{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:37:32Z","timestamp":1793194652672,"version":"4.5.0"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82305167"],"award-info":[{"award-number":["82305167"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574722"],"award-info":[{"award-number":["82574722"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U24A20791"],"award-info":[{"award-number":["U24A20791"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274226"],"award-info":[{"award-number":["82274226"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274443"],"award-info":[{"award-number":["82274443"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2025A1515011906"],"award-info":[{"award-number":["2025A1515011906"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515220036"],"award-info":[{"award-number":["2023A1515220036"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2023GXNSFDA026027"],"award-info":[{"award-number":["2023GXNSFDA026027"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.phymed.2026.158751","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T22:42:57Z","timestamp":1787438577000},"page":"158751","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Antidepressant mechanism of sns in repairing synaptic damage via the GPR120\/NLRP3 pathway-mediated inhibition of microglial M1 polarization"],"prefix":"10.1016","volume":"161","author":[{"given":"Qingying","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuchang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianbin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerun","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158751_bib0001","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13293-016-0087-5","article-title":"Female rats are not more variable than male rats: a meta-analysis of neuroscience studies","volume":"7","author":"Becker","year":"2016","journal-title":"Biol. Sex. Differ."},{"key":"10.1016\/j.phymed.2026.158751_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156240","article-title":"Saikosaponins from Bupleurum scorzonerifolium Willd. Alleviates microglial pyroptosis in depression by binding and inhibiting P2X7 expression","volume":"136","author":"Bi","year":"2025","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.phymed.2026.158751_bib0003","doi-asserted-by":"crossref","DOI":"10.1002\/ddr.70105","article-title":"Oleanolic acid alleviates neuronal ferroptosis in subarachnoid hemorrhage by inhibiting KEAP1-Nrf2 and NF-\u03bab pathways","volume":"86","author":"Bojuan","year":"2025","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.phymed.2026.158751_bib0004","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1016\/j.neuron.2025.09.010","article-title":"Synaptic priming: a framework for pharmacotherapy in depression","volume":"113","author":"Brown","year":"2025","journal-title":"Neuron"},{"key":"10.1016\/j.phymed.2026.158751_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175670","article-title":"Hesperidin may improve depressive symptoms by binding NLRP3 and influencing the pyroptosis pathway in a rat model","volume":"952","author":"Cao","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158751_bib0007","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41577-024-01075-9","article-title":"Inflammasome components as new therapeutic targets in inflammatory disease","volume":"25","author":"Coll","year":"2025","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.phymed.2026.158751_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154395","article-title":"Sinisan alleviates depression-like behaviors by regulating mitochondrial function and synaptic plasticity in maternal separation rats","volume":"106","author":"Deng","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158751_bib0009","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12974-017-0869-7","article-title":"Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation","volume":"14","author":"Dragano","year":"2017","journal-title":"J. Neuroinflammat."},{"key":"10.1016\/j.phymed.2026.158751_bib0010","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1126\/science.1222939","article-title":"Synaptic dysfunction in depression: potential therapeutic targets","volume":"338","author":"Duman","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.phymed.2026.158751_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.115601","article-title":"Yueju pill and its active component- myricetin attenuate the reinstatement of methamphetamine-seeking behavior in mice","volume":"166","author":"Du","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2026.158751_bib0012","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1126\/science.adh7906","article-title":"Defining microglial-synapse interactions","volume":"381","author":"Eyo","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.phymed.2026.158751_bib0013","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41419-020-03347-3","article-title":"DHA\/AA alleviates LPS-induced Kupffer cells pyroptosis via GPR120 interaction with NLRP3 to inhibit inflammasome complexes assembly","volume":"12","author":"Fan","year":"2021","journal-title":"Cell Death. Dis."