{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:37:40Z","timestamp":1793194660279,"version":"4.5.0"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011785","name":"Guangxi Science and Technology Department","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32160160"],"award-info":[{"award-number":["32160160"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20374"],"award-info":[{"award-number":["U22A20374"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011827","name":"Guangxi Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011827","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2024GXNSFAA010443"],"award-info":[{"award-number":["2024GXNSFAA010443"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.phymed.2026.158703","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T15:45:24Z","timestamp":1786376724000},"page":"158703","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Medicarpin triggers Fas cell surface death receptor-mediated apoptosis by inhibiting epidermal growth factor receptor\/signal transducer and activator of transcription 3 pathway and protective autophagy in liver cancer"],"prefix":"10.1016","volume":"161","author":[{"given":"Yong-zhuo","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-ping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-Ji","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-mei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-wei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1666-4082","authenticated-orcid":false,"given":"Jianzhou","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-dong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2475-7783","authenticated-orcid":false,"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158703_bib0001","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41580-019-0173-8","article-title":"Mitochondria as multifaceted regulators of cell death","volume":"21","author":"Bock","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2026.158703_bib0002","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.phymed.2026.158703_bib0003","first-page":"9","article-title":"Concomitant TP53 mutation confers worse prognosis in EGFR-mutated non-small cell lung cancer patients treated with TKIs","author":"Canale","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.phymed.2026.158703_bib0004","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1158\/1078-0432.CCR-16-0966","article-title":"Impact of TP53 mutations on outcome in EGFR-mutated patients treated with first-line tyrosine kinase inhibitors","volume":"23","author":"Canale","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.phymed.2026.158703_bib0005","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2478\/acph-2023-0016","article-title":"Medicarpin induces G1 arrest and mitochondria-mediated intrinsic apoptotic pathway in bladder cancer cells","volume":"73","author":"Chen","year":"2023","journal-title":"Acta Pharm."},{"key":"10.1016\/j.phymed.2026.158703_bib0006","doi-asserted-by":"crossref","first-page":"247","DOI":"10.5483\/BMBRep.2017.50.5.044","article-title":"CRISPR system for genome engineering: the application for autophagy study","volume":"50","author":"Cui","year":"2017","journal-title":"BMB Rep."},{"key":"10.1016\/j.phymed.2026.158703_bib0007","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1002\/ptr.5820","article-title":"Aloe-emodin induces apoptosis in human liver HL-7702 Cells through fas death pathway and the mitochondrial pathway by generating reactive oxygen species","volume":"31","author":"Dong","year":"2017","journal-title":"PhytOther Res."},{"key":"10.1016\/j.phymed.2026.158703_bib0008","first-page":"1","article-title":"Guideline for the diagnosis and treatment of primary liver cancer (2026 edition)","author":"Fan","year":"2026","journal-title":"Chin. J. Clin. Med."},{"key":"10.1016\/j.phymed.2026.158703_bib0009","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s41401-020-0439-x","article-title":"ACSL4 is a predictive biomarker of sorafenib sensitivity in hepatocellular carcinoma","volume":"42","author":"Feng","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2026.158703_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113417","article-title":"Inhibiting G6PD by quercetin promotes degradation of EGFR T790M mutation","volume":"42","author":"Ge","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.phymed.2026.158703_bib0011","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1126\/science.281.5381.1309","article-title":"Mitochondria and apoptosis","volume":"281","author":"Green","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.phymed.2026.158703_bib0012","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1172\/JCI200317970","article-title":"Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms","volume":"112","author":"Haga","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2026.158703_bib0013","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s11658-023-00438-9","article-title":"Deciphering STAT3 signaling potential in hepatocellular carcinoma: tumorigenesis, treatment resistance, and pharmacological significance","volume":"28","author":"Hashemi","year":"2023","journal-title":"Cell Mol. Biol. Lett."