{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:40:33Z","timestamp":1793745633035,"version":"4.6.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009377","name":"Education Department of Hunan Province","doi-asserted-by":"publisher","award":["25A0298"],"award-info":[{"award-number":["25A0298"]}],"id":[{"id":"10.13039\/100009377","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304750"],"award-info":[{"award-number":["82304750"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130109"],"award-info":[{"award-number":["82130109"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U2202214"],"award-info":[{"award-number":["U2202214"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003824","name":"Hunan University","doi-asserted-by":"publisher","award":["[2018] No.3"],"award-info":[{"award-number":["[2018] No.3"]}],"id":[{"id":"10.13039\/501100003824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2026JJ20076"],"award-info":[{"award-number":["2026JJ20076"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2026JJ82229"],"award-info":[{"award-number":["2026JJ82229"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014978","name":"Hunan University of Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014978","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.phymed.2026.158816","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:26:44Z","timestamp":1790137604000},"page":"158816","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Notoginsenoside R1 attenuates post-ischemic pyroptosis: a novel CKLF1-endoplasmic reticulum stress pathway-mediated mechanism"],"prefix":"10.1016","volume":"162","author":[{"given":"Hanlong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shasha","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junpeng","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songwei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naihong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yantao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1647-2825","authenticated-orcid":false,"given":"Qidi","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.phymed.2026.158816_bib0001","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1038\/s41423-022-00922-w","article-title":"How location and cellular signaling combine to activate the NLRP3 inflammasome","volume":"19","author":"Akbal","year":"2022","journal-title":"Cell. Mol. Immunol."},{"issue":"12","key":"10.1016\/j.phymed.2026.158816_bib0002","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1111\/cns.14368","article-title":"Monocyte-related cytokines\/chemokines in cerebral ischemic stroke","volume":"29","author":"Bai","year":"2023","journal-title":"CNS Neurosci. Ther."},{"issue":"8","key":"10.1016\/j.phymed.2026.158816_bib0003","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.1007\/s10787-025-01871-2","article-title":"Chemokine receptor type-5: a key regulator of immunity, disease pathogenesis, and emerging therapeutic target","volume":"33","author":"Bambal","year":"2025","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.phymed.2026.158816_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106577","article-title":"CKLF1\/CCR5 axis is involved in neutrophils migration of rats with transient cerebral ischemia","volume":"85","author":"Chen","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2026.158816_bib0006","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1080737","article-title":"Neuroinflammation and brain\u2013peripheral interaction in ischemic stroke: a narrative review","volume":"13","author":"Cheng","year":"2023","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.phymed.2026.158816_bib0007","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0130635","article-title":"Transcription factor ATF4 induces NLRP1 inflammasome expression during endoplasmic reticulum stress","volume":"10","author":"D\u2019osualdo","year":"2015","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.phymed.2026.158816_bib0008","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1007\/s11011-023-01183-w","article-title":"PERK inhibitor, GSK2606414, ameliorates neuropathological damage, memory and motor functional impairments in cerebral ischemia via PERK\/p-eIF2\u0251\/ATF4\/CHOP signaling","volume":"38","author":"Dhir","year":"2023","journal-title":"Metab. Brain Dis."},{"issue":"1","key":"10.1016\/j.phymed.2026.158816_bib0009","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/imr.12286","article-title":"Initiation and perpetuation of NLRP3 inflammasome activation and assembly","volume":"265","author":"Elliott","year":"2015","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.phymed.2026.158816_bib0010","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.876342","article-title":"Targeting C\u2013C chemokine receptor 5: key to opening the neurorehabilitation window after ischemic stroke","volume":"16","author":"Feng","year":"2022","journal-title":"Front. Cell. Neurosci."},{"issue":"11","key":"10.1016\/j.phymed.2026.158816_bib0011","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1161\/01.STR.28.11.2214","article-title":"Soluble adhesion molecules reflect endothelial cell activation in ischemic stroke and in carotid atherosclerosis","author":"Frijns","year":"1997","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.phymed.2026.158816_bib0012","article-title":"Satellite cell expansion is mediated by P-eIF2\u03b1 dependent Tacc3 translation","volume":"148","author":"Fujita","year":"2020","journal-title":"Development"},{"issue":"2","key":"10.1016\/j.phymed.2026.158816_bib0013","doi-asserted-by":"crossref","first-page":"0","DOI":"10.14336\/AD.2022.0905","article-title":"Cerebral glucose metabolism and potential effects on endoplasmic reticulum stress in stroke","author":"Guo","year":"2022","journal-title":"Aging Dis."