{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:38:47Z","timestamp":1793194727197,"version":"4.5.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82575105"],"award-info":[{"award-number":["82575105"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474540"],"award-info":[{"award-number":["82474540"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374476"],"award-info":[{"award-number":["82374476"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2025ZD1801400"],"award-info":[{"award-number":["2025ZD1801400"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC3507401"],"award-info":[{"award-number":["2024YFC3507401"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.phymed.2026.158781","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:06:57Z","timestamp":1788793617000},"page":"158781","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["AMPK\u03b11 activation enhances mitophagy to counteract hypoxia-induced neuronal apoptosis in cervical spondylotic myelopathy and facilitates functional recovery mediated by rosmarinic acid"],"prefix":"10.1016","volume":"161","author":[{"given":"Pei-Min","family":"Pu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8359-446X","authenticated-orcid":false,"given":"Yu-Xiang","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Pian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0502-1495","authenticated-orcid":false,"given":"Ya-Yun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Li","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9006-4547","authenticated-orcid":false,"given":"Xue-Jun","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0410-7900","authenticated-orcid":false,"given":"Min","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158781_bib0001","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3389\/fnins.2020.00138","article-title":"The pathophysiology of degenerative cervical myelopathy and the physiology of recovery following decompression","volume":"14","author":"Akter","year":"2020","journal-title":"Front. Neurosci."},{"issue":"9","key":"10.1016\/j.phymed.2026.158781_bib0002","doi-asserted-by":"crossref","first-page":"7463","DOI":"10.1007\/s12035-018-0920-4","article-title":"Rosmarinic acid mitigates mitochondrial dysfunction and spinal glial activation in oxaliplatin-induced peripheral neuropathy","volume":"55","author":"Areti","year":"2018","journal-title":"Mol. Neurobiol."},{"issue":"2","key":"10.1016\/j.phymed.2026.158781_bib0003","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/s41582-019-0303-0","article-title":"Degenerative cervical myelopathy - update and future directions","volume":"16","author":"Badhiwala","year":"2020","journal-title":"Nat. Rev. Neurol."},{"issue":"3","key":"10.1016\/j.phymed.2026.158781_bib0004","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1042\/BJ20070797","article-title":"The selectivity of protein kinase inhibitors: a further update","volume":"408","author":"Bain","year":"2007","journal-title":"Biochem. J."},{"issue":"23","key":"10.1016\/j.phymed.2026.158781_bib0005","doi-asserted-by":"crossref","first-page":"7139","DOI":"10.3390\/jcm13237139","article-title":"Degenerative cervical myelopathy: history, physical examination, and diagnosis","volume":"13","author":"Balmaceno-Criss","year":"2024","journal-title":"J. Clin. Med."},{"issue":"2","key":"10.1016\/j.phymed.2026.158781_bib0006","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/ana.22421","article-title":"The blood-spinal cord barrier: morphology and clinical implications","volume":"70","author":"Bartanusz","year":"2011","journal-title":"Ann. Neurol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158781_bib0007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/neu.1995.12.1","article-title":"A sensitive and reliable locomotor rating scale for open field testing in rats","volume":"12","author":"Basso","year":"1995","journal-title":"J. Neurotrauma."},{"key":"10.1016\/j.phymed.2026.158781_bib0008","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.neubiorev.2017.09.007","article-title":"Functional gait analysis in a spinal contusion rat model","volume":"83","author":"Bhimani","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"3","key":"10.1016\/j.phymed.2026.158781_bib0009","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1161\/CIRCRESAHA.116.308301","article-title":"Ablation of adenosine monophosphate-activated protein kinase \u03b11 in vascular smooth muscle cells promotes diet-induced atherosclerotic calcification In vivo","volume":"119","author":"Cai","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2026.158781_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156500","article-title":"Allicin alleviates traumatic brain injury-induced neuroinflammation by enhancing PKC-\u03b4-mediated mitophagy","volume":"139","author":"Cheng","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158781_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2025.115213","article-title":"Anti-inflammatory role of methylprednisolone in the hippocampus prevents depressive-like behavior after spinal cord injury in rats","volume":"305","author":"Fiorin","year":"2026","journal-title":"Physiol. Behav."