{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:37:52Z","timestamp":1793194672602,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NO.U22A20373"],"award-info":[{"award-number":["NO.U22A20373"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174342"],"award-info":[{"award-number":["82174342"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004846","name":"Beijing University of Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004846","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.phymed.2026.158763","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:33:10Z","timestamp":1787787190000},"page":"158763","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["M-SYFSF attenuates diabetic kidney disease by suppressing Piezo1-associated cGAS\u2013STING signalling and tubular pyroptosis"],"prefix":"10.1016","volume":"161","author":[{"given":"Yaotan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyi","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3325-8238","authenticated-orcid":false,"given":"Huixi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weimin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwu","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoxian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.phymed.2026.158763_bib0001","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.2215\/CJN.11491116","article-title":"Diabetic Kidney disease: challenges, progress, and possibilities","volume":"12","author":"Alicic","year":"2017","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phymed.2026.158763_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2020.108515","article-title":"Curcumin reverses diabetic nephropathy in streptozotocin-induced diabetes in rats by inhibition of PKC\u03b2\/p66Shc axis and activation of FOXO-3a","volume":"87","author":"ALTamimi","year":"2021","journal-title":"J. Nutr. Biochem."},{"issue":"10","key":"10.1016\/j.phymed.2026.158763_bib0002","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1093\/jmcb\/mjab066","article-title":"cGAS\u2012STING signaling and function in metabolism and kidney diseases","volume":"13","author":"Bai","year":"2021","journal-title":"J. Mol. Cell. Biol."},{"issue":"10","key":"10.1016\/j.phymed.2026.158763_bib0003","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.2215\/CJN.18641120","article-title":"Transforming the care of patients with diabetic kidney disease","volume":"16","author":"Brosius","year":"2021","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phymed.2026.158763_bib0004","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.cca.2022.04.011","article-title":"Pyroptosis in diabetes and diabetic nephropathy","volume":"531","author":"Cao","year":"2022","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.phymed.2026.158763_bib0005","article-title":"Research and progress of cGAS\/STING\/NLRP3 signaling pathway: a mini review","volume":"16","author":"Chen","year":"2025","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158763_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2025.104592","article-title":"Piezo1 as a therapeutic target in kidney disease: emerging mechanistic insights and translational potential","volume":"31","author":"Choudhary","year":"2026","journal-title":"Drug. Discov. Today"},{"issue":"7","key":"10.1016\/j.phymed.2026.158763_bib0007","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/s41590-023-01526-w","article-title":"Molecular mechanisms of gasdermin D pore-forming activity","volume":"24","author":"Devant","year":"2023","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158763_bib0008","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13020-025-01298-5","article-title":"Modified Shen-Yan-Fang-Shuai formula attenuates diabetic kidney disease progression via regulation of HIF-1\u03b1-mediated mitochondrial energy metabolism","volume":"21","author":"Di","year":"2026","journal-title":"Chin. Med."},{"issue":"13","key":"10.1016\/j.phymed.2026.158763_bib0009","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.3390\/ijms25137130","article-title":"Research progress of pyroptosis in diabetic kidney disease","volume":"25","author":"Fan","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.phymed.2026.158763_bib0010","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.cell.2017.09.039","article-title":"The DNA inflammasome in Human myeloid cells is initiated by a STING-cell death program upstream of NLRP3","volume":"171","author":"Gaidt","year":"2017","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.phymed.2026.158763_bib0011","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.3390\/biomedicines13061424","article-title":"Pathogenesis and therapeutic perspectives of tubular injury in diabetic kidney disease: an update","volume":"13","author":"Geng","year":"2025","journal-title":"Biomedicines"},{"issue":"4","key":"10.1016\/j.phymed.2026.158763_bib0012","doi-asserted-by":"crossref","first-page":"791","DOI":"10.2337\/db16-0796","article-title":"Proximal tubulopathy: prime mover and key therapeutic target in diabetic kidney disease","volume":"66","author":"Gilbert","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.phymed.2026.158763_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154206","article-title":"Shenkang injection protects against renal fibrosis by reducing perforin expression through the STING\/TBK1\/IRF3 signaling pathways in natural killer cells","volume":"104","author":"Hao","year":"2022","journal-title":"Phytomedicine"},{"issue":"15","key":"10.1016\/j.phymed.2026.158763_bib0014","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1056\/NEJMoa2024816","article-title":"Dapagliflozin in patients with chronic kidney disease","volume":"383","author":"Heerspink","year":"2020","journal-title":"N Engl. J. Med."