{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:01:19Z","timestamp":1790370079327,"version":"4.1.0"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012543","name":"Youth Science Foundation of Guangxi Medical University","doi-asserted-by":"publisher","award":["GXMUYSFB2026037"],"award-info":[{"award-number":["GXMUYSFB2026037"]}],"id":[{"id":"10.13039\/501100012543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012543","name":"Youth Science Foundation of Guangxi Medical University","doi-asserted-by":"publisher","award":["GXMUYSF202528"],"award-info":[{"award-number":["GXMUYSF202528"]}],"id":[{"id":"10.13039\/501100012543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017691","name":"Guangxi Key Research and Development Program","doi-asserted-by":"publisher","award":["GuikeAB25069047"],"award-info":[{"award-number":["GuikeAB25069047"]}],"id":[{"id":"10.13039\/501100017691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.phymed.2026.158802","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:12:02Z","timestamp":1789427522000},"page":"158802","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Camellia nitidissima Chi flower extract ameliorates alcoholic liver disease by reshaping bile acid homeostasis and intestinal barrier function"],"prefix":"10.1016","volume":"162","author":[{"given":"Xueting","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingsen","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jichu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuru","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anlong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjie","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxiao","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingchuan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huantian","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8473-536X","authenticated-orcid":false,"given":"Zongsheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qisong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.phymed.2026.158802_bib0001","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1097\/HEP.0000000000000899","article-title":"Alcohol-associated liver disease\u2014global epidemiology","volume":"80","author":"\u00c5berg","year":"2024","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2026.158802_bib0002","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: high performance molecular simulations through multi-level parallelism from laptops to supercomputers","volume":"1-2","author":"Abraham","year":"2015","journal-title":"SoftwareX."},{"issue":"Suppl","key":"10.1016\/j.phymed.2026.158802_bib0003","doi-asserted-by":"crossref","first-page":"S112","DOI":"10.3350\/cmh.2024.0709","article-title":"Alcohol-associated liver disease: natural history, management and novel targeted therapies","volume":"31","author":"Alvarado-Tapias","year":"2025","journal-title":"Clin. Mol. Hepatol."},{"key":"10.1016\/j.phymed.2026.158802_bib0004","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cca.2016.11.014","article-title":"Bile acid preparation and comprehensive analysis by high performance liquid chromatography\u2013high-resolution mass spectrometry","volume":"464","author":"Amplatz","year":"2017","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.phymed.2026.158802_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113165","article-title":"Discovery of natural anti-inflammatory alkaloids: potential leads for the drug discovery for the treatment of inflammation","volume":"213","author":"Bai","year":"2021","journal-title":"Eur. J. Med. Chem."},{"issue":"16","key":"10.1016\/j.phymed.2026.158802_bib0006","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.3390\/foods13162521","article-title":"Effects of several tea-like plants on liver injury induced by alcohol via their antioxidation, anti-inflammation, and regulation of gut microbiota","volume":"13","author":"Cheng","year":"2024","journal-title":"Foods"},{"issue":"2","key":"10.1016\/j.phymed.2026.158802_bib0007","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jhep.2023.03.017","article-title":"Global burden of liver disease: 2023 update","volume":"79","author":"Devarbhavi","year":"2023","journal-title":"J. Hepatol."