{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:37:46Z","timestamp":1793194666970,"version":"4.5.0"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474182"],"award-info":[{"award-number":["82474182"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474217"],"award-info":[{"award-number":["82474217"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.phymed.2026.158767","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:45:04Z","timestamp":1787849104000},"page":"158767","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Metabolic regulation of uridine in diabetic kidney disease and its pharmacological modulation by schisandrin B"],"prefix":"10.1016","volume":"161","author":[{"given":"Yu","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujia","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueke","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghao","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenshen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxia","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0455-0969","authenticated-orcid":false,"given":"Yubo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158767_bib0001","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/pros.20186","article-title":"Co-factors p300 and CBP catch Egr1 in their network","volume":"26","author":"Adamson","year":"2005","journal-title":"Prostate"},{"key":"10.1016\/j.phymed.2026.158767_bib0002","doi-asserted-by":"crossref","first-page":"5062","DOI":"10.1038\/s41467-022-32477-9","article-title":"Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression","volume":"13","author":"Al-Dabet","year":"2022","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.phymed.2026.158767_bib0003","first-page":"3695","article-title":"Effect of uridine on mitochondrial function]","volume":"39","author":"Bai","year":"2023","journal-title":"Sheng Wu Gong Cheng Xue Bao"},{"key":"10.1016\/j.phymed.2026.158767_bib0004","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41580-022-00572-w","article-title":"Metabolites as signalling molecules","volume":"24","author":"Baker","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2026.158767_bib0005","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231810633","article-title":"Effect of chronic treatment with uridine on cardiac mitochondrial dysfunction in the C57BL\/6 mouse model of high-fat diet-streptozotocin-induced diabetes","volume":"23","author":"Belosludtseva","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158767_bib0006","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2026.1767279","article-title":"Uridine inhibits ROS-mediated osteoclast differentiation and alleviates osteoporosis via modulation of PI3K\/Akt-FoxO signaling","volume":"17","author":"Bian","year":"2026","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2026.158767_bib0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00467-018-4157-2","article-title":"Metabolic requirements of the nephron","volume":"35","author":"Cargill","year":"2020","journal-title":"Pediatr. Nephrol."},{"issue":"5","key":"10.1016\/j.phymed.2026.158767_bib0009","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1093\/bbb\/zbag018","article-title":"Schisandrin A alleviates chondrocyte senescence and extracellular matrix degeneration by suppressing PI3K\/Akt signaling pathway","volume":"90","author":"Chen","year":"2026","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.phymed.2026.158767_bib0010","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2025.2543927","article-title":"Sirtuin 3 in diabetic kidney disease: mechanisms and pharmacotherapy","volume":"47","author":"Chen","year":"2025","journal-title":"Ren. Fail."},{"key":"10.1016\/j.phymed.2026.158767_bib0011","doi-asserted-by":"crossref","first-page":"5403","DOI":"10.1038\/s41467-026-72406-8","article-title":"Uridine restores oocyte quality and mitigates female reproductive aging by inhibition of ferroptosis in mice","volume":"17","author":"Chen","year":"2026","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.158767_bib0012","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1042\/CS20150838","article-title":"Mapping time-course mitochondrial adaptations in the kidney in experimental diabetes","volume":"130","author":"Coughlan","year":"2016","journal-title":"Clin. Sci. (Lond)"},{"key":"10.1016\/j.phymed.2026.158767_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102033","article-title":"Epigenetic regulation of TXNIP-mediated oxidative stress and NLRP3 inflammasome activation contributes to SAHH inhibition-aggravated diabetic nephropathy","volume":"45","author":"Dai","year":"2021","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2026.158767_bib0015","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1080\/17460441.2021.1832077","article-title":"Recent advances in drug discovery for diabetic kidney disease","volume":"16","author":"Danta","year":"2021","journal-title":"Expert Opin. Drug Dis."