial barrier affected by bacterial toxins","volume":"12","author":"P\u00e9rez-Reytor","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.phymed.2026.158466_bib0127","doi-asserted-by":"crossref","first-page":"5288","DOI":"10.1016\/j.clnu.2021.08.027","article-title":"Crosstalk among intestinal barrier, gut microbiota and serum metabolome after a polyphenol-rich diet in older subjects with \u201cleaky gut\u201d: the MaPLE trial","volume":"40","author":"Peron","year":"2021","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.phymed.2026.158466_bib0128","doi-asserted-by":"crossref","DOI":"10.1016\/j.copbio.2025.103338","article-title":"Unveiling the prebiotic potential of polyphenols in gut health and metabolism","volume":"95","author":"Petersen","year":"2025","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.phymed.2026.158466_bib0129","doi-asserted-by":"crossref","DOI":"10.1177\/2515690X18790725","article-title":"Effects of turmeric and curcumin dietary supplementation on human gut microbiota: a double-blind, randomized, placebo-controlled pilot study","volume":"23","author":"Peterson","year":"2018","journal-title":"J. Evid. Based Complementary Altern. Med."},{"key":"10.1016\/j.phymed.2026.158466_bib0130","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00217-020-03603-y","article-title":"Mutual influence of polyphenols and Lactobacillus spp. Bacteria in food: a review","volume":"247","author":"Piekarska-Radzik","year":"2021","journal-title":"Eur. Food Res. Technol."},{"key":"10.1016\/j.phymed.2026.158466_bib0131","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1002\/mnfr.201500264","article-title":"Urolithins, gut microbiota-derived metabolites of ellagitannins, inhibit LPS-induced inflammation in RAW 264.7 murine macrophages","volume":"59","author":"Piwowarski","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.phymed.2026.158466_bib0132","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3390\/nu14010137","article-title":"Polyphenols\u2014gut microbiota interrelationship: a transition to a new generation of prebiotics","volume":"14","author":"Plamada","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.158466_bib0133","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.3390\/ijms25063370","article-title":"Resveratrol as a promising nutraceutical: implications in gut microbiota modulation, inflammatory disorders, and colorectal cancer","volume":"25","author":"Prakash","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158466_bib0134","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3390\/ani15030387","article-title":"Tea polyphenol protects the immune barrier and inhibits TLR2\/NF-\u03bab\/MLCK signal activation to prevent inflammatory injury in the intestines of common carp (Cyprinus carpio L.)","volume":"15","author":"Qian","year":"2025","journal-title":"Animals"},{"key":"10.1016\/j.phymed.2026.158466_bib0135","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s13668-025-00645-0","article-title":"Urolithin as a metabolite of ellagitannins and ellagic acid from fruits and nuts produced by the gut microbiota: its role on non-communicable diseases","volume":"14","author":"Ribeiro","year":"2025","journal-title":"Curr. Nutr. Rep."},{"key":"10.1016\/j.phymed.2026.158466_bib0136","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.689456","article-title":"Polyphenol-mediated gut microbiota modulation: toward prebiotics and further","volume":"8","author":"Rodr\u00edguez-Daza","year":"2021","journal-title":"Front. Nutr."},{"key":"10.1016\/j.phymed.2026.158466_bib0137","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3390\/ijms24010045","article-title":"Polyphenols as drivers of a homeostatic gut microecology and immuno-metabolic traits of Akkermansia muciniphila: from mouse to man","volume":"24","author":"Rodr\u00edguez-Daza","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158466_bib0138","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s00217-016-2756-3","article-title":"Polyphenols and secoiridoids in raw material (Olea europaea L. leaves) and commercial food supplements","volume":"243","author":"Romani","year":"2017","journal-title":"Eur. Food Res. Technol."},{"key":"10.1016\/j.phymed.2026.158466_bib0139","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1124\/dmd.110.036640","article-title":"Interactions of green tea catechins with organic anion-transporting polypeptides","volume":"39","author":"Roth","year":"2011","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.phymed.2026.158466_bib0140","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1653378","article-title":"Dietary polyphenols and human health: sources, biological activities, nutritional and immunological aspects, and bioavailability\u2013 a comprehensive review","volume":"16","author":"Saad","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2026.158466_bib0141","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s40813-022-00264-z","article-title":"Effects of different short-chain fatty acids (SCFA) on gene expression of proteins involved in barrier function in IPEC-J2","volume":"8","author":"Saleri","year":"2022","journal-title":"Porc. Health Manag."