{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:21:10Z","timestamp":1793334070470,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.phymed.2026.158557","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:31:00Z","timestamp":1783603860000},"page":"158557","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Capillarisin, a coumarin from Artemisia capillaris, alleviates APAP hepatotoxicity by targeting GSK3\u03b2\/Nrf2 to suppress ferroptosis"],"prefix":"10.1016","volume":"159","author":[{"given":"Ludong","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyuan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tinghan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158557_bib0001","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ejim.2021.10.035","article-title":"Drug-induced liver injury: pathogenesis, epidemiology, clinical features, and practical management","volume":"97","author":"Bj\u00f6rnsson","year":"2022","journal-title":"Eur. J. Intern. Med."},{"key":"10.1016\/j.phymed.2026.158557_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118009","article-title":"Artemisia capillaris thunb. Polysaccharide alleviates cholestatic liver injury through gut microbiota modulation and Nrf2 signaling pathway activation in mice","volume":"327","author":"Cai","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"14","key":"10.1016\/j.phymed.2026.158557_bib0003","doi-asserted-by":"crossref","first-page":"4908","DOI":"10.3390\/ijms21144908","article-title":"Ferroptosis in liver diseases: an overview","volume":"21","author":"Capelletti","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.phymed.2026.158557_bib0004","article-title":"Interventions for paracetamol (acetaminophen) overdose","volume":"2018","author":"Chiew","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"issue":"3","key":"10.1016\/j.phymed.2026.158557_bib0005","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41418-022-00941-0","article-title":"The multifaceted role of ferroptosis in liver disease","volume":"29","author":"Chen","year":"2022","journal-title":"Cell Death. Differ."},{"issue":"11","key":"10.1016\/j.phymed.2026.158557_bib0006","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1007\/s12272-020-01271-w","article-title":"\u03b2-sitosterol attenuates liver injury in a rat model of chronic alcohol intake","volume":"43","author":"Chen","year":"2020","journal-title":"Arch. Pharm. Res."},{"issue":"Pt B","key":"10.1016\/j.phymed.2026.158557_bib0007","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.freeradbiomed.2015.04.029","article-title":"Structural and functional characterization of Nrf2 degradation by glycogen synthase kinase 3\/beta-TrCP","volume":"88","author":"Cuadrado","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2026.158557_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153746","article-title":"A characterized saponin extract of Panax japonicus suppresses hepatocyte EMT and HSC activation in vitro and CCl4-provoked liver fibrosis in mice: roles of its modulatory effects on the akt\/GSK3\u03b2\/Nrf2 cascade","volume":"93","author":"Dai","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158557_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154051","article-title":"Therapeutic efficacy and safety of Yinzhihuang granules with phototherapy in neonatal pathologic jaundice: an updated systematic review and meta-analysis","volume":"100","author":"Feng","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158557_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107650","article-title":"Traditional application and modern pharmacological research of Artemisia annua L","volume":"216","author":"Feng","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2026.158557_bib0011","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/pbi.70398","article-title":"A comprehensive multiomics approach illuminates the biosynthetic mechanism of scoparone in Artemisia capillaris","volume":"24","author":"Guo","year":"2026","journal-title":"Plant Biotechnol J."},{"issue":"11","key":"10.1016\/j.phymed.2026.158557_bib0012","doi-asserted-by":"crossref","first-page":"7534","DOI":"10.1021\/acs.jmedchem.3c00364","article-title":"Discovery of 2-(Anilino)pyrimidine-4-carboxamides as highly potent, selective, and orally active glycogen synthase kinase-3 (GSK-3) inhibitors","volume":"66","author":"Hartz","year":"2023","journal-title":"J. Med. Chem."},{"issue":"2","key":"10.1016\/j.phymed.2026.158557_bib0013","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jhep.2023.03.016","article-title":"ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis","volume":"79","author":"He","year":"2023","journal-title":"J. Hepatol."},{"issue":"10","key":"10.1016\/j.phymed.2026.158557_bib0014","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.3390\/biomedicines9101412","article-title":"The pharmacological effects and pharmacokinetics of active compounds of Artemisia capillaris","volume":"9","author":"Hsueh","year":"2021","journal-title":"Biomedicines."},{"key":"10.1016\/j.phymed.2026.158557_bib0015","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev-pathmechdis-051122-094016","article-title":"Acetaminophen hepatotoxicity: paradigm for understanding mechanisms of drug-induced liver injury","volume":"19","author":"Jaeschke","year":"2024","journal-title":"Annu Rev. Pathol."},{"issue":"12","key":"10.1016\/j.phymed.2026.158557_bib0016","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1007\/s00204-019-02597-1","article-title":"Emerging and established modes of cell death during acetaminophen-induced liver injury","volume":"93","author":"Jaeschke","year":"2019","journal-title":"Arch. Toxicol."