{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T07:19:22Z","timestamp":1787555962968,"version":"build-2736575974"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.phymed.2026.158622","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T14:58:33Z","timestamp":1784645913000},"page":"158622","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Anemoside B4 targets GSK-3\u03b2 to restrain neutrophil activation and ameliorates psoriasis via PKM2\/STAT3 pathway inactivation"],"prefix":"10.1016","volume":"160","author":[{"given":"Shuying","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruinan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianle","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6145-5509","authenticated-orcid":false,"given":"Qiongming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158622_bib0001","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.00772-26","article-title":"Myeloid-derived suppressor cell (MDSC)-like neutrophils induced by pulmonary infection with Coccidioides posadasii exacerbate disease by suppressing CD4(+) T cell immunity","volume":"17","author":"Abdul-Baki","year":"2026","journal-title":"mBio"},{"issue":"12","key":"10.1016\/j.phymed.2026.158622_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2019.165542","article-title":"Glycolysis dependent lactate formation in neutrophils: a metabolic link between NOX-dependent and independent NETosis","volume":"1865","author":"Awasthi","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"issue":"1","key":"10.1016\/j.phymed.2026.158622_bib0003","first-page":"215","article-title":"GSK-3beta reactivation with LY294002 sensitizes hepatoma cells to chemotherapy-induced apoptosis","volume":"27","author":"Beurel","year":"2005","journal-title":"Int. J. Oncol."},{"issue":"Pt 3","key":"10.1016\/j.phymed.2026.158622_bib0004","article-title":"Valine promotes milk synthesis by regulating PKM2 nuclear accumulation and histone H3 acetylation through the TAS1R1-mTOR-DDX39B signaling pathway","volume":"254","author":"Cao","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158622_bib0005","article-title":"CREB1-driven CXCR4(hi) neutrophils promote skin inflammation in mouse models and human patients","volume":"14","author":"Chen","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.phymed.2026.158622_bib0006","article-title":"MYG1 drives glycolysis and colorectal cancer development through nuclear-mitochondrial collaboration","volume":"15","author":"Chen","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.phymed.2026.158622_bib0007","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41392-024-01881-6","article-title":"DNA of neutrophil extracellular traps promote NF-\u03baB-dependent autoimmunity via cGAS\/TLR9 in chronic obstructive pulmonary disease","volume":"9","author":"Chen","year":"2024","journal-title":"Signal Transduct. Target Ther."},{"issue":"1","key":"10.1016\/j.phymed.2026.158622_bib0008","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s10020-024-00907-7","article-title":"SYK promotes the formation of neutrophil extracellular traps by inducing PKM2 nuclear translocation and promoting STAT3 phosphorylation to exacerbate hepatic ischemia-reperfusion injury and tumor recurrence","volume":"30","author":"Chen","year":"2024","journal-title":"Mol. Med."},{"issue":"23","key":"10.1016\/j.phymed.2026.158622_bib0009","doi-asserted-by":"crossref","first-page":"10466","DOI":"10.7150\/thno.45211","article-title":"Dihydroartemisinin ameliorates psoriatic skin inflammation and its relapse by diminishing CD8(+) T-cell memory in wild-type and humanized mice","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics."},{"issue":"1","key":"10.1016\/j.phymed.2026.158622_bib0010","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jaci.2019.09.025","article-title":"Targeting L-type amino acid transporter 1 in innate and adaptive T cells efficiently controls skin inflammation","volume":"145","author":"Cibrian","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"issue":"11","key":"10.1016\/j.phymed.2026.158622_bib0011","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1111\/febs.14075","article-title":"Neutrophil extracellular traps can serve as platforms for processing and activation of IL-1 family cytokines","volume":"284","author":"Clancy","year":"2017","journal-title":"FEBS J."