{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:09:40Z","timestamp":1789996180078,"version":"4.0.1"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015956","name":"Special Project for Research and Development in Key areas of Guangdong Province","doi-asserted-by":"publisher","award":["2020B1111110007"],"award-info":[{"award-number":["2020B1111110007"]}],"id":[{"id":"10.13039\/501100015956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","award":["11122531"],"award-info":[{"award-number":["11122531"]}],"id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","award":["17182681"],"award-info":[{"award-number":["17182681"]}],"id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","award":["14150521"],"award-info":[{"award-number":["14150521"]}],"id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173948"],"award-info":[{"award-number":["82173948"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473341"],"award-info":[{"award-number":["81473341"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204747"],"award-info":[{"award-number":["82204747"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010428","name":"Innovation and Technology Fund","doi-asserted-by":"publisher","award":["ITF"],"award-info":[{"award-number":["ITF"]}],"id":[{"id":"10.13039\/501100010428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012479","name":"General Research Fund of Shanghai Normal University","doi-asserted-by":"publisher","award":["12101123"],"award-info":[{"award-number":["12101123"]}],"id":[{"id":"10.13039\/501100012479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012479","name":"General Research Fund of Shanghai Normal University","doi-asserted-by":"publisher","award":["12100818"],"award-info":[{"award-number":["12100818"]}],"id":[{"id":"10.13039\/501100012479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012479","name":"General Research Fund of Shanghai Normal University","doi-asserted-by":"publisher","award":["12101322"],"award-info":[{"award-number":["12101322"]}],"id":[{"id":"10.13039\/501100012479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012479","name":"General Research Fund of Shanghai Normal University","doi-asserted-by":"publisher","award":["12100615"],"award-info":[{"award-number":["12100615"]}],"id":[{"id":"10.13039\/501100012479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012479","name":"General Research Fund of Shanghai Normal University","doi-asserted-by":"publisher","award":["22100014"],"award-info":[{"award-number":["22100014"]}],"id":[{"id":"10.13039\/501100012479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20160531193812867"],"award-info":[{"award-number":["JCYJ20160531193812867"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001747","name":"Hong Kong Baptist University","doi-asserted-by":"publisher","award":["FRG2\/17-18\/060"],"award-info":[{"award-number":["FRG2\/17-18\/060"]}],"id":[{"id":"10.13039\/501100001747","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001747","name":"Hong Kong Baptist University","doi-asserted-by":"publisher","award":["MPCF-001-2016\/2017"],"award-info":[{"award-number":["MPCF-001-2016\/2017"]}],"id":[{"id":"10.13039\/501100001747","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001747","name":"Hong Kong Baptist University","doi-asserted-by":"publisher","award":["RC-IRMS\/14-15\/06"],"award-info":[{"award-number":["RC-IRMS\/14-15\/06"]}],"id":[{"id":"10.13039\/501100001747","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001747","name":"Hong Kong Baptist University","doi-asserted-by":"publisher","award":["FRG2\/16-17\/002"],"award-info":[{"award-number":["FRG2\/16-17\/002"]}],"id":[{"id":"10.13039\/501100001747","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001747","name":"Hong Kong Baptist University","doi-asserted-by":"publisher","award":["RC-Start-up Grants"],"award-info":[{"award-number":["RC-Start-up Grants"]}],"id":[{"id":"10.13039\/501100001747","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.phymed.2026.158787","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:45:05Z","timestamp":1788882305000},"page":"158787","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Lymph-absorbed Radix Astragali polysaccharide induces IgA production through TLR4-dependent DC-B axis to alleviate colitis"],"prefix":"10.1016","volume":"162","author":[{"given":"Quanwei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuying","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyuan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hauyee","family":"Fung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunghang","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waipo","family":"Chong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxiang","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zonggang","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiping","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanbin","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158787_bib0001","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1001147","article-title":"Enhancing oral vaccine potency by targeting intestinal M cells","volume":"6","author":"Azizi","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.phymed.2026.158787_bib0002","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.4049\/jimmunol.1102157","article-title":"TLR4-mediated AKT activation is MyD88\/TRIF dependent and critical for induction of oxidative phosphorylation and mitochondrial transcription factor A in murine macrophages","volume":"188","author":"Bauerfeld","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.phymed.2026.158787_bib0003","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.immuni.2018.08.011","article-title":"IgA responses to microbiota","volume":"49","author":"Bunker","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.phymed.2026.158787_bib0004","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/cdd.2012.146","article-title":"TLR2-dependent selective autophagy regulates NF-\u03baB lysosomal degradation in