{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:38:15Z","timestamp":1793194695703,"version":"4.5.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["21KJD350004"],"award-info":[{"award-number":["21KJD350004"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["20KJB350007"],"award-info":[{"award-number":["20KJB350007"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20251694"],"award-info":[{"award-number":["BK20251694"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M773587"],"award-info":[{"award-number":["2025M773587"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","award":["KD2023KYJJ020"],"award-info":[{"award-number":["KD2023KYJJ020"]}],"id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","award":["KD2021KYRC010"],"award-info":[{"award-number":["KD2021KYRC010"]}],"id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","award":["KD2021KYRC020"],"award-info":[{"award-number":["KD2021KYRC020"]}],"id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008081","name":"Southeast University","doi-asserted-by":"publisher","award":["CZXM-GSP-RC180"],"award-info":[{"award-number":["CZXM-GSP-RC180"]}],"id":[{"id":"10.13039\/501100008081","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.phymed.2026.158710","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T07:05:55Z","timestamp":1786518355000},"page":"158710","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["FA receptor-targeted pH-sensitive polymeric micelles co-encapsulating quercetin and paclitaxel for synergistic reversal of drug resistance in non-small cell lung cancer"],"prefix":"10.1016","volume":"161","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1045-3595","authenticated-orcid":false,"given":"Huihui","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyue","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongpo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8496-3185","authenticated-orcid":false,"given":"Meiling","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"23","key":"10.1016\/j.phymed.2026.158710_bib0001","first-page":"11211","article-title":"Influence of quercetin on amiodarone pharmacokinetics and biodistribution in rats","volume":"27","author":"Ahmad","year":"2023","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"1","key":"10.1016\/j.phymed.2026.158710_bib0002","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1038\/s41598-025-88044-x","article-title":"Comparative study of degree, neighborhood and reverse degree based indices for drugs used in lung cancer treatment through QSPR analysis","volume":"15","author":"Arockiaraj","year":"2025","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.phymed.2026.158710_bib0003","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1158\/0008-5472.CAN-14-3763","article-title":"Drug combination studies and their synergy quantification using the Chou-Talalay method\u2013letter","volume":"75","author":"Ashton","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.phymed.2026.158710_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2023.101004","article-title":"Natural medicinal compounds target signal transduction pathways to overcome ABC drug efflux transporter-mediated multidrug resistance in cancer","volume":"71","author":"Bharathiraja","year":"2023","journal-title":"Drug Resist. Updat."},{"issue":"2","key":"10.1016\/j.phymed.2026.158710_bib0005","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.apsb.2020.07.023","article-title":"Cathepsin B-responsive and gadolinium-labeled branched glycopolymer-PTX conjugate-derived nanotheranostics for cancer treatment","volume":"11","author":"Cai","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"2","key":"10.1016\/j.phymed.2026.158710_bib0006","doi-asserted-by":"crossref","first-page":"729","DOI":"10.3390\/ijms22020729","article-title":"A micellar formulation of quercetin prevents cisplatin nephrotoxicity","volume":"22","author":"Casanova","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.phymed.2026.158710_bib0007","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s40580-022-00343-5","article-title":"Accurate delivery of pristimerin and paclitaxel by folic acid-linked nano-micelles for enhancing chemosensitivity in cancer therapy","volume":"9","author":"Chen","year":"2022","journal-title":"Nano Converg."},{"key":"10.1016\/j.phymed.2026.158710_bib0008","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jconrel.2022.01.010","article-title":"Emerging nanomedicines of paclitaxel for cancer treatment","volume":"342","author":"Chen","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.phymed.2026.158710_bib0009","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jconrel.2024.12.073","article-title":"Folate-targeted nanoparticles for glutamine metabolism inhibition enhance anti-tumor immunity and suppress tumor growth in ovarian cancer","volume":"379","author":"Chen","year":"2025","journal-title":"J. Control. Release"},{"issue":"2","key":"10.1016\/j.phymed.2026.158710_bib0010","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1158\/0008-5472.CAN-09-1947","article-title":"Drug combination studies and their synergy quantification using the Chou-Talalay method","volume":"70","author":"Chou","year":"2010","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.phymed.2026.158710_bib0011","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1080\/10717544.2022.2120567","article-title":"A novel ligand-modified nanocomposite microparticles improved efficiency of quercetin and paclitaxel delivery in the non-small cell lung cancer","volume":"29","author":"Cui","year":"2022","journal-title":"Drug Deliv."