},{"key":"10.1016\/j.phymed.2026.158622_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2026.157784","article-title":"Qishen Yiqi Dropping Pills ameliorate acute myocardial infarction by modulating PKM2\/STAT3 pathway-mediated metabolic reprogramming in macrophages","volume":"151","author":"Fan","year":"2026","journal-title":"Phytomedicine."},{"key":"10.1016\/j.phymed.2026.158622_bib0013","doi-asserted-by":"crossref","DOI":"10.1093\/femsml\/uqaf040","article-title":"Glucose metabolism controls oxidative burst and lipid mediator production in neutrophils upon microbial challenge","volume":"6","author":"Freitag","year":"2025","journal-title":"MicroLife."},{"issue":"1","key":"10.1016\/j.phymed.2026.158622_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2019.115174","article-title":"Mass spectrometry-based cellular thermal shift assay (CETSA\u00ae) for target deconvolution in phenotypic drug discovery","volume":"28","author":"Friman","year":"2020","journal-title":"Bioorg. Med. Chem."},{"issue":"1","key":"10.1016\/j.phymed.2026.158622_bib0015","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12951-021-00842-3","article-title":"Selenium nanoparticles produce a beneficial effect in psoriasis by reducing epidermal hyperproliferation and inflammation","volume":"19","author":"Gangadevi","year":"2021","journal-title":"J. Nanobiotechnol."},{"issue":"3","key":"10.1016\/j.phymed.2026.158622_bib0016","doi-asserted-by":"crossref","first-page":"968","DOI":"10.3390\/molecules28030968","article-title":"Anemoside B4 exerts hypoglycemic effect by regulating the expression of GLUT4 in HFD\/STZ rats","volume":"28","author":"Gong","year":"2023","journal-title":"Molecules."},{"issue":"4","key":"10.1016\/j.phymed.2026.158622_bib0017","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.18136","article-title":"Anemoside B4 alleviates arthritis pain via suppressing ferroptosis-mediated inflammation","volume":"28","author":"Guo","year":"2024","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.phymed.2026.158622_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154416","article-title":"Anemoside B4 protects against chronic relapsing colitis in mice by modulating inflammatory response, colonic transcriptome and the gut microbiota","volume":"106","author":"Han","year":"2022","journal-title":"Phytomedicine."},{"issue":"1","key":"10.1016\/j.phymed.2026.158622_bib0019","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41420-023-01566-z","article-title":"Depletion of peroxiredoxin II promotes keratinocyte apoptosis and alleviates psoriatic skin lesions via the PI3K\/AKT\/GSK3\u03b2 signaling axis","volume":"9","author":"Han","year":"2023","journal-title":"Cell Death Discov."},{"issue":"8","key":"10.1016\/j.phymed.2026.158622_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.jid.2021.12.021","article-title":"Transcriptomes of MPO-deficient patients with generalized pustular psoriasis reveals expansion of CD4(+) cytotoxic T cells and an involvement of the complement system","volume":"142","author":"Haskamp","year":"2022","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.phymed.2026.158622_bib0021","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.phymed.2018.10.035","article-title":"Anemoside B4 attenuates nephrotoxicity of cisplatin without reducing anti-tumor activity of cisplatin","volume":"56","author":"He","year":"2019","journal-title":"Phytomedicine."},{"key":"10.1016\/j.phymed.2026.158622_bib0022","article-title":"Neutrophil extracellular trap formation is increased in psoriasis and induces human \u03b2-defensin-2 production in epidermal keratinocytes","volume":"6","author":"Hu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2026.158622_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2025.111673","article-title":"Imidazopyrimidine-based pyruvate kinase M2 activator halts diabetic nephropathy progression via modulating epithelial-to-mesenchymal transition and fibrosis","volume":"420","author":"Jain","year":"2025","journal-title":"Chem. Biol. Interact."