{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:01:05Z","timestamp":1790283665124,"version":"4.1.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.phymed.2026.158789","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:39:29Z","timestamp":1788950369000},"page":"158789","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A Non-canonical role of phloretin in renal protection: Targeting WNT2B downregulation to prime PINK1\/ PARKIN-dependent mitophagy and attenuate renal fibrosis"],"prefix":"10.1016","volume":"162","author":[{"given":"Xue","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghui","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caian","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10225","key":"10.1016\/j.phymed.2026.158789_bib0001","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","article-title":"Global, regional, and national burden of chronic kidney disease, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"395","author":"Bikbov","year":"2020","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.phymed.2026.158789_bib0002","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/nrneph.2010.120","article-title":"Renal fibrosis: novel insights into mechanisms and therapeutic targets","volume":"6","author":"Boor","year":"2010","journal-title":"Nat. Rev. Nephrol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158789_bib0003","article-title":"Mitochondrial dysfunction: the hidden catalyst in chronic kidney disease progression","volume":"47","author":"Chen","year":"2025","journal-title":"Ren. Fail."},{"issue":"13","key":"10.1016\/j.phymed.2026.158789_bib0004","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1001\/jama.2019.14745","article-title":"Chronic kidney disease diagnosis and management: a review","volume":"322","author":"Chen","year":"2019","journal-title":"J. Am. Med. Assoc."},{"issue":"10","key":"10.1016\/j.phymed.2026.158789_bib0005","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1007\/s00109-024-02477-x","article-title":"WNT2B high\u2011expressed fibroblasts induce the fibrosis of IBD by promoting NK cells secreting IL-33","volume":"102","author":"Cheng","year":"2024","journal-title":"J. Mol. Med. (Berl)"},{"issue":"3","key":"10.1016\/j.phymed.2026.158789_bib0006","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.cell.2006.10.018","article-title":"Wnt\/beta-catenin signaling in development and disease","volume":"127","author":"Clevers","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2026.158789_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.153111","article-title":"Phloretin ameliorates hyperuricemia-induced chronic renal dysfunction through inhibiting NLRP3 inflammasome and uric acid reabsorption","volume":"66","author":"Cui","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158789_bib0008","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.mam.2018.06.002","article-title":"Cellular and molecular mechanisms of kidney fibrosis","volume":"65","author":"Djudjaj","year":"2019","journal-title":"Mol. Asp. Med."},{"issue":"42","key":"10.1016\/j.phymed.2026.158789_bib0009","doi-asserted-by":"crossref","first-page":"26700","DOI":"10.1021\/acs.jafc.5c05787","article-title":"Phloretin suppresses the mPTP abnormal opening via the SHP-2\/JAK2\/BAX axis to ameliorate nonalcoholic steatohepatitis","volume":"73","author":"Dong","year":"2025","journal-title":"J. Agric. Food Chem."},{"issue":"3","key":"10.1016\/j.phymed.2026.158789_bib0010","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.3390\/ijms25031718","article-title":"Mechanosensitive cation channel piezo1 is involved in renal fibrosis induction","volume":"25","author":"Drobnik","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.phymed.2026.158789_bib0011","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nrneph.2016.54","article-title":"Developmental signalling pathways in renal fibrosis: the roles of Notch, Wnt and Hedgehog","volume":"12","author":"Edeling","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"issue":"7","key":"10.1016\/j.phymed.2026.158789_bib0012","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.tem.2016.05.002","article-title":"Mitochondria\u2013power players in kidney function?","volume":"27","author":"Forbes","year":"2016","journal-title":"Trends Endocrinol. Metab."},{"issue":"7","key":"10.1016\/j.phymed.2026.158789_bib0013","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41581-024-00820-6","article-title":"Chronic kidney disease and the global public health agenda: an international consensus","volume":"20","author":"Francis","year":"2024","journal-title":"Nat. Rev. Nephrol."},{"issue":"24","key":"10.1016\/j.phymed.2026.158789_bib0014","doi-asserted-by":"crossref","first-page":"12421","DOI":"10.1039\/D1FO02577E","article-title":"Phloretin attenuation of hepatic steatosis via an improvement of mitochondrial dysfunction by activating AMPK-dependent signaling pathways in C57BL\/6J mice and HepG2 cells","volume":"12","author":"Han","year":"2021","journal-title":"Food Funct."