},{"key":"10.1016\/j.phymed.2026.158751_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114385","article-title":"Chaihu-Shugan-San inhibits neuroinflammation in the treatment of post-stroke depression through the JAK\/STAT3-GSK3\u03b2\/PTEN\/akt pathway","volume":"160","author":"Fan","year":"2023","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.phymed.2026.158751_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155594","article-title":"Huangqin decoction attenuates spared nerve injury (SNI)-induced neuropathic pain by modulating microglial M1\/M2 polarization partially mediated by intestinal nicotinamide metabolism","volume":"129","author":"Gao","year":"2024","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.phymed.2026.158751_bib0017","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1159\/000502652","article-title":"International society for nutritional psychiatry research practice guidelines for omega-3 fatty acids in the treatment of major depressive disorder","volume":"88","author":"Guu","year":"2019","journal-title":"PsychOther Psychosom."},{"key":"10.1016\/j.phymed.2026.158751_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102010","article-title":"Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy","volume":"44","author":"Han","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.phymed.2026.158751_bib0018","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s43587-025-01028-4","article-title":"Allosteric activation of a cell-type-specific GPR120 inhibits amyloid pathology of Alzheimer's disease","volume":"6","author":"He","year":"2026","journal-title":"Nat. Agin."},{"key":"10.1016\/j.phymed.2026.158751_bib0019","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1038\/s41467-019-09562-7","article-title":"Lower synaptic density is associated with depression severity and network alterations","volume":"10","author":"Holmes","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.158751_bib0020","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13020-025-01283-y","article-title":"Clinical efficacy and multi-omics analysis of Si-Ni-San for depression treatment in breast cancer patients: a randomized, double-blind, placebo-controlled, crossover trial","volume":"21","author":"Hong","year":"2026","journal-title":"Chin. Med."},{"issue":"7","key":"10.1016\/j.phymed.2026.158751_bib0021","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.3390\/nu17071253","article-title":"Beneficial effects of Omega-3 fatty acids on obesity and related metabolic and chronic inflammatory diseases","volume":"17","author":"Jerab","year":"2025","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.158751_bib0022","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70695","article-title":"High-throughput screening reveals that CeeNU acts as a new NLRP3 inflammasome inhibitor","volume":"7","author":"Ji","year":"2026","journal-title":"MedComm"},{"key":"10.1016\/j.phymed.2026.158751_bib0024","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12974-022-02478-y","article-title":"Asperosaponin VI ameliorates the CMS-induced depressive-like behaviors by inducing a neuroprotective microglial phenotype in hippocampus via PPAR-\u03b3 pathway","volume":"19","author":"Jiang","year":"2022","journal-title":"J. Neuroinflammat."},{"issue":"4","key":"10.1016\/j.phymed.2026.158751_bib0025","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s12264-025-01571-5","article-title":"Research progress on the biological function and homeostatic disruption of microglia in the pathogenesis of major depressive disorder","volume":"42","author":"Kong","year":"2026","journal-title":"Neurosci. Bull."},{"issue":"2","key":"10.1016\/j.phymed.2026.158751_bib0026","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S2215-0366(16)30263-2","article-title":"Why is depression more common among women than among men?","volume":"4","author":"Kuehner","year":"2017","journal-title":"Lancet Psychiat."},{"key":"10.1016\/j.phymed.2026.158751_bib0027","doi-asserted-by":"crossref","first-page":"8150","DOI":"10.7150\/thno.115587","article-title":"Targeting complement C3 with Tanshinone I decreases microglia-mediated synaptic engulfment to exert antidepressant effects","volume":"15","author":"Lai","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.phymed.2026.158751_bib0028","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.tins.2023.12.004","article-title":"An integrative view on the cell-type-specific mechanisms of ketamine's antidepressant actions","volume":"47","author":"Lewis","year":"2024","journal-title":"Trends. Neurosci."