{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:13:05Z","timestamp":1785510785359,"version":"3.56.0"},"reference-count":130,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.phymed.2026.158624","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T06:24:38Z","timestamp":1784615078000},"page":"158624","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Polysaccharides-mediated mitochondrial remodeling: role in chemotherapy resistance of gastrointestinal tumors"],"prefix":"10.1016","volume":"159","author":[{"given":"Su","family":"Bu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinrui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxing","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5119-7319","authenticated-orcid":false,"given":"Chao","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chijing","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158624_bib0001","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1124\/jpet.107.133124","article-title":"Differential high-affinity interaction of dectin-1 with natural or synthetic glucans is dependent upon primary structure and is influenced by polymer chain length and side-chain branching","volume":"325","author":"Adams","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.phymed.2026.158624_bib0002","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ijpharm.2011.02.067","article-title":"Spermine grafted galactosylated chitosan for improved nanoparticle mediated gene delivery","volume":"410","author":"Alex","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.phymed.2026.158624_bib0003","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.ijbiomac.2020.06.190","article-title":"Exopolysaccharides from probiotic bacteria and their health potential","volume":"162","author":"Angelin","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2026.158624_bib0004","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1042\/bj3450271","article-title":"Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria","volume":"345","author":"Antonsson","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.phymed.2026.158624_bib0005","first-page":"516","article-title":"The prognostic and predictive value of ERCC-1, p53, bcl-2 and bax in epithelial ovarian cancer","volume":"32","author":"Avraam","year":"2011","journal-title":"Eur. J. Gynaecol. Oncol."},{"key":"10.1016\/j.phymed.2026.158624_bib0006","doi-asserted-by":"crossref","first-page":"510","DOI":"10.3390\/antiox10040510","article-title":"Control of oxidative stress in cancer chemoresistance: spotlight on Nrf2 role","volume":"10","author":"Barrera","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2026.158624_bib0007","doi-asserted-by":"crossref","first-page":"S639","DOI":"10.1016\/S0302-2838(22)00508-5","article-title":"Targeting mitochondria: a link between prostate cancer metabolism and novel therapeutic approaches","volume":"81","author":"Baumgartner","year":"2022","journal-title":"Eur. Urol."},{"key":"10.1016\/j.phymed.2026.158624_bib0008","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.bcp.2009.12.002","article-title":"Increased levels and defective glycosylation of MRPs in ovarian carcinoma cells resistant to oxaliplatin","volume":"79","author":"Beretta","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158624_bib0009","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41698-025-01034-0","article-title":"The role of the gut microbiota in chemotherapy response, efficacy and toxicity: a systematic review","volume":"9","author":"B\u00f6hm","year":"2025","journal-title":"NPJ. Precis. Oncol."},{"key":"10.1016\/j.phymed.2026.158624_bib0010","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ccr.2006.10.020","article-title":"A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth","volume":"11","author":"Bonnet","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.phymed.2026.158624_bib0011","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1021\/bc1000609","article-title":"Efficient gene transfection by histidine-modified chitosan through enhancement of endosomal escape","volume":"21","author":"Chang","year":"2010","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.phymed.2026.158624_bib0012","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s12943-024-02089-6","article-title":"Writers, readers, and erasers RNA modifications and drug resistance in cancer","volume":"23","author":"Chen","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.phymed.2026.158624_bib0013","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41392-018-0018-5","article-title":"The independence of and associations among apoptosis, autophagy, and necrosis","volume":"3","author":"Chen","year":"2018","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2026.158624_bib0014","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.crfs.2022.08.016","article-title":"Structure-immunomodulatory activity relationships of dietary polysaccharides","volume":"5","author":"Chen","year":"2022","journal-title":"Curr. Res. Food Sci."