},{"issue":"9","key":"10.1016\/j.phymed.2026.158789_bib0015","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1681\/ASN.2010101079","article-title":"Targeted inhibition of \u03b2-catenin\/CBP signaling ameliorates renal interstitial fibrosis","volume":"22","author":"Hao","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phymed.2026.158789_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107407","article-title":"Suppression of ZEB1 by Ethyl caffeate attenuates renal fibrosis via switching glycolytic reprogramming","volume":"209","author":"Hu","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2026.158789_bib0017","article-title":"Global, regional, and national burden of chronic kidney disease due to diabetes mellitus type 2 from 1990 to 2021, with projections to 2036: a systematic analysis for the Global Burden of Disease Study 2021","volume":"12","author":"Hu","year":"2025","journal-title":"Front. Med. (Lausanne)"},{"issue":"17","key":"10.1016\/j.phymed.2026.158789_bib0018","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202414673","article-title":"Autophagy related 5 promotes mitochondrial fission and inflammation via HSP90-HIF-1\u03b1-mediated glycolysis in kidney fibrosis","volume":"12","author":"Hu","year":"2025","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.phymed.2026.158789_bib0019","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s41392-023-01379-7","article-title":"Kidney fibrosis: from mechanisms to therapeutic medicines","volume":"8","author":"Huang","year":"2023","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2026.158789_bib0020","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev-physiol-022516-034227","article-title":"Mechanisms of Renal Fibrosis","volume":"80","author":"Humphreys","year":"2018","journal-title":"Annu. Rev. Physiol."},{"issue":"3","key":"10.1016\/j.phymed.2026.158789_bib0021","doi-asserted-by":"crossref","first-page":"e342","DOI":"10.1016\/S2214-109X(24)00050-0","article-title":"The major global burden of chronic kidney disease","volume":"12","author":"Jadoul","year":"2024","journal-title":"Lancet Glob. Health"},{"issue":"12","key":"10.1016\/j.phymed.2026.158789_bib0022","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1172\/JCI200320530","article-title":"Epithelial-mesenchymal transition and its implications for fibrosis","volume":"112","author":"Kalluri","year":"2003","journal-title":"J. Clin. Investig.: Off. J. Am. Soc. Clin. Investig."},{"issue":"6","key":"10.1016\/j.phymed.2026.158789_bib0023","first-page":"1103","article-title":"WNT2B: comparative integromics and clinical applications (Review)","volume":"16","author":"Katoh","year":"2005","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.phymed.2026.158789_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2024.109765","article-title":"Calorie restriction exacerbates folic acid-induced kidney fibrosis by altering mitochondria metabolism","volume":"134","author":"Kim","year":"2024","journal-title":"J. Nutr. Biochem."},{"issue":"22","key":"10.1016\/j.phymed.2026.158789_bib0025","doi-asserted-by":"crossref","first-page":"6516","DOI":"10.1021\/jf034475w","article-title":"Major phenolics in apple and their contribution to the total antioxidant capacity","volume":"51","author":"Lee","year":"2003","journal-title":"J. Agric. Food Chem."},{"issue":"12","key":"10.1016\/j.phymed.2026.158789_bib0027","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/s41419-022-05395-3","article-title":"Tubular \u03b2-catenin alleviates mitochondrial dysfunction and cell death in acute kidney injury","volume":"13","author":"Li","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2026.158789_bib0026","first-page":"102","article-title":"The origin of renal fibroblasts\/myofibroblasts and the signals that trigger fibrosis","volume":"92","author":"Li","year":"2016"},{"issue":"3","key":"10.1016\/j.phymed.2026.158789_bib0028","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0058848","article-title":"Curcumin inhibits transforming growth factor-\u03b21-induced EMT via PPAR\u03b3 pathway, not Smad pathway in renal tubular epithelial cells","volume":"8","author":"Li","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2026.158789_bib0029","series-title":"Separation and Purification of Phloretin from Apple Tree Branches and Design and Evaluation On Its Drug Delivery System","author":"Li","year":"2019"},{"key":"10.1016\/j.phymed.2026.158789_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101254","article-title":"PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation","volume":"26","author":"Lin","year":"2019","journal-title":"Redox Biol."},{"issue":"4","key":"10.1016\/j.phymed.2026.158789_bib0031","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.7150\/ijbs.80775","article-title":"Mitophagy alleviates cisplatin-induced renal tubular epithelial cell ferroptosis through ROS\/HO-1\/GPX4 axis","volume":"19","author":"Lin","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.phymed.2026.158789_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2025.111784","article-title":"Oxidative stress and inflammation in renal fibrosis: novel molecular mechanisms and therapeutic targets","volume":"421","author":"Liu","year":"2025","journal-title":"Chem.-Biol. Interact."