},{"key":"10.1016\/j.phymed.2026.158751_bib0029","doi-asserted-by":"crossref","first-page":"955","DOI":"10.7150\/thno.76553","article-title":"Phloretin decreases microglia-mediated synaptic engulfment to prevent chronic mild stress-induced depression-like behaviors in the mPFC","volume":"13","author":"Li","year":"2023","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.phymed.2026.158751_bib0030","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12974-023-02791-0","article-title":"The involvement of NLRP3 inflammasome in CUMS-induced AD-like pathological changes and related cognitive decline in mice","volume":"20","author":"Li","year":"2023","journal-title":"J. Neuroinflammat."},{"key":"10.1016\/j.phymed.2026.158751_bib0031","article-title":"GSTM2 as the molecular linking of depression-driven colon cancer progression and chemoresistance: reversal by Sinisan","volume":"155","author":"Li","year":"2026","journal-title":"Int. J. Phytother. Phytopharm."},{"issue":"4","key":"10.1016\/j.phymed.2026.158751_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111532","article-title":"Microglial NLRP3 inflammasome activates neurotoxic astrocytes in depression-like mice","volume":"41","author":"Li","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.phymed.2026.158751_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155578","article-title":"Aloe-emodin alleviates cerebral ischemia-reperfusion injury by regulating microglial polarization and pyroptosis through inhibition of NLRP3 inflammasome activation","volume":"129","author":"Li","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158751_bib0034","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41583-024-00876-0","article-title":"Structural neural plasticity evoked by rapid-acting antidepressant interventions","volume":"26","author":"Liao","year":"2025","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.phymed.2026.158751_bib0035","doi-asserted-by":"crossref","first-page":"C1481","DOI":"10.1152\/ajpcell.00322.2024","article-title":"TFEB signaling promotes autophagic degradation of NLRP3 to attenuate neuroinflammation in diabetic encephalopathy","volume":"327","author":"Lin","year":"2024","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.phymed.2026.158751_bib0036","doi-asserted-by":"crossref","DOI":"10.1126\/science.adq9006","article-title":"Nucleotide metabolic rewiring enables NLRP3 inflammasome hyperactivation in obesity","volume":"391","author":"Liu","year":"2026","journal-title":"Science"},{"key":"10.1016\/j.phymed.2026.158751_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157214","article-title":"Alpha-linolenic acid ameliorates T2DM via reshaping gut-liver axis and inflammatory GPR120-NF-\u03bab\/NLRP3 pathway in mouse and rat models","volume":"147","author":"Liu","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158751_bib0038","first-page":"0897","article-title":"Interleukin-4-mediated NLRP3 inflammasome activation in microglia contributes to allergic rhinitis via Central sensitization","author":"Lv","year":"2025","journal-title":"Res. (Wash D C)"},{"issue":"16","key":"10.1016\/j.phymed.2026.158751_bib0039","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.3390\/cells12162062","article-title":"Repetitive transcranial magnetic stimulation reduces depressive-like behaviors, modifies dendritic plasticity, and generates global epigenetic changes in the frontal cortex and hippocampus in a rodent model of chronic stress","volume":"12","author":"Meneses-San Juan","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.phymed.2026.158751_bib0040","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/s41380-024-02695-2","article-title":"Increased expression of ER stress, inflammasome activation, and mitochondrial biogenesis-related genes in peripheral blood mononuclear cells in major depressive disorder","volume":"30","author":"Munshi","year":"2025","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.phymed.2026.158751_bib0041","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1186\/s12974-023-02978-5","article-title":"Central activation of the fatty acid sensor GPR120 suppresses microglia reactivity and alleviates sickness- and anxiety-like behaviors","volume":"20","author":"Nakajima","year":"2023","journal-title":"J. Neuroinflammat."},{"issue":"3","key":"10.1016\/j.phymed.2026.158751_bib0042","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41593-025-02153-4","article-title":"Extracellular matrix proteolysis maintains synapse plasticity during brain development","volume":"29","author":"Nakajo","year":"2026","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phymed.2026.158751_bib0043","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.cell.2010.07.041","article-title":"GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects","volume":"142","author":"Oh","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2026.158751_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2026.177489","article-title":"Engineering synergistic multi-component liposomal systems: from traditional medicine to precision nanotherapeutics for cancer treatment","volume":"541","author":"Pan","year":"2026","journal-title":"Chem. Eng. J."