},{"key":"10.1016\/j.phymed.2026.158624_bib0015","doi-asserted-by":"crossref","first-page":"6076","DOI":"10.3748\/wjg.v18.i42.6076","article-title":"Galactosylated chitosan\/5-fluorouracil nanoparticles inhibit mouse hepatic cancer growth and its side effects","volume":"18","author":"Cheng","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.phymed.2026.158624_bib0016","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.3390\/life11111257","article-title":"Salvia miltiorrhiza protects endothelial dysfunction against mitochondrial oxidative stress","volume":"11","author":"Cheng","year":"2021","journal-title":"Life"},{"key":"10.1016\/j.phymed.2026.158624_bib0017","doi-asserted-by":"crossref","first-page":"479","DOI":"10.4062\/biomolther.2022.017","article-title":"Modulation of reactive oxygen species to overcome 5-fluorouracil resistance","volume":"30","author":"Chun","year":"2022","journal-title":"Biomol. Ther."},{"key":"10.1016\/j.phymed.2026.158624_bib0018","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.immuni.2024.02.014","article-title":"Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8(+) T cell effector functions","volume":"57","author":"Cong","year":"2024","journal-title":"Immunity."},{"key":"10.1016\/j.phymed.2026.158624_bib0019","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1038\/s43018-025-01005-1","article-title":"Cancer-derived mitochondria fuel fibroblasts to become pro-tumorigenic","volume":"6","author":"Delitto","year":"2025","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.phymed.2026.158624_bib0020","article-title":"Enhanced oxidative phosphorylation driven by TACO1 mitochondrial translocation promotes stemness and cisplatin resistance in bladder cancer","volume":"12","author":"Deng","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.phymed.2026.158624_bib0021","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1431968","article-title":"Targeting cellular mitophagy as a strategy for human cancers","volume":"12","author":"Dong","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.phymed.2026.158624_bib0022","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41392-025-02311-x","article-title":"Mitochondrial metabolism and cancer therapeutic innovation","volume":"10","author":"Du","year":"2025","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2026.158624_bib0023","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.3390\/molecules25061351","article-title":"Immunomodulatory effects of Lycium barbarum polysaccharide extract and its uptake behaviors at the cellular level","volume":"25","author":"Feng","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2026.158624_bib0024","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1186\/s12935-021-02207-0","article-title":"Mechanistic study of lncRNA UCA1 promoting growth and cisplatin resistance in lung adenocarcinoma","volume":"21","author":"Fu","year":"2021","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.phymed.2026.158624_bib0025","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1186\/s12876-025-04197-z","article-title":"Evaluation of PINK1 protein expression as a predictive marker for the efficacy of adjuvant chemotherapy in colorectal cancer: a retrospective study","volume":"25","author":"Fujii","year":"2025","journal-title":"BMC. Gastroenterol."},{"key":"10.1016\/j.phymed.2026.158624_bib0026","doi-asserted-by":"crossref","first-page":"664","DOI":"10.3390\/ijms26020664","article-title":"Energy metabolism and stemness and the role of lauric acid in reversing 5-fluorouracil resistance in colorectal cancer cells","volume":"26","author":"Fujiwara-Tani","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158624_bib0027","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.3390\/foods12112133","article-title":"Structure characterization, in vitro antioxidant and anti-tumor activity of sulfated polysaccharide from Siraitia grosvenorii","volume":"12","author":"Gong","year":"2023","journal-title":"Foods"},{"key":"10.1016\/j.phymed.2026.158624_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.133623","article-title":"Applications of polysaccharides in enzyme-triggered oral colon-specific drug delivery systems: a review","volume":"275","author":"Gong","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2026.158624_bib0029","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202301257","article-title":"Targeted reprogramming of vitamin B(3) metabolism as a nanotherapeutic strategy towards chemoresistant cancers","volume":"35","author":"Guo","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.phymed.2026.158624_bib0030","article-title":"Polysaccharides as potential anti-tumor biomacromolecules \u2014 a review","volume":"9","author":"Guo","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.phymed.2026.158624_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116680","article-title":"Angelica sinensis polysaccharide combined with cisplatin reverses cisplatin resistance of ovarian cancer by inducing ferroptosis via regulating GPX4","volume":"175","author":"Guo","year":"2024","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.phymed.2026.158624_bib0032","doi-asserted-by":"crossref","first-page":"19094","DOI":"10.1074\/jbc.M111.322933","article-title":"Microtubule-associated protein 1 light chain 3 (LC3) interacts with