},{"issue":"1","key":"10.1016\/j.phymed.2026.158816_bib0014","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s12974-023-02860-4","article-title":"Targeted ablation of signal transducer and activator of transduction 1 alleviates inflammation by microglia\/macrophages and promotes long-term recovery after ischemic stroke","volume":"20","author":"Han","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.phymed.2026.158816_bib0015","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.704334","article-title":"Mechanism of endoplasmic reticulum stress in cerebral ischemia","volume":"15","author":"Han","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.phymed.2026.158816_bib0016","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.801985","article-title":"Biological functions and regulatory mechanisms of hypoxia-inducible factor-1\u03b1 in ischemic stroke","volume":"12","author":"He","year":"2021","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.phymed.2026.158816_bib0017","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1161\/STROKEAHA.111.626432","article-title":"CHOP silencing reduces acute brain injury in the rat model of subarachnoid hemorrhage","volume":"43","author":"He","year":"2012","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.phymed.2026.158816_bib0018","article-title":"The interplay between cytokines and stroke: a bi-directional Mendelian randomization study","volume":"14","author":"Jiang","year":"2024","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.phymed.2026.158816_bib0019","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1161\/STROKEAHA.120.032810","article-title":"Thrombus composition and efficacy of thrombolysis and thrombectomy in acute ischemic stroke","volume":"52","author":"Jolugbo","year":"2021","journal-title":"Stroke"},{"issue":"5","key":"10.1016\/j.phymed.2026.158816_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2019.01.044","article-title":"CCR5 is a therapeutic target for recovery after stroke and traumatic brain injury","volume":"176","author":"Joy","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2026.158816_bib0021","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.neuint.2014.07.004","article-title":"Inhibition of chemokine-like factor 1 protects against focal cerebral ischemia through the promotion of energy metabolism and anti-apoptotic effect","volume":"76","author":"Kong","year":"2014","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.phymed.2026.158816_bib0022","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.905092","article-title":"Notoginsenoside R1 regulates ischemic myocardial lipid metabolism by activating the AKT\/mTOR signaling pathway","volume":"13","author":"Lei","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"20","key":"10.1016\/j.phymed.2026.158816_bib0023","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202101526","article-title":"Macrophage-disguised manganese dioxide nanoparticles for neuroprotection by reducing oxidative stress and modulating inflammatory microenvironment in acute ischemic stroke","volume":"8","author":"Li","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.phymed.2026.158816_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102384","article-title":"Notoginsenoside R1-loaded mesoporous silica nanoparticles targeting the site of injury through inflammatory cells improves heart repair after myocardial infarction","volume":"54","author":"Li","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.phymed.2026.158816_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112168","article-title":"Targeting pyroptosis to treat ischemic stroke: from molecular pathways to treatment strategy","volume":"133","author":"Li","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2026.158816_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153660","article-title":"Notoginsenoside R1 intervenes degradation and redistribution of tight junctions to ameliorate blood-brain barrier permeability by Caveolin-1\/MMP2\/9 pathway after acute ischemic stroke","volume":"90","author":"Liu","year":"2021","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.phymed.2026.158816_bib0027","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1002\/ptr.7450","article-title":"Notoginsenoside R1 ameliorates mitochondrial dysfunction to circumvent neuronal energy failure in acute phase of focal cerebral ischemia","volume":"36","author":"Liu","year":"2022","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2026.158816_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155238","article-title":"Ginsenoside Rg1 treats ischemic stroke by regulating CKLF1\/CCR5 axis-induced neuronal cell pyroptosis","volume":"123","author":"Long","year":"2024","journal-title":"Phytomedicine"},{"issue":"18","key":"10.1016\/j.phymed.2026.158816_bib0029","doi-asserted-by":"crossref","first-page":"6454","DOI":"10.3390\/ijms21186454","article-title":"Neuroinflammatory mechanisms in ischemic stroke: focus on cardioembolic stroke, background, and therapeutic approaches","volume":"21","author":"Maida","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.phymed.2026.158816_bib0030","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00281-023-00984-6","article-title":"Neuroimaging is the new \u201cspatial omic\u201d: multi-omic approaches to neuro-inflammation and immuno-thrombosis in acute ischemic stroke","volume":"45","author":"Ma\u00efer","year":"2023","journal-title":"Semin. Immunopathol."