{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T03:52:50Z","timestamp":1785901970784,"version":"3.56.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2024NSFSC0689"],"award-info":[{"award-number":["2024NSFSC0689"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014895","name":"Southwest Medical University","doi-asserted-by":"publisher","award":["2024ZXYZX23"],"award-info":[{"award-number":["2024ZXYZX23"]}],"id":[{"id":"10.13039\/501100014895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.phymed.2026.158476","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T23:37:06Z","timestamp":1782171426000},"page":"158476","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Pinocembrin inhibits melanoma progression via Ets1-mediated Smad3 transcription to enhance anti-PD-1 therapy"],"prefix":"10.1016","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1979-9093","authenticated-orcid":false,"given":"Yuan","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Rou","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Bing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6550-8540","authenticated-orcid":false,"given":"Jian-Chun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8160-6797","authenticated-orcid":false,"given":"Rui-Zhi","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Lian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3881-3149","authenticated-orcid":false,"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158476_bib0001","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.immuni.2019.03.024","article-title":"Transforming growth factor-\u03b2 signaling in immunity and cancer","volume":"50","author":"Batlle","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.phymed.2026.158476_bib0002","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/s41467-025-67315-1","article-title":"RAS\/MEK\/PI3K pathway inhibition augments response to CD40 agonism by targeting CD11b(+) Bregs thereby overcoming melanoma PD1-resistance","volume":"17","author":"Chi","year":"2026","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.158476_bib0003","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1002\/1878-0261.12355","article-title":"TGF\u03b21 regulates HGF-induced cell migration and hepatocyte growth factor receptor MET expression via C-ets-1 and miR-128-3p in basal-like breast cancer","volume":"12","author":"Christian","year":"2018","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.phymed.2026.158476_bib0004","article-title":"Molecular dissection of the oncogenic role of ETS1 in the mesenchymal subtypes of head and neck squamous cell carcinoma","volume":"15","author":"Christian","year":"2019","journal-title":"PLoS Genet."},{"key":"10.1016\/j.phymed.2026.158476_bib0005","doi-asserted-by":"crossref","first-page":"9805","DOI":"10.1111\/jcmm.16928","article-title":"AANG: a natural compound formula for overcoming multidrug resistance via synergistic rebalancing the TGF-\u03b2\/Smad signalling in hepatocellular carcinoma","volume":"25","author":"Chung","year":"2021","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.phymed.2026.158476_bib0006","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0260719","article-title":"The efficacy and safety of pinocembrin in a sheep model of bleomycin-induced pulmonary fibrosis","volume":"16","author":"Derseh","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2026.158476_bib0007","article-title":"NSUN5 facilitates hepatocellular carcinoma progression by increasing Smad3 expression","volume":"12","author":"Han","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.phymed.2026.158476_bib0008","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1158\/0008-5472.CAN-19-1668","article-title":"Targeting pan-ETS factors inhibits melanoma progression","volume":"81","author":"Huang","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.phymed.2026.158476_bib0009","first-page":"616","article-title":"Uridine depletion impairs CD8\u207a T cell antitumor activity through N-glycosylation","volume":"38","author":"Jianbiao","year":"2025","journal-title":"Cell Metab."},{"key":"10.1016\/j.phymed.2026.158476_bib0010","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/s41467-025-55876-0","article-title":"CD133(+)PD-L1(+) cancer cells confer resistance to adoptively transferred engineered macrophage-based therapy in melanoma","volume":"16","author":"Jiaojiao","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.158476_bib0011","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/s41392-025-02347-z","article-title":"NADPH oxidase 1\/4 dual inhibition impairs transforming growth factor-beta protumorigenic effects in cholangiocarcinoma cancer-associated fibroblasts","volume":"10","author":"Josep","year":"2025","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2026.158476_bib0012","article-title":"An oncolytic virus-delivered TGF\u03b2 inhibitor overcomes the immunosuppressive tumor microenvironment","volume":"220","author":"Kristin","year":"2023","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.phymed.2026.158476_bib0013","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/ni1197","article-title":"Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma","volume":"6","author":"Laouar","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.phymed.2026.158476_bib0014","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1038\/s41467-019-09634-8","article-title":"Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance","volume":"10","author":"Li","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.158476_bib0015","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1038\/s41388-025-03417-w","article-title":"Therapeutic targeting of the p300\/CBP bromodomain enhances the efficacy of immune checkpoint blockade therapy","volume":"44","author":"Liu","year":"2025","journal-title":"Oncogene"},{"key":"10.1016\/j.phymed.2026.158476_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.120449","article-title":"YinxingGujin decoction suppresses lung adenocarcinoma metastasis by modulating the TGF-\u03b2\/STAT3\/PD-L1 axis: network pharmacology and experimental validation","volume":"353","author":"Liu","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158476_bib0017","doi-asserted-by":"crossref","first-page":"7907","DOI":"10.3390\/ijms25147907","article-title":"Exploiting glycyrrhiza glabra L. (Licorice) Flavanones: licoflavanone's impact on breast cancer cell