},{"issue":"4","key":"10.1016\/j.phymed.2026.158802_bib0008","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/s41564-023-01337-7","article-title":"Bile salt hydrolases shape the bile acid landscape and restrict clostridioides difficile growth in the murine gut","volume":"8","author":"Foley","year":"2023","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.phymed.2026.158802_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.105817","article-title":"Natural terpenoids with anti-inflammatory activities: potential leads for anti-inflammatory drug discovery","volume":"124","author":"Ge","year":"2022","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.phymed.2026.158802_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156215","article-title":"Flavonoids from Rhododendron nivale Hook. F ameliorate alcohol-associated liver disease via activating the ppar\u03b1 signaling pathway","volume":"135","author":"Guo","year":"2024","journal-title":"Phytomedicine"},{"issue":"13","key":"10.1016\/j.phymed.2026.158802_bib0011","doi-asserted-by":"crossref","first-page":"6108","DOI":"10.1039\/D6FO01304J","article-title":"The hawthorn (Crataegus pinnatifida) procyanidin extract attenuates nonalcoholic fatty liver disease in mice via remodeling the bile acid profile driven by gut microbiota and regulating the FXR pathway","volume":"17","author":"Han","year":"2026","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2026.158802_bib0012","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jare.2018.03.005","article-title":"Synopsis of arachidonic acid metabolism: a review","volume":"11","author":"Hanna","year":"2018","journal-title":"J. Adv. Res."},{"issue":"2","key":"10.1016\/j.phymed.2026.158802_bib0013","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s11101-017-9537-x","article-title":"Camellia nitidissima C.W. Chi: a review of botany, chemistry, and pharmacology","volume":"17","author":"He","year":"2018","journal-title":"Phytochem. Rev."},{"issue":"11","key":"10.1016\/j.phymed.2026.158802_bib0014","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41579-023-00904-3","article-title":"The gut-liver axis and gut microbiota in health and liver disease","volume":"21","author":"Hsu","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"issue":"Pt 4","key":"10.1016\/j.phymed.2026.158802_bib0015","article-title":"Water-soluble Poria cocos polysaccharide improves alcoholic liver disease via modulation of gut microbiota-mediated intestinal bile acids-farnesoid X receptor","volume":"330","author":"Huang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"4","key":"10.1016\/j.phymed.2026.158802_bib0016","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1002\/hep.32608","article-title":"Probiotic-derived nanoparticles inhibit ALD through intestinal miR194 suppression and subsequent FXR activation","volume":"77","author":"Jiang","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2026.158802_bib0017","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ijbiomac.2021.07.095","article-title":"Echinacea purpurea polysaccharide prepared by fractional precipitation prevents alcoholic liver injury in mice by protecting the intestinal barrier and regulating liver-related pathways","volume":"187","author":"Jiang","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2026.158802_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156268","article-title":"Proanthocyanidins alleviate acute alcohol liver injury by inhibiting pyroptosis via inhibiting the ROS-MLKL-CTSB-NLRP3 pathway","volume":"136","author":"Jin","year":"2025","journal-title":"Phytomedicine"},{"issue":"7","key":"10.1016\/j.phymed.2026.158802_bib0019","article-title":"Alcohol-related liver disease disrupts bile acid homeostasis and gut microbial bile acid metabolism","volume":"8","author":"Keller","year":"2026","journal-title":"JHEP Rep."},{"key":"10.1016\/j.phymed.2026.158802_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153629","article-title":"Yangonin modulates lipid homeostasis, ameliorates cholestasis and cellular senescence in alcoholic liver disease via activating nuclear receptor FXR","volume":"90","author":"Kong","year":"2021","journal-title":"Phytomedicine"},{"issue":"6","key":"10.1016\/j.phymed.2026.158802_bib0021","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1007\/s10787-025-01743-9","article-title":"Camellia nitidissima Chi extract ameliorates dextran sulfate sodium-induced acute ulcerative colitis in mice by inhibiting TLR4\/NF-\u03bab-mediated inflammatory activation","volume":"33","author":"Li","year":"2025","journal-title":"Inflammopharmacology"},{"issue":"1","key":"10.1016\/j.phymed.2026.158802_bib0022","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/s12072-023-10621-x","article-title":"FXR overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in alcoholic liver disease","volume":"18","author":"Li","year":"2024","journal-title":"Hepatol. Int."