},{"key":"10.1016\/j.phymed.2026.158710_bib0012","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.addr.2020.10.019","article-title":"Robust and smart polypeptide-based nanomedicines for targeted tumor therapy","volume":"160","author":"Deng","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"4","key":"10.1016\/j.phymed.2026.158710_bib0013","first-page":"571","article-title":"Nucleobase-crosslinked poly(2-oxazoline) nanoparticles as paclitaxel carriers with enhanced stability and ultra-high drug loading capacity for breast cancer therapy","volume":"17","author":"Dong","year":"2022","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.phymed.2026.158710_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2019.01.009","article-title":"Collateral sensitivity of natural products in drug-resistant cancer cells","volume":"38","author":"Efferth","year":"2020","journal-title":"Biotechnol. Adv."},{"issue":"2","key":"10.1016\/j.phymed.2026.158710_bib0015","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1021\/nn405155b","article-title":"Polyethylene glycol conjugated polymeric nanocapsules for targeted delivery of quercetin to folate-expressing cancer cells in vitro and in vivo","volume":"8","author":"El-Gogary","year":"2014","journal-title":"ACS Nano"},{"issue":"12","key":"10.1016\/j.phymed.2026.158710_bib0016","first-page":"4402","article-title":"Carrier-free highly drug-loaded biomimetic nanosuspensions encapsulated by cancer cell membrane based on homology and active targeting for the treatment of glioma","volume":"6","author":"Fan","year":"2021","journal-title":"Bioact. Mater."},{"issue":"5","key":"10.1016\/j.phymed.2026.158710_bib0017","doi-asserted-by":"crossref","first-page":"P9","DOI":"10.1164\/rccm.2055P9","article-title":"Treatment of advanced-stage non-small cell lung cancer","volume":"205","author":"Gesthalter","year":"2022","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.phymed.2026.158710_bib0018","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jconrel.2021.02.031","article-title":"Polymeric micelles in drug delivery: an insight of the techniques for their characterization and assessment in biorelevant conditions","volume":"332","author":"Ghezzi","year":"2021","journal-title":"J. Control. Release"},{"issue":"6","key":"10.1016\/j.phymed.2026.158710_bib0019","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1021\/acsmacrolett.7b00379","article-title":"Ring-opening polymerization of N-carboxyanhydrides initiated by a hydroxyl group","volume":"6","author":"Gradi\u0161ar","year":"2017","journal-title":"ACS Macro Lett."},{"issue":"5","key":"10.1016\/j.phymed.2026.158710_bib0020","doi-asserted-by":"crossref","first-page":"4916","DOI":"10.1021\/acsnano.7b01522","article-title":"Quercetin remodels the tumor microenvironment to improve the permeation, retention, and antitumor effects of nanoparticles","volume":"11","author":"Hu","year":"2017","journal-title":"ACS Nano"},{"issue":"4","key":"10.1016\/j.phymed.2026.158710_bib0021","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.chest.2021.12.655","article-title":"Distribution, risk factors, and temporal trends for lung cancer incidence and mortality: a global analysis","volume":"161","author":"Huang","year":"2022","journal-title":"Chest"},{"key":"10.1016\/j.phymed.2026.158710_bib0022","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jconrel.2020.03.049","article-title":"Improved melanoma suppression with target-delivered TRAIL and Paclitaxel by a multifunctional nanocarrier","volume":"325","author":"Huang","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.phymed.2026.158710_bib0023","doi-asserted-by":"crossref","first-page":"8631","DOI":"10.2147\/IJN.S144452","article-title":"pH-triggered surface charge-switchable polymer micelles for the co-delivery of paclitaxel\/disulfiram and overcoming multidrug resistance in cancer","volume":"12","author":"Huo","year":"2017","journal-title":"Int. J. Nanomed."},{"issue":"1","key":"10.1016\/j.phymed.2026.158710_bib0024","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1021\/acsami.6b13805","article-title":"Enhanced antiglioma efficacy of ultrahigh loading capacity Paclitaxel prodrug conjugate self-assembled targeted nanoparticles","volume":"9","author":"Jiang","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.phymed.2026.158710_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121769","article-title":"Nanoradiosensitizer with good tissue penetration and enhances oral cancer radiotherapeutic effect","volume":"289","author":"Jing","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.phymed.2026.158710_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodhyd.2026.112461","article-title":"Solvent effects on quercetin incorporation, release behavior, and antibacterial efficacy in gelatin\/dialdehyde cellulose composite films: a comparative study","volume":"175","author":"Khin","year":"2026","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.phymed.2026.158710_bib0027","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jconrel.2022.12.061","article-title":"Nanocracker capable of simultaneously reversing both P-glycoprotein and tumor microenvironment","volume":"354","author":"Lee","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.phymed.2026.158710_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122537","article-title":"On\/off\"-switchable crosslinked PTX-nanoformulation