hepatoma-derived M2 macrophage differentiation","volume":"20","author":"Chang","year":"2013","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.phymed.2026.158787_bib0005","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.addr.2015.03.007","article-title":"Delivery strategies to enhance oral vaccination against enteric infections","volume":"91","author":"Davitt","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.phymed.2026.158787_bib0006","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.70080","article-title":"Lactobacillus reuteri-mediated dietary xylooligosaccharides enhance jejunal cell survival via suppression of oxygen-dependent apoptotic processes in a pig model","volume":"4","author":"Deng","year":"2025","journal-title":"Imeta"},{"key":"10.1016\/j.phymed.2026.158787_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.110969","article-title":"Astragalus polysaccharides ameliorates experimental colitis by regulating memory B cells metabolism","volume":"394","author":"Deng","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.phymed.2026.158787_bib0008","doi-asserted-by":"crossref","first-page":"5382","DOI":"10.1038\/s41467-021-25767-1","article-title":"Selective targeting of the TLR2\/MyD88\/NF-\u03baB pathway reduces \u03b1-synuclein spreading in vitro and in vivo","volume":"12","author":"Dutta","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.158787_bib0009","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ddtec.2020.09.005","article-title":"Carbohydrate-based adjuvants","volume":"35\u201336","author":"Garcia-Vello","year":"2020","journal-title":"Drug Discov. Today Technol."},{"key":"10.1016\/j.phymed.2026.158787_bib0010","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.addr.2005.12.003","article-title":"Needle-free vaccine delivery","volume":"58","author":"Giudice","year":"2006","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.phymed.2026.158787_bib0011","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/sji.12163","article-title":"Intermittent fasting promotes bacterial clearance and intestinal IgA production in Salmonella typhimurium-infected mice","volume":"79","author":"God\u00ednez-Victoria","year":"2014","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.phymed.2026.158787_bib0012","article-title":"Generation of mouse bone marrow-derived dendritic cells (BM-DCs)","volume":"2","author":"Granucci","year":"2012","journal-title":"Bio-Protoc."},{"key":"10.1016\/j.phymed.2026.158787_bib0013","article-title":"Immunomodulatory effects exerted by Poria Cocos polysaccharides via TLR4\/TRAF6\/NF-\u03baB signaling in vitro and in vivo","volume":"112","author":"Hui","year":"2019","journal-title":"Biomed. Pharmacother.\u202f=\u202fBiomed. Pharmacother."},{"key":"10.1016\/j.phymed.2026.158787_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.147052","article-title":"Vancomycin-sensitive gut microbiota mediate Dendrobii \u03b2-1,4-mannan degradation and anti-colitis activity in mice","volume":"323","author":"Huo","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2026.158787_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.132580","article-title":"Functional fractions of Astragalus polysaccharides as a potential prebiotic to alleviate ulcerative colitis","volume":"271","author":"Huo","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2026.158787_bib0016","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.biomaterials.2018.10.041","article-title":"M cell targeting engineered biomaterials for effective vaccination","volume":"192","author":"Islam","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.phymed.2026.158787_bib0017","article-title":"Quality consistency evaluation of multiorigin Chinese herbal medicine by using a combination of chemical similarity and in vitro bioequivalence: Taraxaci Herba as a case study","author":"Jiang","year":"2025","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.phymed.2026.158787_bib0018","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/ni1471","article-title":"Cell surface 4-1BBL mediates sequential signaling pathways \u201cdownstream\u201d of TLR and is required for sustained TNF production in macrophages","volume":"8","author":"Kang","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.phymed.2026.158787_bib0019","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.68563","article-title":"SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-\u03baB pathway","volume":"10","author":"Khan","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.phymed.2026.158787_bib0020","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.786127","article-title":"A novel polysaccharide isolated from fresh longan (Dimocarpus longan Lour.) activates macrophage via TLR2\/4-Mediated PI3\/AKT and MyD88\/TRAF6 pathways","volume":"12","author":"Lan","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158787_bib0021","doi-asserted-by":"crossref","first-page":"5670","DOI":"10.1016\/j.vaccine.2019.07.098","article-title":"Adjuvant Systems for vaccines: 13\u202fyears of post-licensure experience in diverse populations have progressed the way adjuvanted vaccine safety is investigated and understood","volume":"37","author":"Laup\u00e8ze","year":"2019","journal-title":"Vaccine"},{"key":"10.1016\/j.phymed.2026.158787_bib0022","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0140-6736(23)00966-2","article-title":"Ulcerative colitis","volume":"402","author":"Le Berre","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2026.158787_bib0023","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1038\/s41401-021-00820-3","article-title":"Lupeol protects against cardiac hypertrophy via TLR4-PI3K-Akt-NF-\u03baB pathways","volume":"43","author":"Li","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2026.158787_bib0024","doi-asserted-by":"crossref","first-page":"5968","DOI":"10.1021\/acs.jafc.9b01489","article-title":"Destiny of dendrobium officinale polysaccharide after oral administration: indigestible and nonabsorbing, ends in modulating gut microbiota","volume":"67","author":"Li","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2026.158787_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.140346","article-title":"Anti-inflammation mechanisms of a homogeneous polysaccharide from Phyllanthus emblica L. on DSS induced colitis mice via the gut microbiota and metabolites alteration","volume":"459","author":"Li","year":"2024","journal-title":"Food Chem."