Bnip3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy","volume":"287","author":"Hanna","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2026.158624_bib0033","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-med-012017-043208","article-title":"CD8 T cell exhaustion in chronic infection and cancer: opportunities for interventions","volume":"69","author":"Hashimoto","year":"2018","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.phymed.2026.158624_bib0034","doi-asserted-by":"crossref","first-page":"23534","DOI":"10.1073\/pnas.1902308116","article-title":"SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer","volume":"116","author":"He","year":"2019","journal-title":"Proc. Natl. Acad. Sci. u S. a"},{"key":"10.1016\/j.phymed.2026.158624_bib0035","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0092-8674(00)00187-2","article-title":"BH3-only proteins-essential initiators of apoptotic cell death","volume":"103","author":"Huang","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2026.158624_bib0036","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jbiosc.2011.01.012","article-title":"Preparation of galactosylated chitosan\/tripolyphosphate nanoparticles and application as a gene carrier for targeting SMMC7721 cells","volume":"111","author":"Jiang","year":"2011","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.phymed.2026.158624_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119718","article-title":"Structure elucidation and antitumor activity of a water soluble polysaccharide from Hemicentrotus pulcherrimus","volume":"292","author":"Jiang","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.phymed.2026.158624_bib0038","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nrc3538","article-title":"Decoding and unlocking the BCL-2 dependency of cancer cells","volume":"13","author":"Juin","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.phymed.2026.158624_bib0039","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.cell.2018.04.036","article-title":"Embryogenesis and adult life in the absence of intrinsic apoptosis effectors BAX, BAK, and BOK","volume":"173","author":"Ke","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2026.158624_bib0040","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s12272-013-0276-2","article-title":"Cancer multidrug resistance: mechanisms involved and strategies for circumvention using a drug delivery system","volume":"37","author":"Kibria","year":"2014","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.phymed.2026.158624_bib0041","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3390\/biomedicines11020529","article-title":"Low-molecular-weight \u03b2-1,3-1,6-glucan derived from Aureobasidium pullulans exhibits anticancer activity by inducing apoptosis in colorectal cancer cells","volume":"11","author":"Kim","year":"2023","journal-title":"Biomedicines."},{"key":"10.1016\/j.phymed.2026.158624_bib0042","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.3390\/antiox10091429","article-title":"Redox regulation in aging lungs and therapeutic implications of antioxidants in COPD","volume":"10","author":"Kiyokawa","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2026.158624_bib0043","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.94438.3","article-title":"Insights into metabolic heterogeneity of colorectal cancer gained from fluorescence lifetime imaging","volume":"13","author":"Komarova","year":"2024","journal-title":"Elife"},{"key":"10.1016\/j.phymed.2026.158624_bib0044","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.120080","article-title":"PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating serine 65","volume":"2","author":"Kondapalli","year":"2012","journal-title":"Open. Biol."},{"key":"10.1016\/j.phymed.2026.158624_bib0045","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nature14893","article-title":"The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy","volume":"524","author":"Lazarou","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2026.158624_bib0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116172","article-title":"Astragalus polysaccharide ameliorates CD8(+) T cell dysfunction through STAT3\/gal-3\/LAG3 pathway in inflammation-induced colorectal cancer","volume":"171","author":"Li","year":"2024","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.phymed.2026.158624_bib0047","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jare.2023.11.027","article-title":"The role of gut microbiota and metabolites in cancer chemotherapy","volume":"64","author":"Li","year":"2024","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.phymed.2026.158624_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156316","article-title":"Polygonatum sibiricum polysaccharide ameliorates skeletal muscle aging and mitochondrial dysfunction via PI3K\/Akt\/mTOR signaling pathway","volume":"136","author":"Li","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158624_bib0049","article-title":"Modulation of redox homeostasis: a strategy to overcome cancer drug