{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T07:20:11Z","timestamp":1787556011803,"version":"build-2736575974"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009581","name":"Shaanxi Province Health Commission","doi-asserted-by":"publisher","award":["2023PT-10"],"award-info":[{"award-number":["2023PT-10"]}],"id":[{"id":"10.13039\/501100009581","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011710","name":"Shaanxi Province Department of Science and Technology","doi-asserted-by":"publisher","award":["2023-CX-TD-76"],"award-info":[{"award-number":["2023-CX-TD-76"]}],"id":[{"id":"10.13039\/501100011710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007547","name":"Air Force Medical University","doi-asserted-by":"publisher","award":["LHJJ2023-YX21"],"award-info":[{"award-number":["LHJJ2023-YX21"]}],"id":[{"id":"10.13039\/501100007547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007547","name":"Air Force Medical University","doi-asserted-by":"publisher","award":["LHJJ2024-YX03"],"award-info":[{"award-number":["LHJJ2024-YX03"]}],"id":[{"id":"10.13039\/501100007547","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.phymed.2026.158651","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:41:51Z","timestamp":1785253311000},"page":"158651","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Wedelolactone targets SORBS1 to regulate glycolipid metabolism and suppress inflammation, thereby alleviating diet-induced MASH via multiple pathways"],"prefix":"10.1016","volume":"160","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7431-3753","authenticated-orcid":false,"given":"Wei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weimin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuxing","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meina","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingru","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158651_bib0001","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1698631","article-title":"Exploring the therapeutic potential of baicalin against MCF-7 breast cancer cells: biochemical, in vitro, and computational perspectives","volume":"16","author":"Ali","year":"2026","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158651_bib0002","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/35025089","article-title":"CAP defines a second signalling pathway required for insulin-stimulated glucose transport","volume":"407","author":"Baumann","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2026.158651_bib0003","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.tips.2024.08.009","article-title":"Rezdiffra (resmetirom): a THR-beta agonist for non-alcoholic steatohepatitis","volume":"45","author":"Brisnovali","year":"2024","journal-title":"Trends. Pharmacol. Sci."},{"key":"10.1016\/j.phymed.2026.158651_bib0004","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S1875-5364(25)60821-1","article-title":"A comprehensive review on wedelolactone: natural sources, total synthesis, and pharmacological activities","volume":"23","author":"Cai","year":"2025","journal-title":"Chin. J. Nat. Medicines"},{"key":"10.1016\/j.phymed.2026.158651_bib0005","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.3390\/biom10091332","article-title":"Rescue of hepatic phospholipid remodeling defectin iPLA2\u03b2-null mice attenuates obese but not non-obese fatty liver","volume":"10","author":"Chamulitrat","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.phymed.2026.158651_bib0006","first-page":"1140","article-title":"SORBS1 serves a metastatic role via suppression of AHNAK in colorectal cancer cell lines","volume":"56","author":"Cho","year":"2020","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.phymed.2026.158651_bib0007","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.intimp.2018.04.037","article-title":"Wedelolactone inhibits osteoclastogenesis but enhances osteoblastogenesis through altering different semaphorins production","volume":"60","author":"Deng","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2026.158651_bib0008","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/s41573-024-01084-2","article-title":"Therapeutic landscape of metabolic dysfunction-associated steatohepatitis (MASH)","volume":"24","author":"Do","year":"2025","journal-title":"Nat. Rev. Drug Discovery"},{"key":"10.1016\/j.phymed.2026.158651_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154740","article-title":"Ameliorative effects of mangiferin derivative TPX on insulin resistance via PI3K\/AKT and AMPK signaling pathways in human HepG2 and HL-7702 hepatocytes","volume":"114","author":"Fan","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158651_bib0010","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/s41575-023-00846-4","article-title":"Recompensation in cirrhosis: unravelling the evolving natural history of nonalcoholic fatty liver disease","volume":"21","author":"Feng","year":"2024","journal-title":"Nat. Rev. Gastro. Hepat."},{"key":"10.1016\/j.phymed.2026.158651_bib0011","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.phymed.2026.158651_bib0012","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/hep.29820","article-title":"Tumor progression locus 2 in hepatocytes potentiates both liver and systemic metabolic disorders in mice","volume":"69","author":"Gong","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2026.158651_bib0013","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.3524","article-title":"A variation in SORBS1 is associated with type 2 diabetes and high-density lipoprotein cholesterol in Chinese population","volume":"38","author":"Gong","year":"2022","journal-title":"Diabetes Metab. Res"},{"key":"10.1016\/j.phymed.2026.158651_bib0014","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1001\/jama.2020.10434","article-title":"Nonalcoholic steatohepatitis","volume":"324","author":"Grajower","year":"2020","journal-title":"JAMA J. Am. Med. Assoc."