with improved precise delivery for NSCLC brain metastases and restrained adverse reaction over nab-PTX","volume":"307","author":"Li","year":"2024","journal-title":"Biomaterials"},{"issue":"12","key":"10.1016\/j.phymed.2026.158710_bib0029","doi-asserted-by":"crossref","first-page":"11756","DOI":"10.1021\/acsnano.4c13277","article-title":"Spatial regulation of cancer-associated fibroblasts and tumor cells via pH-responsive bispecific antibody delivery for enhanced chemo-immunotherapy synergy","volume":"19","author":"Liu","year":"2025","journal-title":"ACS Nano"},{"issue":"3","key":"10.1016\/j.phymed.2026.158710_bib0030","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201601009","article-title":"Quercetin-based modified porous silicon nanoparticles for enhanced inhibition of doxorubicin-resistant cancer cells","volume":"6","author":"Liu","year":"2017","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.phymed.2026.158710_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.02.042","article-title":"Long-acting bioengineered platelets with internal doxorubicin loaded and external quercetin liposomes anchored for post-surgical tumor therapy","volume":"381","author":"Lu","year":"2025","journal-title":"J. Control. Release"},{"issue":"7","key":"10.1016\/j.phymed.2026.158710_bib0032","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.7150\/ijbs.41686","article-title":"Quercetin reverses docetaxel resistance in prostate cancer via androgen receptor and PI3K\/Akt signaling pathways","volume":"16","author":"Lu","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.phymed.2026.158710_bib0033","article-title":"TRAIL-induced apoptosis in TRAIL-resistant breast carcinoma through quercetin cotreatment","volume":"12","author":"Manouchehri","year":"2018","journal-title":"Breast Cancer (Auckl.)"},{"issue":"3","key":"10.1016\/j.phymed.2026.158710_bib0034","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.apsb.2021.09.024","article-title":"Engineering a folic acid-decorated ultrasmall gemcitabine nanocarrier for breast cancer therapy: dual targeting of tumor cells and tumor-associated macrophages","volume":"12","author":"Moharil","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2026.158710_bib0035","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.carbpol.2018.09.020","article-title":"Multifunctional quercetin conjugated chitosan nano-micelles with P-gp inhibition and permeation enhancement of anticancer drug","volume":"203","author":"Mu","year":"2019","journal-title":"Carbohydr. Polym."},{"issue":"10","key":"10.1016\/j.phymed.2026.158710_bib0036","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1142\/S2737416524500509","article-title":"Differentially expressed genes in lung cancer: molecular docking of hypoxanthine guanine-phosphoribosyl transferase with dibutyl phthalate","volume":"23","author":"Naveed","year":"2024","journal-title":"J. Comput. Biophys. Chem."},{"issue":"3","key":"10.1016\/j.phymed.2026.158710_bib0037","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.tem.2021.12.003","article-title":"Emerging roles for folate receptor FOLR1 in signaling and cancer","volume":"33","author":"Nawaz","year":"2022","journal-title":"Trends. Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.phymed.2026.158710_bib0038","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1002\/med.20239","article-title":"Overcoming tumor multidrug resistance using drugs able to evade P-glycoprotein or to exploit its expression","volume":"32","author":"Nobili","year":"2012","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.phymed.2026.158710_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122329","article-title":"Folate conjugated nanomedicines for selective inhibition of mTOR signaling in polycystic kidneys at clinically relevant doses","volume":"302","author":"Pala","year":"2023","journal-title":"Biomaterials"},{"issue":"20","key":"10.1016\/j.phymed.2026.158710_bib0040","doi-asserted-by":"crossref","first-page":"12711","DOI":"10.1021\/acsami.6b03505","article-title":"Acidic pH-triggered drug-eluting nanocomposites for Magnetic resonance imaging-monitored intra-arterial drug delivery to hepatocellular carcinoma","volume":"8","author":"Park","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.phymed.2026.158710_bib0041","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2020.12.011","article-title":"pH-sensitive multi-drug liposomes targeting folate receptor \u03b2 for efficient treatment of non-small cell lung cancer","volume":"330","author":"Park","year":"2021","journal-title":"J. Control. Release"},{"issue":"8","key":"10.1016\/j.phymed.2026.158710_bib0042","doi-asserted-by":"crossref","first-page":"3252","DOI":"10.1016\/j.apsb.2023.02.021","article-title":"Self-assembled nanoformulations of paclitaxel for enhanced cancer theranostics","volume":"13","author":"Pei","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2026.158710_bib0043","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jconrel.2015.01.026","article-title":"Self-assembled nanoscale coordination polymers carrying oxaliplatin and gemcitabine for synergistic combination therapy of pancreatic cancer","volume":"201","author":"Poon","year":"2015","journal-title":"J. Control. Release"},{"issue":"2","key":"10.1016\/j.phymed.2026.158710_bib0044","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1039\/C9TB02055A","article-title":"Programmed co-delivery of platinum nanodrugs and gemcitabine by a clustered nanocarrier for precision chemotherapy for