},{"issue":"2","key":"10.1016\/j.phymed.2026.158763_bib0015","doi-asserted-by":"crossref","DOI":"10.1093\/jmcb\/mjac005","article-title":"Intervention of cGAS\u2012STING signaling in sterile inflammatory diseases","volume":"14","author":"Hong","year":"2022","journal-title":"J. Mol. Cell. Biol."},{"issue":"12","key":"10.1016\/j.phymed.2026.158763_bib0016","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/s41423-023-01086-x","article-title":"Mitochondrial DNA-triggered innate immune response: mechanisms and diseases","volume":"20","author":"Hu","year":"2023","journal-title":"Cell. Mol. Immunol."},{"issue":"13","key":"10.1016\/j.phymed.2026.158763_bib0017","doi-asserted-by":"crossref","first-page":"4058","DOI":"10.3390\/molecules27134058","article-title":"How Curcumin targets inflammatory mediators in diabetes: therapeutic insights and possible solutions","volume":"27","author":"Hussain","year":"2022","journal-title":"Molecules"},{"issue":"6","key":"10.1016\/j.phymed.2026.158763_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2024.103576","article-title":"The role of mitochondrial dysfunction in kidney injury and disease","volume":"23","author":"Jia","year":"2024","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.phymed.2026.158763_bib0019","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1185317","article-title":"Oxidative stress and inflammation in diabetic nephropathy: role of polyphenols","volume":"14","author":"Jin","year":"2023","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.phymed.2026.158763_bib0021","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/s12276-023-00965-7","article-title":"Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway","volume":"55","author":"Kim","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.phymed.2026.158763_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.178155","article-title":"The cGAS-STING axis in kidney disease: mechanisms and therapeutic potential","volume":"1006","author":"Li","year":"2025","journal-title":"Eur. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.phymed.2026.158763_bib0024","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1681\/ASN.0000000634","article-title":"PIEZO1-Mediated calcium signaling and podocyte injury in diabetic kidney disease","volume":"36","author":"Li","year":"2025","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phymed.2026.158763_bib0023","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.jare.2025.07.015","article-title":"Direct pharmacological targeting of Piezo1 by paeoniflorin: a novel therapeutic approach for renal fibrosis","volume":"82","author":"Li","year":"2026","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.phymed.2026.158763_bib0025","doi-asserted-by":"crossref","DOI":"10.1093\/burnst\/tkaf054","article-title":"Piezo1 and tissue fibrosis: insights into its role and potential for modulation","volume":"13","author":"Lin","year":"2025","journal-title":"Burns Trauma."},{"issue":"5","key":"10.1016\/j.phymed.2026.158763_bib0026","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s10157-023-02448-5","article-title":"Cytosolic mtDNA-cGAS-STING axis contributes to sepsis-induced acute kidney injury via activating the NLRP3 inflammasome","volume":"28","author":"Luo","year":"2024","journal-title":"Clin. Exp. Nephrol."},{"key":"10.1016\/j.phymed.2026.158763_bib0027","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/4319057","article-title":"Renoprotective effect of the Shen-Yan-Fang-Shuai formula by inhibiting TNF-\u03b1\/NF-\u03bab signaling pathway in diabetic rats","author":"Lv","year":"2017","journal-title":"J. Diabetes Res."},{"issue":"12","key":"10.1016\/j.phymed.2026.158763_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.108463","article-title":"Gasdermin D promotes hyperuricemia-induced renal tubular injury through RIG-I\/caspase-1 pathway","volume":"26","author":"Ma","year":"2023","journal-title":"iScience"},{"issue":"11","key":"10.1016\/j.phymed.2026.158763_bib0029","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41576-019-0151-1","article-title":"DNA sensing by the cGAS-STING pathway in health and disease","volume":"20","author":"Motwani","year":"2019","journal-title":"Nat. Rev. Genet."},{"issue":"1","key":"10.1016\/j.phymed.2026.158763_bib0030","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s40104-023-00878-5","article-title":"Chronic heat stress induces renal fibrosis and mitochondrial dysfunction in laying hens","volume":"14","author":"Nanto-Hara","year":"2023","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.phymed.2026.158763_bib0031","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.coi.2017.10.011","article-title":"Recent advances in inflammasome biology","volume":"50","author":"Place","year":"2018","journal-title":"Curr. Opin. Immunol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158763_bib0032","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1080\/13880209.2024.2314705","article-title":"Advances in traditional Chinese medicine research in diabetic kidney disease treatment","volume":"62","author":"Shen","year":"2024","journal-title":"Pharm. Biol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158763_bib0033","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s12026-025-09648-z","article-title":"The cGAS-STING axis: a comprehensive review from immune defense to disease pathogenesis","volume":"73","author":"Sood","year":"2025","journal-title":"Immunol. Res."