},{"issue":"Pt 2","key":"10.1016\/j.phymed.2026.158557_bib0017","article-title":"Artemisia capillaris thunb. Water extract alleviates metabolic dysfunction-associated steatotic liver disease disease by inhibiting miR-34a-5p to activate Sirt1-mediated hepatic lipid metabolism","volume":"338","author":"Liang","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158557_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106563","article-title":"Nrf2 and its dependent autophagy activation cooperatively counteract ferroptosis to alleviate acute liver injury","volume":"187","author":"Liu","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2026.158557_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155573","article-title":"Optimized therapeutic potential of Yinchenhao decoction for cholestatic hepatitis by combined network meta-analysis and network pharmacology","volume":"129","author":"Luo","year":"2024","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.phymed.2026.158557_bib0020","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3390\/antiox14030307","article-title":"Formoterol, a clinically approved drug, inhibits ferroptosis by suppressing lipid peroxidation and attenuates APAP-induced acute liver injury","volume":"14","author":"Nghiem","year":"2025","journal-title":"Antioxid. (Basel)"},{"key":"10.1016\/j.phymed.2026.158557_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103117","article-title":"Inhibition of glycogen synthase kinase-3 enhances NRF2 protein stability, nuclear localisation and target gene transcription in pancreatic beta cells","volume":"71","author":"Patibandla","year":"2024","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2026.158557_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155380","article-title":"Celastrol inhibits oligodendrocyte and neuron ferroptosis to promote spinal cord injury recovery","volume":"128","author":"Shen","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158557_bib0023","doi-asserted-by":"crossref","first-page":"0167","DOI":"10.34133\/bmr.0167","article-title":"Natural polyphenol-mediated inhibition of ferroptosis alleviates oxidative damage and inflammation in acute liver injury","volume":"29","author":"Su","year":"2025","journal-title":"Biomater. Res."},{"key":"10.1016\/j.phymed.2026.158557_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2025.111724","article-title":"Formoterol, a clinically approved drug, inhibits ferroptosis by suppressing lipid peroxidation and attenuates APAP-induced acute liver injury","volume":"421","author":"Teng","year":"2025","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.phymed.2026.158557_bib0025","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: the role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.phymed.2026.158557_bib0026","article-title":"Glycogen synthase kinase 3 \u03b2 hepatocyte deletion attenuates ferroptosis and metabolic dysfunction-associated steatohepatitis in mice","volume":"20","author":"Warasnhe","year":"2026","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.phymed.2026.158557_bib0027","first-page":"1582","article-title":"Leonurine protects cardiac function following acute myocardial infarction through anti\u2011apoptosis by the PI3K\/AKT\/GSK3\u03b2 signaling pathway","volume":"18","author":"Xu","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"5","key":"10.1016\/j.phymed.2026.158557_bib0028","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1007\/s00204-020-02714-5","article-title":"Role of ferroptosis in acetaminophen-induced hepatotoxicity","volume":"94","author":"Yamada","year":"2020","journal-title":"Arch. Toxicol."},{"issue":"37","key":"10.1016\/j.phymed.2026.158557_bib0029","doi-asserted-by":"crossref","first-page":"17248","DOI":"10.1039\/D5SC04324G","article-title":"Discovery of an allosteric 14-3-3 inhibitor for suppressing NRF2-driven cancer via phenotypic screening and chemoproteomic-based target deconvolution","volume":"16","author":"Zhao","year":"2025","journal-title":"Chem. Sci."},{"issue":"1","key":"10.1016\/j.phymed.2026.158557_bib0030","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.apsb.2020.06.016","article-title":"SIRT6 as a key event linking P53 and NRF2 counteracts APAP-induced hepatotoxicity through inhibiting oxidative stress and promoting hepatocyte proliferation","volume":"11","author":"Zhou","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2026.158557_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115097","article-title":"Xanthohumol protect against acetaminophen-induced hepatotoxicity via Nrf2 activation through the AMPK\/Akt\/GSK3\u03b2 pathway","volume":"165","author":"Zhu","year":"2023","journal-title":"Biomed. PharmacOther"},{"issue":"1","key":"10.1016\/j.phymed.2026.158557_bib0032","doi-asserted-by":"crossref","DOI":"10.1080\/13510002.2025.2529695","article-title":"Sesamin protects against acetaminophen-induced nephrotoxicity by suppressing HMOX1-mediated apoptosis and ferroptosis","volume":"30","author":"Zhu","year":"2025","journal-title":"Redox. Rep."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326007889?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326007889?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T14:44:55Z","timestamp":1785509095000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326007889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":32,"alternative-id":["S0944711326007889"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158557","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Capillarisin, a coumarin from Artemisia capillaris, alleviates APAP hepatotoxicity by targeting GSK3\u03b2\/Nrf2 to suppress ferroptosis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158557","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"158557"}}