},{"issue":"6","key":"10.1016\/j.phymed.2026.158751_bib0045","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1503\/jpn.170192","article-title":"Abnormal protein and mRNA expression of inflammatory cytokines in the prefrontal cortex of depressed individuals who died by suicide","volume":"43","author":"Pandey","year":"2018","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.phymed.2026.158751_bib0046","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s12974-022-02482-2","article-title":"GPR120 modulates epileptic seizure and neuroinflammation mediated by NLRP3 inflammasome","volume":"19","author":"Qin","year":"2022","journal-title":"J. Neuroinflammat."},{"issue":"1","key":"10.1016\/j.phymed.2026.158751_bib0047","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13020-025-01315-7","article-title":"From classical Chinese formula to modern mechanism: how Xiao-Yao-San modulates key signaling pathways in depression","volume":"21","author":"Qu","year":"2026","journal-title":"Chin. Med."},{"issue":"1","key":"10.1016\/j.phymed.2026.158751_bib0048","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-20527-3","article-title":"Identification of stigmasterol derived AChE inhibitors for Alzheimer's disease using high throughput virtual screening and molecular dynamics simulations","volume":"15","author":"Rahman","year":"2025","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.phymed.2026.158751_bib0049","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1176\/ajp.2006.163.11.1905","article-title":"Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report","volume":"163","author":"Rush","year":"2006","journal-title":"Am. J. Psychiatry"},{"issue":"16","key":"10.1016\/j.phymed.2026.158751_bib0050","doi-asserted-by":"crossref","first-page":"8675","DOI":"10.3390\/ijms25168675","article-title":"Omega-3 polyunsaturated fatty acids in depression","volume":"25","author":"Serefko","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.phymed.2026.158751_bib0051","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.biopsych.2025.06.030","article-title":"Structural connectome architecture shapes cortical atrophy in major depressive disorder: a Chinese DIRECT consortium study","volume":"99","author":"Shen","year":"2026","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phymed.2026.158751_bib0052","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2026.1729885","article-title":"GuiLingJi ameliorates mild cognitive impairment by targeting unsaturated fatty acid metabolism to inhibit GPR120\/NF-\u03bab mediated neuroinflammation","volume":"17","author":"Shi","year":"2026","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158751_bib0053","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/ptr.8039","article-title":"Stigmasterol regulates microglial M1\/M2 polarization via the TLR4\/NF-\u03bab pathway to alleviate neuropathic pain","volume":"38","author":"Si","year":"2024","journal-title":"PhytOther Res."},{"key":"10.1016\/j.phymed.2026.158751_bib0054","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1038\/s41593-023-01326-3","article-title":"ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain","volume":"26","author":"Stratoulias","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phymed.2026.158751_bib0055","first-page":"515","article-title":"Paeoniflorin alleviates depression by inhibiting the activation of NLRP3 inflammasome via promoting mitochondrial autophagy","volume":"22","author":"Su","year":"2024","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.phymed.2026.158751_bib0056","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.phymed.2026.158751_bib0057","doi-asserted-by":"crossref","first-page":"9803","DOI":"10.1038\/s41467-024-54007-5","article-title":"Complement and microglia activation mediate stress-induced synapse loss in layer 2\/3 of the medial prefrontal cortex in male mice","volume":"15","author":"Tillmon","year":"2024","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.phymed.2026.158751_bib0058","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202200089","article-title":"DHA-enriched phospholipids exhibit anti-depressant effects by immune and neuroendocrine regulation in mice: a study on dose- and structure-activity relationship","volume":"67","author":"Wang","year":"2023","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.phymed.2026.158751_bib73","doi-asserted-by":"crossref","DOI":"10.4028\/b-wjQRP6","article-title":"Microglial Ffar4 deficiency promotes cognitive