{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T07:20:16Z","timestamp":1787556016518,"version":"build-2736575974"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008402","name":"Chengdu University of Traditional Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.phymed.2026.158683","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:35:48Z","timestamp":1785800148000},"page":"158683","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Single-cell and bulk RNA-seq with machine learning reveals CCNB1\/CDK1-mediated G2\/M arrest as key anti-HCC mechanism of Fuzheng Xiaozheng Prescription"],"prefix":"10.1016","volume":"160","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0089-7666","authenticated-orcid":false,"given":"Xia","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiexiong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangsen","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7259-2087","authenticated-orcid":false,"given":"Yuxi","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cen","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quansheng","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158683_bib0001","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.tips.2025.10.015","article-title":"Sodium's role and therapeutic targeting in cancer","volume":"47","author":"An","year":"2026","journal-title":"Trends. Pharmacol. Sci."},{"key":"10.1016\/j.phymed.2026.158683_bib0002","doi-asserted-by":"crossref","first-page":"8641","DOI":"10.3390\/ijms25168641","article-title":"Fibrosis and hepatocarcinogenesis: role of gene-environment interactions in liver disease progression","volume":"25","author":"Banerjee","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158683_bib0003","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.3390\/ijms26062578","article-title":"Study on the mechanism of formononetin against hepatocellular carcinoma: regulating metabolic pathways of ferroptosis and cell cycle","volume":"26","author":"Bao","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158683_bib0004","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0154525","article-title":"5-Hydroxy-7-methoxyflavone triggers mitochondrial-associated cell death via reactive oxygen species signaling in Human colon carcinoma cells","volume":"11","author":"Bhardwaj","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2026.158683_bib0005","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.phymed.2026.158683_bib0006","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202400769R","article-title":"Cell cycle machinery in oncology: a comprehensive review of therapeutic targets","volume":"38","author":"Cavalu","year":"2024","journal-title":"FASEB J."},{"key":"10.1016\/j.phymed.2026.158683_bib0007","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1038\/s41586-025-08935-x","article-title":"Cell cycle duration determines oncogenic transformation capacity","volume":"641","author":"Chen","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2026.158683_bib0008","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1080\/14786419.2013.768988","article-title":"Antinociceptive effect of 7-methoxyflavone isolated from Zornia brasiliensis","volume":"27","author":"da Silva","year":"2013","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.phymed.2026.158683_bib0009","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1177\/1535370219898141","article-title":"Mechanisms of liver fibrosis and its role in liver cancer","volume":"245","author":"Dhar","year":"2020","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.phymed.2026.158683_bib0010","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jhep.2024.08.028","article-title":"EASL Clinical Practice Guidelines on the management of hepatocellular carcinoma","volume":"82","year":"2025","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2026.158683_bib0011","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.canlet.2019.05.036","article-title":"The circular RNA circ-Ccnb1 dissociates Ccnb1\/Cdk1 complex suppressing cell invasion and tumorigenesis","volume":"459","author":"Fang","year":"2019","journal-title":"Cancer Lett."},{"key":"10.1016\/j.phymed.2026.158683_bib0012","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/s41586-022-05289-6","article-title":"Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis","volume":"610","author":"Filliol","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2026.158683_bib0013","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20181441","article-title":"Bioinformatics identification of crucial genes and pathways associated with hepatocellular carcinoma","volume":"38","author":"Gao","year":"2018","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.phymed.2026.158683_bib0014","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.3390\/cancers17182971","article-title":"Impact of serum albumin levels on prognosis and recurrence in patients with hepatocellular carcinoma","volume":"17","author":"Hayata","year":"2025","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.phymed.2026.158683_bib0015","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.2174\/0113816128322791240722064234","article-title":"Network pharmacology to reveal the mechanism of Fufang Banmao Capsule for treating unresectable primary liver cancer and clinical data validation","volume":"30","author":"Hu","year":"2024","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.phymed.2026.158683_bib0016","doi-asserted-by":"crossref","first-page":"239","DOI":"10.17998\/jlc.2025.08.21","article-title":"Navigating liver cancer with mouse models: a comprehensive overview of HCC experimental systems","volume":"25","author":"Kim","year":"2025","journal-title":"J. Liver Cancer"},{"key":"10.1016\/j.phymed.2026.158683_bib0017","doi-asserted-by":"crossref","DOI":"10.1155\/jamc\/4646858","article-title":"The active ingredients and potential mechanism of Qijia Rougan decoction in autophagy and hepatic stellate cell activation modulation in liver fibrogenesis","volume":"2025","author":"Li","year":"2025","journal-title":"J. Anal. Methods Chem."