},{"issue":"12","key":"10.1016\/j.phymed.2026.158781_bib0012","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1016\/j.molcel.2023.04.022","article-title":"The mitochondrial intermembrane space protein mitofissin drives mitochondrial fission required for mitophagy","volume":"83","author":"Fukuda","year":"2023","journal-title":"Mol. Cell"},{"issue":"4","key":"10.1016\/j.phymed.2026.158781_bib0013","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.4103\/NRR.NRR-D-24-01029","article-title":"Mitophagy: a key regulator in the pathophysiology and treatment of spinal cord injury","volume":"21","author":"Gu","year":"2026","journal-title":"Neural. Regen Res."},{"key":"10.1016\/j.phymed.2026.158781_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.177882","article-title":"Rosmarinic acid attenuates blood-brain barrier dysfunction to improve cerebral ischemia\/reperfusion injury in mice","volume":"1003","author":"Guo","year":"2025","journal-title":"Eur. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.phymed.2026.158781_bib0015","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/exd.14773","article-title":"Rosmarinic acid alleviates ultraviolet-mediated skin aging via attenuation of mitochondrial and ER stress responses","volume":"32","author":"Gupta","year":"2023","journal-title":"Exp. Dermatol."},{"issue":"17","key":"10.1016\/j.phymed.2026.158781_bib70","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.3390\/nu14173508","article-title":"Rosmarinic acid attenuates rotenone-induced neurotoxicity in SH-SY5Y Parkinson\u2019s disease cell model through Abl inhibition","volume":"14","author":"Han","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.158781_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchemneu.2021.102008","article-title":"Rosmarinic acid attenuates lipopolysaccharide-induced neuroinflammation and cognitive impairment in rats","volume":"117","author":"Hassanzadeh-Taheri","year":"2021","journal-title":"J. Chem. Neuroanat."},{"issue":"2","key":"10.1016\/j.phymed.2026.158781_bib0017","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158781_bib0018","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1007\/s12035-025-05576-z","article-title":"SIRT3\/AMPK-driven mitophagy failure underlies methylmercury-induced neurotoxicity: evidence from humans to cells","volume":"63","author":"Hu","year":"2026","journal-title":"Mol. Neurobiol."},{"issue":"6","key":"10.1016\/j.phymed.2026.158781_bib0019","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1111\/cns.13114","article-title":"Exercise activates lysosomal function in the brain through AMPK-SIRT1-TFEB pathway","volume":"25","author":"Huang","year":"2019","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.phymed.2026.158781_bib0020","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2026.1805529","article-title":"Blood-spinal cord barrier disruption after spinal cord injury: a time-dependent mechanistic review","volume":"20","author":"Jiang","year":"2026","journal-title":"Front. Cell Neurosci."},{"issue":"8","key":"10.1016\/j.phymed.2026.158781_bib0021","doi-asserted-by":"crossref","first-page":"10245","DOI":"10.1007\/s12035-025-04892-8","article-title":"Potent ameliorative effects of Rosmarinic Acid on tramadol-induced neurotoxicity in the brain and hippocampus; by suppressing oxidative stress, apoptosis, ER stress, and regulating cognitive functions","volume":"62","author":"Karaca","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"22 Suppl 1","key":"10.1016\/j.phymed.2026.158781_bib0022","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1097\/BRS.0b013e3182a7f2c3","article-title":"Pathophysiology and natural history of cervical spondylotic myelopathy","volume":"38","author":"Karadimas","year":"2013","journal-title":"Spine"},{"key":"10.1016\/j.phymed.2026.158781_bib0023","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.nbd.2013.02.013","article-title":"A novel experimental model of cervical spondylotic myelopathy (CSM) to facilitate translational research","volume":"54","author":"Karadimas","year":"2013","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/j.phymed.2026.158781_bib0024","doi-asserted-by":"crossref","first-page":"213","DOI":"10.31616\/asj.2022.0440","article-title":"Update of the natural history, pathophysiology, and treatment strategies of degenerative cervical myelopathy: a narrative review","volume":"17","author":"Kim","year":"2023","journal-title":"Asian Spine J."