},{"key":"10.1016\/j.phymed.2026.158767_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2024.156037","article-title":"Disruption of branched-chain amino acid homeostasis promotes the progression of DKD via enhancing inflammation and fibrosis-associated epithelial-mesenchymal transition","volume":"162","author":"Deng","year":"2025","journal-title":"Metabolism"},{"key":"10.1016\/j.phymed.2026.158767_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156446","article-title":"Mechanism exploration of Wenshen Jianpi decoction on renoprotection in diabetic nephropathy via transcriptomics and metabolomics","volume":"139","author":"Deng","year":"2025","journal-title":"Phytomedicine"},{"issue":"6","key":"10.1016\/j.phymed.2026.158767_bib0018","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.3390\/biomedicines14061351","article-title":"Schisandrin B attenuates renal fibrotic remodeling in association with restoration of a ppar\u03b1-related tubular fatty-acid oxidation program","volume":"14","author":"Deng","year":"2026","journal-title":"Biomedicines"},{"key":"10.1016\/j.phymed.2026.158767_bib0019","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2004299","article-title":"Acetylation of ets-1 is the key to chromatin remodeling for miR-192 expression","volume":"6","author":"Dong","year":"2013","journal-title":"Sci. Signal."},{"issue":"6","key":"10.1016\/j.phymed.2026.158767_bib0020","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/s41419-024-06833-0","article-title":"Mitochondrial metabolic reprogramming in diabetic kidney disease","volume":"15","author":"Fan","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2026.158767_bib0022","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1038\/jid.2012.479","article-title":"p300 is elevated in systemic sclerosis and its expression is positively regulated by TGF-\u03b2: epigenetic feed-forward amplification of fibrosis","volume":"133","author":"Ghosh","year":"2013","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.phymed.2026.158767_bib0023","article-title":"Metabolomic and cellular mechanisms of drug-induced ototoxicity and nephrotoxicity: therapeutic implications of uric acid modulation","volume":"12","author":"Guo","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.phymed.2026.158767_bib0025","doi-asserted-by":"crossref","first-page":"F1418","DOI":"10.1152\/ajprenal.00477.2011","article-title":"The transcription factor ETS-1 regulates angiotensin II-stimulated fibronectin production in mesangial cells","volume":"302","author":"Hua","year":"2012","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.phymed.2026.158767_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155162","article-title":"Baicalin ameliorates renal fibrosis by upregulating CPT1\u03b1-mediated fatty acid oxidation in diabetic kidney disease","volume":"122","author":"Hu","year":"2024","journal-title":"Phytomedicine"},{"issue":"12","key":"10.1016\/j.phymed.2026.158767_bib0027","doi-asserted-by":"crossref","first-page":"5717","DOI":"10.1002\/ptr.70059","article-title":"Targeting mitochondrial dysfunction by natural products for the treatment of diabetic kidney disease","volume":"39","author":"Huo","year":"2025","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2026.158767_bib0028","doi-asserted-by":"crossref","first-page":"9929","DOI":"10.3390\/ijms22189929","article-title":"Uridine treatment of the first known case of SLC25A36 deficiency","volume":"22","author":"Jasper","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158767_bib0029","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.3390\/cells10112832","article-title":"Metabolomics in diabetes and diabetic complications: insights from epidemiological studies","volume":"10","author":"Jin","year":"2021","journal-title":"Cells."},{"key":"10.1016\/j.phymed.2026.158767_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154552","article-title":"Asiatic acid attenuates tubular injury in diabetic kidney disease by regulating mitochondrial dynamics via the nrf-2 pathway","volume":"109","author":"Ji","year":"2023","journal-title":"Phytomedicine"},{"issue":"Suppl 1","key":"10.1016\/j.phymed.2026.158767_bib0031","doi-asserted-by":"crossref","DOI":"10.1186\/1423-0127-17-S1-S25","article-title":"Effect of beta-alanine treatment on mitochondrial taurine level and 5-taurinomethyluridine content","volume":"17","author":"Jong","year":"2010","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.phymed.2026.158767_bib0032","doi-asserted-by":"crossref","DOI":"10.1177\/20503121221137005","article-title":"Integrated bioinformatics analysis reveals novel key biomarkers in diabetic nephropathy","volume":"10","author":"Joshi","year":"2022","journal-title":"SAGE Open Med."},{"key":"10.1016\/j.phymed.2026.158767_bib0033","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.kint.2016.08.021","article-title":"An overview of renal metabolomics","volume":"91","author":"Kalim","year":"2017","journal-title":"Kidney Int."