{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:51:23Z","timestamp":1791996683009,"version":"4.4.0"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.phymed.2026.158863","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:51:27Z","timestamp":1791672687000},"page":"158863","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Therapeutic efficacy and dosing regimen evidence synthesis of Ursolic Acid for liver injury: A preclinical systematic review with machine learning"],"prefix":"10.1016","volume":"162","author":[{"given":"Xi-Yuan","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Rui","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158863_bib0001","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1111\/apt.17930","article-title":"Review article: pathogenesis of MASLD and MASH - role of insulin resistance and lipotoxicity","volume":"59","author":"Bansal","year":"2024","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"4","key":"10.1016\/j.phymed.2026.158863_bib0002","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","article-title":"Operating characteristics of a rank correlation test for publication bias","volume":"50","author":"Begg","year":"1994","journal-title":"Biometrics"},{"issue":"20","key":"10.1016\/j.phymed.2026.158863_bib0003","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252011213","article-title":"Activation of Nrf2 and FXR via natural compounds in liver inflammatory disease","volume":"25","author":"Belka","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.phymed.2026.158863_bib0004","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41423-021-00768-8","article-title":"Autoimmmune hepatitis","volume":"19","author":"Beretta-Piccoli","year":"2022","journal-title":"Cell Mol. Immunol."},{"issue":"5","key":"10.1016\/j.phymed.2026.158863_bib0005","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/S2468-1253(21)00472-6","article-title":"Global change in hepatitis C virus prevalence and cascade of care between 2015 and 2020: a modelling study","volume":"7","author":"Blach","year":"2022","journal-title":"Lancet Gastroenterol. Hepatol."},{"issue":"6","key":"10.1016\/j.phymed.2026.158863_bib0006","doi-asserted-by":"crossref","first-page":"7499","DOI":"10.1109\/TNNLS.2022.3229161","article-title":"Deep Neural networks and tabular data: a survey","volume":"35","author":"Borisov","year":"2024","journal-title":"IEEe Trans. Neural Netw. Learn. Syst."},{"issue":"5","key":"10.1016\/j.phymed.2026.158863_bib0007","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1007\/s11101-024-10058-6","article-title":"Quantitative analysis of epigallocatechin-3-gallate in treating renal injury via meta-analysis and machine learning","volume":"24","author":"Chen","year":"2025","journal-title":"Phytochem. Rev."},{"key":"10.1016\/j.phymed.2026.158863_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154325","article-title":"Ursolic acid alleviates tetrandrine-induced hepatotoxicity by competitively binding to the substrate-binding site of glutathione S-transferases","volume":"104","author":"Chu","year":"2022","journal-title":"Phytomedicine"},{"issue":"11","key":"10.1016\/j.phymed.2026.158863_bib0009","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1093\/ibd\/izad276","article-title":"Incidence and prevalence of primary sclerosing cholangitis: a meta-analysis of population-based studies","volume":"30","author":"Cooper","year":"2023","journal-title":"Inflamm. Bowel. Dis."},{"key":"10.1016\/j.phymed.2026.158863_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114588","article-title":"Medicinal plants used against hepatic disorders in Bangladesh: a comprehensive review","volume":"282","author":"Das","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158863_bib0011","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s11658-024-00631-4","article-title":"Paeoniflorin protects hepatocytes from APAP-induced damage through launching autophagy via the MAPK\/mTOR signaling pathway","volume":"29","author":"Deng","year":"2024","journal-title":"Cell Mol. Biol. Lett."},{"issue":"2","key":"10.1016\/j.phymed.2026.158863_bib0012","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jhep.2023.03.017","article-title":"Global burden of liver disease: 2023 update","volume":"79","author":"Devarbhavi","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2026.158863_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2024.104460","article-title":"Ursolic acid suppresses fatty liver-associated hepatocellular carcinoma by regulating lipid metabolism","volume":"60","author":"Dong","year":"2024","journal-title":"Food Biosci."},{"issue":"2","key":"10.1016\/j.phymed.2026.158863_bib0014","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.0006-341X.2000.00455.x","article-title":"Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis","volume":"56","author":"Duval","year":"2000","journal-title":"Biometrics"},{"key":"10.1016\/j.phymed.2026.158863_bib0015","article-title":"Developing clinical prediction models: a step-by-step guide","volume":"386","author":"Efthimiou","year":"2024","journal-title":"Bmj-British Med. J."},{"issue":"7109","key":"10.1016\/j.phymed.2026.158863_bib0016","first-page":"629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ (Clin. Res. Ed.)"