{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T07:19:40Z","timestamp":1787555980437,"version":"build-2736575974"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012156","name":"Shenzhen Technical Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.phymed.2026.158672","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:23:05Z","timestamp":1785453785000},"page":"158672","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Loki Zupa alleviates type 2-high acute asthma airway inflammation by regulating the glutathione metabolism-ferroptosis axis"],"prefix":"10.1016","volume":"160","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7644-4386","authenticated-orcid":false,"given":"Huijie","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maimaititusun","family":"Yalikun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiemin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5953-4507","authenticated-orcid":false,"given":"Qiaoqi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5194-367X","authenticated-orcid":false,"given":"Jingcheng","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158672_bib0001","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00281-019-00776-x","article-title":"Omics for the future in asthma","volume":"42","author":"Abdel-Aziz","year":"2020","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.phymed.2026.158672_bib0002","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41392-024-02088-5","article-title":"In defence of ferroptosis","volume":"10","author":"Alves","year":"2025","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.phymed.2026.158672_bib0003","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s41581-023-00689-x","article-title":"Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney","volume":"19","author":"Bay\u0131r","year":"2023","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.phymed.2026.158672_bib0004","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.immuni.2024.03.019","article-title":"Ironing out the role of ferroptosis in immunity","volume":"57","author":"Bell","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.phymed.2026.158672_bib0005","doi-asserted-by":"crossref","first-page":"548","DOI":"10.3390\/antiox12030548","article-title":"Oxidativestress and inflammation in acute and chronic lung Injuries","volume":"12","author":"Bezerra","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2026.158672_bib0006","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s12943-025-02337-3","article-title":"Reprogrammed immuno-metabolic environment of cancer: the driving force of ferroptosis resistance","volume":"24","author":"Bhowmick","year":"2025","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.phymed.2026.158672_bib0007","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13045-024-01564-3","article-title":"Ferroptosis: principles and significance in health and disease","volume":"17","author":"Chen","year":"2024","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.phymed.2026.158672_bib0008","first-page":"26","article-title":"GSTM1 suppresses cardiac fibrosis post-myocardial infarction through inhibiting lipid peroxidation and ferroptosis","volume":"12","author":"Chen","year":"2025","journal-title":"Mil. Med. Res."},{"key":"10.1016\/j.phymed.2026.158672_bib0009","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.freeradbiomed.2023.09.004","article-title":"TFEB regulates cellular labile iron and prevents ferroptosis in a TfR1-dependent manner","volume":"208","author":"Chen","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2026.158672_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106682","article-title":"Integrating network analysis and experimental validation to reveal the mitophagy-associated mechanism of Yiqi Huoxue (YQHX) prescription in the treatment of myocardial ischemia\/reperfusion injury","volume":"189","author":"Chen","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2026.158672_bib0011","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13020-024-00918-w","article-title":"Recent advances in the potential effects of natural products from traditional Chinese medicine against respiratory diseases targeting ferroptosis","volume":"19","author":"Chen","year":"2024","journal-title":"Chin. Med."},{"key":"10.1016\/j.phymed.2026.158672_bib0012","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/s41419-023-05716-0","article-title":"The interaction between ferroptosis and inflammatory signaling pathways","volume":"14","author":"Chen","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2026.158672_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2024.106488","article-title":"A natural protopanaxatriol from Panax notoginseng enhances osteosarcoma sensitivity to ferroptosis via ASCL4 upregulation","volume":"122","author":"Chen","year":"2024","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.phymed.2026.158672_bib0014","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1038\/s41556-024-01360-8","article-title":"A guideline on the molecular ecosystem regulating ferroptosis","volume":"26","author":"Dai","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.phymed.2026.158672_bib0015","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41580-024-00703-5","article-title":"The cell biology of ferroptosis","volume":"25","author":"Dixon","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2026.158672_bib0016","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.phymed.2026.158672_bib0017","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1089\/ars.2011.4198","article-title":"Glutathione redox control of asthma: from molecular mechanisms to therapeutic opportunities","volume":"17","author":"Fitzpatrick","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.phymed.2026.158672_bib0018","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41392-022-01004-z","article-title":"ACSL4, PUFA, and ferroptosis: new arsenal in anti-tumor immunity","volume":"7","author":"Gan","year":"2022","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.phymed.2026.158672_bib0019","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1517\/17460441.2015.1032936","article-title":"The MM\/PBSA and MM\/GBSA methods to estimate ligand-binding affinities","volume":"10","author":"Genheden","year":"2015","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.phymed.2026.158672_bib0020","series-title":"Global Strategy for Asthma Management and Prevention [WWW Document]","year":"2025"},{"key":"10.1016\/j.phymed.2026.158672_bib0021","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70116","article-title":"Ferroptosis in pulmonary disease and lung cancer: molecular mechanisms, crosstalk regulation, and therapeutic strategies","volume":"6","author":"Guo","year":"2025","journal-title":"MedComm"},{"key":"10.1016\/j.phymed.2026.158672_bib0022","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1038\/s41423-025-01357-9","article-title":"Immunotherapy for asthma","volume":"22","author":"Hammad","year":"2025","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.phymed.2026.158672_bib0023","first-page":"5","article-title":"Study on the abnormal body fluid classification of asthma in Uyghur medicine and its relationship with the oxidation-antioxidant system","volume":"4","author":"Hamurat","year":"1999","journal-title":"Chinese J. Ethnomed. Ethnopharm."