{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:12:40Z","timestamp":1785510760804,"version":"3.56.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.phymed.2026.158515","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T16:12:23Z","timestamp":1782749543000},"page":"158515","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Euodia rutaecarpa (Juss.) Benth. var. officinalis (Dode) Huang and evodiamine ameliorate N-methyl-N\u2032-nitro-N-nitrosoguanidine-induced chronic atrophic gastritis in rats via the phosphatidylinositol 3-kinase\/protein kinase B\/nuclear factor kappa-B pathway"],"prefix":"10.1016","volume":"159","author":[{"given":"Liping","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzhuo","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianmei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7558-7182","authenticated-orcid":false,"given":"Jing","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayin","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqun","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5798-4405","authenticated-orcid":false,"given":"Aihua","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158515_bib0001","first-page":"161","article-title":"Gastric epithelial carcinogenesis: from atrophic gastritis, intestinal metaplasia, and dysplasia to invasive adenocarcinoma","volume":"24","author":"Bosch","year":"2019","journal-title":"AJSP Rev. Rep."},{"key":"10.1016\/j.phymed.2026.158515_bib0002","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.phymed.2026.158515_bib0003","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jep.2016.05.024","article-title":"Multicomponent, multitarget integrated adjustment\u2013Metabolomics study of qizhiweitong particles curing gastrointestinal motility disorders in mice induced by atropine","volume":"189","author":"Chang","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158515_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115495","article-title":"Major indole alkaloids in evodia rutaecarpa: the latest insights and review of their impact on gastrointestinal diseases","volume":"167","author":"Chen","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2026.158515_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154826","article-title":"Tibetan medicine liuwei muxiang pills (LWMX pills) effectively protects mice from chronic non-atrophic gastritis","volume":"115","author":"Dhondrup","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158515_bib0007","doi-asserted-by":"crossref","first-page":"6294","DOI":"10.3390\/molecules28176294","article-title":"Rutaecarpine ameliorates murine n-methyl-n\u2019-nitro-n-nitrosoguanidine-induced chronic atrophic gastritis by sonic hedgehog pathway","volume":"28","author":"He","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2026.158515_bib0008","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.2147\/DDDT.S428783","article-title":"Metabolomics profiles reveal the efficacy of wuzhuyu decoction on patients with chronic non-atrophic gastritis","volume":"17","author":"Hu","year":"2023","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.phymed.2026.158515_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116912","article-title":"Research on drug treatment and the novel signaling pathway of chronic atrophic gastritis","volume":"176","author":"Jia","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2026.158515_bib0010","first-page":"215","article-title":"The mechanism of evodiamine regulating the EGFR\/MAPK\/ERK pathway in rats with chronic atrophic gastritis induced by Helicobacter pylori","volume":"31","author":"Li","year":"2025","journal-title":"Hebei Med."},{"key":"10.1016\/j.phymed.2026.158515_bib0011","article-title":"Precancerous pathways to gastric cancer: a review of experimental animal models recapitulating the correa cascade","volume":"13","author":"Li","year":"2025","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.phymed.2026.158515_bib0012","first-page":"184","article-title":"The protective effect of evodiamine on the gastric mucosal epithelial cells of rats with alcoholic gastric ulcers","volume":"50","author":"Li","year":"2022","journal-title":"J. South Cent. Med. Sci."},{"key":"10.1016\/j.phymed.2026.158515_bib0013","doi-asserted-by":"crossref","first-page":"5905","DOI":"10.2147\/DDDT.S487371","article-title":"Zuojin pill alleviates precancerous lesions of gastric cancer by modulating the MEK\/ERK\/c-myc pathway: an integrated approach of network pharmacology, molecular dynamics simulation, and experimental validation","volume":"Volume 18","author":"Liang","year":"2024","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.phymed.2026.158515_bib0014","doi-asserted-by":"crossref","first-page":"9843","DOI":"10.2147\/IJN.S459510","article-title":"Evodiamine: a extremely potential drug development candidate of alkaloids from evodia rutaecarpa","volume":"Volume 19","author":"Lin","year":"2024","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.phymed.2026.158515_bib0015","doi-asserted-by":"crossref","first-page":"127","DOI":"10.4103\/sjg.sjg_383_22","article-title":"Analysis of high risk factors for chronic atrophic gastritis","volume":"29","author":"Lin","year":"2023","journal-title":"Saudi J. Gastroenterol."},{"key":"10.1016\/j.phymed.2026.158515_bib0016","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/s41419-020-02998-6","article-title":"PI3K\/AKT pathway as a key link modulates the multidrug resistance of cancers","volume":"11","author":"Liu","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2026.158515_bib0017","article-title":"Traditional Chinese medicine in the treatment of chronic atrophic gastritis, precancerous lesions and gastric cancer","volume":"337","author":"Liu","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158515_bib0018","first-page":"218","article-title":"Risk assessment models of integrative medicine indicators for malignant transformation of chronic atrophic gastritis: a registry study protocol","volume":"6","author":"Liu","year":"2019","journal-title":"J. Trad. Chin. Med. Sci."},{"key":"10.1016\/j.phymed.2026.158515_bib0019","doi-asserted-by":"crossref","first-page":"4080","DOI":"10.4251\/wjgo.v16.i10.4080","article-title":"Update understanding on diagnosis and histopathological examination of atrophic gastritis: a review","volume":"16","author":"Ma","year":"2024","journal-title":"World J. Gastrointest. Oncol."