},{"key":"10.1016\/j.phymed.2026.158703_bib0014","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/s41573-022-00571-8","article-title":"Drugging p53 in cancer: one protein, many targets","volume":"22","author":"Hassin","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.phymed.2026.158703_bib0015","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1038\/s41467-023-37223-3","article-title":"Domain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities","volume":"14","author":"Ho","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.158703_bib0016","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s13045-021-01169-0","article-title":"Targeting mutant p53 for cancer therapy: direct and indirect strategies","volume":"14","author":"Hu","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.phymed.2026.158703_bib0017","doi-asserted-by":"crossref","first-page":"7071","DOI":"10.1158\/0008-5472.CAN-11-0128","article-title":"p53 modulates acquired resistance to EGFR inhibitors and radiation","volume":"71","author":"Huang","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.phymed.2026.158703_bib0018","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S1097-2765(01)00199-X","article-title":"Cooperation between STAT3 and c-jun suppresses Fas transcription","volume":"7","author":"Ivanov","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/j.phymed.2026.158703_bib0019","doi-asserted-by":"crossref","first-page":"D1670","DOI":"10.1093\/nar\/gkae973","article-title":"Generic Diagramming Platform (GDP): a comprehensive database of high-quality biomedical graphics","volume":"53","author":"Jiang","year":"2025","journal-title":"Nucleic. Acids. Res."},{"key":"10.1016\/j.phymed.2026.158703_bib0020","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/s41586-021-03741-7","article-title":"EGFR activation limits the response of liver cancer to lenvatinib","volume":"595","author":"Jin","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2026.158703_bib0021","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/1471-2407-8-144","article-title":"Modulatory role of phospholipase D in the activation of signal transducer and activator of transcription (STAT)-3 by thyroid oncogenic kinase RET\/PTC","volume":"8","author":"Kim","year":"2008","journal-title":"BMC. Cancer"},{"key":"10.1016\/j.phymed.2026.158703_bib0022","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2020.1797280","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)","volume":"17","author":"Klionsky","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2026.158703_bib0023","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.4161\/auto.6.8.13366","article-title":"Roles of autophagy in cetuximab-mediated cancer therapy against EGFR","volume":"6","author":"Li","year":"2010","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2026.158703_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155089","article-title":"Andrographolide causes p53-independent HCC cell death through p62 accumulation and impaired DNA damage repair","volume":"121","author":"Li","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158703_bib0025","first-page":"1724","article-title":"Exploration of the mechanism of medicarpin inhibiting the proliferation of hepatoma cells via the p53-dependent cell cycle regulation pathway based on network pharmacology and cell experiment","volume":"47","author":"Li","year":"2024","journal-title":"J. Beijing Univ. Tradition. Chin. Med."},{"key":"10.1016\/j.phymed.2026.158703_bib0026","article-title":"Naringenin enhances the efficacy of ferroptosis inducers by attenuating aerobic glycolysis by activating the AMPK-PGC1\u03b1 signalling axis in liver cancer","volume":"10","author":"Li","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.phymed.2026.158703_bib0027","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/s41401-020-0478-3","article-title":"Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma","volume":"42","author":"Li","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2026.158703_bib0028","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.jhep.2004.02.020","article-title":"A protective role of Stat3 in Fas mediated apoptosis of the liver","volume":"40","author":"Liedtke","year":"2004","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2026.158703_bib0029","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.tips.2018.10.004","article-title":"Autophagy in Cancer: Regulation by Small Molecules","volume":"39","author":"Limpert","year":"2018","journal-title":"Trends. Pharmacol. Sci."},{"key":"10.1016\/j.phymed.2026.158703_bib0030","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12943-024-02046-3","article-title":"Ubiquitination and deubiquitination in cancer: from mechanisms to novel therapeutic approaches","volume":"23","author":"Liu","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.phymed.2026.158703_bib0031","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cell.2009.02.024","article-title":"Principles of cancer therapy: oncogene and non-oncogene addiction","volume":"136","author":"Luo","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2026.158703_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106299","article-title":"Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines","volume":"82","author":"Mansoori","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2026.158703_bib0033","doi-asserted-by":"crossref","first-page":"5810","DOI":"10.1038\/s41467-023-41518-w","article-title":"The