{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T07:20:17Z","timestamp":1787556017151,"version":"build-2736575974"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.phymed.2026.158647","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T06:38:18Z","timestamp":1785220698000},"page":"158647","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Gasdermin D regulates choroidal blood flow and axial elongation in high myopia and therapeutic potential of apigenin"],"prefix":"10.1016","volume":"160","author":[{"given":"Yujuan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9478-9501","authenticated-orcid":false,"given":"Jingyi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4426-631X","authenticated-orcid":false,"given":"Yunhe","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9245-0921","authenticated-orcid":false,"given":"Shihui","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifeng","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongsheng","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"21","key":"10.1016\/j.phymed.2026.158647_bib0001","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242115839","article-title":"Intraperitoneal injection of MCC950 inhibits the progression of myopia in form-deprivation myopic mice","volume":"24","author":"Chen","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.phymed.2026.158647_bib0002","doi-asserted-by":"crossref","first-page":"27","DOI":"10.31083\/j.fbl2802027","article-title":"Up-regulation of NLRP3 in the sclera correlates with myopia progression in a form-deprivation myopia mouse model","volume":"28","author":"Chen","year":"2023","journal-title":"Front Biosci (Landmark Ed)"},{"issue":"12","key":"10.1016\/j.phymed.2026.158647_bib0003","doi-asserted-by":"crossref","first-page":"e1221","DOI":"10.1016\/S2214-109X(17)30393-5","article-title":"Global causes of blindness and distance vision impairment 1990-2020: a systematic review and meta-analysis","volume":"5","author":"Flaxman","year":"2017","journal-title":"Lancet Glob. Health"},{"issue":"7347","key":"10.1016\/j.phymed.2026.158647_bib0004","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1136\/bmj.324.7347.1195","article-title":"Myopia","volume":"324","author":"Fredrick","year":"2002","journal-title":"BMJ"},{"issue":"12","key":"10.1016\/j.phymed.2026.158647_bib0005","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/cr.2015.139","article-title":"Gasdermin D is an executor of pyroptosis and required for interleukin-1\u03b2 secretion","volume":"25","author":"He","year":"2015","journal-title":"Cell Res."},{"issue":"14","key":"10.1016\/j.phymed.2026.158647_bib0006","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1167\/iovs.64.14.15","article-title":"Topical application of bunazosin hydrochloride suppresses myopia progression with an increase in choroidal blood perfusion","volume":"64","author":"Jeong","year":"2023","journal-title":"Invest. Ophthalmol. Visual Sci."},{"issue":"7575","key":"10.1016\/j.phymed.2026.158647_bib0007","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nature15541","article-title":"Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling","volume":"526","author":"Kayagaki","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2026.158647_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115517","article-title":"Inhibitory effect of miR-138-5p on choroidal fibrosis in lens-induced myopia guinea pigs via suppressing the HIF-1\u03b1 signaling pathway","volume":"211","author":"Li","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158647_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154743","article-title":"Anti-inflammatory effect of Danhong injection through inhibition of GSDMD-mediated pyroptosis","volume":"113","author":"Li","year":"2023","journal-title":"Phytomedicine"},{"issue":"6418","key":"10.1016\/j.phymed.2026.158647_bib0010","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1126\/science.aau2818","article-title":"Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death","volume":"362","author":"Orning","year":"2018","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.phymed.2026.158647_bib0011","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S2225-4110(16)30052-9","article-title":"Anti-inflammatory activity of traditional Chinese medicinal herbs","volume":"1","author":"Pan","year":"2011","journal-title":"J. Tradit. Complement. Med."},{"issue":"2","key":"10.1016\/j.phymed.2026.158647_bib0012","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1167\/iovs.18-25221","article-title":"Prevention and management of myopia and myopic pathology","volume":"60","author":"Saw","year":"2019","journal-title":"Invest. Ophthalmol. Visual Sci."},{"issue":"7575","key":"10.1016\/j.phymed.2026.158647_bib0013","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.phymed.2026.158647_bib0014","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40662-023-00345-2","article-title":"Choroidal vasculature act as predictive biomarkers of long-term ocular elongation in myopic children treated with orthokeratology: a prospective cohort study","volume":"10","author":"Wu","year":"2023","journal-title":"Eye Vis. (Lond)"},{"issue":"1","key":"10.1016\/j.phymed.2026.158647_bib0015","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1167\/iovs.62.1.8","article-title":"Assessment of choroidal vascularity and choriocapillaris blood perfusion in anisomyopic adults by SS-OCT\/OCTA","volume":"62","author":"Wu","year":"2021","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"10.1016\/j.phymed.2026.158647_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2023.109509","article-title":"Choroidal blood perfusion could predict the sensitivity of myopia formation in Guinea pigs","volume":"232","author":"Yang","year":"2023","journal-title":"Exp. Eye Res."},{"issue":"8","key":"10.1016\/j.phymed.2026.158647_bib0017","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.1167\/iovs.18-26397","article-title":"Changes in choroidal thickness and choroidal blood perfusion in Guinea pig myopia","volume":"60","author":"Zhang","year":"2019","journal-title":"Invest. Ophthalmol. Visual Sci."},{"issue":"6549","key":"10.1016\/j.phymed.2026.158647_bib0018","doi-asserted-by":"crossref","DOI":"10.1126\/science.abg0269","article-title":"The lysosomal rag-ragulator complex licenses RIPK1 and caspase-8-mediated pyroptosis by Yersinia","volume":"372","author":"Zheng","year":"2021","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.phymed.2026.158647_bib0019","article-title":"Choroidal blood perfusion as a potential \"rapid predictive index\" for myopia development and progression","volume":"8","author":"Zhou","year":"2021","journal-title":"Eye Vis. (Lond)"},{"issue":"15","key":"10.1016\/j.phymed.2026.158647_bib0020","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1167\/iovs.62.15.30","article-title":"Decreased choroidal blood perfusion induces myopia in Guinea pigs","volume":"62","author":"Zhou","year":"2021","journal-title":"Invest. Ophthalmol. Visual Sci."},{"issue":"13","key":"10.1016\/j.phymed.2026.158647_bib0021","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1167\/iovs.61.13.25","article-title":"Increased choroidal blood perfusion can inhibit form deprivation myopia in Guinea pigs","volume":"61","author":"Zhou","year":"2020","journal-title":"Invest. Ophthalmol. Visual Sci."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326008780?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326008780?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T06:30:40Z","timestamp":1787553040000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326008780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":21,"alternative-id":["S0944711326008780"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158647","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gasdermin D regulates choroidal blood flow and axial elongation in high myopia and therapeutic potential of apigenin","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158647","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158647"}}