},{"key":"10.1016\/j.phymed.2026.158802_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155693","article-title":"Bruceine A alleviates alcoholic liver disease by inhibiting AIM2 inflammasome activation via activating FXR","volume":"130","author":"Li","year":"2024","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.phymed.2026.158802_bib0024","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2402547","article-title":"Prebiotic inulin controls Th17 cells mediated central nervous system autoimmunity through modulating the gut microbiota and short chain fatty acids","volume":"16","author":"Li","year":"2024","journal-title":"Gut. Microbes"},{"issue":"6","key":"10.1016\/j.phymed.2026.158802_bib0025","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1124\/pharmrev.124.000978","article-title":"Bile acid signaling in metabolic and inflammatory diseases and drug development","volume":"76","author":"Li","year":"2024","journal-title":"Pharmacol. Rev."},{"issue":"1","key":"10.1016\/j.phymed.2026.158802_bib0026","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3390\/biomedicines13010074","article-title":"Gut microbiota as emerging players in the development of alcohol-related liver disease","volume":"13","author":"Li","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.phymed.2026.158802_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2024.109767","article-title":"Refining the Rab7-V1G1 axis to mitigate iron deposition: protective effects of quercetin in alcoholic liver disease","volume":"135","author":"Lin","year":"2025","journal-title":"J. Nutr. Biochem."},{"issue":"3","key":"10.1016\/j.phymed.2026.158802_bib0028","doi-asserted-by":"crossref","first-page":"658","DOI":"10.3390\/nu14030658","article-title":"Improving lipophagy by restoring Rab7 cycle: protective effects of quercetin on ethanol-induced liver steatosis","volume":"14","author":"Lin","year":"2022","journal-title":"Nutrients"},{"issue":"7","key":"10.1016\/j.phymed.2026.158802_bib0029","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202300343","article-title":"Ethanol-induced hepatic ferroptosis is mediated by PERK-dependent MAMs formation: preventive role of quercetin","volume":"68","author":"Lin","year":"2024","journal-title":"Mol. Nutr. Food Res."},{"issue":"9","key":"10.1016\/j.phymed.2026.158802_bib0030","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/s00018-022-04509-6","article-title":"New insights into the bile acid-based regulatory mechanisms and therapeutic perspectives in alcohol-related liver disease","volume":"79","author":"Liu","year":"2022","journal-title":"Cell Mol. Life Sci."},{"issue":"8","key":"10.1016\/j.phymed.2026.158802_bib0031","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.5108","article-title":"Pharmacokinetic studies of ginsenosides Rk1 and Rg5 in rats by UFLC\u2013MS\/MS","volume":"35","author":"Ma","year":"2021","journal-title":"Biomed. Chromatogr."},{"issue":"3","key":"10.1016\/j.phymed.2026.158802_bib0032","doi-asserted-by":"crossref","DOI":"10.1172\/JCI176345","article-title":"Alcohol-associated liver disease","volume":"134","author":"Mackowiak","year":"2024","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2026.158802_bib0033","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.clnu.2025.01.022","article-title":"Protein supplementation differentially alters gut microbiota and associated liver injury recovery in mouse model of alcohol-related liver disease","volume":"46","author":"Mittal","year":"2025","journal-title":"Clin. Nutr."},{"issue":"1","key":"10.1016\/j.phymed.2026.158802_bib0034","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/liv.15374","article-title":"Altered ethanol metabolism and increased oxidative stress enhance alcohol-associated liver injury in farnesoid X receptor-deficient mice","volume":"43","author":"Morel","year":"2023","journal-title":"Liver. Int."},{"issue":"5","key":"10.1016\/j.phymed.2026.158802_bib0035","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1002\/hep4.1885","article-title":"Development of alcohol-associated Hepatitis is associated with specific changes in gut-modified bile acids","volume":"6","author":"Muthiah","year":"2022","journal-title":"Hepatol. Commun."},{"issue":"2","key":"10.1016\/j.phymed.2026.158802_bib0036","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"issue":"1","key":"10.1016\/j.phymed.2026.158802_bib0037","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jcmgh.2021.08.014","article-title":"Aryl hydrocarbon receptor deficiency in intestinal epithelial cells aggravates alcohol-related liver disease","volume":"13","author":"Qian","year":"2022","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.phymed.2026.158802_bib0038","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3350\/cmh.2025.0921","article-title":"Novel biomarkers for alcohol-associated liver disease and their implications across clinical settings","volume":"32","author":"Rama","year":"2026","journal-title":"Clin. Mol. Hepatol."