},{"key":"10.1016\/j.phymed.2026.158863_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112445","article-title":"Multimodal modulation of hepatic ischemia\/reperfusion-induced injury by phytochemical agents: a mechanistic evaluation of hepatoprotective potential and safety profiles","volume":"138","author":"Elsayed Abouzed","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.phymed.2026.158863_bib0018","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/hep.32285","article-title":"Hepatic fibrosis: 2022 unmet needs and a blueprint for the future","volume":"75","author":"Friedman","year":"2022","journal-title":"Hepatology"},{"issue":"33","key":"10.1016\/j.phymed.2026.158863_bib0019","doi-asserted-by":"crossref","first-page":"17699","DOI":"10.1021\/acs.est.4c11313","article-title":"Predicting the sorption capacity of perfluoroalkyl and polyfluoroalkyl substances in soils: meta-analysis and machine learning modeling","volume":"59","author":"Fu","year":"2025","journal-title":"Environ. Sci. Technol."},{"issue":"Pt 2","key":"10.1016\/j.phymed.2026.158863_bib0020","article-title":"The raw and vinegar-processed Curcuma phaeocaulis Val. Ameliorate TAA-induced zebrafish liver injury by inhibiting TLR4\/MyD88\/NF-\u03baB signaling pathway","volume":"319","author":"Gao","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.phymed.2026.158863_bib0021","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/liv.14800","article-title":"Rodent models of cholestatic liver disease: a practical guide for translational research","volume":"41","author":"Gijbels","year":"2021","journal-title":"Liver Int."},{"issue":"1","key":"10.1016\/j.phymed.2026.158863_bib0022","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1080\/10618600.2014.907095","article-title":"Peeking inside the black box: visualizing statistical learning with plots of individual conditional expectation","volume":"24","author":"Goldstein","year":"2015","journal-title":"J. Computat. Graphic. Stat."},{"key":"10.1016\/j.phymed.2026.158863_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116927","article-title":"Chinese herbal medicines: the modulator of nonalcoholic fatty liver disease targeting oxidative stress","volume":"318","author":"Gong","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.phymed.2026.158863_bib0024","doi-asserted-by":"crossref","DOI":"10.1172\/JCI162533","article-title":"Mitochondria- and NOX4-dependent antioxidant defense mitigates progression to nonalcoholic steatohepatitis in obesity","volume":"134","author":"Greatorex","year":"2023","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.phymed.2026.158863_bib0025","first-page":"269","article-title":"Ursolic acid modulates estrogen conversion to relieve inflammation in metabolic dysfunction-associated steatotic liver disease via HSD17B14","volume":"13","author":"Gu","year":"2025","journal-title":"J. Clin. Transl. Hepatol."},{"key":"10.1016\/j.phymed.2026.158863_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2023.102280","article-title":"Global incidence and prevalence of autoimmune hepatitis, 1970-2022: a systematic review and meta-analysis","volume":"65","author":"Hahn","year":"2023","journal-title":"EClinicalMedicine"},{"issue":"10","key":"10.1016\/j.phymed.2026.158863_bib0027","doi-asserted-by":"crossref","first-page":"e430","DOI":"10.1097\/TP.0000000000004258","article-title":"Prolyl hydroxylase inhibition mitigates allograft injury during liver transplantation","volume":"106","author":"Harnoss","year":"2022","journal-title":"Transplantation"},{"issue":"5","key":"10.1016\/j.phymed.2026.158863_bib0028","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.3390\/pharmaceutics15051381","article-title":"Machine learning for exposure-response analysis: methodological considerations and confirmation of their importance via computational experimentations","volume":"15","author":"Harun","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.phymed.2026.158863_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.eswa.2021.114899","article-title":"A novel hybrid ensemble model based on tree-based method and deep learning method for default prediction","volume":"176","author":"He","year":"2021","journal-title":"Expert. Syst. Appl."},{"key":"10.1016\/j.phymed.2026.158863_bib0030","first-page":"3989","article-title":"A bioinformatic and mechanistic study elicits the antifibrotic effect of ursolic acid through the attenuation of oxidative stress with the involvement of ERK, PI3K\/Akt, and p38 MAPK signaling pathways in human hepatic stellate cells and rat liver","volume":"9","author":"He","year":"2015","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.phymed.2026.158863_bib0031","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1471-2288-14-43","article-title":"SYRCLE's risk of bias tool for animal studies","volume":"14","author":"Hooijmans","year":"2014","journal-title":"BMC. Med. Res. Methodol."},{"issue":"17","key":"10.1016\/j.phymed.2026.158863_bib0032","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.3390\/cells12172129","article-title":"Liver injury and regeneration: current understanding, new approaches, and future perspectives","volume":"12","author":"Hora","year":"2023","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.phymed.2026.158863_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.arabjc.2023.105513","article-title":"The protective effect of Dogwood preparation on hepatic ischemia-reperfusion injury in mice by down-regulating PTGS2","volume":"17","author":"Hou","year":"2024","journal-title":"Arab. J. Chem."