bioenergetics","volume":"25","author":"Luca","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158476_bib0018","doi-asserted-by":"crossref","first-page":"15388","DOI":"10.1021\/acsnano.3c00295","article-title":"Perfluorotributylamine-loaded albumin nanoparticles downregulate platelet-derived TGF\u03b2 to inhibit tumor metastasis","volume":"17","author":"Luo","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.phymed.2026.158476_bib0019","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/s41568-025-00819-6","article-title":"Revisiting the TGF\u03b2 paradox: insights from HPV-driven cancer and the DNA damage response","volume":"25","author":"Mary Helen","year":"2025","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.phymed.2026.158476_bib0020","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.ccell.2025.02.012","article-title":"Overcoming melanoma therapy resistance with RAF-MEK and FAK inhibition","volume":"43","author":"Mathieu","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.phymed.2026.158476_bib0021","doi-asserted-by":"crossref","first-page":"7","DOI":"10.14740\/wjon1349","article-title":"Cutaneous malignant melanoma: a review of early diagnosis and management","volume":"12","author":"Naik","year":"2021","journal-title":"World J. Oncol."},{"key":"10.1016\/j.phymed.2026.158476_bib0022","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202407967","article-title":"Neuropeptide precursor VGF promotes liver metastatic colonization of g\u03b1q mutant uveal melanoma by facilitating tumor microenvironment via paracrine loops","volume":"11","author":"Ouyang","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.phymed.2026.158476_bib0023","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/379850","article-title":"Pinocembrin: a novel natural compound with versatile pharmacological and biological activities","volume":"2013","author":"Rasul","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.phymed.2026.158476_bib0024","article-title":"Multiplex gene-editing strategy to engineer allogeneic EGFR-targeting CART-cells with improved efficacy against solid tumors","volume":"16","author":"Ryan","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.158476_bib0025","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.3390\/molecules24122323","article-title":"Advances in biosynthesis, pharmacology, and pharmacokinetics of pinocembrin, a promising natural small-molecule drug","volume":"24","author":"Shen","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2026.158476_bib0026","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.ccell.2025.02.001","article-title":"FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma","volume":"43","author":"Simone","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.phymed.2026.158476_bib0027","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001674","article-title":"TGF-\u03b2 signalling is required for CD4\u207a T cell homeostasis but dispensable for regulatory T cell function","volume":"11","author":"Sledzi\u0144ska","year":"2013","journal-title":"PLoS Biol."},{"key":"10.1016\/j.phymed.2026.158476_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103349","article-title":"UBR5 mediates colorectal cancer chemoresistance by attenuating ferroptosis via lys 11 ubiquitin-dependent stabilization of Smad3-Slc7a11 signaling","volume":"76","author":"Song","year":"2024","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2026.158476_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2024.108613","article-title":"Immunotherapy in melanoma: can we predict response to treatment with circulating biomarkers","volume":"256","author":"Splendiani","year":"2024","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2026.158476_bib0030","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1038\/onc.2010.619","article-title":"TGF-\u03b2-induced IRAK-M expression in tumor-associated macrophages regulates lung tumor growth","volume":"30","author":"Standiford","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.phymed.2026.158476_bib0031","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/ni.2499","article-title":"Absence of signaling into CD4\u207a cells via C3aR and C5aR enables autoinductive TGF-\u03b21 signaling and induction of Foxp3\u207a regulatory T cells","volume":"14","author":"Strainic","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.phymed.2026.158476_bib0032","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s40169-017-0147-4","article-title":"ETS-targeted therapy: can it substitute for MEK inhibitors","volume":"6","author":"Tetsu","year":"2017","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.phymed.2026.158476_bib0033","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/s41392-025-02280-1","article-title":"Immune evasion in cancer: mechanisms and cutting-edge therapeutic approaches","volume":"10","author":"Tufail","year":"2025","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2026.158476_bib0034","article-title":"USP35 acts as a deubiquitinating enzyme for ID3 to promote immune escape in colorectal cancer","volume":"13","author":"Wenxin","year":"2026","journal-title":"Adv. Sci."},{"key":"10.1016\/j.phymed.2026.158476_bib0035","article-title":"Blockades of effector T cell senescence and exhaustion synergistically enhance antitumor immunity and immunotherapy","volume":"10","author":"Xia","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.phymed.2026.158476_bib0036","article-title":"Engineered cryo-shocked cancer cells deliver dual-,function gene medicines for melanoma immunotherapy","volume":"38","author":"Yali","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.phymed.2026.158476_bib0037","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.canlet.2018.05.026","article-title":"Pinocembrin induces ER stress mediated apoptosis and suppresses autophagy in melanoma cells","volume":"431","author":"Zheng","year":"2018","journal-title":"Cancer Lett."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326007075?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326007075?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T03:32:32Z","timestamp":1785900752000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326007075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":37,"alternative-id":["S0944711326007075"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158476","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pinocembrin inhibits melanoma progression via Ets1-mediated Smad3 transcription to enhance anti-PD-1 therapy","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158476","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158476"}}