{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:04:24Z","timestamp":1789974264109,"version":"4.0.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012562","name":"Gansu University of Chinese Medicine","doi-asserted-by":"publisher","award":["2026CXZX-922"],"award-info":[{"award-number":["2026CXZX-922"]}],"id":[{"id":"10.13039\/501100012562","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012562","name":"Gansu University of Chinese Medicine","doi-asserted-by":"publisher","award":["25JRRA258"],"award-info":[{"award-number":["25JRRA258"]}],"id":[{"id":"10.13039\/501100012562","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.phymed.2026.158799","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T09:49:28Z","timestamp":1789120168000},"page":"158799","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Integrating network pharmacology and proteomics to elucidate the mechanism of Allium macrostemon total saponins in alleviating high-altitude acute lung injury"],"prefix":"10.1016","volume":"162","author":[{"given":"Keke","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0167-9165","authenticated-orcid":false,"given":"Renjie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhe","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0166-5401","authenticated-orcid":false,"given":"Xia","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianxie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoxing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158799_bib0001","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41392-025-02531-1","article-title":"Altitude hypoxia and hypoxemia: pathogenesis and management","volume":"11","author":"Cai","year":"2026","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.phymed.2026.158799_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.imbio.2024.152809","article-title":"The involvement of oxidative stress and the TLR4\/NF-\u03bab\/NLRP3 pathway in acute lung injury induced by high-altitude hypoxia","volume":"229","author":"Cao","year":"2024","journal-title":"Immunobiology"},{"key":"10.1016\/j.phymed.2026.158799_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114851","article-title":"Isolation and identification of the components in Cybister chinensis Motschulsky against inflammation and their mechanisms of action based on network pharmacology and molecular docking","volume":"285","author":"Che","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"12","key":"10.1016\/j.phymed.2026.158799_bib0003","first-page":"990","article-title":"Determination of macrostemonoside I in allium macrostemon Bunge extract by HPLC","volume":"31","author":"Chen","year":"2006","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.phymed.2026.158799_bib0004","article-title":"Ginsenoside Rg1 prevents and treats acute pulmonary injury induced by high-altitude hypoxia","volume":"25","author":"Chen","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158799_bib0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/mmr.2025.13580","article-title":"Reduced iron bioavailability drives acute high-altitude lung injury through HIF1\u03b1 activation and mitophagy","volume":"32","author":"Geng","year":"2025","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.phymed.2026.158799_bib0007","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1644436","article-title":"Pharmacological targeting of ferroptosis in hypoxia-induced pulmonary edema: therapeutic potential of ginsenoside Rg3 through activation of the PI3K\/AKT pathway","volume":"16","author":"He","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158799_bib0008","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1506483","article-title":"Eleutheroside B alleviates oxidative stress and neuroinflammation by inhibiting the JAK2\/STAT3 signaling pathway in a rat high altitude cerebral edema model","volume":"15","author":"He","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158799_bib0009","first-page":"254","article-title":"Research progress on modern pharmacological effects of Zhishi Xiebai Guizhi Decoction","volume":"29","author":"He","year":"2023","journal-title":"Chin. J. Exp. Tradit. Med. Formul."},{"key":"10.1016\/j.phymed.2026.158799_bib0010","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s10735-021-10039-5","article-title":"Isoorientin suppresses sepsis-induced acute lung injury in mice by activating an EPCR-dependent JAK2\/STAT3 pathway","volume":"53","author":"Hu","year":"2022","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.phymed.2026.158799_bib0011","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1080\/13880209.2021.1998139","article-title":"Compound Danshen Dripping pill inhibits high altitude-induced hypoxic damage by suppressing oxidative stress and inflammatory responses","volume":"59","author":"Hu","year":"2021","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.phymed.2026.158799_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154329","article-title":"Luteolin ameliorates hypoxia-induced pulmonary hypertension via regulating HIF-2\u03b1-arg-NO axis and PI3K-AKT-eNOS-NO signaling pathway","volume":"104","author":"Ji","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158799_bib0013","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1002\/ptr.6443","article-title":"Effect and mechanism of verbascoside on hypoxic memory injury in plateau","volume":"33","author":"Li","year":"2019","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2026.158799_bib0014","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.3390\/nu17152406","article-title":"Trans-sodium crocetinate ameliorates high-altitude acute lung injury via modulating EGFR\/PI3K\/AKT\/NF-\u03bab signaling axis","volume":"17","author":"Liang","year":"2025","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.158799_bib0015","article-title":"Insights into the pharmacodynamics and pharmacokinetics of meldonium after exposure to acute high altitude","volume":"14","author":"Liu","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158799_bib0016","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1513\/AnnalsATS.202004-327CME","article-title":"COVID-19 lung injury and high-altitude pulmonary edema: a false equation with dangerous implications","volume":"17","author":"Luks","year":"2020","journal-title":"Ann. Am. Thorac. Soc."