},{"key":"10.1016\/j.phymed.2026.158466_bib0142","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1124\/dmd.104.002337","article-title":"Citrus juices inhibit the function of human organic anion-transporting polypeptide oatp-B","volume":"33","author":"Satoh","year":"2005","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.phymed.2026.158466_bib0143","doi-asserted-by":"crossref","first-page":"770","DOI":"10.3390\/pathogens11070770","article-title":"Polyphenols: bioavailability, microbiome interactions and cellular effects on health in humans and animals","volume":"11","author":"Scott","year":"2022","journal-title":"Pathogens"},{"key":"10.1016\/j.phymed.2026.158466_bib0144","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1039\/C4FO00092G","article-title":"Description of urolithin production capacity from ellagic acid of two human intestinal gordonibacter species","volume":"5","author":"Selma","year":"2014","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2026.158466_bib0145","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3390\/metabo14080399","article-title":"Systematic insights into the relationship between the microbiota\u2013gut\u2013brain axis and stroke with the focus on tryptophan metabolism","volume":"14","author":"Shen","year":"2024","journal-title":"Metabolites"},{"key":"10.1016\/j.phymed.2026.158466_bib0146","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.00025","article-title":"The role of short-chain fatty acids from gut microbiota in gut-brain communication","volume":"11","author":"Silva","year":"2020","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.phymed.2026.158466_bib0147","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13122062","article-title":"Effects of polyphenols on P-glycoprotein (ABCB1) activity","volume":"13","author":"Singh","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.phymed.2026.158466_bib0148","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3003307","article-title":"MEANtools integrates multi-omics data to identify metabolites and predict biosynthetic pathways","volume":"23","author":"Singh","year":"2025","journal-title":"PLoS Biol"},{"key":"10.1016\/j.phymed.2026.158466_bib0149","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.1103836","article-title":"Butyrate producers, \u201cThe Sentinel of Gut\u201d: their intestinal significance with and beyond butyrate, and prospective use as microbial therapeutics","volume":"13","author":"Singh","year":"2023","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.phymed.2026.158466_bib0150","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1021\/acs.jproteome.4c00594","article-title":"Large-scale metabolite imaging gallery of mouse organ tissues to study spatial metabolism","volume":"24","author":"Smith","year":"2025","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.phymed.2026.158466_bib0151","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jhep.2025.02.033","article-title":"Integrative metabolism in MASLD and MASH: pathophysiology and emerging mechanisms","volume":"83","author":"Steinberg","year":"2025","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2026.158466_bib0152","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s11101-016-9459-z","article-title":"The chemistry of gut microbial metabolism of polyphenols","volume":"15","author":"Stevens","year":"2016","journal-title":"Phytochem. Rev."},{"key":"10.1016\/j.phymed.2026.158466_bib0153","doi-asserted-by":"crossref","first-page":"4558","DOI":"10.1002\/ptr.7575","article-title":"Quercetin improves high-fat diet-induced obesity by modulating gut microbiota and metabolites in C57BL\/6J mice","volume":"36","author":"Su","year":"2022","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2026.158466_bib0154","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s12011-012-9448-z","article-title":"Effects of green tea supplementation on elements, total antioxidants, lipids, and glucose values in the serum of obese patients","volume":"149","author":"Suliburska","year":"2012","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.phymed.2026.158466_bib0155","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/s41522-024-00610-9","article-title":"Unlocking gut-liver-brain axis communication metabolites: energy metabolism, immunity and barriers","volume":"10","author":"Sun","year":"2024","journal-title":"NPJ Biofilms Microbiomes"},{"key":"10.1016\/j.phymed.2026.158466_bib0156","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.3390\/foods14071270","article-title":"Hydroxytyrosol ameliorates colon inflammation: mechanistic insights into anti-inflammatory effects, inhibition of the TLR4\/NF-\u03bab signaling pathway, Gut Microbiota Modulation, and Liver Protection","volume":"14","author":"Tang","year":"2025","journal-title":"Foods"},{"key":"10.1016\/j.phymed.2026.158466_bib0157","first-page":"1","article-title":"Modulation of short-chain fatty acids as potential therapy method for type 2 diabetes mellitus","volume":"2021","author":"Tang","year":"2021","journal-title":"Can. J. Infect. Dis. Med. Microbiol."