},{"key":"10.1016\/j.phymed.2026.158767_bib0034","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2003389","article-title":"TGF-\u03b2 induces acetylation of chromatin and of ets-1 to alleviate repression of miR-192 in diabetic nephropathy","volume":"6","author":"Kato","year":"2013","journal-title":"Sci. Signal."},{"issue":"2","key":"10.1016\/j.phymed.2026.158767_bib0035","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/jdi.70231","article-title":"The biology of PKM2 in the metabolism and senescence in diabetic kidney disease","volume":"17","author":"Kayes","year":"2026","journal-title":"J. Diabetes Investig."},{"key":"10.1016\/j.phymed.2026.158767_bib0036","doi-asserted-by":"crossref","first-page":"9968","DOI":"10.3390\/ijms24129968","article-title":"Lysophosphatidic acid induces podocyte pyroptosis in diabetic nephropathy by an increase of Egr1 expression via downregulation of EzH2","volume":"24","author":"Kim","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158767_bib0037","doi-asserted-by":"crossref","first-page":"4081","DOI":"10.1039\/C9FO00360F","article-title":"Uridine\/UMP metabolism and their function on the gut in segregated early weaned piglets","volume":"10","author":"Li","year":"2019","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2026.158767_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157164","article-title":"Schisandra chinensis mixture attenuates diabetic kidney disease VDAC1\/Grp75\/IP3R-mediated MAMs stabilization and apoptosis-autophagy regulation","volume":"147","author":"Li","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158767_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.106272","article-title":"Schisandrin B ameliorates acute liver injury by regulating EGFR-mediated activation of autophagy","volume":"130","author":"Li","year":"2023","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.phymed.2026.158767_bib0040","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jchromb.2019.03.008","article-title":"Targeted UPLC-MS\/MS high-throughput metabolomics approach to assess the purine and pyrimidine metabolism","volume":"1113","author":"Liu","year":"2019","journal-title":"J. Chromatogr. B."},{"key":"10.1016\/j.phymed.2026.158767_bib0041","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jgg.2022.01.006","article-title":"The mechanisms of nucleotide actions in insulin resistance","volume":"49","author":"Liu","year":"2022","journal-title":"J. Genet. Genom. = Yi Chuan Xue Bao"},{"key":"10.1016\/j.phymed.2026.158767_bib0042","doi-asserted-by":"crossref","first-page":"7851","DOI":"10.3390\/molecules28237851","volume":"28","author":"Liu","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2026.158767_bib0043","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41421-021-00361-3","article-title":"Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor","volume":"8","author":"Liu","year":"2022","journal-title":"Cell Discov."},{"key":"10.1016\/j.phymed.2026.158767_bib0044","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1210\/endrev\/bnz010","article-title":"The new biology of diabetic kidney disease-mechanisms and therapeutic implications","volume":"41","author":"Lytvyn","year":"2020","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.phymed.2026.158767_bib0045","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.abb.2018.07.006","article-title":"The role of mitochondrial KATP channel in anti-inflammatory effects of uridine in endotoxemic mice","volume":"654","author":"Mironova","year":"2018","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.phymed.2026.158767_bib0047","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.bbrc.2018.11.128","article-title":"Schisandrin B alleviates diabetic nephropathy through suppressing excessive inflammation and oxidative stress","volume":"508","author":"Mou","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"12","key":"10.1016\/j.phymed.2026.158767_bib0048","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1016\/j.ekir.2024.09.019","article-title":"Unraveling diabetic kidney disease: the roles of mitochondrial dysfunction and immunometabolism","volume":"9","author":"Narongkiatikhun","year":"2024","journal-title":"Kidney Int. Rep."},{"key":"10.1016\/j.phymed.2026.158767_bib0049","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.devcel.2021.02.009","article-title":"Quality control of the mitochondrion","volume":"56","author":"Ng","year":"2021","journal-title":"Dev. Cell"},{"key":"10.1016\/j.phymed.2026.158767_bib0050","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2026.1817400","article-title":"Therapeutic targets for diabetic nephropathy identified by druggable genome mendelian randomization: the role of the gut microbiota-metabolite axis","volume":"17","author":"Niu","year":"2026","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.phymed.2026.158767_bib0051","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41586-023-06073-w","article-title":"Uridine-derived ribose fuels glucose-restricted pancreatic