{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T07:19:20Z","timestamp":1787555960697,"version":"build-2736575974"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012175","name":"Zhejiang Administration Bureau of Traditional Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012175","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.phymed.2026.158614","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T15:04:36Z","timestamp":1784559876000},"page":"158614","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Tetrastigma hemsleyanum Diels &amp; Gilg ameliorates alcohol-associated liver disease by modulating the gut-liver axis and ferroptosis"],"prefix":"10.1016","volume":"160","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7938-8444","authenticated-orcid":false,"given":"Lianghui","family":"Zhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1611-2958","authenticated-orcid":false,"given":"Qian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuechun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqing","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinbao","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.phymed.2026.158614_bib45","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jhep.2019.10.003","article-title":"The gut-liver axis in liver disease: Pathophysiological basis for therapy","volume":"72","author":"Albillos","year":"2020","journal-title":"J. Hepatol."},{"issue":"5","key":"10.1016\/j.phymed.2026.158614_bib0001","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.jceh.2022.02.001","article-title":"Current medical treatment for alcohol-associated liver disease","volume":"12","author":"Ayares","year":"2022","journal-title":"J. Clin. Exp. Hepatol."},{"issue":"1547555","key":"10.1016\/j.phymed.2026.158614_bib0002","article-title":"Differential effects of high-fat diet on salivary and gut microbiota","volume":"15","author":"Bai","year":"2025","journal-title":"Front. Cell Infect. Microbiol."},{"issue":"0","key":"10.1016\/j.phymed.2026.158614_bib0003","first-page":"1","article-title":"Chronic alcohol consumption compromises gut barrier integrity and promotes endotoxemia: implications for sepsis susceptibility in immunocompromised hosts","volume":"2026","author":"Bhunyakarnjanarat","year":"2026","journal-title":"Animal. Model. Exp. Med."},{"issue":"110436","key":"10.1016\/j.phymed.2026.158614_bib0004","article-title":"HAO1 negatively regulates liver macrophage activation via the NF-kappaB pathway in alcohol-associated liver disease","volume":"99","author":"Chen","year":"2022","journal-title":"Cell Signal."},{"issue":"10","key":"10.1016\/j.phymed.2026.158614_bib0005","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1038\/s41401-020-00597-x","article-title":"Deletion of TLR4 attenuates lipopolysaccharide-induced acute liver injury by inhibiting inflammation and apoptosis","volume":"42","author":"Chen","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"issue":"11","key":"10.1016\/j.phymed.2026.158614_bib0006","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70458","article-title":"The gut\u2012liver axis in liver disease: molecular mechanisms and therapeutic targets","volume":"6","author":"Chen","year":"2025","journal-title":"MedComm"},{"issue":"12","key":"10.1016\/j.phymed.2026.158614_bib0007","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26125442","article-title":"Prolonged intestinal ethanol absorption and oxidative stress: revisiting the gut-liver axis in alcohol-associated disease","volume":"26","author":"Chung","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.phymed.2026.158614_bib0008","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1186\/s12967-025-06573-5","article-title":"Fecal microbiota transplantation from Helicobacter pylori carriers following bismuth quadruple therapy exacerbates alcohol-related liver disease in mice via LPS-induced activation of hepatic TLR4\/NF-kappaB\/NLRP3 signaling","volume":"23","author":"Gao","year":"2025","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.phymed.2026.158614_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e23336","article-title":"Kaempferol and nicotiflorin ameliorated alcohol-induced liver injury in mice by miR-138-5p\/SIRT1\/FXR and gut microbiota","volume":"10","author":"Ge","year":"2024","journal-title":"Heliyon"},{"issue":"3","key":"10.1016\/j.phymed.2026.158614_bib0010","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1093\/ibd\/izx029","article-title":"A cross-talk between microbiota-derived short-chain fatty acids and the host mucosal immune system regulates intestinal homeostasis and inflammatory bowel disease","volume":"24","author":"Goncalves","year":"2018","journal-title":"Inflamm. Bowel. Dis."},{"issue":"2","key":"10.1016\/j.phymed.2026.158614_bib0011","doi-asserted-by":"crossref","DOI":"10.1210\/jendso\/bvz039","article-title":"Intestinal barrier dysfunction, LPS translocation, and disease development","volume":"4","author":"Ghosh","year":"2020","journal-title":"J. Endocr. Soc."