},{"key":"10.1016\/j.phymed.2026.158466_bib0158","doi-asserted-by":"crossref","DOI":"10.3390\/fermentation11080427","article-title":"Response of Akkermansia muciniphila to bioactive compounds: effects on its abundance and activity","volume":"11","author":"Temis-Cortina","year":"2025","journal-title":"Fermentation"},{"key":"10.1016\/j.phymed.2026.158466_bib0159","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1080\/10408398.2018.1437023","article-title":"Polyphenols and bioavailability: an update","volume":"59","author":"Teng","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.phymed.2026.158466_bib0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2024.149176","article-title":"Cross-talk between adipose tissue and microbiota-gut-brain-axis in brain development and neurological disorder","volume":"1844","author":"Thakur","year":"2024","journal-title":"Brain Res."},{"key":"10.1016\/j.phymed.2026.158466_bib0161","doi-asserted-by":"crossref","DOI":"10.1016\/j.crbiot.2026.100386","article-title":"Sustainable ultrasound-assisted extraction of Miliusa velutina stem bark: optimization, in vitro-in silico anti-metabolic syndrome evaluation, and life cycle assessment","volume":"11","author":"Thien Duc","year":"2026","journal-title":"Curr. Res. Biotechnol."},{"key":"10.1016\/j.phymed.2026.158466_bib0162","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202400685","article-title":"Tea polyphenols reduced obesity by modulating gut microbiota-SCFAs-barrier and inflammation in high-fat diet-induced mice","volume":"68","author":"Tian","year":"2024","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.phymed.2026.158466_bib0163","doi-asserted-by":"crossref","DOI":"10.3390\/nu14173494","article-title":"The therapeutic relevance of urolithins, intestinal metabolites of ellagitannin-rich food: a systematic review of In vivo studies","volume":"14","author":"Tow","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.158466_bib0164","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2023.108457","article-title":"Bile acid metabolism and signaling: emerging pharmacological targets of dietary polyphenols","volume":"248","author":"Tveter","year":"2023","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2026.158466_bib0165","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3945\/ajcn.110.000075","article-title":"Prebiotic evaluation of cocoa-derived flavanols in healthy humans by using a randomized, controlled, double-blind, crossover intervention study123","volume":"93","author":"Tzounis","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.phymed.2026.158466_bib0166","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/914273","article-title":"Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects","volume":"2012","author":"Vauzour","year":"2012","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.phymed.2026.158466_bib0167","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1002\/ptr.70268","article-title":"Redox paradox of polyphenols: bioavailability, hormesis, and safety concerns","volume":"40","author":"Vrankova","year":"2026","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2026.158466_bib0168","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s12276-021-00677-w","article-title":"Role of the gut\u2013brain axis in energy and glucose metabolism","volume":"54","author":"Wachsmuth","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.phymed.2026.158466_bib0169","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.784211","article-title":"Caffeic acid supplement alleviates colonic inflammation and oxidative stress potentially through improved gut microbiota community in mice","volume":"12","author":"Wan","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.phymed.2026.158466_bib0170","article-title":"Hesperetin alleviated experimental colitis via regulating ferroptosis and gut microbiota","volume":"16","author":"Wang","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.158466_bib0171","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/17425255.2019.1559815","article-title":"An update on polyphenol disposition via coupled metabolic