},{"key":"10.1016\/j.phymed.2026.158787_bib0026","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.carbpol.2017.12.058","article-title":"A review of polysaccharides from Schisandra chinensis and Schisandra sphenanthera: properties, functions and applications","volume":"184","author":"Li","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.phymed.2026.158787_bib0027","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.3390\/molecules23071563","article-title":"Interference of quercetin on astragalus polysaccharide-induced macrophage activation","volume":"23","author":"Li","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2026.158787_bib0028","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1002\/pca.3502","article-title":"Characterization of quality marker for mume fructus pulp by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry-based untargeted metabolomics combined with biological activities","volume":"36","author":"Liu","year":"2025","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.phymed.2026.158787_bib0029","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.ijbiomac.2018.01.070","article-title":"Polygonatum sibiricum polysaccharides play anti-cancer effect through TLR4-MAPK\/NF-\u03baB signaling pathways","volume":"111","author":"Long","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2026.158787_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119584","article-title":"Evolution of the ultrastructure and polysaccharide composition of flax fibres over time: when history meets science","volume":"291","author":"Melelli","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.phymed.2026.158787_bib0031","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-22851-4","article-title":"Prevention of Shiga toxin 1-caused colon injury by plant-derived recombinant IgA","volume":"12","author":"Nakanishi","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2026.158787_bib0032","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/pca.70032","article-title":"Polysaccharides as the key differentiator in raw and processed pinellia ternata tubers: immunostimulatory effects and mechanism of action","volume":"37","author":"Ngo","year":"2026","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.phymed.2026.158787_bib0033","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1080\/19490976.2017.1310357","article-title":"Intestinal IgA as a modulator of the gut microbiota","volume":"8","author":"Okai","year":"2017","journal-title":"Gut. Microbes."},{"key":"10.1016\/j.phymed.2026.158787_bib0034","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nmicrobiol.2016.103","article-title":"High-affinity monoclonal IgA regulates gut microbiota and prevents colitis in mice","volume":"1","author":"Okai","year":"2016","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.phymed.2026.158787_bib0035","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41385-019-0227-4","article-title":"IgA and the intestinal microbiota: the importance of being specific","volume":"13","author":"Pabst","year":"2020","journal-title":"Mucosal. Immunol."},{"key":"10.1016\/j.phymed.2026.158787_bib0036","article-title":"Reporting animal research: explanation and elaboration for the ARRIVE guidelines 2.0","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol."},{"key":"10.1016\/j.phymed.2026.158787_bib0037","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/s12917-020-02451-y","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"16","author":"Percie du Sert","year":"2020","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.phymed.2026.158787_bib0038","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s41577-020-00479-7","article-title":"A guide to vaccinology: from basic principles to new developments","volume":"21","author":"Pollard","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.phymed.2026.158787_bib0039","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaf4822","article-title":"IgA production requires B cell interaction with subepithelial dendritic cells in Peyer\u2019s patches","volume":"352","author":"Reboldi","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.phymed.2026.158787_bib0040","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.4049\/jimmunol.171.7.3684","article-title":"CD11b+ Peyer\u2019s patch dendritic cells secrete IL-6 and induce IgA secretion from naive B cells","volume":"171","author":"Sato","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.phymed.2026.158787_bib0041","series-title":"Mucosal Vaccines (Second Edition)","first-page":"487","article-title":"Chapter 28 - M Cell-Targeted Vaccines","author":"Sato","year":"2020"},{"key":"10.1016\/j.phymed.2026.158787_bib0042","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1002\/pca.3540","article-title":"Targeted neuroprotection in sporadic Alzheimer\u2019s disease: UPLC-ESI-MS\/MS profiling and bilosome-mediated delivery of crateva magna and its endophytic fungal extracts","volume":"36","author":"Talaat","year":"2025","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.phymed.2026.158787_bib0043","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.mucimm.2023.12.002","article-title":"MZB1-mediated IgA secretion suppresses the development and progression of colorectal cancer triggered by gut inflammation","volume":"17","author":"Tang","year":"2024","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.phymed.2026.158787_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113015","article-title":"Extraction, structure, and activity of polysaccharide from Radix