},{"key":"10.1016\/j.phymed.2026.158651_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.106046","article-title":"Deoxyhypusine hydroxylase as a novel pharmacological target for ischemic stroke via inducing a unique post-translational hypusination modification","volume":"176","author":"Guo","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2026.158651_bib0016","doi-asserted-by":"crossref","first-page":"5220","DOI":"10.7150\/thno.71400","article-title":"Loss of MLKL ameliorates liver fibrosis by inhibiting hepatocyte necroptosis and hepatic stellate cell activation","volume":"12","author":"Guo","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.phymed.2026.158651_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2022.105355","article-title":"Wedelolactone: a molecule of interests","volume":"164","author":"Ha","year":"2023","journal-title":"Fitoterapia"},{"key":"10.1016\/j.phymed.2026.158651_bib0018","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/s41591-023-02242-6","article-title":"Challenges and opportunities in NASH drug development","volume":"29","author":"Harrison","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.phymed.2026.158651_bib0019","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1056\/NEJMoa2309000","article-title":"A phase 3, randomized, controlled trial of resmetirom in NASH with liver fibrosis","volume":"390","author":"Harrison","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phymed.2026.158651_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157172","article-title":"Celastrol ameliorates metabolic dysfunction associated steatohepatitis by regulating the CYP7B1-mediated alternative bile acid synthetic pathway","volume":"147","author":"Hu","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158651_bib0021","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1002\/hep.32066","article-title":"Salidroside activates the AMP-activated protein kinase pathway to suppress nonalcoholic steatohepatitis in mice","volume":"74","author":"Hu","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2026.158651_bib0022","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.1038\/s41591-025-03799-0","article-title":"Modulation of metabolic, inflammatory and fibrotic pathways by semaglutide in metabolic dysfunction-associated steatohepatitis","volume":"31","author":"Jara","year":"2025","journal-title":"Nat. Med."},{"key":"10.1016\/j.phymed.2026.158651_bib0023","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1210\/me.2003-0294","article-title":"Skeletal muscle cells and adipocytes differ in their reliance on TC10 and Rac for insulin-induced actin remodeling","volume":"18","author":"JeBailey","year":"2004","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.phymed.2026.158651_bib0024","doi-asserted-by":"crossref","first-page":"42436","DOI":"10.1074\/jbc.M108297200","article-title":"Insulin-stimulated GLUT4 translocation in adipocytes is dependent upon cortical actin remodeling","volume":"276","author":"Kanzaki","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2026.158651_bib0025","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/sj.cdd.4401325","article-title":"Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex","volume":"11","author":"Kobori","year":"2004","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.phymed.2026.158651_bib0026","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/hep.32221","article-title":"Breviscapine alleviates NASH by inhibiting TGF-\u03b2-activated kinase 1-dependent signaling","volume":"76","author":"Lan","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2026.158651_bib0027","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1002\/hep.31749","article-title":"Cordycepin ameliorates nonalcoholic steatohepatitis by activation of the AMP-activated protein kinase signaling pathway","volume":"74","author":"Lan","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2026.158651_bib0028","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nm1550","article-title":"Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance","volume":"13","author":"Lesniewski","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.phymed.2026.158651_bib0029","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1006\/geno.2001.6541","article-title":"Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-abl during insulin signaling in the hepatoma cell line Hep3B","volume":"74","author":"Lin","year":"2001","journal-title":"Genomics"},{"key":"10.1016\/j.phymed.2026.158651_bib0030","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/j.cell.2021.04.015","article-title":"Mechanisms and disease consequences of nonalcoholic fatty liver disease","volume":"184","author":"Loomba","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2026.158651_bib0031","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.jare.2024.12.016","article-title":"Natural small molecule hinokitone mitigates NASH fibrosis by targeting regulation of FXR-mediated hepatocyte apoptosis","volume":"76","author":"Ma","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.phymed.2026.158651_bib0032","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev-pharmtox-010715-103715","article-title":"The cellular thermal shift assay: a novel biophysical assay for In situ drug target engagement and mechanistic biomarker studies","volume":"56","author":"Martinez Molina","year":"2016","journal-title":"Annu. Rev. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158651_bib0033","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.tem.2024.02.007","article-title":"Current status and future trends of the global burden of MASLD","volume":"35","author":"Miao","year":"2024","journal-title":"Trends Endocrin. Met."},{"key":"10.1016\/j.phymed.2026.158651_bib0034","doi-asserted-by":"crossref","first-page":"729","DOI":"10.3390\/ijms18040729","article-title":"Wedelolactone acts as proteasome inhibitor in breast cancer cells","volume":"18","author":"Nehybova","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158651_bib0035","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1039\/C5NP00101C","article-title":"Target identification of natural products and bioactive compounds using affinity-based probes","volume":"33","author":"Pan","year":"2016","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.phymed.2026.158651_bib0036","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.3892\/ijo.2012.1664","article-title":"Wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKC\u03b5 without inhibiting Akt","volume":"41","author":"Sarveswaran","year":"2012","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.phymed.2026.158651_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2022.155164","article-title":"The interactions of CAP and LYN with the insulin signaling transducer CBL play an important role in polycystic ovary syndrome","volume":"131","author":"Shen","year":"2022","journal-title":"Metabolism"},{"key":"10.1016\/j.phymed.2026.158651_bib0038","first-page":"10","article-title":"Comparison of pharmacological therapies in metabolic dysfunction-associated steatohepatitis for fibrosis regression and MASH resolution: systematic review and network meta-analysis","author":"Souza","year":"2025","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2026.158651_bib0039","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1172\/JCI200112348","article-title":"Insulin-induced cortical actin remodeling promotes