pathways","volume":"15","author":"Wang","year":"2019","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.phymed.2026.158466_bib0172","article-title":"The role of intestinal flora in metabolic dysfunction-associated steatotic liver disease and treatment strategies","volume":"11","author":"Wang","year":"2025","journal-title":"Front. Med. (Lausanne)"},{"key":"10.1016\/j.phymed.2026.158466_bib0173","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3390\/microorganisms8040527","article-title":"Role of gut microbiota in neuroendocrine regulation of carbohydrate and lipid metabolism via the microbiota-gut-brain-liver axis","volume":"8","author":"Wang","year":"2020","journal-title":"Microorganisms"},{"key":"10.1016\/j.phymed.2026.158466_bib0174","article-title":"Gut microbiota\u2013neuroinflammation axis: a new mechanism and therapeutic target for comorbid depression in epilepsy","volume":"50","author":"Wang","year":"2025","journal-title":"Brain Behav. Immun. Health"},{"key":"10.1016\/j.phymed.2026.158466_bib0175","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.3390\/antiox11061212","article-title":"Dietary polyphenol, gut microbiota, and health benefits","volume":"11","author":"Wang","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2026.158466_bib0176","article-title":"Efficacy of dietary polyphenol supplement in patients with non-alcoholic fatty liver disease: a network meta-analysis","volume":"12","author":"Wang","year":"2025","journal-title":"Front. Nutr."},{"key":"10.1016\/j.phymed.2026.158466_bib0177","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1021\/acs.jafc.1c00751","article-title":"Dietary polyphenols to combat nonalcoholic fatty liver disease via the gut\u2013brain\u2013liver axis: a review of possible mechanisms","volume":"69","author":"Wang","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2026.158466_bib0178","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1146\/annurev-food-060721-023817","article-title":"Bioavailability of food polyphenols: current state of knowledge","volume":"16","author":"Williamson","year":"2025","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"10.1016\/j.phymed.2026.158466_bib0179","first-page":"24","article-title":"Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols","volume":"139","author":"Williamson","year":"2017","journal-title":"Biochem. Pharmacol. 5th Int. Conf. Mech. Action Nutraceuticals"},{"key":"10.1016\/j.phymed.2026.158466_bib0180","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.3390\/foods13162520","article-title":"Naringenin promotes gastrointestinal motility in mice by impacting the SCF\/c-kit pathway and gut microbiota","volume":"13","author":"Wu","year":"2024","journal-title":"Foods"},{"key":"10.1016\/j.phymed.2026.158466_bib0181","doi-asserted-by":"crossref","first-page":"25573","DOI":"10.1021\/acs.jafc.5c03760","article-title":"New insights into the structural profiling of polyphenol aggregates from Pu-erh tea and their anti-inflammatory activity via the TLR4\/MyD88\/NF-\u03bab signaling pathway and gut microbiota","volume":"73","author":"Wu","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2026.158466_bib0182","doi-asserted-by":"crossref","DOI":"10.1002\/efd2.21","article-title":"Recent advances on the stability of dietary polyphenols","volume":"3","author":"Xiao","year":"2022","journal-title":"eFood"},{"key":"10.1016\/j.phymed.2026.158466_bib0183","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.3390\/nu10111618","article-title":"The immunomodulatory and anti-inflammatory role of polyphenols","volume":"10","author":"Yahfoufi","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.158466_bib0184","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s41392-023-01673-4","article-title":"Gut liver brain axis in diseases: the implications for therapeutic interventions","volume":"8","author":"Yan","year":"2023","journal-title":"Sig. Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2026.158466_bib0185","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.3390\/foods12173315","article-title":"Effects of fermentation on bioactivity and the composition of polyphenols contained in polyphenol-rich foods: a review","volume":"12","author":"Yang","year":"2023","journal-title":"Foods"},{"key":"10.1016\/j.phymed.2026.158466_bib0186","doi-asserted-by":"crossref","DOI":"10.1016\/j.advnut.2025.100545","article-title":"Tea polyphenol epigallocatechin gallate and the gut\u2013Health axis: unraveling structural characteristics, metabolic pathways, and systemic benefits","volume":"16","author":"Yang","year":"2025","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.phymed.2026.158466_bib0187","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3390\/cimb48020201","article-title":"Diet-induced browning of white adipose tissue: molecular targets, mechanisms, and therapeutic