resistance","volume":"14","author":"Li","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158624_bib0050","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1158\/1541-7786.MCR-07-2130","article-title":"SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism","volume":"6","author":"Liang","year":"2008","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.phymed.2026.158624_bib0051","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1038\/s41467-026-68542-w","article-title":"1,3-and 1,4-linked polysaccharides uptake in intestinal cells relies on clathrin\/dynamin 1\/Rab5-dependent endocytosis","volume":"17","author":"Liao","year":"2026","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.158624_bib0052","doi-asserted-by":"crossref","DOI":"10.1038\/srep18629","article-title":"Biofunctionalization of selenium nanoparticle with Dictyophora indusiata polysaccharide and its antiproliferative activity through death-receptor and mitochondria-mediated apoptotic pathways","volume":"5","author":"Liao","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2026.158624_bib0053","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.ijbiomac.2018.01.048","article-title":"Cardioprotection activity and mechanism of astragalus polysaccharide in vivo and in vitro","volume":"111","author":"Liu","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2026.158624_bib0054","doi-asserted-by":"crossref","first-page":"6201","DOI":"10.21037\/tcr-24-933","article-title":"ABALON regulates mitophagy and 5-FU sensitivity in colorectal cancer via PINK1-Parkin pathway","volume":"13","author":"Liu","year":"2024","journal-title":"Transl. Cancer Res."},{"key":"10.1016\/j.phymed.2026.158624_bib0055","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/ncb2422","article-title":"Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells","volume":"14","author":"Liu","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.phymed.2026.158624_bib0056","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2025.110437","article-title":"PINK1-mediated mitochondrial autophagy protects lens epithelial cells by reducing ROS and apoptosis","volume":"258","author":"Liu","year":"2025","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.phymed.2026.158624_bib0057","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/s12943-022-01680-z","article-title":"Biological and pharmacological roles of m(6)A modifications in cancer drug resistance","volume":"21","author":"Liu","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.phymed.2026.158624_bib0058","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s12885-018-4061-y","article-title":"Contrasting roles of H3K4me3 and H3K9me3 in regulation of apoptosis and gemcitabine resistance in human pancreatic cancer cells","volume":"18","author":"Lu","year":"2018","journal-title":"BMC. Cancer"},{"key":"10.1016\/j.phymed.2026.158624_bib0059","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/2851349","article-title":"Astragalus polysaccharide attenuates cisplatin-induced acute kidney injury by suppressing oxidative damage and mitochondrial dysfunction","volume":"2020","author":"Ma","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.phymed.2026.158624_bib0060","doi-asserted-by":"crossref","first-page":"89108","DOI":"10.18632\/oncotarget.19059","article-title":"Can polysaccharide K improve therapeutic efficacy and safety in gastrointestinal cancer? A systematic review and network meta-analysis","volume":"8","author":"Ma","year":"2017","journal-title":"Oncotarget."},{"key":"10.1016\/j.phymed.2026.158624_bib0061","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/6501046","article-title":"Measurement and clinical significance of biomarkers of oxidative stress in humans","volume":"2017","author":"Marrocco","year":"2017","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.phymed.2026.158624_bib0062","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1111\/j.1349-7006.1996.tb03128.x","article-title":"Lentinan enhances sensitivity of mouse colon 26 tumor to cis-diamminedichloroplatinum (II) and decreases glutathione transferase expression","volume":"87","author":"Murata","year":"1996","journal-title":"Jpn. J. Cancer Res."},{"key":"10.1016\/j.phymed.2026.158624_bib0063","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3390\/pharmaceutics16010043","article-title":"Chitosan and cyclodextrins-versatile materials used to create drug delivery systems for gastrointestinal cancers","volume":"16","author":"Najm","year":"2023","journal-title":"Pharmaceutics."},{"key":"10.1016\/j.phymed.2026.158624_bib0064","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13073-025-01488-8","article-title":"DNA repair and the contribution to chemotherapy resistance","volume":"17","author":"Nesic","year":"2025","journal-title":"Genome Med."},{"key":"10.1016\/j.phymed.2026.158624_bib0065","doi-asserted-by":"crossref","first-page":"301","DOI":"10.4161\/auto.7.3.14509","article-title":"Autophagy receptors in developmental clearance of mitochondria","volume":"7","author":"Novak","year":"2011","journal-title":"Autophagy."