{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T07:20:01Z","timestamp":1787556001947,"version":"build-2736575974"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.phymed.2026.158640","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T01:13:05Z","timestamp":1784855585000},"page":"158640","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Folic acid alleviates neuroinflammation after intracerebral hemorrhage by epigenetically regulating the AMPD2\/DCK\/NF-\u03baB pathway"],"prefix":"10.1016","volume":"160","author":[{"given":"Yinbin","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menglu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zifeng","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3598-9747","authenticated-orcid":false,"given":"Yi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158640_bib0001","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12987-025-00689-y","article-title":"Neuroprotective role of pyrroloquinoline quinone in folate deficiency-induced blood-brain barrier disruption","volume":"22","author":"Aboulhassane","year":"2025","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.phymed.2026.158640_bib0002","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.cell.2013.07.005","article-title":"AMPD2 regulates GTP synthesis and is mutated in a potentially treatable neurodegenerative brainstem disorder","volume":"154","author":"Akizu","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2026.158640_bib0003","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s11910-023-01282-2","article-title":"Neuroinflammation in acute ischemic and hemorrhagic stroke","volume":"23","author":"Alsbrook","year":"2023","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.phymed.2026.158640_bib0004","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abd6279","article-title":"Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage","volume":"6","author":"Askenase","year":"2021","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.phymed.2026.158640_bib0005","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.828780","article-title":"Metabolic and epigenetic regulation by estrogen in adipocytes","volume":"13","author":"Bjune","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.phymed.2026.158640_bib0006","article-title":"Behavioral and neurochemical effects of folic acid in a mouse model of depression induced by TNF-\u03b1. Behav","volume":"414","author":"Budni","year":"2021","journal-title":"Brain Res"},{"key":"10.1016\/j.phymed.2026.158640_bib0007","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1016\/j.ejrad.2012.12.026","article-title":"Epidemiology and genetics of intracranial aneurysms","volume":"82","author":"Caranci","year":"2013","journal-title":"Eur. J. Radiol."},{"key":"10.1016\/j.phymed.2026.158640_bib0008","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2528095123","article-title":"Dietary folic acid prevents peripheral neuropathy in mouse models of neural tube defects and type 2 diabetes","volume":"123","author":"Chakraborty","year":"2026","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phymed.2026.158640_bib0009","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/imm.13569","article-title":"Targeting deoxycytidine kinase improves symptoms in mouse models of multiple sclerosis","volume":"168","author":"Chen","year":"2023","journal-title":"Immunology"},{"key":"10.1016\/j.phymed.2026.158640_bib0010","doi-asserted-by":"crossref","first-page":"4795","DOI":"10.1111\/jcmm.14368","article-title":"Folic acid deficiency enhanced microglial immune response via the Notch1\/nuclear factor kappa B p65 pathway in hippocampus following rat brain I\/R injury and BV2 cells","volume":"23","author":"Cheng","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.phymed.2026.158640_bib0011","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/s41418-020-00708-5","article-title":"Ubiquitination in the regulation of inflammatory cell death and cancer","volume":"28","author":"Cockram","year":"2021","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.phymed.2026.158640_bib0012","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.redox.2018.08.005","article-title":"Folic acid modulates VPO1 DNA methylation levels and alleviates oxidative stress-induced apoptosis in vivo and in vitro","volume":"19","author":"Cui","year":"2018","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2026.158640_bib0013","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1007\/s10787-023-01314-w","article-title":"Folic acid improved memory and learning function in a rat model of neuroinflammation induced by lipopolysaccharide","volume":"32","author":"Darbandi","year":"2024","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.phymed.2026.158640_bib0014","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13054-020-2749-2","article-title":"Surgery for spontaneous intracerebral hemorrhage","volume":"24","author":"De Oliveira Manoel","year":"2020","journal-title":"Crit. Care"},{"key":"10.1016\/j.phymed.2026.158640_bib0015","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202002658RR","article-title":"Surface AMP deaminase 2 as a novel regulator modifying extracellular adenine nucleotide metabolism","volume":"35","author":"Ehlers","year":"2021","journal-title":"FASEB J."