},{"key":"10.1016\/j.phymed.2026.158683_bib0018","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12943-024-02213-6","article-title":"Tailoring traditional Chinese medicine in cancer therapy","volume":"24","author":"Li","year":"2025","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.phymed.2026.158683_bib0019","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.3390\/ph17091159","article-title":"Knockdown and overexpression experiments to investigate the inhibitory mechanism of Fuzheng Xiaozheng Prescription, an effective Chinese herbal formula for the clinical treatment of hepatocellular carcinoma","volume":"17","author":"Li","year":"2024","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.phymed.2026.158683_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114801","article-title":"Fuzheng Xiaozheng prescription relieves rat hepatocellular carcinoma through improving anti-inflammation capacity and regulating lipid related metabolisms","volume":"284","author":"Li","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158683_bib0021","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2147\/JHC.S346047","article-title":"Current perspective of traditional Chinese medicines and active ingredients in the therapy of hepatocellular carcinoma","volume":"9","author":"Li","year":"2022","journal-title":"J. HepatoCell Carcinoma"},{"key":"10.1016\/j.phymed.2026.158683_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154226","article-title":"Fuzheng Xiaozheng prescription exerts anti-hepatocellular carcinoma effects by improving lipid and glucose metabolisms via regulating circRNA-miRNA-mRNA networks","volume":"103","author":"Liu","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158683_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114913","article-title":"Anti-hepatocellular carcinoma efficacy of Fuzheng Xiaozheng prescription and its interventional mechanism studies","volume":"285","author":"Liu","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158683_bib0024","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tcb.2021.07.001","article-title":"Cell cycle on the crossroad of tumorigenesis and cancer therapy","volume":"32","author":"Liu","year":"2022","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.phymed.2026.158683_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.152930","article-title":"Effects of adjuvant traditional Chinese medicine therapy on long-term survival in patients with hepatocellular carcinoma","volume":"62","author":"Liu","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158683_bib0026","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1089\/acm.2019.0334","article-title":"Fufang Banmao Capsule, a traditional Chinese medicinal formulation, enhances the survival of patients with hepatocellular carcinoma and Vp3-4 portal vein tumor thrombosis undergoing supportive treatment","volume":"26","author":"Liu","year":"2020","journal-title":"J. Altern. Complement. Med."},{"key":"10.1016\/j.phymed.2026.158683_bib0027","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/s41586-024-07517-7","article-title":"Single-cell nascent RNA sequencing unveils coordinated global transcription","volume":"631","author":"Mahat","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2026.158683_bib0028","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1016\/j.cgh.2019.07.060","article-title":"Contemporary epidemiology of chronic liver disease and cirrhosis","volume":"18","author":"Moon","year":"2020","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2026.158683_bib0029","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.3390\/cancers15133269","article-title":"Risk of treatment failure and death after ablation in hepatocellular carcinoma patients-a multiparametric prediction","volume":"15","author":"Munoz-Martinez","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.phymed.2026.158683_bib0030","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.3748\/wjg.v29.i8.1243","article-title":"Predictors of early and late hepatocellular carcinoma recurrence","volume":"29","author":"Nevola","year":"2023","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.phymed.2026.158683_bib0031","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.freeradbiomed.2023.05.001","article-title":"Discovery of 3,7-dimethoxyflavone that inhibits liver fibrosis based on dual mechanisms of antioxidant and inhibitor of activated hepatic stellate cell","volume":"204","author":"Park","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2026.158683_bib0032","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/tpj.15567","article-title":"Cell cycle checkpoint control in response to DNA damage by environmental stresses","volume":"109","author":"Pedroza-Garcia","year":"2022","journal-title":"Plant J."},{"key":"10.1016\/j.phymed.2026.158683_bib0033","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ydbio.2019.03.014","article-title":"Lack of cyclin B1 in zebrafish causes lengthening of G2 and M phases","volume":"451","author":"Petrachkova","year":"2019","journal-title":"Dev. Biol."},{"key":"10.1016\/j.phymed.2026.158683_bib0034","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.jhep.2021.11.018","article-title":"BCLC strategy for prognosis prediction and treatment recommendation: the 2022 update","volume":"76","author":"Reig","year":"2022","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2026.158683_bib0035","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1177\/15353702211049149","article-title":"CCNB1 promotes the development of hepatocellular carcinoma by mediating DNA replication in the cell cycle","volume":"247","author":"Rong","year":"2022","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.phymed.2026.158683_bib0036","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.phrs.2018.11.035","article-title":"Cyclin-dependent protein serine\/threonine kinase inhibitors as anticancer drugs","volume":"139","author":"Roskoski","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2026.158683_bib0037","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/s41571-023-00825-3","article-title":"Global trends in hepatocellular carcinoma epidemiology: implications for screening, prevention and