},{"issue":"1","key":"10.1016\/j.phymed.2026.158781_bib0026","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2020.1797280","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1","volume":"17","author":"Klionsky","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2026.158781_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.135615","article-title":"Sulfiredoxin-1 protects spinal cord neurons against oxidative stress in the oxygen-glucose deprivation\/reoxygenation model through the bax\/cytochrome c\/caspase 3 apoptosis pathway","volume":"744","author":"Lan","year":"2021","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.phymed.2026.158781_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101817","article-title":"PINK1\/Parkin-mediated mitophagy in neurodegenerative diseases","volume":"84","author":"Li","year":"2023","journal-title":"Ageing Res. Rev."},{"issue":"12","key":"10.1016\/j.phymed.2026.158781_bib0029","doi-asserted-by":"crossref","first-page":"5364","DOI":"10.7150\/thno.72713","article-title":"Impairment of autophagy after spinal cord injury potentiates neuroinflammation and motor function deficit in mice","volume":"12","author":"Li","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.phymed.2026.158781_bib0030","doi-asserted-by":"crossref","unstructured":"Li, Y., Xiang, J., Zhang, J., Lin, J., Wu, Y., Wang, X., 2020. Inhibition of Brd4 by JQ1 promotes functional recovery from spinal cord injury by activating autophagy. Front. Cell Neurosci.. 14, 555591. https:\/\/doi.org\/10.3389\/fncel.2020.555591.","DOI":"10.3389\/fncel.2020.555591"},{"issue":"5","key":"10.1016\/j.phymed.2026.158781_bib0031","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s12264-019-00368-7","article-title":"Pros and cons: autophagy in acute spinal cord injury","volume":"35","author":"Li","year":"2019","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.phymed.2026.158781_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2026.178722","article-title":"Rosmarinic acid ameliorates cognitive impairment in sepsis-associated encephalopathy by preserving blood-brain barrier integrity and suppressing pyroptosis of brain endothelial cells","volume":"1019","author":"Liu","year":"2026","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158781_bib0033","article-title":"Identification and validation of glucocorticoid receptor and programmed cell death-related genes in spinal cord injury using machine learning","volume":"15","author":"Lu","year":"2025","journal-title":"Sci. Rep."},{"issue":"6642","key":"10.1016\/j.phymed.2026.158781_bib0034","doi-asserted-by":"crossref","DOI":"10.1126\/science.abj5559","article-title":"Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1","volume":"380","author":"Malik","year":"2023","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.phymed.2026.158781_bib0035","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70543","article-title":"Felodipine promotes the recovery of mice with spinal cord injury by activating macrolipophagy through the AMPK-mTOR pathway","volume":"29","author":"Mao","year":"2025","journal-title":"J. Cell Mol. Med."},{"issue":"1","key":"10.1016\/j.phymed.2026.158781_bib69","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1124\/jpet.102.033340","article-title":"Metabolism and disposition of resveratrol in rats: extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model","volume":"302","author":"Marier","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"2","key":"10.1016\/j.phymed.2026.158781_bib0036","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3122\/jabfm.2020.02.190195","article-title":"Cervical Spondylotic Myelopathy: a guide to diagnosis and management","volume":"33","author":"McCormick","year":"2020","journal-title":"J. Am. Board Fam. Med."},{"issue":"24","key":"10.1016\/j.phymed.2026.158781_bib0037","doi-asserted-by":"crossref","first-page":"e1462","DOI":"10.5435\/JAAOS-D-25-00026","article-title":"Diagnosis and management of degenerative cervical myelopathy","volume":"33","author":"Mechas","year":"2025","journal-title":"J. Am. Acad. Orthop. Surg."},{"issue":"9","key":"10.1016\/j.phymed.2026.158781_bib0038","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/ncb2329","article-title":"The AMPK signalling pathway coordinates cell growth, autophagy and metabolism","volume":"13","author":"Mihaylova","year":"2011","journal-title":"Nat. Cell Biol."},{"issue":"11","key":"10.1016\/j.phymed.2026.158781_bib0039","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1111\/bph.15802","article-title":"Altered blood-brain barrier and blood-spinal cord barrier dynamics in amyotrophic lateral sclerosis: impact on medication efficacy and safety","volume":"179","author":"Pan","year":"2022","journal-title":"Br. J. Pharmacol."