},{"key":"10.1016\/j.phymed.2026.158640_bib0016","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12974-021-02073-7","article-title":"Efficacy and tolerability of folate-aminopterin therapy in a rat focal model of multiple sclerosis","volume":"18","author":"Elo","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.phymed.2026.158640_bib0017","doi-asserted-by":"crossref","first-page":"3990","DOI":"10.1038\/s44319-024-00218-2","article-title":"IMPDH2 filaments protect from neurodegeneration in AMPD2 deficiency","volume":"25","author":"Flores-Mendez","year":"2024","journal-title":"EMBO Rep."},{"key":"10.1016\/j.phymed.2026.158640_bib0018","doi-asserted-by":"crossref","first-page":"5606","DOI":"10.1073\/pnas.062066299","article-title":"A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status","volume":"99","author":"Friso","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phymed.2026.158640_bib0019","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.12998\/wjcc.v8.i15.3197","article-title":"Overexpression o AMPD2 indicates poor prognosis in colorectal cancer patients via the Notch3 sfignaling pathway","volume":"8","author":"Gao","year":"2020","journal-title":"World J. Clin. Cases"},{"key":"10.1016\/j.phymed.2026.158640_bib0020","first-page":"1","article-title":"DNA hypomethylation of DOCK1 leading to high expression correlates with neurologic deterioration and poor function outcomes after spontaneous intracerebral hemorrhage","volume":"2021","author":"Gao","year":"2021","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.phymed.2026.158640_bib0021","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1186\/s12967-018-1739-5","article-title":"NovelmiRNA-25 inhibits AMPD2 in peripheral blood mononuclear cells of patients with systemic lupus erythematosus and represents a promising novel biomarker","volume":"16","author":"Guo","year":"2018","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.phymed.2026.158640_bib0022","doi-asserted-by":"crossref","first-page":"494","DOI":"10.7150\/thno.101024","article-title":"Inhibition of Bruton's tyrosine kinase restricts neuroinflammation following intracerebral hemorrhage","volume":"15","author":"Hao","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.phymed.2026.158640_bib0023","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1007\/s12028-019-00787-4","article-title":"Genetic variability and trajectories of DNA methylation may support a role for HAMP in patient outcomes after aneurysmal subarachnoid hemorrhage","volume":"32","author":"Heinsberg","year":"2020","journal-title":"Neurocrit. Care"},{"key":"10.1016\/j.phymed.2026.158640_bib0024","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1016\/S0140-6736(24)00642-1","volume":"403","author":"Hilkens","year":"2024","journal-title":"Stroke Lancet"},{"key":"10.1016\/j.phymed.2026.158640_bib0025","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.cca.2020.11.013","article-title":"Epigenetic factors in atherosclerosis: DNA methylation, folic acid metabolism, and intestinal microbiota","volume":"512","author":"Hou","year":"2021","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.phymed.2026.158640_bib0026","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12456","article-title":"dCK negatively regulates the NRF2\/ARE axis and ROS production in pancreatic cancer","volume":"51","author":"Hu","year":"2018","journal-title":"Cell Prolif."},{"key":"10.1016\/j.phymed.2026.158640_bib0027","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s13148-024-01685-z","article-title":"Estrogen-mediated DNMT1 and DNMT3A recruitment by EZH2 silences miR-570-3p that contributes to papillary thyroid malignancy through DPP4","volume":"16","author":"Hu","year":"2024","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.phymed.2026.158640_bib0028","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s12974-022-02558-z","article-title":"Aprepitant attenuates NLRC4-dependent neuronal pyroptosis via NK1R\/PKCdelta pathway in a mouse model of intracerebral hemorrhage","volume":"19","author":"Jin","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.phymed.2026.158640_bib0029","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1868-7083-5-3","article-title":"Pharmacokinetic and pharmacodynamic analysis of 5-aza-2\u2032-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapy","volume":"5","author":"Karahoca","year":"2013","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.phymed.2026.158640_bib0030","first-page":"97","article-title":"Applications of advances in therapeutic electrical stimulation techniques and technologies in precision peripheral nerve repair: a narrative review","volume":"2","author":"Kennedy","year":"2025","journal-title":"Adv Technol. Neurosci."},{"key":"10.1016\/j.phymed.2026.158640_bib0031","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/s41431-018-0098-2","article-title":"Clinical and genetic spectrum of AMPD2-related pontocerebellar hypoplasia type 9","volume":"26","author":"Kortum","year":"2018","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.phymed.2026.158640_bib0032","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s12035-025-05421-3","article-title":"Nobiletin reduces LPS-induced neuroinflammation through TLR4\/MyD88\/NF-kappaB and oxidative stress via Nrf2\/HO-1 signaling in Human microglial HMC3 cells","volume":"63","author":"Kritika","year":"2026","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phymed.2026.158640_bib0033","first-page":"1","article-title":"Curcumenol inhibits malignant progression and promotes ferroptosis via the SLC7A11\/NF\u2011kappaB\/TGF\u2011beta pathway in triple\u2011negative breast cancer","volume":"56","author":"Li","year":"2025","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.phymed.2026.158640_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110744","article-title":"Revisiting the role of the complement system in intracerebral hemorrhage and therapeutic prospects","volume":"123","author":"Li","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2026.158640_bib0035","first-page":"161","article-title":"Comparisons in microglial responses to ischemic\u2013hypoxic brain injury in neonatal and adult mice analyzed by transcriptome integration and deconvolution technologies","volume":"2","author":"Liu","year":"2025","journal-title":"Adv Technol. Neurosci."