astragali","volume":"150","author":"Tang","year":"2022","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.phymed.2026.158787_bib0045","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3390\/biom9090389","article-title":"Extraction, structural characterization, and biological functions of lycium barbarum polysaccharides: a review","volume":"9","author":"Tian","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.phymed.2026.158787_bib0046","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/s41392-025-02549-5","article-title":"p53: from understanding its structure to advances in therapeutic targeting","volume":"11","author":"Wang","year":"2026","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2026.158787_bib0047","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jep.2015.12.060","article-title":"TLR-4 may mediate signaling pathways of Astragalus polysaccharide RAP induced cytokine expression of RAW264.7 cells","volume":"179","author":"Wei","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158787_bib0048","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.ijbiomac.2021.04.055","article-title":"Structural differences of polysaccharides from Astragalus before and after honey processing and their effects on colitis mice","volume":"182","author":"Wu","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2026.158787_bib0049","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2019.115223","article-title":"Polysaccharide enhanced NK cell cytotoxicity against pancreatic cancer via TLR4\/MAPKs\/NF-\u03baB pathway in vitro\/vivo","volume":"225","author":"Xie","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.phymed.2026.158787_bib0050","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1007\/s00018-015-1892-4","article-title":"Regulation of intestinal IgA responses","volume":"72","author":"Xiong","year":"2015","journal-title":"Cell. Mol. Life Sci.: CMLS"},{"key":"10.1016\/j.phymed.2026.158787_bib0051","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41419-020-02824-z","article-title":"TLR4 promotes microglial pyroptosis via lncRNA-F630028O10Rik by activating PI3K\/AKT pathway after spinal cord injury","volume":"11","author":"Xu","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2026.158787_bib0052","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1111\/jpn.13771","article-title":"Effect of in ovo administration of Newcastle disease vaccine conjugated with Astragalus polysaccharide on growth performance, intestinal development, and mucosal immunity in broiler chickens","volume":"107","author":"Xue","year":"2023","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"10.1016\/j.phymed.2026.158787_bib0053","first-page":"39","article-title":"M cell-targeted mucosal vaccine strategies","volume":"354","author":"Yamamoto","year":"2012","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.phymed.2026.158787_bib0054","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.ijbiomac.2019.08.174","article-title":"A polysaccharide isolated from the fruits of Physalis alkekengi L. induces RAW264.7 macrophages activation via TLR2 and TLR4-mediated MAPK and NF-\u03baB signaling pathways","volume":"140","author":"Yang","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2026.158787_bib0055","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2021.738816","article-title":"Effects of in ovo injection of astragalus polysaccharide on the intestinal development and mucosal immunity in broiler chickens","volume":"8","author":"Yang","year":"2021","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.phymed.2026.158787_bib0056","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.carbpol.2011.08.045","article-title":"Separation, structure characterization, conformation and immunomodulating effect of a hyperbranched heteroglycan from Radix Astragali","volume":"87","author":"Yin","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.phymed.2026.158787_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119952","article-title":"M cells of mouse and human Peyer\u2019s patches mediate the lymphatic absorption of an Astragalus hyperbranched heteroglycan","volume":"296","author":"Zhang","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.phymed.2026.158787_bib0058","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119653","article-title":"A lymphatic route for a hyperbranched heteroglycan from Radix Astragali to trigger immune responses after oral dosing","volume":"292","author":"Zhang","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.phymed.2026.158787_bib0059","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118443","article-title":"Cordyceps polysaccharide marker CCP modulates immune responses via highly selective TLR4\/MyD88\/p38 axis","volume":"271","author":"Zhang","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.phymed.2026.158787_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113258","article-title":"Peucedanum praeruptorum Dunn polysaccharides regulate macrophage inflammatory response through TLR2\/TLR4-mediated MAPK and NF-\u03baB pathways","volume":"152","author":"Zhao","year":"2022","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.phymed.2026.158787_bib0061","article-title":"Astragalus polysaccharides exerts immunomodulatory effects via TLR4-mediated MyD88-dependent signaling pathway in vitro and in vivo","volume":"7","author":"Zhou","year":"2017","journal-title":"Sci. Rep."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326010172?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326010172?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:41:31Z","timestamp":1789994491000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326010172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":61,"alternative-id":["S0944711326010172"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158787","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lymph-absorbed Radix Astragali polysaccharide induces IgA production through TLR4-dependent DC-B axis to alleviate colitis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158787","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"158787"}}