},{"issue":"12","key":"10.1016\/j.phymed.2026.158781_bib0040","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1080\/15548627.2021.1898748","article-title":"AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3","volume":"17","author":"Paquette","year":"2021","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.phymed.2026.158781_bib0041","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1038\/s41467-023-38401-z","article-title":"Redefining the role of AMPK in autophagy and the energy stress response","volume":"14","author":"Park","year":"2023","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.phymed.2026.158781_bib0042","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1080\/15548627.2024.2435238","article-title":"AMPK protects proximal tubular epithelial cells from lysosomal dysfunction and dedifferentiation induced by lipotoxicity","volume":"21","author":"Pierre","year":"2025","journal-title":"Autophagy"},{"issue":"3","key":"10.1016\/j.phymed.2026.158781_bib0043","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1111\/jcmm.13978","article-title":"AMPK\u03b12 knockout enhances tumour inflammation through exacerbated liver injury and energy deprivation-associated AMPK\u03b11 activation","volume":"23","author":"Qiu","year":"2019","journal-title":"J. Cell Mol. Med."},{"issue":"5","key":"10.1016\/j.phymed.2026.158781_bib0044","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1002\/ptr.7825","article-title":"Molecular mechanisms of neuroprotective offerings by rosmarinic acid against neurodegenerative and other CNS pathologies","volume":"37","author":"Ravaria","year":"2023","journal-title":"Phytother. Res."},{"issue":"1","key":"10.1016\/j.phymed.2026.158781_bib0045","first-page":"38","article-title":"Effect of duration of acute spinal cord compression in a new acute cord injury model in the rat","volume":"10","author":"Rivlin","year":"1978","journal-title":"Surg. Neurol."},{"issue":"5","key":"10.1016\/j.phymed.2026.158781_bib0046","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41419-024-06662-1","article-title":"Pirh2 modulates the mitochondrial function and cytochrome c-mediated neuronal death during Alzheimer's disease","volume":"15","author":"Singh","year":"2024","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.phymed.2026.158781_bib0047","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.3390\/jcm10061214","article-title":"Degenerative cervical myelopathy: insights into its pathobiology and molecular mechanisms","volume":"10","author":"Tu","year":"2021","journal-title":"J. Clin. Med."},{"issue":"4","key":"10.1016\/j.phymed.2026.158781_bib0048","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1046\/j.1471-4159.1999.721707.x","article-title":"Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system","volume":"72","author":"Turnley","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.phymed.2026.158781_bib0049","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2025.111407","article-title":"Artesunate alleviates cerebral ischemia\/reperfusion injury by suppressing FUNDC1-mediated excessive mitophagy","volume":"228","author":"Wang","year":"2025","journal-title":"Brain Res. Bull."},{"issue":"7","key":"10.1016\/j.phymed.2026.158781_bib0050","doi-asserted-by":"crossref","DOI":"10.1093\/jmcb\/mjaf030","article-title":"AMPK maintains the activation of hepatic stellate cells through mitophagy-induced metabolic reprogramming","volume":"17","author":"Wang","year":"2026","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2026.158781_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.carpath.2025.107742","article-title":"The anti-atherosclerosis effect and molecular mechanism of AMPK\u03b11 by polarizing monocytes to an M2 phenotype via cell-intrinsic lysosomal lipolysis","volume":"78","author":"Wang","year":"2025","journal-title":"Cardiovasc. Pathol.: Official J. Soc. Cardiovasc. Pathol."},{"key":"10.1016\/j.phymed.2026.158781_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110272","article-title":"Emerging role of transcription factor EB in mitochondrial quality control","volume":"128","author":"Wang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2026.158781_bib0053","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155448","article-title":"Rosmarinic acid mitigates acrylamide induced neurotoxicity via suppressing endoplasmic reticulum stress and inflammation in mouse hippocampus","volume":"126","author":"Wang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158781_bib0054","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154866","article-title":"Morin exhibits a neuroprotective effect in MPTP-induced Parkinson's disease model via TFEB\/AMPK-mediated mitophagy","volume":"116","author":"Wang","year":"2023","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.phymed.2026.158781_bib0055","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.7150\/ijbs.57825","article-title":"Betulinic acid inhibits pyroptosis in spinal cord injury by augmenting autophagy via the AMPK-mTOR-TFEB signaling pathway","volume":"17","author":"Wu","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.phymed.2026.158781_bib0056","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154250","article-title":"Artemisia Leaf Extract protects against neuron toxicity by TRPML1 activation and promoting autophagy\/mitophagy clearance in both in vitro and in vivo models of MPP+\/MPTP-induced Parkinson's disease","volume":"104","author":"Wu","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158781_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102842","article-title":"Bidirectional regulation of neuronal autophagy in ischemic stroke: mechanisms and therapeutic potential","volume":"111","author":"Wu","year":"2025","journal-title":"Ageing Res. Rev."