therapy","volume":"20","author":"Singal","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.phymed.2026.158683_bib0038","article-title":"Artificial intelligence and machine learning in pharmacological research: bridging the gap between data and drug discovery","volume":"15","author":"Singh","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.phymed.2026.158683_bib0039","series-title":"DEN-Induced Hepatocellular Carcinoma in Animal Model","author":"Sivakumari","year":"2023"},{"key":"10.1016\/j.phymed.2026.158683_bib0040","doi-asserted-by":"crossref","first-page":"11471","DOI":"10.1007\/s00432-023-05004-6","article-title":"The role of CXCL8 and CCNB1 in predicting hepatocellular carcinoma in the context of cirrhosis: implications for early detection and immune-based therapies","volume":"149","author":"Sun","year":"2023","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.phymed.2026.158683_bib0041","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.bbrc.2021.02.117","article-title":"CDK1 inhibitor controls G2\/M phase transition and reverses DNA damage sensitivity","volume":"550","author":"Sunada","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phymed.2026.158683_bib0042","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s10555-023-10084-4","article-title":"Hepatocellular carcinoma: molecular mechanism, targeted therapy, and biomarkers","volume":"42","author":"Wang","year":"2023","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.phymed.2026.158683_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114174","article-title":"Identification of the molecular targets and mechanisms of compound mylabris capsules for hepatocellular carcinoma treatment through network pharmacology and bioinformatics analysis","volume":"276","author":"Wei","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158683_bib0044","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.7150\/thno.25487","article-title":"Blocking CDK1\/PDK1\/beta-catenin signaling by CDK1 inhibitor RO3306 increased the efficacy of sorafenib treatment by targeting cancer stem cells in a preclinical model of hepatocellular carcinoma","volume":"8","author":"Wu","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.phymed.2026.158683_bib0045","article-title":"Single-cell sequencing combined with bulk RNA seq reveals the roles of natural killer cell in prognosis and immunotherapy of hepatocellular carcinoma","volume":"15","author":"Wu","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2026.158683_bib0046","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/s12957-025-03816-z","article-title":"Multiple-omics analysis of aggrephagy-related cellular patterns and development of an aggrephagy-related signature for hepatocellular carcinoma","volume":"23","author":"Xie","year":"2025","journal-title":"World J. Surg. Oncol."},{"key":"10.1016\/j.phymed.2026.158683_bib0047","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12906-023-03975-0","article-title":"Cantharidin suppresses hepatocellular carcinoma development by regulating EZH2\/H3K27me3-dependent cell cycle progression and antitumour immune response","volume":"23","author":"Yan","year":"2023","journal-title":"BMC Complement. Med. Ther."},{"key":"10.1016\/j.phymed.2026.158683_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114806","article-title":"Cyclin-dependent kinase 1 as a potential target for lycorine against hepatocellular carcinoma","volume":"193","author":"Yin","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158683_bib0049","first-page":"25","article-title":"Network pharmacology: towards the artificial intelligence-based precision traditional Chinese medicine","author":"Zhang","year":"2023","journal-title":"Brief. Bioinform."},{"key":"10.1016\/j.phymed.2026.158683_bib0050","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s12672-025-02182-2","article-title":"Identification of CCNB1 as a biomarker for cellular senescence in hepatocellular carcinoma: a bioinformatics and experimental validation study","volume":"16","author":"Zhang","year":"2025","journal-title":"Discov. Oncol."},{"key":"10.1016\/j.phymed.2026.158683_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115794","article-title":"Qijia rougan formula ameliorates ECM deposition in hepatic fibrosis by regulating the JAK1\/STAT6-microRNA-23a feedback loop in macrophage M2 polarization","volume":"168","author":"Zheng","year":"2023","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.phymed.2026.158683_bib0052","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1007\/s00403-025-03896-7","article-title":"METTL3-modified exosomes from adipose-derived stem cells enhance the proliferation and migration of dermal fibroblasts by mediating m6A modification of CCNB1 mRNA","volume":"317","author":"Zhou","year":"2025","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.phymed.2026.158683_bib0053","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175268","article-title":"7-Methoxyisoflavone suppresses vascular endothelial inflammation by inhibiting the expression of endothelial adhesion molecules","volume":"933","author":"Zhu","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158683_bib0054","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.925289","article-title":"CDK1, CCNB1, and CCNB2 are prognostic biomarkers and correlated with immune infiltration in hepatocellular carcinoma","volume":"26","author":"Zou","year":"2020","journal-title":"Med. Sci. Monit."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326009153?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326009153?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T06:30:38Z","timestamp":1787553038000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326009153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":54,"alternative-id":["S0944711326009153"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158683","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single-cell and bulk RNA-seq with machine learning reveals CCNB1\/CDK1-mediated G2\/M arrest as key anti-HCC mechanism of Fuzheng Xiaozheng Prescription","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158683","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158683"}}