},{"key":"10.1016\/j.phymed.2026.158672_bib0024","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00764-021-00087-8","article-title":"Qualitative and quantitative analyses of labiatenic acid, apigenin and buddleoside in Hyssopus officinalis by high-performance thin-layer chromatography","volume":"34","author":"Han","year":"2021","journal-title":"J. Planar Chromatogr."},{"key":"10.1016\/j.phymed.2026.158672_bib0025","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2015.25","article-title":"Asthma","volume":"1","author":"Holgate","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.phymed.2026.158672_bib0026","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1021\/ci100275a","article-title":"Assessing the performance of the MM\/PBSA and MM\/GBSA methods. 1. The accuracy of binding free energy calculations based on molecular dynamics simulations","volume":"51","author":"Hou","year":"2011","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.phymed.2026.158672_bib0027","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1080\/13880209.2022.2104327","article-title":"Louki Zupa decoction attenuates the airway inflammation in acute asthma mice induced by ovalbumin through IL-33\/ST2-NF-\u03baB\/GSK3\u03b2 \/mTOR signalling pathway","volume":"60","author":"Huang","year":"2022","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.phymed.2026.158672_bib0028","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S2213-2600(24)00383-7","article-title":"Asthma: epidemiology, risk factors, and opportunities for prevention and treatment","volume":"13","author":"Jayasooriya","year":"2025","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.phymed.2026.158672_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.jshs.2025.101032","article-title":"Exerkines: potential regulators of ferroptosis","volume":"14","author":"Jia","year":"2025","journal-title":"J. Sport Health Sci."},{"key":"10.1016\/j.phymed.2026.158672_bib0030","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2026.158672_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103660","article-title":"Protein S-glutathionylation confers cellular resistance to ferroptosis induced by glutathione depletion","volume":"83","author":"Ju","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.phymed.2026.158672_bib0032","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.3390\/cells10092177","article-title":"A universal approach to analyzing transmission electron microscopy with imageJ","volume":"10","author":"Lam","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.phymed.2026.158672_bib0033","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s12016-025-09053-2","article-title":"Inhalant mediated allergy: immunobiology, clinical manifestations and diagnosis","volume":"68","author":"Lam","year":"2025","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.phymed.2026.158672_bib0034","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1038\/s41590-025-02212-9","article-title":"The immunology of asthma","volume":"26","author":"Lambrecht","year":"2025","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.phymed.2026.158672_bib0035","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/nm.2737","article-title":"The airway epithelium in asthma","volume":"18","author":"Lambrecht","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.phymed.2026.158672_bib0036","article-title":"Osthole inhibits proliferation and induces autophagy-dependent ferroptosis of cervical cancer cells through induction of TFR1","volume":"136","author":"Li","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158672_bib0037","first-page":"842","article-title":"Study on the determination of total polyphenols and total flavonoids and antioxidant activity in compound Loki Zupa","volume":"44","author":"Li","year":"2021","journal-title":"J. Xinjiang Med. Univ."},{"key":"10.1016\/j.phymed.2026.158672_bib0038","doi-asserted-by":"crossref","DOI":"10.1080\/13510002.2024.2444755","article-title":"CEACAM5 exacerbates asthma by inducing ferroptosis and autophagy in airway epithelial cells through the JAK\/STAT6-dependent pathway","volume":"30","author":"Liu","year":"2025","journal-title":"Redox Rep."},{"key":"10.1016\/j.phymed.2026.158672_bib0039","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70268","article-title":"Oxidative stress: signaling pathways, biological functions, and disease","volume":"6","author":"Liu","year":"2025","journal-title":"MedComm"},{"key":"10.1016\/j.phymed.2026.158672_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153894","article-title":"Dihydroquercetin suppresses cigarette smoke induced ferroptosis in the pathogenesis of chronic obstructive pulmonary disease by activating Nrf2-mediated pathway","volume":"96","author":"Liu","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158672_bib0041","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3389\/fphar.2018.00351","article-title":"A multicenter, randomized, double-Blind, placebo-controlled study of the effects of Loki Zupa in patients with chronic asthma","volume":"9","author":"Lv","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158672_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103100","article-title":"IL-13 facilitates ferroptotic death in asthmatic epithelial cells via SOCS1-mediated ubiquitinated degradation of SLC7A11","volume":"71","author":"Miao","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.phymed.2026.158672_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2021.101026","article-title":"Molecular mechanisms of oxidative stress in asthma","volume":"85","author":"Michaeloudes","year":"2022","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.phymed.2026.158672_bib0044","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/s41580-025-00843-2","article-title":"Recommendations for robust and reproducible research on