},{"issue":"1","key":"10.1016\/j.phymed.2026.158622_bib0024","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1038\/s41467-025-67917-9","article-title":"Dynamic neutrophil-keratinocyte communication network centered on IL-36\/TNFSF15 responses characterizes inflammatory responses in generalized pustular psoriasis","volume":"17","author":"Jiang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.158622_bib0025","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fnmol.2011.00040","article-title":"GSK-3: functional insights from cell biology and animal models","volume":"4","author":"Kaidanovich-Beilin","year":"2011","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.phymed.2026.158622_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.117020","article-title":"Enhancement of MAVS UFMylation and inhibition of lysosomal degradation of MAVS aggregates: new findings on broad-spectrum antiviral mechanism of Anemoside B4","volume":"239","author":"Kang","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158622_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.152934","article-title":"Anti-inflammatory and immune-modulatory properties of anemoside B4 isolated from Pulsatilla chinensis in vivo","volume":"64","author":"Kang","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158622_bib0028","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.eng.2025.06.036","article-title":"Innovative strategies in natural product drug discovery: the case of anemoside B4","volume":"54","author":"Kang","year":"2025","journal-title":"Engineering"},{"issue":"2","key":"10.1016\/j.phymed.2026.158622_bib0029","doi-asserted-by":"crossref","DOI":"10.1111\/exd.15026","article-title":"Increased neutrophil-derived IL-17A identified in generalized pustular psoriasis","volume":"33","author":"Lan","year":"2024","journal-title":"Exp. Dermatol."},{"issue":"7","key":"10.1016\/j.phymed.2026.158622_bib0030","doi-asserted-by":"crossref","first-page":"ITC49","DOI":"10.7326\/AITC201804030","article-title":"Psoriasis","volume":"168","author":"Lebwohl","year":"2018","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.phymed.2026.158622_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.118448","article-title":"Reprogramming macrophage polarization with a small molecule G3I: enhancing tumor suppression and inflammation control","volume":"191","author":"Lee","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2026.158622_bib0032","article-title":"STAT3 suppresses palmitic acid-induced apoptosis and fatty acid oxidation dysfunction in bovine mammary epithelial cells by transcriptionally activating CPT1A","author":"Li","year":"2026","journal-title":"Sci. China Life Sci"},{"issue":"1","key":"10.1016\/j.phymed.2026.158622_bib0033","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41420-023-01787-2","article-title":"Neutrophil extracellular traps and neutrophilic dermatosis: an update review","volume":"10","author":"Li","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.phymed.2026.158622_bib0034","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1016\/j.biopha.2018.10.062","article-title":"Rutaecarpine inhibited imiquimod-induced psoriasis-like dermatitis via inhibiting the NF-\u03baB and TLR7 pathways in mice","volume":"109","author":"Li","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2026.158622_bib0035","series-title":"Anemoside B4 alleviates colitis by targeting pyruvate carboxylase","author":"Liang","year":"2022"},{"issue":"3","key":"10.1016\/j.phymed.2026.158622_bib0036","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00011-023-01840-x","article-title":"Anemoside B4, a new pyruvate carboxylase inhibitor, alleviates colitis by reprogramming macrophage function","volume":"73","author":"Liang","year":"2024","journal-title":"Inflamm. Res."},{"issue":"8","key":"10.1016\/j.phymed.2026.158622_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2025.167998","article-title":"Dimeric PKM2 induces ferroptosis from intestinal ischemia\/reperfusion in mice by histone H4 lysine 12 lactylation-mediated HMGB1 transcription activation through the lactic acid\/p300 axis","volume":"1871","author":"Liu","year":"2025","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"issue":"9","key":"10.1016\/j.phymed.2026.158622_bib0038","doi-asserted-by":"crossref","first-page":"3916","DOI":"10.1016\/j.apsb.2024.06.029","article-title":"Icaritin inhibits the progression of urothelial cancer by suppressing PADI2-mediated neutrophil infiltration and neutrophil extracellular trap formation","volume":"14","author":"Mou","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2026.158622_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156407","article-title":"Anemoside B4 targets NEK7 to inhibit NLRP3 inflammasome activation and alleviate MSU-induced acute gouty arthritis by modulating the NF-\u03baB signaling pathway","volume":"138","author":"Ni","year":"2025","journal-title":"Phytomedicine."},{"issue":"1","key":"10.1016\/j.phymed.2026.158622_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.xjidi.2021.100066","article-title":"Identification of keratinocyte mitogens: implications for hyperproliferation in psoriasis and atopic dermatitis","volume":"2","author":"Niehues","year":"2022","journal-title":"JID Innov."