tumor microenvironment shows a hierarchy of cell-cell interactions dominated by fibroblasts","volume":"14","author":"Mayer","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.158703_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2020.113803","article-title":"Qualitative and quantitative analysis of the major constituents in Spatholobi Caulis by UFLC-Triple TOF-MS\/MS and UFLC-QTRAP-MS\/MS","volume":"194","author":"Mei","year":"2021","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.phymed.2026.158703_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2020.102043","article-title":"The role of autophagy in resistance to targeted therapies","volume":"88","author":"Mele","year":"2020","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.phymed.2026.158703_bib0036","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.semcancer.2020.03.016","article-title":"Targeting STAT3 signaling pathway in cancer by agents derived from Mother Nature","volume":"80","author":"Mohan","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.phymed.2026.158703_bib0037","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1182\/blood-2007-06-096529","article-title":"Semaphorin3A signaling controls Fas (CD95)-mediated apoptosis by promoting Fas translocation into lipid rafts","volume":"111","author":"Moretti","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.phymed.2026.158703_bib0038","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.genet.33.1.29","article-title":"Fas ligand-induced apoptosis","volume":"33","author":"Nagata","year":"1999","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.phymed.2026.158703_bib0039","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.cell.2023.11.044","article-title":"Cell death","volume":"187","author":"Newton","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2026.158703_bib0040","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0092-8674(02)00963-7","article-title":"Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains","volume":"110","author":"Ogiso","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2026.158703_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2019.07.001","article-title":"A pharmacogenomic landscape in human liver cancers","volume":"36","author":"Qiu","year":"2019","journal-title":"Cancer Cell"},{"key":"10.1016\/j.phymed.2026.158703_bib0042","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrclinonc.2017.151","article-title":"Therapeutic targeting of p53: all mutants are equal, but some mutants are more equal than others","volume":"15","author":"Sabapathy","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.phymed.2026.158703_bib0043","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/ng.3252","article-title":"Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets","volume":"47","author":"Schulze","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.phymed.2026.158703_bib0044","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1002\/jcb.30313","article-title":"Maintenance of increased bone mass after PTH withdrawal by sequential medicarpin treatment via augmentation of cAMP-PKA pathway","volume":"123","author":"Sharma","year":"2022","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.phymed.2026.158703_bib0045","article-title":"Adverse event profiles of EGFR-TKI: network meta-analysis and disproportionality analysis of the FAERS database","volume":"16","author":"Shi","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158703_bib0046","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/s41392-023-01383-x","article-title":"Tumor cell plasticity in targeted therapy-induced resistance: mechanisms and new strategies","volume":"8","author":"Shi","year":"2023","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2026.158703_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217715","article-title":"Identification and characterization of Bufalin as a novel EGFR degrader","volume":"623","author":"Tai","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.phymed.2026.158703_bib0048","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jare.2022.03.012","article-title":"GPX2 is a potential therapeutic target to induce cell apoptosis in lenvatinib against hepatocellular carcinoma","volume":"44","author":"Tan","year":"2023","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.phymed.2026.158703_bib0049","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2019.112978","article-title":"Bioavailability, tissue distribution and excretion studies of a potential anti-osteoporotic agent, medicarpin, in female rats using validated LC-MS\/MS method","volume":"180","author":"Taneja","year":"2020","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.phymed.2026.158703_bib0050","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.429","article-title":"Medicarpin, a legume phytoalexin sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the induction of DR5 and activation of the ROS-JNK-CHOP pathway","volume":"5","author":"Trivedi","year":"2014","journal-title":"Cell Death. Dis."