},{"issue":"6","key":"10.1016\/j.phymed.2026.158802_bib0039","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1097\/HEP.0000000000000924","article-title":"Gut\u2013liver axis: recent concepts in pathophysiology in alcohol-associated liver disease","volume":"80","author":"Raya Tonetti","year":"2024","journal-title":"Hepatology"},{"issue":"8000","key":"10.1016\/j.phymed.2026.158802_bib0040","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/s41586-023-06990-w","article-title":"Bile salt hydrolase catalyses formation of amine-conjugated bile acids","volume":"626","author":"Rimal","year":"2024","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.phymed.2026.158802_bib0041","first-page":"53","article-title":"Validated RP-HPLC method to estimate eugenol from commercial formulations like Caturjata Churna, Lavangadi Vati, Jatiphaladi Churna, Sitopaladi Churna and clove oil","volume":"6","author":"Saran","year":"2013","journal-title":"J. Pharm. Res."},{"issue":"7","key":"10.1016\/j.phymed.2026.158802_bib0042","doi-asserted-by":"crossref","first-page":"4485","DOI":"10.1002\/ptr.70373","article-title":"Ginsenoside Rg5 ameliorates ferroptosis in ethanol-induced acute liver injury by activating FTO-YTHDF2-Nrf2 signal","volume":"40","author":"Shan","year":"2026","journal-title":"PhytOther. Res."},{"issue":"10","key":"10.1016\/j.phymed.2026.158802_bib0043","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1038\/s41423-025-01291-w","article-title":"Immunological mechanisms and emerging therapeutic targets in alcohol-associated liver disease","volume":"22","author":"Shen","year":"2025","journal-title":"Cell Mol. Immunol."},{"issue":"8","key":"10.1016\/j.phymed.2026.158802_bib0044","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.chom.2024.06.008","article-title":"Dietary fiber alleviates alcoholic liver injury via Bacteroides acidifaciens and subsequent ammonia detoxification","volume":"32","author":"Shen","year":"2024","journal-title":"Cell Host. Microbe."},{"issue":"8","key":"10.1016\/j.phymed.2026.158802_bib0045","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1111\/jphp.13282","article-title":"Pharmacokinetic, bioavailability and tissue distribution study of astilbin in rats","volume":"72","author":"Shi","year":"2020","journal-title":"J. Pharm. Pharmacol."},{"issue":"9","key":"10.1016\/j.phymed.2026.158802_bib0046","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3390\/metabo9090173","article-title":"A facile profiling method of short chain fatty acids using liquid chromatography-mass spectrometry","volume":"9","author":"Song","year":"2019","journal-title":"Metabolites"},{"issue":"2","key":"10.1016\/j.phymed.2026.158802_bib0047","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jaci.2022.11.007","article-title":"Dietary fiber and SCFAs in the regulation of mucosal immunity","volume":"151","author":"Tan","year":"2023","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.phymed.2026.158802_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2026.120272","article-title":"Liupao tea alleviates high-fat diet-induced obesity by re-establishing metabolic homeostasis of short-chain fatty acids and chenodeoxycholic acid","volume":"242","author":"Tan","year":"2026","journal-title":"Food Res. Int."},{"issue":"Pt 1","key":"10.1016\/j.phymed.2026.158802_bib0049","article-title":"Neutral polysaccharide from Dendrobium officinale alleviates acute alcohol-induced liver injury via the gut microbiota-short chain fatty acids-liver axis","volume":"317","author":"Tao","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2026.158802_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155814","article-title":"Hydroxysafflor yellow A ameliorates alcohol-induced liver injury through PI3K\/akt and STAT3\/NF-\u03bab signaling pathways","volume":"132","author":"Wang","year":"2024","journal-title":"Phytomedicine"},{"issue":"6","key":"10.1016\/j.phymed.2026.158802_bib0051","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.jgr.2025.08.003","article-title":"Comparison of different ginsenosides with C-3 or C-6 sugar moieties on activities in alcohol-induced liver injury mice","volume":"49","author":"Wang","year":"2025","journal-title":"J. Ginseng. Res."},{"issue":"6","key":"10.1016\/j.phymed.2026.158802_bib0052","doi-asserted-by":"crossref","first-page":"496","DOI":"10.2174\/1389200223666220609151836","article-title":"Protective effects of grape seed proanthocyanidin extract in preventing DSS induced ulcerative colitis based on pharmacodynamic, pharmacokinetic and tissue distribution","volume":"23","author":"Wang","year":"2022","journal-title":"Curr. Drug Metab."