},{"key":"10.1016\/j.phymed.2026.158624_bib0066","doi-asserted-by":"crossref","first-page":"3606","DOI":"10.1038\/s41467-020-17384-1","article-title":"Coordinate \u03b2-adrenergic inhibition of mitochondrial activity and angiogenesis arrest tumor growth","volume":"11","author":"Nuevo-Tapioles","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.158624_bib0067","doi-asserted-by":"crossref","first-page":"14002","DOI":"10.3390\/ijms131114002","article-title":"Bacterial exopolysaccharides: functionality and prospects","volume":"13","author":"Nwodo","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158624_bib0068","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/ncomms2016","article-title":"PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria","volume":"3","author":"Okatsu","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.158624_bib0069","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122116","article-title":"Mitochondrial transfer restores impaired liver functions by AMPK\/mTOR\/PI3K-AKT pathways in metabolic syndrome","volume":"332","author":"Paliwal","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2026.158624_bib0070","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1471-2121-8-16","article-title":"The N-terminus and alpha-5, alpha-6 helices of the pro-apoptotic protein Bax, modulate functional interactions with the anti-apoptotic protein bcl-xL","volume":"8","author":"Parikh","year":"2007","journal-title":"BMC. Cell Biol."},{"key":"10.1016\/j.phymed.2026.158624_bib0071","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.110376","article-title":"Astragalus polysaccharides sensitize ovarian cancer stem cells to PARPi by inhibiting mitophagy via PINK1\/Parkin signaling","volume":"27","author":"Peng","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.phymed.2026.158624_bib0072","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.7150\/ijms.33106","article-title":"The extracts of Astragalus membranaceus enhance chemosensitivity and reduce tumor indoleamine 2,3-dioxygenase expression","volume":"16","author":"Phacharapiyangkul","year":"2019","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.phymed.2026.158624_bib0073","article-title":"Coriolus (Trametes) versicolor mushroom to reduce adverse effects from chemotherapy or radiotherapy in people with colorectal cancer","volume":"11","author":"Pilkington","year":"2022","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.phymed.2026.158624_bib0074","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111233","article-title":"SHMT2-mediated mitochondrial serine metabolism drives 5-FU resistance by fueling nucleotide biosynthesis","volume":"40","author":"Pranzini","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.phymed.2026.158624_bib0075","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.833077","article-title":"Albuca bracteata polysaccharides attenuate AOM\/DSS-induced colon tumorigenesis via regulating oxidative stress, inflammation and gut microbiota in mice","volume":"13","author":"Qin","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158624_bib0076","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41420-025-02670-y","article-title":"Mitochondrial metabolic reprogramming in colorectal cancer: mechanisms of resistance and future clinical interventions","volume":"11","author":"Qiu","year":"2025","journal-title":"Cell Death. Discov."},{"key":"10.1016\/j.phymed.2026.158624_bib0077","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s00438-025-02252-8","article-title":"Identification of oxidative stress-related subgroups and signature genes for the prediction of prognosis and immune microenvironment in thyroid cancer","volume":"300","author":"Qiu","year":"2025","journal-title":"Mol. Genet. Genomics."},{"key":"10.1016\/j.phymed.2026.158624_bib0078","doi-asserted-by":"crossref","DOI":"10.3390\/app112211041","article-title":"Beneficial oxidative stress-related trans-resveratrol effects in the treatment and prevention of breast cancer","volume":"11","author":"Quarta","year":"2021","journal-title":"Appl. Sci."},{"key":"10.1016\/j.phymed.2026.158624_bib0079","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176979","article-title":"Resistance to 5-fluorouracil: the molecular mechanisms of development in colon cancer cells","volume":"983","author":"Radenkovi\u0107","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158624_bib0080","doi-asserted-by":"crossref","first-page":"9451","DOI":"10.3390\/ijms22179451","article-title":"Battling chemoresistance in cancer: root causes and strategies to uproot them","volume":"22","author":"Ramos","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158624_bib0081","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1111\/jcmm.13110","article-title":"Overviews on the cellular uptake mechanism of polysaccharide colloidal nanoparticles","volume":"21","author":"Salatin","year":"2017","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.phymed.2026.158624_bib0082","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.trecan.2022.10.004","article-title":"Endogenous and imposed determinants of apoptotic vulnerabilities in cancer","volume":"9","author":"Sarosiek","year":"2023","journal-title":"Trends. Cancer"},{"key":"10.1016\/j.phymed.2026.158624_bib0083","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/s41590-020-00834-9","article-title":"Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion","volume":"22","author":"Scharping","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.phymed.2026.158624_bib0084","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.freeradbiomed.2018.09.014","article-title":"Role of GPX4 in ferroptosis and its pharmacological implication","volume":"133","author":"Seibt","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2026.158624_bib0085","doi-asserted-by":"crossref","first-page":"179","DOI":"10.18388\/pb.2021_610","article-title":"Natural polysaccharides as drug delivery system in colorectal cancer therapy","volume":"71","author":"Senkowska","year":"2025","journal-title":"Postepy. Biochem."