cancer","volume":"618","author":"Nwosu","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2026.158767_bib0052","doi-asserted-by":"crossref","first-page":"18698","DOI":"10.1074\/jbc.RA119.010176","article-title":"The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1","volume":"294","author":"O'Hara","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2026.158767_bib0053","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1681\/ASN.0000000754","article-title":"Fortifying the diabetic kidney disease treatment armamentarium: multitarget senotherapeutic and regenerative strategies","volume":"36","author":"Patel","year":"2025","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phymed.2026.158767_bib0054","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/s41392-023-01399-3","article-title":"Small molecule metabolites: discovery of biomarkers and therapeutic targets","volume":"8","author":"Qiu","year":"2023","journal-title":"Signal Transduct. Tar."},{"key":"10.1016\/j.phymed.2026.158767_bib0055","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.cmet.2018.02.011","article-title":"Therapeutic potential of NAD-boosting molecules: the in vivo evidence","volume":"27","author":"Rajman","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.phymed.2026.158767_bib0056","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1126\/science.adh2771","article-title":"Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis","volume":"383","author":"Sahu","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.phymed.2026.158767_bib0057","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/s42255-023-00774-2","article-title":"Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions","volume":"5","author":"Skinner","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.phymed.2026.158767_bib0058","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/s41419-022-04803-y","article-title":"IGFBP5 promotes diabetic kidney disease progression by enhancing PFKFB3-mediated endothelial glycolysis","volume":"13","author":"Song","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2026.158767_bib0059","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2018.12.031","article-title":"AMPK in microvascular complications of diabetes and the beneficial effects of AMPK activators from plants","volume":"73","author":"Shrikanth","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158767_bib0060","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1206154","article-title":"Identification of endoplasmic reticulum stress-related biomarkers of diabetes nephropathy based on bioinformatics and machine learning","volume":"14","author":"Su","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.phymed.2026.158767_bib0061","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2025.1669557","article-title":"Natural compounds regulating fatty acid oxidation in the treatment of diabetic kidney disease","volume":"12","author":"Sun","year":"2025","journal-title":"Front. Nutr."},{"key":"10.1016\/j.phymed.2026.158767_bib0063","doi-asserted-by":"crossref","DOI":"10.1177\/14791641211058856","article-title":"Early detection of diabetic nephropathy in patient with type 2 diabetes mellitus: a review of the literature","volume":"18","author":"Thipsawat","year":"2021","journal-title":"Diab. Vasc. Dis. Res."},{"key":"10.1016\/j.phymed.2026.158767_bib0064","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2022.10.008","article-title":"Spatial dynamic metabolomics identifies metabolic cell fate trajectories in human kidney differentiation","volume":"29","author":"Wang","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.phymed.2026.158767_bib0065","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.883658","article-title":"Screening and identification of hub genes in the development of early diabetic kidney disease based on weighted gene co-expression network analysis","volume":"13","author":"Wei","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.phymed.2026.158767_bib0066","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/S0006-2952(99)00341-X","article-title":"Purinergic and pyrimidinergic receptors as potential drug targets","volume":"59","author":"Williams","year":"2000","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158767_bib0067","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2025.2473506","article-title":"Machine-learning assisted discovery unveils novel interplay between gut microbiota and host metabolic disturbance in diabetic kidney disease","volume":"17","author":"Wu","year":"2025","journal-title":"Gut Microbes."},{"key":"10.1016\/j.phymed.2026.158767_bib0068","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/j.tjnut.2025.04.017","article-title":"Endogenous Metabolites in metabolic diseases: pathophysiologic roles and therapeutic implications","volume":"155","author":"Xiao","year":"2025","journal-title":"J. Nutr."},{"key":"10.1016\/j.phymed.2026.158767_bib83","first-page":"140","article-title":"Evalution of renal function protection of Schisandrin B in rats with type 2 diabetic nephropathy based on HMGB1\/TLR4 pathway","volume":"48","author":"Xiong","year":"2019","journal-title":"J. Med. Res."