},{"key":"10.1016\/j.phymed.2026.158789_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118116","article-title":"Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1\/PINK1\/mitophagy axis","volume":"257","author":"Liu","year":"2020","journal-title":"Life Sci."},{"issue":"6","key":"10.1016\/j.phymed.2026.158789_bib0034","doi-asserted-by":"crossref","first-page":"3782","DOI":"10.1039\/C9FO00373H","article-title":"Quercetin inhibits kidney fibrosis and the epithelial to mesenchymal transition of the renal tubular system involving suppression of the Sonic Hedgehog signaling pathway","volume":"10","author":"Liu","year":"2019","journal-title":"Food Funct."},{"issue":"12","key":"10.1016\/j.phymed.2026.158789_bib0035","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/nrneph.2011.149","article-title":"Cellular and molecular mechanisms of renal fibrosis","volume":"7","author":"Liu","year":"2011","journal-title":"Nat. Rev. Nephrol."},{"issue":"10","key":"10.1016\/j.phymed.2026.158789_bib0036","doi-asserted-by":"crossref","DOI":"10.1038\/s41581-021-00473-9","article-title":"Publisher correction: sustainable development goals relevant to kidney health: an update on progress","volume":"17","author":"Luyckx","year":"2021","journal-title":"Nat. Rev. Nephrol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158789_bib0037","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.devcel.2009.06.016","article-title":"Wnt\/beta-catenin signaling: components, mechanisms, and diseases","volume":"17","author":"MacDonald","year":"2009","journal-title":"Dev. Cell"},{"issue":"6","key":"10.1016\/j.phymed.2026.158789_bib0038","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrneph.2016.48","article-title":"TGF-\u03b2: the master regulator of fibrosis","volume":"12","author":"Meng","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"issue":"2","key":"10.1016\/j.phymed.2026.158789_bib0039","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgph.0001467","article-title":"National health policies and strategies for addressing chronic kidney disease: data from the International Society of Nephrology Global Kidney Health Atlas","volume":"3","author":"Neuen","year":"2023","journal-title":"PLOS Glob. Public Health"},{"key":"10.1016\/j.phymed.2026.158789_bib0040","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.7113","article-title":"Metabolomic and biochemical characterization of a new model of the transition of acute kidney injury to chronic kidney disease induced by folic acid","volume":"7","author":"Perales-Quintana","year":"2019","journal-title":"PeerJ."},{"issue":"1","key":"10.1016\/j.phymed.2026.158789_bib0041","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2024.2343817","article-title":"DKK3 promotes renal fibrosis by increasing MFF-mediated mitochondrial dysfunction in Wnt\/\u03b2-catenin pathway-dependent manner","volume":"46","author":"Song","year":"2024","journal-title":"Ren. Fail."},{"issue":"2","key":"10.1016\/j.phymed.2026.158789_bib0042","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1007\/s10528-024-10756-y","article-title":"Wnt\/\u03b2-catenin pathway aggravates renal fibrosis by activating PUM2 transcription to repress YME1L-mediated mitochondrial homeostasis","volume":"63","author":"Song","year":"2025","journal-title":"Biochem. Genet."},{"issue":"9","key":"10.1016\/j.phymed.2026.158789_bib0043","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/s41581-020-0309-2","article-title":"Autophagy in kidney homeostasis and disease","volume":"16","author":"Tang","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.phymed.2026.158789_bib0044","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.intimp.2016.03.029","article-title":"Rutin ameliorates kidney interstitial fibrosis in rats with obstructive nephropathy","volume":"35","author":"Wang","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2026.158789_bib0045","doi-asserted-by":"crossref","first-page":"7795","DOI":"10.2147\/DDDT.S520262","article-title":"Cytoskeleton rearrangement decreases mitochondrial fatty acid oxidation in renal tubular epithelial cells contributing to renal fibrogenesis","author":"Wang","year":"2025","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.phymed.2026.158789_bib0046","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.toxlet.2017.10.021","article-title":"Resveratrol attenuates oxidative damage through activating mitophagy in an in vitro model of Alzheimer's disease","volume":"282","author":"Wang","year":"2018","journal-title":"Toxicol. Lett."},{"issue":"3","key":"10.1016\/j.phymed.2026.158789_bib0047","article-title":"Apple phlorizin attenuates oxidative stress in Drosophila melanogaster","volume":"43","author":"Wang","year":"2019","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.phymed.2026.158789_bib0048","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.2147\/DDDT.S321879","article-title":"Puerarin alleviates UUO-induced inflammation and fibrosis by regulating the NF-\u03baB P65\/STAT3 and TGF\u03b21\/Smads signaling pathways","author":"Wang","year":"2021","journal-title":"Drug Des. Dev. Ther."