},{"key":"10.1016\/j.phymed.2026.158624_bib0086","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.139177","article-title":"Polysaccharide-based drug delivery targeted approach for colon cancer treatment: a comprehensive review","volume":"302","author":"Shao","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2026.158624_bib0087","doi-asserted-by":"crossref","first-page":"6015","DOI":"10.1007\/s11010-025-05377-x","article-title":"Mitochondrial dysfunction in hepatocellular carcinoma: from metabolism to targeted therapies","volume":"480","author":"Sharafi","year":"2025","journal-title":"Mol. Cell Biochem."},{"key":"10.1016\/j.phymed.2026.158624_bib0088","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156958","article-title":"Targeting tumor metabolism: the dual attack of emodin on glycolysis and oxidative phosphorylation in esophageal squamous cell carcinoma","volume":"144","author":"Su","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158624_bib0089","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/cbin.11938","article-title":"Small extracellular vesicles derived from human adipose-derived stem cells regulate energetic metabolism through the activation of YAP\/TAZ pathway facilitating angiogenesis","volume":"47","author":"Sun","year":"2023","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.phymed.2026.158624_bib0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2025.123708","article-title":"A galacturonan from sea buckthorn (Hippophae rhamnoides L.) berry modulates dyslipidemia by promoting hepatic lipolysis and mitochondrial oxidation","volume":"363","author":"Sun","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.phymed.2026.158624_bib0091","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13046-023-02638-9","article-title":"METTL3 promotes chemoresistance in small cell lung cancer by inducing mitophagy","volume":"42","author":"Sun","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.phymed.2026.158624_bib0092","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nrm2952","article-title":"Mitochondria and cell death: outer membrane permeabilization and beyond","volume":"11","author":"Tait","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2026.158624_bib0093","article-title":"Molecular and cellular paradigms of multidrug resistance in cancer","volume":"5","author":"Vaidya","year":"2022","journal-title":"Cancer Rep."},{"key":"10.1016\/j.phymed.2026.158624_bib0094","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.3390\/life11111269","article-title":"Oxidative stress, mitochondrial function and adaptation to exercise: new perspectives in nutrition","volume":"11","author":"Vargas-Mendoza","year":"2021","journal-title":"Life"},{"key":"10.1016\/j.phymed.2026.158624_bib0095","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/s41467-018-02915-8","article-title":"Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance","volume":"9","author":"Wang","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.158624_bib0096","doi-asserted-by":"crossref","first-page":"610","DOI":"10.18632\/oncotarget.13481","article-title":"A polysaccharide from Lentinus edodes inhibits human colon cancer cell proliferation and suppresses tumor growth in athymic nude mice","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.phymed.2026.158624_bib0097","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2025.151519","article-title":"Lectin-like oxidized low-density lipoprotein receptor-1 reduces 5-FU sensitivity in gastric cancer cells via JAK\/STAT\/NOX4 axis","volume":"753","author":"Wang","year":"2025","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phymed.2026.158624_bib0098","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/s41419-024-06870-9","article-title":"BNIP3-mediated mitophagy boosts the competitive growth of lenvatinib-resistant cells via energy metabolism reprogramming in HCC","volume":"15","author":"Wang","year":"2024","journal-title":"Cell Death. Dis."},{"key":"10.1016\/j.phymed.2026.158624_bib0099","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S2468-1253(23)00366-7","article-title":"Global, regional, and national lifetime risks of developing and dying from gastrointestinal cancers in 185 countries: a population-based systematic analysis of GLOBOCAN","volume":"9","author":"Wang","year":"2024","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2026.158624_bib0100","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s10020-025-01151-3","article-title":"WBP1 regulates mitochondrial function and ferroptosis to modulate chemoresistance in colorectal cancer","volume":"31","author":"Wang","year":"2025","journal-title":"Mol. Med."