},{"key":"10.1016\/j.phymed.2026.158703_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2022.215880","article-title":"Sorafenib combined with STAT3 knockdown triggers ER stress-induced HCC apoptosis and cGAS-STING-mediated anti-tumor immunity","volume":"547","author":"Wang","year":"2022","journal-title":"Cancer Lett."},{"key":"10.1016\/j.phymed.2026.158703_bib0052","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1111\/bph.15350","article-title":"Quercetin induces p53-independent cancer cell death through lysosome activation by the transcription factor EB and Reactive Oxygen Species-dependent ferroptosis","volume":"178","author":"Wang","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158703_bib0053","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s43556-024-00184-0","article-title":"Signaling pathways in liver cancer: pathogenesis and targeted therapy","volume":"5","author":"Xue","year":"2024","journal-title":"Mol. Biomed."},{"key":"10.1016\/j.phymed.2026.158703_bib0054","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ccell.2024.01.007","article-title":"Precision treatment in advanced hepatocellular carcinoma","volume":"42","author":"Yang","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.phymed.2026.158703_bib0055","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1111\/cbdd.14309","article-title":"Medicarpin suppresses proliferation and triggeres apoptosis by upregulation of BID, BAX, CASP3, CASP8, and CYCS in glioblastoma","volume":"102","author":"Ying","year":"2023","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.phymed.2026.158703_bib0056","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.ijbiomac.2020.02.010","article-title":"FAS\/FAS-L-mediated apoptosis and autophagy of SPC-A-1 cells induced by water-soluble polysaccharide from Polygala tenuifolia","volume":"150","author":"Yu","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2026.158703_bib0057","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1124\/pharmrev.123.000906","article-title":"Targeting epidermal growth factor receptor for cancer treatment: abolishing both kinase-dependent and kinase-independent functions of the receptor","volume":"75","author":"Zhang","year":"2023","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.phymed.2026.158703_bib0058","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/s41392-022-00966-4","article-title":"Targeted protein degradation: mechanisms, strategies and application","volume":"7","author":"Zhao","year":"2022","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2026.158703_bib0059","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1038\/s12276-022-00878-x","article-title":"Simultaneous treatment with sorafenib and glucose restriction inhibits hepatocellular carcinoma in vitro and in vivo by impairing SIAH1-mediated mitophagy","volume":"54","author":"Zhou","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.phymed.2026.158703_bib0060","doi-asserted-by":"crossref","first-page":"338","DOI":"10.4161\/auto.18721","article-title":"Andrographolide sensitizes cisplatin-induced apoptosis via suppression of autophagosome-lysosome fusion in human cancer cells","volume":"8","author":"Zhou","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2026.158703_bib0061","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/s41401-018-0005-y","article-title":"Varacin-1, a novel analog of varacin C, induces p53-independent apoptosis in cancer cells through ROS-mediated reduction of XIAP","volume":"40","author":"Zhou","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2026.158703_bib0062","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1080\/15548627.2021.1984656","article-title":"Full-coverage regulations of autophagy by ROS: from induction to maturation","volume":"18","author":"Zhou","year":"2022","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2026.158703_bib0063","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/cr.2013.11","article-title":"Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion","volume":"23","author":"Zhou","year":"2013","journal-title":"Cell Res."},{"key":"10.1016\/j.phymed.2026.158703_bib0064","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s12943-020-01258-7","article-title":"Targeting STAT3 in cancer immunotherapy","volume":"19","author":"Zou","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.phymed.2026.158703_bib0065","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2015.05.061","article-title":"Genetic landscape and biomarkers of hepatocellular carcinoma","volume":"149","author":"Zucman-Rossi","year":"2015","journal-title":"Gastroenterology"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326009347?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326009347?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:04:49Z","timestamp":1793192689000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326009347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":65,"alternative-id":["S0944711326009347"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158703","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Medicarpin triggers Fas cell surface death receptor-mediated apoptosis by inhibiting epidermal growth factor receptor\/signal transducer and activator of transcription 3 pathway and protective autophagy in liver cancer","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158703","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158703"}}