ferroptosis","volume":"26","author":"Mishima","year":"2025","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2026.158672_bib0045","doi-asserted-by":"crossref","DOI":"10.1172\/JCI151685","article-title":"15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation","volume":"132","author":"Nagasaki","year":"2022","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2026.158672_bib0046","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.tips.2021.11.004","article-title":"Network pharmacology: curing causal mechanisms instead of treating symptoms","volume":"43","author":"Nogales","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.phymed.2026.158672_bib0047","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.pharmthera.2017.04.003","article-title":"Inhaled efficacious dose translation from rodent to human: a retrospective analysis of clinical standards for respiratory diseases","volume":"178","author":"Phillips","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2026.158672_bib0048","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/jcc.21372","article-title":"Fast and accurate predictions of binding free energies using MM-PBSA and MM-GBSA","volume":"31","author":"Rastelli","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.phymed.2026.158672_bib0049","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1021\/acscentsci.7b00589","article-title":"Resolving the role of lipoxygenases in the initiation and execution of ferroptosis","volume":"4","author":"Shah","year":"2018","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.phymed.2026.158672_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2026.2655834","article-title":"Ferritinophagy and organ injury","volume":"22","author":"Shao","year":"2026","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2026.158672_bib0051","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/s41586-025-09331-1","article-title":"Epithelial cell membrane perforation induces allergic airway inflammation","volume":"645","author":"Shi","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2026.158672_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102970","article-title":"Molecular mechanism of interleukin-17A regulating airway epithelial cell ferroptosis based on allergic asthma airway inflammation","volume":"68","author":"Song","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.phymed.2026.158672_bib0053","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111001","article-title":"TMT-based quantitative proteomics reveals suppression of SLC3A2 and ATP1A3 expression contributes to the inhibitory role of acupuncture on airway inflammation in an OVA-induced mouse asthma model","volume":"134","author":"Tang","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2026.158672_bib0054","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157746","article-title":"Verbascoside mitigated ferroptosis in asthma pathogenesis and suppressed macrophages chemotaxis and inflammation","volume":"150","author":"Tang","year":"2026","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158672_bib0055","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/ptr.70124","article-title":"Icariin inhibits NF-\u03baB signaling in asthmatic lung epithelium by promoting Nrf2 signaling","volume":"40","author":"Wang","year":"2026","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2026.158672_bib0056","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13020-016-0094-9","article-title":"Loki zupa (Luooukezupa) decoction reduced airway inflammation in an OVA-induced asthma mouse model","volume":"11","author":"Wei","year":"2016","journal-title":"Chin. Med."},{"key":"10.1016\/j.phymed.2026.158672_bib0057","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.immuni.2025.11.018","article-title":"Tolerance to ferroptosis facilitates lipid metabolism and pathogenic type 2 immunity in allergic airway inflammation","volume":"59","author":"Wientjens","year":"2026","journal-title":"Immunity"},{"key":"10.1016\/j.phymed.2026.158672_bib0058","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1183\/09031936.03.00017003a","article-title":"Biomarkers of lipid peroxidation, airway inflammation and asthma","volume":"21","author":"Wood","year":"2003","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.phymed.2026.158672_bib0059","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2024.101050","article-title":"The molecular and metabolic landscape of ferroptosis in respiratory diseases: pharmacological aspects","volume":"15","author":"Wu","year":"2025","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.phymed.2026.158672_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115351","article-title":"Integrated systems pharmacology and transcriptomics to dissect the mechanisms of Loki Zupa decoction in the treatment of murine allergic asthma","volume":"294","author":"Xie","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158672_bib0061","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155738","article-title":"Targeting ferroptosis using chinese herbal compounds to treat respiratory diseases","volume":"130","author":"Xu","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158672_bib0062","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s10565-025-10049-z","article-title":"Loss of YTHDF1 suppresses the progression of malignant rhabdoid tumor of the kidney by regulating Glutathione S-transferase Mu 2 (GSTM2)","volume":"41","author":"Xiong","year":"2025","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.phymed.2026.158672_bib0063","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3390\/molecules31020205","article-title":"Study on comprehensive quality control of herba hyssopi based on chemical components and pharmacological mechanism action","volume":"31","author":"Zhao","year":"2026","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2026.158672_bib0064","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.tcb.2025.01.005","article-title":"Autophagy-dependent versus autophagy-independent ferroptosis","volume":"35","author":"Zhu","year":"2025","journal-title":"Trends Cell Biol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326009049?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326009049?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T06:25:14Z","timestamp":1787552714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326009049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":64,"alternative-id":["S0944711326009049"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158672","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loki Zupa alleviates type 2-high acute asthma airway inflammation by regulating the glutathione metabolism-ferroptosis axis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158672","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158672"}}