},{"issue":"6","key":"10.1016\/j.phymed.2026.158614_bib0012","doi-asserted-by":"crossref","first-page":"G1159","DOI":"10.1152\/ajpgi.00407.2004","article-title":"Polyamines are necessary for synthesis and stability of occludin protein in intestinal epithelial cells","volume":"288","author":"Guo","year":"2005","journal-title":"Am. J. Physiol. Gastrointest. Liver. Physiol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158614_bib0013","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/hep.26321","article-title":"Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice","volume":"58","author":"Hartmann","year":"2013","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.phymed.2026.158614_bib0014","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s11894-999-0023-5","article-title":"Intestinal permeability, leaky gut, and intestinal disorders","volume":"1","author":"Hollander","year":"1999","journal-title":"Curr. Gastroenterol. Rep."},{"issue":"11","key":"10.1016\/j.phymed.2026.158614_bib0015","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41579-023-00904-3","article-title":"The gut-liver axis and gut microbiota in health and liver disease","volume":"21","author":"Hsu","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"issue":"114314","key":"10.1016\/j.phymed.2026.158614_bib0016","article-title":"HPLC fingerprinting-based multivariate analysis of chemical components in Tetrastigma Hemsleyanum Diels et Gilg: correlation to their antioxidant and neuraminidase inhibition activities","volume":"205","author":"Jiang","year":"2021","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"9","key":"10.1016\/j.phymed.2026.158614_bib0017","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1111\/jgh.17038","article-title":"Compositional and metabolomic shifts of the gut microbiome in alcohol-related liver disease","volume":"40","author":"Kuo","year":"2025","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"910292","key":"10.1016\/j.phymed.2026.158614_bib0018","article-title":"System X(c) (-)\/GSH\/GPX4 axis: an important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy","volume":"13","author":"Li","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"4302130","key":"10.1016\/j.phymed.2026.158614_bib0019","article-title":"Flavonoids of Tetrastigma hemsleyanum Diels et Gilg against acute hepatic injury by blocking PI3K\/AKT signaling pathway","volume":"2025","author":"Li","year":"2025","journal-title":"Mediators. Inflamm."},{"issue":"115465","key":"10.1016\/j.phymed.2026.158614_bib0020","article-title":"Naotaifang formula attenuates OGD\/R-induced inflammation and ferroptosis by regulating microglial M1\/M2 polarization through BMP6\/SMADs signaling pathway","volume":"167","author":"Liao","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.phymed.2026.158614_bib0021","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1042\/CS20210778","article-title":"Gut microbiota-derived butyrate regulates gut mucus barrier repair by activating the macrophage\/WNT\/ERK signaling pathway","volume":"136","author":"Liang","year":"2022","journal-title":"Clin. Sci."},{"issue":"21","key":"10.1016\/j.phymed.2026.158614_bib0022","doi-asserted-by":"crossref","first-page":"8564","DOI":"10.1039\/D5FO02499D","article-title":"Mung bean (Vigna radiata L.) ethanol extract alleviates alcoholic liver injury with modulation of the gut microbiota and spermidine elevation","volume":"16","author":"Liu","year":"2025","journal-title":"Food Funct."},{"issue":"3","key":"10.1016\/j.phymed.2026.158614_bib0023","doi-asserted-by":"crossref","DOI":"10.1172\/JCI176345","article-title":"Alcohol-associated liver disease","volume":"134","author":"Mackowiak","year":"2024","journal-title":"J. Clin. Invest."},{"issue":"10190","key":"10.1016\/j.phymed.2026.158614_bib0024","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1016\/S0140-6736(18)32744-2","article-title":"Global alcohol exposure between 1990 and 2017 and forecasts until 2030: a modelling study","volume":"393","author":"Manthey","year":"2019","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.phymed.2026.158614_bib0026","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1093\/jn\/nxac167","article-title":"Mild to moderate food deprivation increases hepcidin and results in hypoferremia and tissue iron sequestration in mice","volume":"152","author":"Murphy","year":"2022","journal-title":"J. Nutr."},{"issue":"1","key":"10.1016\/j.phymed.2026.158614_bib0027","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00281-024-01035-4","article-title":"Role of polyamines in intestinal mucosal barrier function","volume":"47","author":"Nakamura","year":"2025","journal-title":"Semin. Immunopathol."},{"issue":"6","key":"10.1016\/j.phymed.2026.158614_bib0028","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1097\/HEP.0000000000000924","article-title":"Gut-liver axis: recent concepts in pathophysiology in alcohol-associated liver disease","volume":"80","author":"Raya Tonetti","year":"2024","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.phymed.2026.158614_bib0029","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24010449","article-title":"Lipid peroxidation and iron metabolism: two corner stones in the homeostasis control of ferroptosis","volume":"24","author":"Rochette","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.phymed.2026.158614_bib0030","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/S1470-2045(21)00279-5","article-title":"Global burden of cancer in 2020 attributable to alcohol consumption: a population-based study","volume":"22","author":"Rumgay","year":"2021","journal-title":"Lancet Oncol."