},{"issue":"4","key":"10.1016\/j.phymed.2026.158802_bib0053","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1515\/mr-2024-0020","article-title":"Dysregulated bile acid homeostasis: unveiling its role in metabolic diseases","volume":"4","author":"Wang","year":"2024","journal-title":"Med. Rev."},{"key":"10.1016\/j.phymed.2026.158802_bib0054","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155938","article-title":"Shengmai San formula alleviates high-fat diet-induced obesity in mice through gut microbiota-derived bile acid promotion of M2 macrophage polarization and thermogenesis","volume":"133","author":"Wang","year":"2024","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.phymed.2026.158802_bib0055","doi-asserted-by":"crossref","DOI":"10.1080\/07853890.2023.2216942","article-title":"Astragaloside IV ameliorate acute alcohol-induced liver injury in mice via modulating gut microbiota and regulating NLRP3\/caspase-1 signaling pathway","volume":"55","author":"Wu","year":"2023","journal-title":"Ann. Med."},{"key":"10.1016\/j.phymed.2026.158802_bib0056","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.786682","article-title":"Grape seed proanthocyanidin alleviates intestinal inflammation through gut microbiota-bile acid crosstalk in mice","volume":"8","author":"Wu","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.phymed.2026.158802_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155055","article-title":"Kaempferol ameliorated alcoholic liver disease through inhibiting hepatic bile acid synthesis by targeting intestinal FXR-FGF15 signaling","volume":"120","author":"Xiao","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158802_bib0058","doi-asserted-by":"crossref","DOI":"10.1016\/j.fochx.2022.100441","article-title":"Cinnamaldehyde microcapsules enhance bioavailability and regulate intestinal flora in mice","volume":"15","author":"Xiao","year":"2022","journal-title":"Food Chem. X."},{"issue":"20","key":"10.1016\/j.phymed.2026.158802_bib0059","doi-asserted-by":"crossref","first-page":"6084","DOI":"10.1021\/acs.jafc.2c00633","article-title":"Propionate ameliorates alcohol-induced liver injury in mice via the gut\u2013liver axis: focus on the improvement of intestinal permeability","volume":"70","author":"Xu","year":"2022","journal-title":"J. Agric. Food Chem."},{"issue":"17","key":"10.1016\/j.phymed.2026.158802_bib0060","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.3390\/nu14173662","article-title":"Hawk tea flavonoids as natural hepatoprotective agents alleviate acute liver damage by reshaping the intestinal microbiota and modulating the Nrf2 and NF-\u03bab signaling pathways","volume":"14","author":"Xu","year":"2022","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.phymed.2026.158802_bib0061","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1186\/s12967-023-04166-8","article-title":"Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease","volume":"21","author":"Yan","year":"2023","journal-title":"J. Transl. Med."},{"issue":"25","key":"10.1016\/j.phymed.2026.158802_bib0062","doi-asserted-by":"crossref","first-page":"7074","DOI":"10.1021\/acs.jafc.1c02362","article-title":"Dietary ursolic acid prevents alcohol-induced liver injury via gut-liver axis homeostasis modulation: the key role of microbiome manipulation","volume":"69","author":"Yan","year":"2021","journal-title":"J. Agric. Food Chem."},{"issue":"2","key":"10.1016\/j.phymed.2026.158802_bib0063","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/s41401-024-01383-9","article-title":"Oral administration of astilbin mitigates acetaminophen-induced acute liver injury in mice by modulating the gut microbiota","volume":"46","author":"Yang","year":"2025","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2026.158802_bib0064","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155834","article-title":"Integrated bioinformatics and multiomics reveal Liupao tea extract alleviating NAFLD via regulating hepatic lipid metabolism and gut microbiota","volume":"132","author":"Yang","year":"2024","journal-title":"Phytomedicine"},{"issue":"Pt A","key":"10.1016\/j.phymed.2026.158802_bib0065","article-title":"Multi-omics analysis reveals the mechanism of Cistanche deserticola against alcoholic liver disease via bile salt hydrolase and SCD1","volume":"355","author":"Yuan","year":"2026","journal-title":"J. Ethnopharmacol."