},{"key":"10.1016\/j.phymed.2026.158640_bib0036","doi-asserted-by":"crossref","first-page":"417","DOI":"10.7150\/thno.77694","article-title":"Targeting WWP1 ameliorates cardiac ischemic injury by suppressing KLF15-ubiquitination mediated myocardial inflammation","volume":"13","author":"Lu","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.phymed.2026.158640_bib0037","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1161\/CIRCRESAHA.121.319949","article-title":"Cerebral hemorrhage: pathophysiology, treatment, and future directions","volume":"130","author":"Magid-Bernstein","year":"2022","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2026.158640_bib0038","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2016.07.006","article-title":"Aging and peripheral lipopolysaccharide can modulate epigenetic regulators and decrease IL-1beta promoter DNA methylation in microglia","volume":"47","author":"Matt","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.phymed.2026.158640_bib0039","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.tig.2022.03.010","article-title":"DNA methylation: a historical perspective","volume":"38","author":"Mattei","year":"2022","journal-title":"Trends Genet."},{"key":"10.1016\/j.phymed.2026.158640_bib0040","article-title":"Computational modelling folate metabolism and DNA methylation: implications for understanding health and ageing","volume":"19","author":"Mc Auley","year":"2018","journal-title":"Brief. Bioinform."},{"key":"10.1016\/j.phymed.2026.158640_bib0041","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/npp.2012.112","article-title":"DNA methylation and its basic function","volume":"38","author":"Moore","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phymed.2026.158640_bib0042","doi-asserted-by":"crossref","first-page":"11482","DOI":"10.1016\/S0021-9258(19)38422-4","article-title":"Adenylate deaminase. A multigene family in humans and rats","volume":"265","author":"Morisaki","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2026.158640_bib0043","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/s12974-018-1308-0","article-title":"Ibrutinib suppresses LPS-induced neuroinflammatory responses in BV2 microglial cells and wild-type mice","volume":"15","author":"Nam","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.phymed.2026.158640_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2021.104193","article-title":"Folic acid alleviates the blood brain barrier permeability and oxidative stress and prevents cognitive decline in sepsis-surviving rats","volume":"137","author":"Novochadlo","year":"2021","journal-title":"Microvasc. Res."},{"issue":"2","key":"10.1016\/j.phymed.2026.158640_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.neumar.2025.100037","article-title":"Values of epigenetic markers in Parkinson's disease as biomarkers and therapeutic targets: a narrative review","volume":"2","author":"Parikh","year":"2025","journal-title":"NeuroMarkers"},{"key":"10.1016\/j.phymed.2026.158640_bib0046","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1177\/17474930241307876","article-title":"World Stroke Organization (WSO): global intracerebral hemorrhage factsheet 2025","volume":"20","author":"Parry-Jones","year":"2025","journal-title":"Int. J. Stroke"},{"key":"10.1016\/j.phymed.2026.158640_bib0047","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1007\/s12035-019-01812-5","article-title":"Ancestral folate promotes neuronal regeneration in serial generations of progeny","volume":"57","author":"Patel","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phymed.2026.158640_bib0048","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41572-023-00424-7","article-title":"Intracerebral haemorrhage","volume":"9","author":"Puy","year":"2023","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.phymed.2026.158640_bib0049","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/s12964-023-01274-2","article-title":"RU.521 mitigates subarachnoid hemorrhage-induced brain injury via regulating microglial polarization and neuroinflammation mediated by the cGAS\/STING\/NF-kappaB pathway","volume":"21","author":"Shao","year":"2023","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.phymed.2026.158640_bib0050","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/s12974-018-1227-0","article-title":"Inflammation and blood-brain barrier breach remote from the primary injury following neurotrauma","volume":"15","author":"Smith","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.phymed.2026.158640_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102489","article-title":"Unraveling the protein post-translational modification landscape: neuroinflammation and neuronal death after stroke","volume":"101","author":"Tao","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.phymed.2026.158640_bib0052","doi-asserted-by":"crossref","DOI":"10.1186\/s11658-020-00245-6","article-title":"Beyond K48 and K63: non-canonical protein ubiquitination","volume":"26","author":"Tracz","year":"2021","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.phymed.2026.158640_bib0053","doi-asserted-by":"crossref","first-page":"29","DOI":"10.5853\/jos.2019.02236","article-title":"Neuroinflammation after intracerebral hemorrhage and potential therapeutic targets","volume":"22","author":"Tschoe","year":"2020","journal-title":"J. Stroke"},{"issue":"Pt 2","key":"10.1016\/j.phymed.2026.158640_bib0054","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1042\/bj3120401","article-title":"Characterization of human AMP deaminase 2 (AMPD2) gene expression reveals alternative transcripts encoding variable N-terminal extensions of isoform L","volume":"312","author":"Van Den Bergh","year":"1995","journal-title":"Biochem. J."