},{"key":"10.1016\/j.phymed.2026.158624_bib0101","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155242","article-title":"Systematic review and meta-analysis on the efficacy and safety of injectable lentinan combined with chemotherapy in the treatment of gastric cancer","volume":"123","author":"Wang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158624_bib0102","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2025.114932","article-title":"Apoptosis and mitochondrial DNA damaged induced by zn\u00b2\u207a\/ca\u00b2\u207a dual-ions overload for colorectal cancer improved immunotherapy","volume":"255","author":"Wang","year":"2025","journal-title":"Colloids. Surf. B Biointerfaces."},{"key":"10.1016\/j.phymed.2026.158624_bib0103","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.bbrc.2021.08.030","article-title":"Apaf1 nanoLuc biosensors identified lentinan as a potent synergizer of cisplatin in targeting hepatocellular carcinoma cells","volume":"577","author":"Wang","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phymed.2026.158624_bib0104","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s10020-025-01182-w","article-title":"USP14 inhibits mitophagy and promotes tumorigenesis and chemosensitivity through deubiquitinating BAG4 in microsatellite instability-high colorectal cancer","volume":"31","author":"Wang","year":"2025","journal-title":"Mol. Med."},{"key":"10.1016\/j.phymed.2026.158624_bib0105","first-page":"1640","article-title":"Astragalus polysaccharides reverse gefitinib resistance by inhibiting mesenchymal transformation in lung adenocarcinoma cells","volume":"12","author":"Wei","year":"2020","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.phymed.2026.158624_bib0106","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/1471-0528.17327","article-title":"High co-expression of SLC7A11 and GPX4 as a predictor of platinum resistance and poor prognosis in patients with epithelial ovarian cancer","volume":"129","author":"Wu","year":"2022","journal-title":"BJOG."},{"key":"10.1016\/j.phymed.2026.158624_bib0107","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1097\/CM9.0000000000002108","article-title":"Cancer statistics in China and United States, 2022: profiles, trends, and determinants","volume":"135","author":"Xia","year":"2022","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.phymed.2026.158624_bib0108","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202501369R","article-title":"USP44 regulates chemoresistance induced by ROS and the MAPK\/NF-\u03baB pathway through the stabilization of ITGB4 in gastric cancer","volume":"39","author":"Xiao","year":"2025","journal-title":"FASEB J."},{"key":"10.1016\/j.phymed.2026.158624_bib0109","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.fshw.2023.02.002","article-title":"Apoptosis of colon cancer CT-26 cells induced polysaccharide from Cyclocarya paliurus and its phosphorylated derivative via intrinsic mitochondrial passway","volume":"12","author":"Xie","year":"2023","journal-title":"Food Sci. Hum. Wellness"},{"key":"10.1016\/j.phymed.2026.158624_bib0110","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.canlet.2016.11.018","article-title":"Doxorubicin-induced mitophagy contributes to drug resistance in cancer stem cells from HCT8 human colorectal cancer cells","volume":"388","author":"Yan","year":"2017","journal-title":"Cancer Lett."},{"key":"10.1016\/j.phymed.2026.158624_bib0111","doi-asserted-by":"crossref","first-page":"7119","DOI":"10.1021\/acs.nanolett.2c02226","article-title":"Controlling nanoparticle uptake in innate immune cells with heparosan polysaccharides","volume":"22","author":"Yang","year":"2022","journal-title":"Nano Lett."},{"key":"10.1016\/j.phymed.2026.158624_bib0112","doi-asserted-by":"crossref","first-page":"4840","DOI":"10.1016\/j.bmcl.2010.06.106","article-title":"Fluorine-18 labeled galactosylated chitosan for asialoglycoprotein-receptor-mediated hepatocyte imaging","volume":"20","author":"Yang","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.phymed.2026.158624_bib0113","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.144297","article-title":"Ionized Angelica polysaccharides derivatives slow tumor growth in vivo and induce the apoptosis of HepG2 cells via mitochondria death receptor-mediated pathways in vitro","volume":"315","author":"Yang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2026.158624_bib0114","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.126484","article-title":"Preclinical pharmacokinetics-related pharmacological effects of orally administered polysaccharides from traditional Chinese medicines: a review","volume":"252","author":"Ye","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2026.158624_bib0115","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.phymed.2011.09.077","article-title":"Polysaccharide peptides from Coriolus versicolor competitively inhibit model cytochrome P450 enzyme probe substrates metabolism in human liver microsomes","volume":"19","author":"Yeung","year":"2012","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158624_bib0116","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1147641","article-title":"Immunomodulatory