NSCLC tumors","volume":"8","author":"Shi","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.phymed.2026.158710_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2016.05.050","article-title":"Synergistic active targeting of dually integrin \u03b1v\u03b23\/CD44-targeted nanoparticles to B16F10 tumors located at different sites of mouse bodies","volume":"235","author":"Shi","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.phymed.2026.158710_bib0046","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.jconrel.2022.03.060","article-title":"Erythrocyte-biomimetic nanosystems to improve antitumor effects of paclitaxel on epithelial cancers","volume":"345","author":"Song","year":"2022","journal-title":"J. Control. Release"},{"issue":"15","key":"10.1016\/j.phymed.2026.158710_bib0047","article-title":"Plant natural flavonoids against multidrug resistant pathogens","volume":"8","author":"Song","year":"2021","journal-title":"Adv. Sci. (Weinh)"},{"issue":"4","key":"10.1016\/j.phymed.2026.158710_bib0048","article-title":"Pulmonary delivery of mucus-traversing PF127-modified silk fibroin nanoparticles loading with quercetin for lung cancer therapy","volume":"18","author":"Tang","year":"2023","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.phymed.2026.158710_bib0049","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.jconrel.2024.12.077","article-title":"Corrigendum to 'Quercetin-loaded freeze-dried nanomicelles: improving absorption and anti-glioma efficiency in vitro and in vivo.' [G. Wang et al. \/Journal of Controlled Release 235 (2016) 276-290.]","volume":"379","author":"Wang","year":"2025","journal-title":"J. Control. Release"},{"issue":"26","key":"10.1016\/j.phymed.2026.158710_bib0050","doi-asserted-by":"crossref","first-page":"7654","DOI":"10.1016\/j.biomaterials.2014.05.053","article-title":"Amphiphilic carboxymethyl chitosan-quercetin conjugate with P-gp inhibitory properties for oral delivery of paclitaxel","volume":"35","author":"Wang","year":"2014","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.phymed.2026.158710_bib0051","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1080\/10717544.2017.1378940","article-title":"Glioma and microenvironment dual targeted nanocarrier for improved antiglioblastoma efficacy","volume":"24","author":"Wang","year":"2017","journal-title":"Drug Deliv."},{"key":"10.1016\/j.phymed.2026.158710_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111442","article-title":"Targeted delivery of quercetin by nanoparticles based on chitosan sensitizing paclitaxel-resistant lung cancer cells to paclitaxel","volume":"119","author":"Wang","year":"2021","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.phymed.2026.158710_bib0053","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jconrel.2020.01.012","article-title":"Transferrin-binding peptide functionalized polymersomes mediate targeted doxorubicin delivery to colorectal cancer in vivo","volume":"319","author":"Wei","year":"2020","journal-title":"J. Control. Release"},{"issue":"11","key":"10.1016\/j.phymed.2026.158710_bib0054","doi-asserted-by":"crossref","first-page":"12511","DOI":"10.1021\/acsnano.9b02875","article-title":"Nanoformulated codelivery of quercetin and alantolactone promotes an antitumor response through synergistic immunogenic cell death for microsatellite-stable colorectal cancer","volume":"13","author":"Zhang","year":"2019","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.phymed.2026.158710_bib0055","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.canlet.2011.09.013","article-title":"YHHU0895, a novel synthetic small-molecule microtubule-destabilizing agent, effectively overcomes P-glycoprotein-mediated tumor multidrug resistance","volume":"314","author":"Zhao","year":"2012","journal-title":"Cancer Lett."},{"issue":"5","key":"10.1016\/j.phymed.2026.158710_bib0056","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1002\/med.21963","article-title":"Advances of antitumor drug discovery in traditional Chinese medicine and natural active products by using multi-active components combination","volume":"43","author":"Zhao","year":"2023","journal-title":"Med. Res. Rev."},{"issue":"23","key":"10.1016\/j.phymed.2026.158710_bib0057","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202401020","article-title":"Stimuli-responsive aptamer-drug conjugates for targeted drug delivery and controlled drug release","volume":"13","author":"Zhu","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.phymed.2026.158710_bib0058","article-title":"Effective therapy of advanced breast cancer through synergistic anticancer by paclitaxel and P-glycoprotein inhibitor","volume":"26","author":"Zhu","year":"2024","journal-title":"Mater. Today Bio."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326009414?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326009414?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:09:28Z","timestamp":1793192968000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326009414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":58,"alternative-id":["S0944711326009414"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158710","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FA receptor-targeted pH-sensitive polymeric micelles co-encapsulating quercetin and paclitaxel for synergistic reversal of drug resistance in non-small cell lung cancer","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158710","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158710"}}