},{"issue":"7","key":"10.1016\/j.phymed.2026.158816_bib0031","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1161\/STROKEAHA.110.578369","article-title":"Systemic and intraplaque mediators of inflammation are increased in patients symptomatic for ischemic stroke","volume":"41","author":"Montecucco","year":"2010","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.phymed.2026.158816_bib0032","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/ana.26129","article-title":"Mechanisms of ischemic stroke in patients with cancer: a prospective study","volume":"90","author":"Navi","year":"2021","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.phymed.2026.158816_bib0033","first-page":"259","article-title":"Pyroptosis in ischemic stroke: roles, mechanisms, and therapeutic strategies","volume":"44","author":"Qi","year":"2026","journal-title":"Restor. Neurol. Neurosci."},{"issue":"7575","key":"10.1016\/j.phymed.2026.158816_bib0034","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.phymed.2026.158816_bib0035","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.phymed.2026.158816_bib0036","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s11739-023-03201-2","article-title":"Inflammatory biomarkers of ischemic stroke","volume":"18","author":"Tirandi","year":"2023","journal-title":"Intern. Emerg. Med."},{"key":"10.1016\/j.phymed.2026.158816_bib0037","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.3389\/fphar.2019.01204","article-title":"Notoginsenoside R1 for organs ischemia\/reperfusion injury: a preclinical systematic review","volume":"10","author":"Tong","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158816_bib0038","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2020.577927","article-title":"Ablation of GSDMD improves outcome of ischemic stroke through blocking canonical and non-canonical inflammasomes dependent pyroptosis in microglia","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Neurol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158816_bib0039","article-title":"Notoginsenoside R1 alleviates oxygen\u2013glucose deprivation\/reoxygenation injury by suppressing endoplasmic reticulum calcium release via PLC","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"issue":"S 1\u20132","key":"10.1016\/j.phymed.2026.158816_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-510X(00)00386-5","article-title":"Brain ischemia and reperfusion: molecular mechanisms of neuronal injury","author":"White","year":"2000","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.phymed.2026.158816_bib0041","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3389\/fncel.2017.00319","article-title":"KCa3.1 Inhibition switches the astrocyte phenotype during astrogliosis associated with ischemic stroke via endoplasmic reticulum stress and MAPK signaling pathways","volume":"11","author":"Yu","year":"2017","journal-title":"Front. Cell. Neurosci."},{"issue":"10","key":"10.1016\/j.phymed.2026.158816_bib0042","doi-asserted-by":"crossref","first-page":"7448","DOI":"10.1007\/s12035-024-04050-6","article-title":"Neuroinflammation targeting pyroptosis: molecular mechanisms and therapeutic perspectives in stroke","volume":"61","author":"Yuan","year":"2024","journal-title":"Mol. Neurobiol."},{"issue":"8","key":"10.1016\/j.phymed.2026.158816_bib0043","doi-asserted-by":"crossref","first-page":"3598","DOI":"10.4103\/NRR.NRR-D-24-01189","article-title":"Intermittent theta-burst stimulation promotes neurovascular unit remodeling after ischemic stroke in a mouse model","volume":"21","author":"Zhang","year":"2025","journal-title":"Neural Regen. Res."},{"issue":"5","key":"10.1016\/j.phymed.2026.158816_bib0044","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/s41401-021-00746-w","article-title":"Neuronal chemokine-like-factor 1 (CKLF1) up-regulation promotes M1 polarization of microglia in rat brain after stroke","volume":"43","author":"Zhou","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2026.158816_bib0045","article-title":"Notoginsenoside R1 improves cerebral ischemia\/reperfusion injury by promoting neurogenesis via the BDNF\/Akt\/CREB pathway","volume":"12","author":"Zhu","year":"2021","journal-title":"Front. Pharmacol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326010469?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326010469?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:42:03Z","timestamp":1791326523000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326010469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":44,"alternative-id":["S0944711326010469"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158816","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Notoginsenoside R1 attenuates post-ischemic pyroptosis: a novel CKLF1-endoplasmic reticulum stress pathway-mediated mechanism","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158816","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158816"}}