},{"issue":"1","key":"10.1016\/j.phymed.2026.158622_bib0041","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/bjd.19380","article-title":"Role of regulatory T cells in psoriasis pathogenesis and treatment","volume":"184","author":"Nussbaum","year":"2021","journal-title":"Br. J. Dermatol."},{"issue":"4","key":"10.1016\/j.phymed.2026.158622_bib0042","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/s41423-019-0261-x","article-title":"Keratinocytes costimulate naive human T cells via CD2: a potential target to prevent the development of proinflammatory Th1 cells in the skin","volume":"17","author":"Orlik","year":"2020","journal-title":"Cell. Mol. Immunol."},{"issue":"24","key":"10.1016\/j.phymed.2026.158622_bib0043","doi-asserted-by":"crossref","first-page":"4907","DOI":"10.1111\/bph.15673","article-title":"The STING antagonist H-151 ameliorates psoriasis via suppression of STING\/NF-\u03baB-mediated inflammation","volume":"178","author":"Pan","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158622_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.116004","article-title":"Ephrin B3 exacerbates colitis and colitis-associated colorectal cancer","volume":"220","author":"Qiao","year":"2024","journal-title":"Biochem. Pharmacol."},{"issue":"9","key":"10.1016\/j.phymed.2026.158622_bib0045","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1016\/j.jaip.2025.07.025","article-title":"Pathogenesis of chronic spontaneous urticaria with or without angioedema","volume":"13","author":"Saini","year":"2025","journal-title":"J. Allergy Clin. Immunol. Pract."},{"issue":"1","key":"10.1016\/j.phymed.2026.158622_bib0046","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1080\/13880209.2023.2173248","article-title":"Panax notoginseng saponins (PNS) attenuate Th17 cell differentiation in CIA mice via inhibition of nuclear PKM2-mediated STAT3 phosphorylation","volume":"61","author":"Shen","year":"2023","journal-title":"Pharm Biol."},{"key":"10.1016\/j.phymed.2026.158622_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109243","article-title":"miR-181-5p attenuates neutrophilic inflammation in asthma by targeting DEK","volume":"112","author":"Song","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.phymed.2026.158622_bib0048","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.jaci.2016.07.025","article-title":"MicroRNA-146a suppresses IL-17-mediated skin inflammation and is genetically associated with psoriasis","volume":"139","author":"Srivastava","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"issue":"7","key":"10.1016\/j.phymed.2026.158622_bib0049","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2024.04.022","article-title":"Metabolic coordination between skin epithelium and type 17 immunity sustains chronic skin inflammation","volume":"57","author":"Subudhi","year":"2024","journal-title":"Immunity"},{"issue":"8","key":"10.1016\/j.phymed.2026.158622_bib0050","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1038\/s41423-021-00718-4","article-title":"PKM2 controls the degranulation of secondary and tertiary granules in neutrophils by phosphorylating SNAP-23","volume":"18","author":"Sun","year":"2021","journal-title":"Cell. Mol. Immunol."},{"issue":"11","key":"10.1016\/j.phymed.2026.158622_bib0051","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.71243","article-title":"Hierarchical disruption of the tryptophan-melatonin axis contributes to glioma progression Through AKT\/ERK\/STAT3 Signalling","volume":"30","author":"Tan","year":"2026","journal-title":"J. Cell. Mol. Med."},{"issue":"4","key":"10.1016\/j.phymed.2026.158622_bib0052","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1159\/000346243","article-title":"Rapid downregulation of innate immune cells, interleukin-12 and interleukin-23 in generalized pustular psoriasis with infliximab in combination with acitretin","volume":"225","author":"Tang","year":"2012","journal-title":"Dermatology."},{"key":"10.1016\/j.phymed.2026.158622_bib0053","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112733","article-title":"Artemisia monosperma essential oil nanoformulations alleviate imiquimod-induced psoriasis-like dermatitis in mice","volume":"139","author":"Tawfik","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158622_bib0054","doi-asserted-by":"crossref","DOI":"10.1002\/clt2.70145","article-title":"T cell\/mast cell crosstalk in the skin of patients suffering from immune-mediated diseases, focusing on chronic spontaneous urticaria","volume":"16","author":"Toubi","year":"2026","journal-title":"Clin Transl Allergy."