GLUT4 insertion at muscle cell membrane ruffles","volume":"108","author":"Tong","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2026.158651_bib0040","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s00395-014-0411-3","article-title":"The adapter protein c-cbl-associated protein (CAP) protects from acute CVB3-mediated myocarditis through stabilization of type I interferon production and reduced cytotoxicity","volume":"109","author":"Valaperti","year":"2014","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.phymed.2026.158651_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106822","article-title":"The adaptor protein c-cbl-associated protein (CAP) limits pro-inflammatory cytokine expression by inhibiting the NF-kappaB pathway","volume":"87","author":"Vdovenko","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2026.158651_bib0042","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1002\/hep.22541","article-title":"Switch from type II to I Fas\/CD95 death signaling on in vitro culturing of primary hepatocytes","volume":"48","author":"Walter","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2026.158651_bib0045","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.jare.2025.05.014","article-title":"Hyperoside modulates bile acid and fatty acid metabolism, presenting a potentially promising treatment for non-alcoholic fatty liver disease","volume":"80","author":"Wang","year":"2026","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.phymed.2026.158651_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155124","article-title":"Wedelolactone alleviates cholestatic liver injury by regulating FXR-bile acid-NF-kB\/Nrf2 axis to reduce bile acid accumulation and its subsequent inflammation and oxidative stress","volume":"122","author":"Wang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158651_bib0046","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.gendis.2021.02.008","article-title":"Comparison of hepatic gene expression profiles between three mouse models of nonalcoholic fatty liver disease","volume":"9","author":"Xiang","year":"2022","journal-title":"Genes. Dis."},{"key":"10.1016\/j.phymed.2026.158651_bib0047","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.jare.2025.07.048","article-title":"Multi-target regulation by artemether in MAFLD through EGFR\/HSP90 pathways","volume":"83","author":"Xu","year":"2026","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.phymed.2026.158651_bib0048","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202414587","article-title":"Isoquercitrin alleviates diabetic nephropathy by inhibiting STAT3 phosphorylation and dimerization","volume":"12","author":"Xuan","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.phymed.2026.158651_bib0049","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153843","article-title":"Phytochemical wedelolactone reverses obesity by prompting adipose browning through SIRT1\/AMPK\/PPARa pathway via targeting nicotinamide N-methyltransferase","volume":"94","author":"Yao","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158651_bib0050","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1161\/CIRCRESAHA.119.315861","article-title":"Celastrol attenuates angiotensin II-induced cardiac remodeling by targeting STAT3","volume":"126","author":"Ye","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2026.158651_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119557","article-title":"Wedelolactone activates the PI3K\/AKT\/NRF2 and SLC7A11\/GPX4 signalling pathways to alleviate oxidative stress and ferroptosis and improve sepsis-induced liver injury","volume":"344","author":"Yin","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158651_bib0052","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41392-020-00447-6","article-title":"Small molecule induces mitochondrial fusion for neuroprotection via targeting CK2 without affecting its conventional kinase activity","volume":"6","author":"Zeng","year":"2021","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2026.158651_bib0053","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1021\/acscentsci.2c01424","article-title":"Macrophage inactivation by small molecule wedelolactone via targeting SEH for the treatment of LPS-induced acute lung injury","volume":"9","author":"Zhang","year":"2023","journal-title":"ACS. Cent. Sci."},{"key":"10.1016\/j.phymed.2026.158651_bib0054","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1089\/rej.2024.0053","article-title":"Wedelolactone attenuates liver fibrosis and hepatic stellate cell activation by suppressing the hippo pathway","volume":"27","author":"Zhang","year":"2024","journal-title":"Rejuv. Res."},{"key":"10.1016\/j.phymed.2026.158651_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155237","article-title":"Ethanol extract of Verbena officinalis alleviates MCAO-induced ischaemic stroke by inhibiting IL17A pathway-regulated neuroinflammation","volume":"123","author":"Zhang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158651_bib0056","article-title":"Neuroinflammation inhibition by small-molecule targeting USP7 noncatalytic domain for neurodegenerative disease therapy","volume":"8","author":"Zhang","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.phymed.2026.158651_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157329","article-title":"Angelica sinensis and Scutellaria baicalensis synergistically alleviates metabolic dysfunction-associated steatohepatitis via promoting adipose tissue-to-liver tissue communication","volume":"148","author":"Zhao","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158651_bib0058","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3350\/cmh.2024.0047","article-title":"Ursolic acid targets secreted phosphoprotein 1 to regulate Th17 cells against metabolic dysfunction-associated steatotic liver disease","volume":"30","author":"Zheng","year":"2024","journal-title":"Clin. Mol. Hepatol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326008822?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326008822?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T06:29:54Z","timestamp":1787552994000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326008822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":57,"alternative-id":["S0944711326008822"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158651","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Wedelolactone targets SORBS1 to regulate glycolipid metabolism and suppress inflammation, thereby alleviating diet-induced MASH via multiple pathways","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158651","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158651"}}