potential","volume":"48","author":"Yang","year":"2026","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.phymed.2026.158466_bib0188","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12986-025-01022-y","article-title":"The effects of polyphenols on gut microbial metabolites and composition in neurodegenerative diseases: a systematic review","volume":"22","author":"Zafari","year":"2025","journal-title":"Nutr. Metab. (Lond)"},{"key":"10.1016\/j.phymed.2026.158466_bib0189","article-title":"Urolithin A attenuates hyperuricemic nephropathy in fructose-fed mice by impairing STING-NLRP3 axis-mediated inflammatory response via restoration of parkin-dependent mitophagy","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158466_bib0190","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1039\/D5FO02858B","article-title":"Chlorogenic acid improves DSS-induced colitis in mice by regulating the gut microbiota","volume":"17","author":"Zhang","year":"2026","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2026.158466_bib0191","doi-asserted-by":"crossref","first-page":"5151","DOI":"10.1039\/D5FO00484E","article-title":"Preventive and controlling effects of N-acetylneuraminic acid in regulating glucose and lipid metabolism disorders via the gut-liver axis in high-fat diet mice","volume":"16","author":"Zhang","year":"2025","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2026.158466_bib0192","doi-asserted-by":"crossref","first-page":"7577","DOI":"10.1039\/D4FO00563E","article-title":"Edible bird\u2019s nest regulates glucose and lipid metabolic disorders via the gut\u2013liver axis in obese mice","volume":"15","author":"Zhang","year":"2024","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2026.158466_bib0193","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.671353","article-title":"Quercetin ameliorates gut microbiota dysbiosis that drives hypothalamic damage and hepatic lipogenesis in monosodium glutamate-induced abdominal obesity","volume":"8","author":"Zhao","year":"2021","journal-title":"Front. Nutr."},{"key":"10.1016\/j.phymed.2026.158466_bib0194","article-title":"Potential roles of gut microbes in biotransformation of natural products: an overview","volume":"13","author":"Zhao","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.phymed.2026.158466_bib0195","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.180","article-title":"The gut microbiota-aromatic hydrocarbon receptor (AhR) axis mediates the anticolitic effect of polyphenol-rich extracts from Sanghuangporus","volume":"3","author":"Zhong","year":"2024","journal-title":"Imeta"},{"key":"10.1016\/j.phymed.2026.158466_bib0196","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1039\/D2FO02523J","article-title":"Thyme (Thymus vulgaris L.) polyphenols ameliorate DSS-induced ulcerative colitis of mice by mitigating intestinal barrier damage, regulating gut microbiota, and suppressing TLR4\/NF-\u03bab-NLRP3 inflammasome pathways","volume":"14","author":"Zhou","year":"2023","journal-title":"Food Funct"},{"key":"10.1016\/j.phymed.2026.158466_bib0197","doi-asserted-by":"crossref","first-page":"10014","DOI":"10.1039\/D3FO02177G","article-title":"Black chokeberry (Aronia melanocarpa L.) polyphenols attenuate obesity-induced colonic inflammation by regulating gut microbiota and the TLR4\/NF-\u03bab signaling pathway in high fat diet-fed rats","volume":"14","author":"Zhu","year":"2023","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2026.158466_bib0198","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3390\/bioengineering13020144","article-title":"Transformer models, graph networks, and generative AI in Gut microbiome research: a narrative review","volume":"13","author":"Zhu","year":"2026","journal-title":"Bioengineering (Basel)"},{"key":"10.1016\/j.phymed.2026.158466_bib0199","doi-asserted-by":"crossref","first-page":"3915","DOI":"10.1007\/s11101-025-10124-7","article-title":"Advances on resource, biosynthesis pathway, bioavailability, and bioactivity of dihydrodaidzein","volume":"24","author":"Zou","year":"2025","journal-title":"Phytochem. Rev."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326006975?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326006975?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T14:40:01Z","timestamp":1785508801000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326006975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":199,"alternative-id":["S0944711326006975"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158466","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Indirect pharmacology of phytopolyphenols: The role of intermediate substances in cross-organ regulation and phenotypic outcomes","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158466","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158466"}}