function and anti-tumor mechanism of natural polysaccharides: a review","volume":"14","author":"Ying","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2026.158624_bib0117","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103048","article-title":"Redox changes and cellular senescence in Alzheimer's disease","volume":"70","author":"Yu","year":"2024","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2026.158624_bib0118","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.3390\/nu14091710","article-title":"Enhanced growth inhibition and apoptosis induction in human colon carcinoma HT-29 cells of soluble longan polysaccharides with a covalent chemical selenylation","volume":"14","author":"Yu","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.158624_bib0119","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/s41590-022-01219-w","article-title":"Stem-like' precursors are the fount to sustain persistent CD8(+) T cell responses","volume":"23","author":"Zehn","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.phymed.2026.158624_bib0120","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202004766","article-title":"Fighting against drug-resistant tumors using a dual-responsive Pt(IV)\/Ru(II) bimetallic polymer","volume":"32","author":"Zeng","year":"2020","journal-title":"Adv. Mater."},{"key":"10.1016\/j.phymed.2026.158624_bib0121","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/s13046-022-02439-6","article-title":"Mitochondria dysfunction in CD8+ T cells as an important contributing factor for cancer development and a potential target for cancer treatment: a review","volume":"41","author":"Zhang","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.phymed.2026.158624_bib0122","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.898240","article-title":"Anti-gastric cancer activity of the cell-free culture supernatant of serofluid dish and lactiplantibacillus plantarum YT013","volume":"10","author":"Zhang","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.phymed.2026.158624_bib0123","doi-asserted-by":"crossref","first-page":"539","DOI":"10.3390\/fermentation9060539","article-title":"Exopolysaccharide from lactiplantibacillus plantarum YT013 and its apoptotic activity on gastric cancer AGS cells","volume":"9","author":"Zhang","year":"2023","journal-title":"Fermentation"},{"key":"10.1016\/j.phymed.2026.158624_bib0124","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00394-025-03794-8","article-title":"Anti-colorectal cancer effect and mechanism of a polysaccharide from Ruditapes philippinarum","volume":"64","author":"Zhang","year":"2025","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.phymed.2026.158624_bib0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.123203","article-title":"Structural characteization and anti-colorectal cancer activity of a fucogalactan purified from Ganoderma tsugae","volume":"352","author":"Zhang","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.phymed.2026.158624_bib0126","doi-asserted-by":"crossref","first-page":"5416","DOI":"10.3390\/molecules28145416","article-title":"Structural modification and biological activity of polysaccharides","volume":"28","author":"Zhao","year":"2023","journal-title":"Molecules."},{"key":"10.1016\/j.phymed.2026.158624_bib0127","doi-asserted-by":"crossref","first-page":"7344","DOI":"10.1021\/acs.jafc.1c00349","article-title":"Mechanism of lentinan intestinal absorption: clathrin-mediated endocytosis and macropinocytosis","volume":"69","author":"Zheng","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2026.158624_bib0128","article-title":"Astragalus polysaccharides exerts immunomodulatory effects via TLR4-mediated MyD88-dependent signaling pathway in vitro and in vivo","volume":"7","author":"Zhou","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2026.158624_bib0129","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122346","article-title":"Lycium barbarum polysaccharides attenuate oxidative stress and mitochondrial toxicity induced by mixed plasticizers in HepG2 cells through activation of Nrf2","volume":"336","author":"Zhou","year":"2024","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2026.158624_bib0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcmgh.2024.101425","article-title":"Early onset colorectal cancer: molecular underpinnings accelerating occurrence","volume":"19","author":"Zinkeng","year":"2025","journal-title":"Cell Mol. Gastroenterol. Hepatol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132600855X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132600855X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T14:47:30Z","timestamp":1785509250000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S094471132600855X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":130,"alternative-id":["S094471132600855X"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158624","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polysaccharides-mediated mitochondrial remodeling: role in chemotherapy resistance of gastrointestinal tumors","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158624","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158624"}}