},{"key":"10.1016\/j.phymed.2026.158622_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154862","article-title":"CETSA and thermal proteome profiling strategies for target identification and drug discovery of natural products","volume":"116","author":"Tu","year":"2023","journal-title":"Phytomedicine."},{"issue":"9","key":"10.1016\/j.phymed.2026.158622_bib0056","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.4049\/jimmunol.0802999","article-title":"Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23\/IL-17 axis","volume":"182","author":"Van der Fits","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.phymed.2026.158622_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2026.116640","article-title":"Ailanthone ameliorates CCl(4)-induced liver fibrosis by targeting PKM2-mediated macrophage M1 polarization and glycolytic reprogramming","volume":"179","author":"Wan","year":"2026","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2026.158622_bib0058","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.freeradbiomed.2025.10.006","article-title":"Acrolein-induced PKM2 modification drives NETosis and glioma progression","volume":"241","author":"Wang","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2026.158622_bib0059","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2026.116962","article-title":"Brain-derived HMGB1 mediates periodontal inflammation after ischemic stroke through the STAT3\/NLRP3 inflammasome pathway","volume":"184","author":"Wang","year":"2026","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2026.158622_bib0060","doi-asserted-by":"crossref","DOI":"10.1155\/mi\/8822728","article-title":"Baicalin Modulates glycolysis via the PKC\/Raf\/MEK\/ERK and PI3K\/AKT signaling pathways to attenuate IFN-I-induced neutrophil NETosis","author":"Wei","year":"2025","journal-title":"Mediators Inflamm."},{"issue":"2","key":"10.1016\/j.phymed.2026.158622_bib0061","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41418-025-01547-y","article-title":"Targeting KAT8 alleviates self-RNA-driven skin inflammation by modulating histone H4 lysine 16 acetylation in psoriasis","volume":"33","author":"Xiang","year":"2026","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.phymed.2026.158622_bib0062","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s12943-017-0748-y","article-title":"HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma","volume":"16","author":"Xu","year":"2017","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.phymed.2026.158622_bib0063","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118595","article-title":"Exposure to BDE-209 triggers necroptosis by activating the JAK2\/STAT3 signaling pathway, thereby exacerbating neuroinflammation","volume":"302","author":"Yang","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.phymed.2026.158622_bib0064","article-title":"Da-Yuan-Yin decoction suppresses NETs formation, inhibits the IL-23\/JAK2\/STAT3 signalling pathway, and modulates metabolic profiles and gut microbiota composition in damp-heat syndrome","volume":"57","author":"Yang","year":"2025","journal-title":"Ann. Med."},{"key":"10.1016\/j.phymed.2026.158622_bib0065","article-title":"Activator-mediated Pyruvate Kinase M2 Activation Contributes to Endotoxin Tolerance by Promoting mitochondrial biogenesis","volume":"11","author":"Yi","year":"2020","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.phymed.2026.158622_bib0066","doi-asserted-by":"crossref","first-page":"3757","DOI":"10.1016\/j.ymthe.2025.05.013","article-title":"Renal tubular epithelial IGFBP7 interacts with PKM2 to drive renal lipid accumulation and fibrosis","volume":"33","author":"Yu","year":"2025","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.phymed.2026.158622_bib0067","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1038\/s42003-024-07227-w","article-title":"PKM2-mediated STAT3 phosphorylation promotes acute liver failure via regulating NLRP3-dependent pyroptosis","volume":"7","author":"Yu","year":"2024","journal-title":"Commun. Biol."