},{"key":"10.1016\/j.phymed.2026.158767_bib0069","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156672","article-title":"Schisandrin B regulates mitochondrial dynamics via AKT1 activation and mitochondrial targeting to ameliorate renal ischemia-reperfusion injury","volume":"141","author":"Xu","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158767_bib0070","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1016\/j.immuni.2024.05.025","article-title":"Cellular spermine targets JAK signaling to restrain cytokine-mediated autoimmunity","volume":"57","author":"Xu","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.phymed.2026.158767_bib0071","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2022.155195","article-title":"Mitochondrial dysfunction in diabetic tubulopathy","volume":"131","author":"Yao","year":"2022","journal-title":"Metabolism."},{"key":"10.1016\/j.phymed.2026.158767_bib0072","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.molcel.2004.06.030","article-title":"Coactivating factors p300 and CBP are transcriptionally crossregulated by Egr1 in prostate cells, leading to divergent responses","volume":"15","author":"Yu","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.phymed.2026.158767_bib0074","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.600561","article-title":"Exploration the mechanism of doxorubicin-induced heart failure in rats by integration of proteomics and metabolomics data","volume":"11","author":"Yuan","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158767_bib0075","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.3789","article-title":"Clinical metabolomics characteristics of diabetic kidney disease: a meta-analysis of 1875 cases with diabetic kidney disease and 4503 controls","volume":"40","author":"Yuan","year":"2024","journal-title":"Diabetes-Metab. Res."},{"key":"10.1016\/j.phymed.2026.158767_bib0076","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s13167-021-00269-8","article-title":"Functional metabolome profiling may improve individual outcomes in colorectal cancer management implementing concepts of predictive, preventive, and personalized medical approach","volume":"13","author":"Yuan","year":"2022","journal-title":"EPMA J."},{"key":"10.1016\/j.phymed.2026.158767_bib0077","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1038\/s43587-024-00669-1","article-title":"A metabolic atlas of blood cells in young and aged mice identifies uridine as a metabolite to rejuvenate aged hematopoietic stem cells","volume":"4","author":"Zeng","year":"2024","journal-title":"Nat. Aging"},{"key":"10.1016\/j.phymed.2026.158767_bib0078","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jep.2012.02.007","article-title":"Schisandra chinensis fruit extract attenuates albuminuria and protects podocyte integrity in a mouse model of streptozotocin-induced diabetic nephropathy","volume":"141","author":"Zhang","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158767_bib0079","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/s13098-025-01780-y","article-title":"Serum metabolic profiling in diabetic kidney disease patients using ultra-high performance liquid chromatography-tandem mass spectrometry","volume":"17","author":"Zhang","year":"2025","journal-title":"Diabetol. Metab. Syndr."},{"key":"10.1016\/j.phymed.2026.158767_bib0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2022.105376","article-title":"Schisandrin ameliorates diabetic nephropathy via regulating of PI3K\/Akt\/NF-\u03baB-mediated inflammation and TGF-\u03b21-induced fibrosis in HFD\/STZ-induced C57BL\/6J mice","volume":"100","author":"Zhang","year":"2023","journal-title":"J. Func. Foods"},{"issue":"1","key":"10.1016\/j.phymed.2026.158767_bib0081","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12882-025-03953-3","article-title":"New insights in the treatment of DKD: recent advances and future prospects","volume":"26","author":"Zhao","year":"2025","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.phymed.2026.158767_bib82","unstructured":"Liu, D., Li, C., Xu, Y., Kang, N., 2021. Research progress on anti-diabetic mechanism of Wuweizi (Schisandrae Chinensis Fructus) against diabetes and its complications. Guid. J. Tradit. Chin. Med. Pharm. 27 128-132+141."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326009980?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326009980?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:07:29Z","timestamp":1793192849000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326009980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":76,"alternative-id":["S0944711326009980"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158767","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolic regulation of uridine in diabetic kidney disease and its pharmacological modulation by schisandrin B","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158767","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"158767"}}