},{"issue":"12","key":"10.1016\/j.phymed.2026.158802_bib0066","doi-asserted-by":"crossref","first-page":"5723","DOI":"10.1021\/acs.jctc.5b00716","article-title":"Refinement of the sugar-phosphate backbone torsion beta for AMBER force fields improves the description of Z- and B-DNA","volume":"11","author":"Zgarbov\u00e1","year":"2015","journal-title":"J. Chem. Theory. Comput."},{"issue":"12","key":"10.1016\/j.phymed.2026.158802_bib0067","doi-asserted-by":"crossref","first-page":"4378","DOI":"10.1002\/jsfa.10471","article-title":"Camellia nitidissima Chi flower extract alleviates obesity and related complications and modulates gut microbiota composition in rats with high-fat-diet-induced obesity","volume":"100","author":"Zhang","year":"2020","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.phymed.2026.158802_bib0068","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2021.122531","article-title":"Integrated plasma and liver gas chromatography mass spectrometry and liquid chromatography mass spectrometry metabolomics to reveal physiological functions of sodium taurocholate cotransporting polypeptide (NTCP) with an Ntcp knockout mouse model","volume":"1165","author":"Zhang","year":"2021","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"issue":"6","key":"10.1016\/j.phymed.2026.158802_bib0069","doi-asserted-by":"crossref","first-page":"955","DOI":"10.3390\/foods14060955","article-title":"Grifola frondosa polysaccharide F2 ameliorates disordered glucose and lipid metabolism in prediabetic mice by modulating bile acids","volume":"14","author":"Zhang","year":"2025","journal-title":"Foods"},{"issue":"1","key":"10.1016\/j.phymed.2026.158802_bib0070","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1080\/13880209.2020.1739719","article-title":"Hepatoprotective effects of Camellia nitidissima aqueous ethanol extract against CCl(4)-induced acute liver injury in SD rats related to Nrf2 and NF-\u03bab signalling","volume":"58","author":"Zhang","year":"2020","journal-title":"Pharm. Biol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158802_bib0071","doi-asserted-by":"crossref","first-page":"387","DOI":"10.7150\/ijbs.121475","article-title":"Schisandrin B targets PXR to enhance bile acid metabolism and alleviate ANIT-induced cholestatic liver injury via dual pathways","volume":"22","author":"Zhang","year":"2026","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.phymed.2026.158802_bib0072","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1038\/s41467-023-37459-z","article-title":"Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice","volume":"14","author":"Zhao","year":"2023","journal-title":"Nat. Commun."},{"issue":"22","key":"10.1016\/j.phymed.2026.158802_bib0073","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.2174\/0113816128342642250111055339","article-title":"Crippled hepatocarcinogenesis inhibition of quercetin in glycolysis pathway with hepatic Farnesoid X receptor deficiency","volume":"31","author":"Zhong","year":"2025","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.phymed.2026.158802_bib0074","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116576","article-title":"Network pharmacology integrated with experimental validation revealed potential molecular mechanisms of camellia nitidissima C. W. Chi in the treatment of lung cancer","volume":"314","author":"Zhou","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.phymed.2026.158802_bib0075","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1002\/fsn3.1543","article-title":"Correlation analysis between filamentous fungi and chemical compositions in a pu-erh type tea after a long-term storage","volume":"8","author":"Zhou","year":"2020","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.phymed.2026.158802_bib0076","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175096","article-title":"Ameliorative effects of chlorogenic acid on alcoholic liver injury in mice via gut microbiota informatics","volume":"928","author":"Zhu","year":"2022","journal-title":"Eur. J. Pharmacol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326010329?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326010329?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:17:00Z","timestamp":1790367420000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326010329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":76,"alternative-id":["S0944711326010329"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158802","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Camellia nitidissima Chi flower extract ameliorates alcoholic liver disease by reshaping bile acid homeostasis and intestinal barrier function","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158802","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158802"}}