impairment in the context of metabolic syndrome","volume":"10","author":"Wang","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.phymed.2026.158751_bib0059","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113926","article-title":"Facilitating microglia M2 polarization alleviates p-synephrine-induced depressive-like behaviours in CSDS mice via the 5-HT6R-FYN-ERK1\/2 pathway","volume":"147","author":"Wang","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2026.158751_bib0060","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1126\/science.adx4142","article-title":"Dysfunction in primate dorsolateral prefrontal area 46 affects motivation and anxiety","volume":"389","author":"Wood","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.phymed.2026.158751_bib0061","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157454","article-title":"Syringin attenuates Alzheimer's disease-associated neuroinflammation by inhibiting NLRP3 inflammasome activation","volume":"148","author":"Xu","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158751_bib0062","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.immuni.2013.05.015","article-title":"Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation","volume":"38","author":"Yan","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.phymed.2026.158751_bib0063","doi-asserted-by":"crossref","DOI":"10.1016\/j.jad.2025.119436","article-title":"BMI trajectories, changes and their potential associations with the risk of depression during adulthood: a cross-sectional study from NHANES 2005-2018","volume":"386","author":"Yang","year":"2025","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.phymed.2026.158751_bib0064","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.121024","article-title":"Banxia Houpo decoction reduces lysosomal leakage of prefrontal astrocytes through the OGT-CTSB-NLRP3 pathway to improve depressive-like behaviors","volume":"359","author":"Yang","year":"2026","journal-title":"J. Ethnopharmacol."},{"issue":"7","key":"10.1016\/j.phymed.2026.158751_bib0065","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1039\/D5FO00252D","article-title":"GPR120 internalization: a key mechanism for EPA in antidepressant action","volume":"16","author":"Yu","year":"2025","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2026.158751_bib0066","article-title":"Sinisan ameliorates early-life stress-induced depressive-like behaviors by repairing DRN synaptic damage through CaSR","volume":"16","author":"Yu","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158751_bib0067","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.tins.2023.12.003","article-title":"Tuning neural circuits and behaviors by microglia in the adult brain","volume":"47","author":"Zhao","year":"2024","journal-title":"Trends. Neurosci."},{"key":"10.1016\/j.phymed.2026.158751_bib0068","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.176603","article-title":"Role of microglia polarization induced by glucose metabolism disorder in the cognitive impairment of mice from PM(2.5) exposure","volume":"954","author":"Zheng","year":"2024","journal-title":"Sci Total Env."},{"key":"10.1016\/j.phymed.2026.158751_bib0069","doi-asserted-by":"crossref","first-page":"3564","DOI":"10.4103\/NRR.NRR-D-24-00628","article-title":"Nerve root magnetic stimulation regulates the synaptic plasticity of injured spinal cord by ascending sensory pathway","volume":"20","author":"Zheng","year":"2025","journal-title":"Neural Regener. Res."},{"key":"10.1016\/j.phymed.2026.158751_bib0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118529","article-title":"Neural Circuit Mechanisms of Sinisan formula for the Treatment of adolescent depression: prefrontal cortex to dorsal raphe nucleus","volume":"334","author":"Zhou","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158751_bib0071","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adx2666","article-title":"Acute REM sleep deprivation alleviated depression-like behavior mediated by inhibiting VIP neurons in the mPFC","volume":"11","author":"Zhu","year":"2025","journal-title":"Sci. Adv."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326009827?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326009827?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:08:08Z","timestamp":1793192888000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326009827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":70,"alternative-id":["S0944711326009827"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158751","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antidepressant mechanism of sns in repairing synaptic damage via the GPR120\/NLRP3 pathway-mediated inhibition of microglial M1 polarization","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158751","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"158751"}}