},{"issue":"102577","key":"10.1016\/j.phymed.2026.158614_bib0031","article-title":"ALDH2 deficiency increases susceptibility to binge alcohol-induced gut leakiness, endotoxemia, and acute liver injury in mice through the gut-liver axis","volume":"59","author":"Rungratanawanich","year":"2023","journal-title":"Redox. Biol."},{"issue":"2","key":"10.1016\/j.phymed.2026.158614_bib0032","doi-asserted-by":"crossref","first-page":"C341","DOI":"10.1152\/ajpcell.00074.2024","article-title":"The role of polyamine metabolism in cellular function and physiology","volume":"327","author":"Schibalski","year":"2024","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"119579","key":"10.1016\/j.phymed.2026.158614_bib0033","article-title":"Tangshenning formula alleviates tubular injury in diabetic kidney disease via the Sestrin2\/AMPK\/PGC-1alpha axis: restoration of mitochondrial function and inhibition of ferroptosis","volume":"345","author":"Shan","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"14","key":"10.1016\/j.phymed.2026.158614_bib0034","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.phymed.2026.158614_bib0035","article-title":"Hyperbaric oxygen therapy in alleviating cerebral ischemia-reperfusion injury via the BMP6\/Smad-hepcidin pathway","volume":"21","author":"Wang","year":"2026","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.phymed.2026.158614_bib0036","doi-asserted-by":"crossref","first-page":"5491","DOI":"10.1038\/s41467-025-61067-8","article-title":"ACSS2 protects against alcohol-induced hepatocyte ferroptosis through regulation of hepcidin expression","volume":"16","author":"Wang","year":"2025","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.phymed.2026.158614_bib0037","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1111\/jgh.15512","article-title":"Gut-liver-axis: barrier function of liver sinusoidal endothelial cell","volume":"36","author":"Wang","year":"2021","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"Pt B","key":"10.1016\/j.phymed.2026.158614_bib0038","article-title":"Alcoholic liver disease: mechanistic insights and therapeutic potential of traditional Chinese medicine through preclinical and clinical evidence","volume":"353","author":"Wu","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158614_bib0039","series-title":"Research on the Extraction of Tripterygium Glycosides, Their Vitro Antioxidant Activity, and Their Effects on Human Ovarian Adenocarcinoma Cell Line SKOV3","author":"Yin","year":"2021"},{"issue":"120743","key":"10.1016\/j.phymed.2026.158614_bib0040","article-title":"An integrated approach of experiment validation and single-cell RNA sequencing reveal dual-pathway inhibition of NLRP3\/ferroptosis by flavonoids of Sanyeqing fibrous root in acute lung injury","volume":"356","author":"Zhan","year":"2026","journal-title":"J. Ethnopharmacol."},{"issue":"18","key":"10.1016\/j.phymed.2026.158614_bib0041","doi-asserted-by":"crossref","DOI":"10.3390\/nu15184025","article-title":"Lonicera Caerulea Juice alleviates alcoholic liver disease by regulating intestinal flora and the FXR-FGF15 signaling pathway","volume":"15","author":"Zhang","year":"2023","journal-title":"Nutrients"},{"issue":"157853","key":"10.1016\/j.phymed.2026.158614_bib0042","article-title":"Spermidine alleviates ethanol-induced hepatocyte ferroptosis by restoring hepatic iron homeostasis via the gut-liver axis","volume":"152","author":"Zhang","year":"2026","journal-title":"Phytomedicine"},{"issue":"38","key":"10.1016\/j.phymed.2026.158614_bib0043","doi-asserted-by":"crossref","first-page":"21181","DOI":"10.1021\/acs.jafc.4c04762","article-title":"Ursolic acid ameliorates alcoholic liver injury through attenuating oxidative stress-mediated ferroptosis and modulating gut microbiota","volume":"72","author":"Zhou","year":"2024","journal-title":"J. Agric. Food Chem."},{"issue":"9","key":"10.1016\/j.phymed.2026.158614_bib0044","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.jpha.2023.05.005","article-title":"Ginsenoside Rk2, a dehydroprotopanaxadiol saponin, alleviates alcoholic liver disease via regulating NLRP3 and NLRP6 inflammasome signaling pathways in mice","volume":"13","author":"Zou","year":"2023","journal-title":"J. Pharm. Anal."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326008457?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326008457?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T06:21:20Z","timestamp":1787552480000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326008457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":44,"alternative-id":["S0944711326008457"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158614","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tetrastigma hemsleyanum Diels & Gilg ameliorates alcohol-associated liver disease by modulating the gut-liver axis and ferroptosis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158614","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158614"}}