},{"key":"10.1016\/j.phymed.2026.158799_bib0017","doi-asserted-by":"crossref","first-page":"13488","DOI":"10.1021\/acs.jafc.5c00077","article-title":"Malvidin alleviates lipopolysaccharide-induced acute lung injury by modulating JAK2\/STAT3 signaling to inhibit macrophage M1 polarization and oxidative stress","volume":"73","author":"Mao","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2026.158799_bib0018","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/s41434-024-00457-x","article-title":"Superoxide dismutase 1-modified dental pulp stem cells alleviate high-altitude pulmonary edema by inhibiting oxidative stress through the Nrf2\/HO-1 pathway","volume":"31","author":"Mao","year":"2024","journal-title":"Gene Ther."},{"key":"10.1016\/j.phymed.2026.158799_bib0019","doi-asserted-by":"crossref","first-page":"11403","DOI":"10.2147\/JIR.S498299","article-title":"Mechanism of Qingdai in alleviating acute lung injury by inhibiting the JAK2\/STAT3 signaling pathway","volume":"17","author":"Qi","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.phymed.2026.158799_bib0020","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.jgr.2024.03.001","article-title":"Ginsenoside Rg1 alleviates vascular remodeling in hypoxia-induced pulmonary hypertension mice through the calpain-1\/STAT3 signaling pathway","volume":"48","author":"Ran","year":"2024","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.phymed.2026.158799_bib0021","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202409499","article-title":"Dexmedetomidine ameliorates myocardial ischemia-reperfusion injury by inhibiting MDH2 lactylation via regulating metabolic reprogramming","volume":"11","author":"She","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.phymed.2026.158799_bib0022","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1007\/s12033-024-01067-z","article-title":"Transcription factor STAT3-activated LDHB promotes tumor properties of endometrial cancer cells by inducing MDH2 expression","volume":"67","author":"Shen","year":"2025","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.phymed.2026.158799_bib0023","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12014-025-09566-0","article-title":"Dimethyl fumarate alleviates inflammation during high altitude hypoxia induced acute lung injury by upregulating Nrf2\/SLC7A11 pathway in ferroptosis","volume":"22","author":"Wang","year":"2025","journal-title":"Clin. Proteomics"},{"key":"10.1016\/j.phymed.2026.158799_bib0024","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s40101-020-00242-w","article-title":"NOD-like receptors mediate inflammatory lung injury during plateau hypoxia exposure","volume":"39","author":"Wang","year":"2020","journal-title":"J. Physiol. Anthropol."},{"key":"10.1016\/j.phymed.2026.158799_bib0025","first-page":"73","article-title":"Research progress on chemical constituents and pharmacological effects of Allium macrostemon Bunge","volume":"40","author":"Wang","year":"2021","journal-title":"Chin. Wild Plant Resour."},{"key":"10.1016\/j.phymed.2026.158799_bib0026","article-title":"Sodium hydrosulfide protects rats from hypobaric-hypoxia-induced acute lung injury","volume":"25","author":"Wang","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158799_bib0027","first-page":"223","article-title":"Study on chemical constituents from different polar parts of allium macrostemon Bunge. Chin","volume":"60","author":"Wu","year":"2025","journal-title":"Pharm. J."},{"key":"10.1016\/j.phymed.2026.158799_bib0028","doi-asserted-by":"crossref","first-page":"5060","DOI":"10.1002\/fsn3.2459","article-title":"Protective effect of salidroside on hypoxia-related liver oxidative stress and inflammation via Nrf2 and JAK2\/STAT3 signaling pathways","volume":"9","author":"Xiong","year":"2021","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.phymed.2026.158799_bib0029","doi-asserted-by":"crossref","first-page":"985","DOI":"10.3390\/ph17080985","article-title":"Evaluation of crocetin as a protective agent in high altitude hypoxia-induced organ damage","volume":"17","author":"Yang","year":"2024","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.phymed.2026.158799_bib0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252111604","article-title":"MDH2 promotes hepatocellular carcinoma growth through ferroptosis evasion via stabilizing GPX4","volume":"25","author":"Yu","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158799_bib0031","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/iep.12434","article-title":"High-altitude hypoxia-induced rat alveolar cell injury by increasing autophagy","volume":"103","author":"Zhao","year":"2022","journal-title":"Int. J. Exp. Pathol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326010299?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326010299?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:24:31Z","timestamp":1789971871000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326010299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":31,"alternative-id":["S0944711326010299"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158799","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrating network pharmacology and proteomics to elucidate the mechanism of Allium macrostemon total saponins in alleviating high-altitude acute lung injury","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158799","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158799"}}