},{"issue":"8","key":"10.1016\/j.phymed.2026.158622_bib0068","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1111\/1440-1681.13103","article-title":"FGF19 sustains the high proliferative ability of keratinocytes in psoriasis through the regulation of Wnt\/GSK-3\u03b2\/\u03b2-catenin signalling via FGFR4","volume":"46","author":"Yu","year":"2019","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.phymed.2026.158622_bib0069","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1038\/s44321-026-00453-1","article-title":"Mitochondrial activity promotes neutrophil degranulation and endothelial dysfunction in systemic infections","volume":"18","author":"Zakrzewski","year":"2026","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.phymed.2026.158622_bib0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123626","article-title":"A metallic metabolic nano-regulator reprograms the PKM2\/HIF-1\u03b1\/DLAT axis to amplify tumor-specific cuproptosis","volume":"325","author":"Zhan","year":"2026","journal-title":"Biomaterials"},{"key":"10.1016\/j.phymed.2026.158622_bib0071","article-title":"A machine learning integrated multi-omics framework for risk prediction and target discovery in insomnia aggravated sepsis induced acute lung injury","volume":"17","author":"Zhang","year":"2026","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.phymed.2026.158622_bib0072","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/bph.15983","article-title":"Allicin ameliorates imiquimod-induced psoriasis-like skin inflammation via disturbing the interaction of keratinocytes with IL-17A","volume":"180","author":"Zhang","year":"2023","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158622_bib0073","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12964-022-00824-4","article-title":"Neutrophil degranulation and myocardial infarction","volume":"20","author":"Zhang","year":"2022","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.phymed.2026.158622_bib0074","doi-asserted-by":"crossref","first-page":"13535","DOI":"10.2147\/JIR.S544019","article-title":"Mechanistic insights into Qin Bi Yin for psoriasis treatment using network pharmacology, experimental validation, and molecular docking","volume":"Volume 18","author":"Zhang","year":"2025","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.phymed.2026.158622_bib0075","article-title":"Hyperforin ameliorates imiquimod-induced psoriasis-like murine skin inflammation by modulating IL-17A-producing \u03b3\u03b4 T cells","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158622_bib0076","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13020-020-00410-1","article-title":"Anemoside B4 ameliorates TNBS-induced colitis through S100A9\/MAPK\/NF-\u03baB signaling pathway","volume":"16","author":"Zhang","year":"2021","journal-title":"Chin. Med."},{"issue":"1","key":"10.1016\/j.phymed.2026.158622_bib0077","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1080\/13510002.2022.2123841","article-title":"The protective effect of proanthocyanidins on the psoriasis-like cell models via PI3K\/AKT and HO-1","volume":"27","author":"Zhao","year":"2022","journal-title":"Redox Rep."},{"issue":"1","key":"10.1016\/j.phymed.2026.158622_bib0078","article-title":"PKM2 modulates chemotherapy sensitivity by regulating autophagy and predicts the prognosis and immunity in pancancer","volume":"15","author":"Zheng","year":"2025","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.phymed.2026.158622_bib0079","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202503580R","article-title":"Simvastatin targets PKM2 to alter metabolic reprogramming in hepatic stellate cells and mitigate liver fibrosis","volume":"40","author":"Zhou","year":"2026","journal-title":"FASEB J."},{"issue":"Pt 2","key":"10.1016\/j.phymed.2026.158622_bib0080","article-title":"A review on the role of pyruvate kinase M2 in cancer: from metabolic switch to transcriptional regulation","volume":"330","author":"Zulfareen","year":"2025","journal-title":"Int. J. Biol. Macromol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326008536?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326008536?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T06:21:39Z","timestamp":1787552499000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326008536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":80,"alternative-id":["S0944711326008536"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158622","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anemoside B4 targets GSK-3\u03b2 to restrain neutrophil activation and ameliorates psoriasis via PKM2\/STAT3 pathway inactivation","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158622","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158622"}}