},{"key":"10.1016\/j.phymed.2026.158515_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2022.463417","article-title":"Ultra-performance chromatography-electrospray tandem mass spectrometry analysis of bile acid profiles in the enterohepatic circulation following geniposide and acetaminophen\u2013induced liver injury","volume":"1680","author":"Qin","year":"2022","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.phymed.2026.158515_bib0021","series-title":"Molecular Mechanisms of inflammation: induction, Resolution and Escape By Helicobacter pylori","first-page":"53","article-title":"Genetic polymorphisms in inflammatory and other regulators in gastric cancer: risks and clinical consequences","author":"Rudnicka","year":"2019"},{"key":"10.1016\/j.phymed.2026.158515_bib0022","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1038\/s41395-018-0353-8","article-title":"OLGA gastritis staging for the prediction of gastric cancer risk: a long\u2013term follow-up study of 7436 patients","volume":"113","author":"Rugge","year":"2018","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.phymed.2026.158515_bib0023","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/j.2040-4603.2020.tb00101.x","article-title":"Gastric peptides\u2013gastrin and somatostatin","volume":"10","author":"Schubert","year":"2020","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.phymed.2026.158515_bib0024","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.biopha.2018.12.033","article-title":"Evodiamine prevents dextran sulfate sodium\u2013induced murine experimental colitis via the regulation of NF-\u03bab and NLRP3 inflammasome","volume":"110","author":"Shen","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2026.158515_bib0025","article-title":"Risk of progression in patients with chronic atrophic gastritis: a retrospective study","volume":"12","author":"Sun","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.phymed.2026.158515_bib0026","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.semcancer.2019.12.008","article-title":"Natural products targeting the PI3K-akt-mTOR signaling pathway in cancer: a novel therapeutic strategy","volume":"80","author":"Tewari","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.phymed.2026.158515_bib0027","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.644638","article-title":"Berberine attenuates chronic atrophic gastritis induced by MNNG and its potential mechanism","volume":"12","author":"Tong","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158515_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113893","article-title":"Zuojin pill ameliorates chronic atrophic gastritis induced by MNNG through TGF-\u03b21\/PI3K\/akt axis","volume":"271","author":"Tong","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158515_bib0029","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.797605","article-title":"Amelioration of AOM\/DSS\u2013induced murine colitis-associated cancer by evodiamine intervention is primarily associated with gut microbiota\u2013metabolism\u2013inflammatory signaling axis","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158515_bib0030","volume":"279","author":"Wang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158515_bib0031","article-title":"Research on the signaling pathway and the related mechanism of traditional chinese medicine intervention in chronic gastritis of the \u201cinflammation\u2013cancer transformation","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158515_bib0032","first-page":"92","article-title":"Multivariate analysis in metabolomics","volume":"1","author":"Worley","year":"2013","journal-title":"Curr. Metabolomics"},{"key":"10.1016\/j.phymed.2026.158515_bib0033","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0014-2999(02)02687-0","article-title":"Effects of evodiamine on gastrointestinal motility in male rats","volume":"457","author":"Wu","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158515_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117901","article-title":"The active components and potential mechanisms of wuji wan in the treatment of ethanol\u2013induced gastric ulcer: an integrated metabolomics, network pharmacology and experimental validation","volume":"326","author":"Wu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158515_bib0035","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s13659-023-00369-0","article-title":"Traditional chinese medicine euodiae fructus: botany, traditional use, phytochemistry, pharmacology, toxicity and quality control","volume":"13","author":"Xiao","year":"2023","journal-title":"Nat. Prod. Bioprospect."},{"key":"10.1016\/j.phymed.2026.158515_bib0036","first-page":"4649","article-title":"Effects of pogostemon cablin on gastrointestinal function of rats with syndrome of damp retention in middle\u2013jiao","volume":"42","author":"Xu","year":"2017","journal-title":"Chin. J. Chin. Mater. Med."},{"key":"10.1016\/j.phymed.2026.158515_bib0037","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.3390\/ijms22073385","article-title":"Evodiamine inhibits helicobacter pylori growth and Helicobacter pylori\u2013induced inflammation","volume":"22","author":"Yang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158515_bib0038","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.3390\/cimb44090298","article-title":"Induction of apoptosis and effect on the FAK\/AKT\/mTOR signal pathway by evodiamine in gastric cancer cells","volume":"44","author":"Yang","year":"2022","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.phymed.2026.158515_bib0039","first-page":"88","article-title":"The mechanism of action of weiwei tongtiao decoction on chronic atrophic gastritis in rats based on the NF-\u03bab signaling pathway","volume":"29","author":"You","year":"2023","journal-title":"Chin. J. Exp. Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2026.158515_bib0040","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1309\/DFLELPGPNV5LK6B1","article-title":"Clinicopathologic implications of genetic instability in intestinal\u2013type gastric cancer and intestinal metaplasia as a precancerous lesion: proof of field cancerization in the stomach","volume":"129","author":"Zaky","year":"2008","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.phymed.2026.158515_bib0041","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1021\/cr3003533","article-title":"Protein analysis by shotgun\/bottom\u2013up proteomics","volume":"113","author":"Zhang","year":"2013","journal-title":"Chem. Rev."},{"key":"10.1016\/j.phymed.2026.158515_bib0042","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3892\/mmr.2022.12704","article-title":"Protection against ulcerative colitis and colorectal cancer by evodiamine via anti-inflammatory effects","volume":"25","author":"Zhang","year":"2022","journal-title":"Mol. Med. Rep."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326007464?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326007464?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T14:49:22Z","timestamp":1785509362000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326007464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":41,"alternative-id":["S0944711326007464"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158515","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Euodia rutaecarpa (Juss.) Benth. var. officinalis (Dode) Huang and evodiamine ameliorate N-methyl-N\u2032-nitro-N-nitrosoguanidine-induced chronic atrophic gastritis in rats via the phosphatidylinositol 3-kinase\/protein kinase B\/nuclear factor kappa-B pathway","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158515","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158515"}}