},{"issue":"4","key":"10.1016\/j.phymed.2026.158763_bib0035","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/s41581-019-0234-4","article-title":"Innate immunity in diabetic kidney disease","volume":"16","author":"Tang","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"issue":"3","key":"10.1016\/j.phymed.2026.158763_bib0034","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/s41581-019-0110-2","article-title":"Macrophages: versatile players in renal inflammation and fibrosis","volume":"15","author":"Tang","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.phymed.2026.158763_bib0036","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.998574","article-title":"NLRP3-mediated pyroptosis in diabetic nephropathy","volume":"13","author":"Wan","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158763_bib0038","article-title":"Tubular injury in diabetic kidney disease: molecular mechanisms and potential therapeutic perspectives","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.phymed.2026.158763_bib0037","article-title":"The effects of cGAS-STING inhibition in liver disease, kidney disease, and cellular senescence","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.phymed.2026.158763_bib0039","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nri.2017.21","article-title":"Mitochondrial DNA in innate immune responses and inflammatory pathology","volume":"17","author":"West","year":"2017","journal-title":"Nat. rev. Immunol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158763_bib0040","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1080\/13880209.2024.2351946","article-title":"Traditional Chinese medicine improved diabetic kidney disease through targeting gut microbiota","volume":"62","author":"Wu","year":"2024","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.phymed.2026.158763_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102691","article-title":"STING mediates hepatocyte pyroptosis in liver fibrosis by epigenetically activating the NLRP3 inflammasome","volume":"62","author":"Xiao","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.phymed.2026.158763_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103471","article-title":"Cardiomyocyte-specific Piezo1 deficiency mitigates ischemia-reperfusion injury by preserving mitochondrial homeostasis","volume":"79","author":"Xu","year":"2025","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158763_bib0043","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1080\/13880209.2023.2241521","article-title":"Integrating network pharmacology and experimental validation to decipher the mechanism of the Chinese herbal prescription modified Shen-Yan-Fang-Shuai formula in treating diabetic nephropathy","volume":"61","author":"Yu","year":"2023","journal-title":"Pharm. Biol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158763_bib0044","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/s41392-022-01036-5","article-title":"Signaling pathways of chronic kidney diseases, implications for therapeutics","volume":"7","author":"Yuan","year":"2022","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2026.158763_bib0045","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.940716","article-title":"Pharmacological inhibition of STING\/TBK1 signaling attenuates myeloid fibroblast activation and macrophage to myofibroblast transition in renal fibrosis","volume":"13","author":"Zeng","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.phymed.2026.158763_bib0046","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2024.2415519","article-title":"Piezo1 facilitates the initiation and progression of renal fibrosis by mediating cell apoptosis and mitochondrial dysfunction","volume":"46","author":"Zhang","year":"2024","journal-title":"Ren. Fail."},{"issue":"7","key":"10.1016\/j.phymed.2026.158763_bib0047","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.152330","article-title":"Mechanosensitive Piezo1 channels mediate renal fibrosis","volume":"7","author":"Zhao","year":"2022","journal-title":"JCI insight"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326009943?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326009943?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:05:29Z","timestamp":1793192729000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326009943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":47,"alternative-id":["S0944711326009943"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158763","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"M-SYFSF attenuates diabetic kidney disease by suppressing Piezo1-associated cGAS\u2013STING signalling and tubular pyroptosis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158763","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158763"}}