},{"issue":"15","key":"10.1016\/j.phymed.2026.158781_bib68","doi-asserted-by":"crossref","first-page":"3654","DOI":"10.1021\/jf400002x","article-title":"Preparation and oral bioavailability study of curcuminoid-loaded microemulsion","volume":"61","author":"Xiao","year":"2013","journal-title":"J. of agri. and food chem."},{"issue":"4","key":"10.1016\/j.phymed.2026.158781_bib0058","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12859","article-title":"Melatonin restores endoplasmic reticulum homeostasis to protect injured neurons in a rat model of chronic cervical cord compression","volume":"74","author":"Yao","year":"2023","journal-title":"J. Pineal Res."},{"issue":"4","key":"10.1016\/j.phymed.2026.158781_bib0059","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1007\/s12640-013-9397-0","article-title":"Induction of neuronal mitophagy in acute spinal cord injury in rats","volume":"24","author":"Yu","year":"2013","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.phymed.2026.158781_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2022.114006","article-title":"Rosmarinic acid relieves LPS-induced sickness and depressive-like behaviors in mice by activating the BDNF\/Nrf2 signaling and autophagy pathway","volume":"433","author":"Yu","year":"2022","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.phymed.2026.158781_bib0061","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2513172122","article-title":"Mechanical compression induces neuronal apoptosis, reduces synaptic activity, and promotes glial neuroinflammation in mice and humans","volume":"123","author":"Zarodniuk","year":"2026","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"2","key":"10.1016\/j.phymed.2026.158781_bib0062","doi-asserted-by":"crossref","first-page":"810","DOI":"10.7150\/thno.78370","article-title":"3,4-Dimethoxychalcone, a caloric restriction mimetic, enhances TFEB-mediated autophagy and alleviates pyroptosis and necroptosis after spinal cord injury","volume":"13","author":"Zhang","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.phymed.2026.158781_bib0063","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2022.114055","article-title":"Metformin attenuates early brain injury after subarachnoid hemorrhage in rats via AMPK-dependent mitophagy","volume":"353","author":"Zhang","year":"2022","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.phymed.2026.158781_bib0064","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.freeradbiomed.2020.01.014","article-title":"Echinacoside attenuates inflammatory response in a rat model of cervical spondylotic myelopathy via inhibition of excessive mitochondrial fission","volume":"152","author":"Zhou","year":"2020","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.phymed.2026.158781_bib0065","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/jnc.15011","article-title":"Muscone suppresses inflammatory responses and neuronal damage in a rat model of cervical spondylotic myelopathy by regulating Drp1-dependent mitochondrial fission","volume":"155","author":"Zhou","year":"2020","journal-title":"J. Neurochem."},{"issue":"8","key":"10.1016\/j.phymed.2026.158781_bib0066","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1016\/j.apsb.2024.05.012","article-title":"Mitophagy and cGAS-STING crosstalk in neuroinflammation","volume":"14","author":"Zhou","year":"2024","journal-title":"Acta Pharm. Sin B"},{"issue":"Pt A","key":"10.1016\/j.phymed.2026.158781_bib0067","article-title":"Shenqisherong pill ameliorates neuronal apoptosis by inhibiting the JNK\/caspase-3 signaling pathway in a rat model of cervical cord compression","volume":"318","author":"Zhu","year":"2024","journal-title":"J. Ethnopharmacol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326010111?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326010111?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:14:33Z","timestamp":1793193273000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326010111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":69,"alternative-id":["S0944711326010111"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158781","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AMPK\u03b11 activation enhances mitophagy to counteract hypoxia-induced neuronal apoptosis in cervical spondylotic myelopathy and facilitates functional recovery mediated by rosmarinic acid","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158781","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"158781"}}