},{"issue":"1","key":"10.1016\/j.phymed.2026.158789_bib0049","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12951-021-01122-w","article-title":"Ceria nanoparticles ameliorate renal fibrosis by modulating the balance between oxidative phosphorylation and aerobic glycolysis","volume":"20","author":"Wang","year":"2022","journal-title":"J. Nanobiotechnology."},{"issue":"11","key":"10.1016\/j.phymed.2026.158789_bib0050","first-page":"418","article-title":"Renal-protection effect and the potential mechanism of phloretin in mice with type-2 diabetic nephropathy","volume":"44","author":"Wang","year":"2023","journal-title":"Sh. Gongye ke-ji"},{"issue":"5","key":"10.1016\/j.phymed.2026.158789_bib0051","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1080\/15548627.2023.2287930","article-title":"LYC inhibits the AKT signaling pathway to activate autophagy and ameliorate TGFB-induced renal fibrosis","volume":"20","author":"Wang","year":"2024","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2026.158789_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104489","article-title":"Phloretin ameliorates dextran sulfate sodium-induced ulcerative colitis in mice by regulating the gut microbiota","volume":"150","author":"Wu","year":"2019","journal-title":"Pharmacol. Res."},{"issue":"2","key":"10.1016\/j.phymed.2026.158789_bib0053","doi-asserted-by":"crossref","DOI":"10.1002\/fft2.70136","article-title":"Targeting the Nrf2\/TGF-\u03b21\/Smad signaling pathway: a novel strategy for urolithin a to alleviate renal fibrosis","volume":"7","author":"Wu","year":"2026","journal-title":"Food Front."},{"issue":"4","key":"10.1016\/j.phymed.2026.158789_bib0054","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1111\/jcmm.15948","article-title":"FoxM1 promotes Wnt\/\u03b2-catenin pathway activation and renal fibrosis via transcriptionally regulating multi-Wnts expressions","volume":"25","author":"Xie","year":"2021","journal-title":"J. Cell Mol. Med."},{"issue":"4","key":"10.1016\/j.phymed.2026.158789_bib0055","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/ame2.12194","article-title":"Folic acid-induced animal model of kidney disease","volume":"4","author":"Yan","year":"2021","journal-title":"Anim. Models Exp. Med."},{"issue":"1","key":"10.1016\/j.phymed.2026.158789_bib0056","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41420-025-02929-4","article-title":"IL\u20111 receptor antagonism attenuates renal fibrosis via RNF182\u2011driven MFN2 destabilization and mitochondrial dysfunction","volume":"12","author":"Yang","year":"2025","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.phymed.2026.158789_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152973","article-title":"Comparison of two different toxin-induced kidney fibrosis models in terms of inflammatory responses","volume":"463","author":"Yang","year":"2021","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.phymed.2026.158789_bib0058","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0925-4773(98)00040-9","article-title":"Structure and expression of Wnt13, a novel mouse Wnt2 related gene","volume":"73","author":"Zakin","year":"1998","journal-title":"Mech. Dev."},{"issue":"1","key":"10.1016\/j.phymed.2026.158789_bib0059","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s11658-025-00820-9","article-title":"The novel circular RNA circG6pc attenuates oxidative stress and mitochondrial damage through miR-7018-5p\/Aldh6a1 axis in kidney fibrosis","volume":"30","author":"Zhao","year":"2025","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"2","key":"10.1016\/j.phymed.2026.158789_bib0060","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/labinvest.2015.153","article-title":"Wnt\/\u03b2-catenin signaling in kidney injury and repair: a double-edged sword","volume":"96","author":"Zhou","year":"2016","journal-title":"Lab. Invest."},{"issue":"2","key":"10.1016\/j.phymed.2026.158789_bib0061","first-page":"1985","article-title":"Synergistic inhibition of colon cancer cell growth by a combination of atorvastatin and phloretin","volume":"15","author":"Zhou","year":"2018","journal-title":"Oncol. Lett."},{"issue":"1","key":"10.1016\/j.phymed.2026.158789_bib0062","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1080\/0886022X.2017.1305409","article-title":"Puerarin attenuates renal fibrosis by reducing oxidative stress induced-epithelial cell apoptosis via MAPK signal pathways in vivo and in vitro","volume":"39","author":"Zhou","year":"2017","journal-title":"Ren. Fail."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326010196?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326010196?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:16:26Z","timestamp":1790280986000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326010196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":62,"alternative-id":["S0944711326010196"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158789","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Non-canonical role of phloretin in renal protection: Targeting WNT2B downregulation to prime PINK1\/ PARKIN-dependent mitophagy and attenuate renal fibrosis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158789","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"158789"}}