},{"key":"10.1016\/j.phymed.2026.158640_bib0055","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/s41420-025-02388-x","article-title":"HSP90 regulates dCK stability and inhibits ionizing radiation-induced ferroptosis in cervical cancer cells","volume":"11","author":"Wang","year":"2025","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.phymed.2026.158640_bib0056","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12974-023-02721-0","article-title":"Regulatory T cells alleviate myelin loss and cognitive dysfunction by regulating neuroinflammation and microglial pyroptosis via TLR4\/MyD88\/NF-kappaB pathway in LPC-induced demyelination","volume":"20","author":"Wang","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.phymed.2026.158640_bib0057","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1038\/s41401-023-01062-1","article-title":"Aspirin triggers ferroptosis in hepatocellular carcinoma cells through restricting NF-kappaB p65-activated SLC7A11 transcription","volume":"44","author":"Wang","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2026.158640_bib0058","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s12974-026-03729-y","article-title":"Curcumin reduces neuroinflammation and oxidative stress in a stroke model by epigenetically regulating ADRB2 methylation through JAK2\/STAT3 and Nrf2\/HO-1 pathways","volume":"23","author":"Wei","year":"2026","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.phymed.2026.158640_bib0059","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13148-022-01248-0","article-title":"Atheroprotective mechanism by which folic acid regulates monocyte subsets and function through DNA methylation","volume":"14","author":"Xiang","year":"2022","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.phymed.2026.158640_bib0060","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1186\/s12974-022-02678-6","article-title":"Lactate attenuates astrocytic inflammation by inhibiting ubiquitination and degradation of NDRG2 under oxygen-glucose deprivation conditions","volume":"19","author":"Xu","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.phymed.2026.158640_bib0061","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s10528-023-10430-9","article-title":"Identification and analysis of DNA methylation inflammation-related key genes in intracerebral hemorrhage","volume":"62","author":"Xu","year":"2024","journal-title":"Biochem. Genet."},{"key":"10.1016\/j.phymed.2026.158640_bib0062","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114780","article-title":"Macrophage NRF1 promotes mitochondrial protein turnover via the ubiquitin proteasome system to limit mitochondrial stress and inflammation","volume":"43","author":"Yan","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.phymed.2026.158640_bib0063","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2023.112039","article-title":"AMPD2 plays important roles in regulating hepatic glucose and lipid metabolism","volume":"577","author":"Yang","year":"2023","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.phymed.2026.158640_bib0064","article-title":"Genome-wide DNA methylation pattern in whole blood associated with primary intracerebral hemorrhage","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2026.158640_bib0065","article-title":"USP38 Couples histone ubiquitination and methylation via KDM5B to resolve inflammation","volume":"8","author":"Zhao","year":"2021","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.phymed.2026.158640_bib0066","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.3390\/ijms17111939","article-title":"The role of deoxycytidine kinase (dCK) in radiation-induced cell death","volume":"17","author":"Zhong","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158640_bib0067","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.3892\/etm.2021.10506","article-title":"Fumaric acid and succinic acid treat gestational hypertension by downregulating the expression of KCNMB1 and TET1","volume":"22","author":"Zhou","year":"2021","journal-title":"Exp. Ther. Med."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326008718?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326008718?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T06:28:30Z","timestamp":1787552910000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326008718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":67,"alternative-id":["S0944711326008718"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158640","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Folic acid alleviates neuroinflammation after intracerebral hemorrhage by epigenetically regulating the AMPD2\/DCK\/NF-\u03baB pathway","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158640","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158640"}}