},{"key":"10.1016\/j.phymed.2026.158863_bib0034","article-title":"Ursolic acid drug-drug nanocrystals ameliorate cholestatic liver injury via inhibiting oxidative stress and regulating bile acid metabolism","volume":"16","author":"Hu","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158863_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156650","article-title":"The efficacy and toxicity equilibrium of emodin for liver injury: a bidirectional meta-analysis and machine learning","volume":"142","author":"Hu","year":"2025","journal-title":"Phytomedicine"},{"issue":"11","key":"10.1016\/j.phymed.2026.158863_bib0036","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-024-07217-0","article-title":"MIST1 regulates endoplasmic reticulum stress-induced hepatic apoptosis as a candidate marker of fatty liver disease progression","volume":"15","author":"Hur","year":"2024","journal-title":"Cell Death. Dis."},{"issue":"1","key":"10.1016\/j.phymed.2026.158863_bib0037","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41577-021-00549-4","article-title":"Immunobiology and pathogenesis of hepatitis B virus infection","volume":"22","author":"Iannacone","year":"2022","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.phymed.2026.158863_bib0038","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/mnfr.201400399","article-title":"Ursolic acid improves lipid and glucose metabolism in high-fat-fed C57BL\/6J mice by activating peroxisome proliferator-activated receptor alpha and hepatic autophagy","volume":"59","author":"Jia","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"issue":"2","key":"10.1016\/j.phymed.2026.158863_bib0039","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.intimp.2015.10.024","article-title":"Oleanolic acid ameliorates dextran sodium sulfate-induced colitis in mice by restoring the balance of Th17\/treg cells and inhibiting NF-\u03bab signaling pathway","volume":"29","author":"Kang","year":"2015","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158863_bib0040","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s00018-022-04658-8","article-title":"Liver-derived metabolites as signaling molecules in fatty liver disease","volume":"80","author":"Keles","year":"2023","journal-title":"Cell. Mol. Life Sci."},{"issue":"3","key":"10.1016\/j.phymed.2026.158863_bib0041","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41575-020-00372-7","article-title":"Molecular and cellular mechanisms of liver fibrosis and its regression","volume":"18","author":"Kisseleva","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.phymed.2026.158863_bib0042","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jcm.2016.02.012","article-title":"A guideline of selecting and reporting intraclass correlation coefficients for reliability research","volume":"15","author":"Koo","year":"2016","journal-title":"J. Chiropr. Med."},{"key":"10.1016\/j.phymed.2026.158863_bib0043","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1758-2946-6-10","article-title":"Cross-validation pitfalls when selecting and assessing regression and classification models","volume":"6","author":"Krstajic","year":"2014","journal-title":"J. Cheminform."},{"issue":"8","key":"10.1016\/j.phymed.2026.158863_bib0044","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202504763RR","article-title":"Targeting JAK2: genetic and pharmacological inhibition attenuates immune-mediated liver injury by suppressing proinflammatory macrophage","volume":"40","author":"Li","year":"2026","journal-title":"FASEB J."},{"issue":"44","key":"10.1016\/j.phymed.2026.158863_bib0045","doi-asserted-by":"crossref","first-page":"11647","DOI":"10.1021\/acs.jafc.8b04116","article-title":"Ursolic acid, a novel liver X receptor \u03b1 (LXR\u03b1) antagonist inhibiting ligand-induced nonalcoholic fatty liver and drug-induced lipogenesis","volume":"66","author":"Lin","year":"2018","journal-title":"J. Agric. Food Chem."},{"issue":"3","key":"10.1016\/j.phymed.2026.158863_bib0046","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/liv.13940","article-title":"Oleanolic acid reprograms the liver to protect against hepatotoxicants, but is hepatotoxic at high doses","volume":"39","author":"Liu","year":"2019","journal-title":"Liver Int."},{"issue":"3","key":"10.1016\/j.phymed.2026.158863_bib0047","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.etap.2014.03.011","article-title":"Ursolic acid protects mouse liver against CCl4-induced oxidative stress and inflammation by the MAPK\/NF-\u03bab pathway","volume":"37","author":"Ma","year":"2014","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158863_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154233","article-title":"Ursolic acid inhibits the cholesterol biosynthesis and alleviates high fat diet-induced hypercholesterolemia via irreversible inhibition of HMGCS1 in vivo","volume":"103","author":"Ma","year":"2022","journal-title":"Phytomedicine"},{"issue":"7","key":"10.1016\/j.phymed.2026.158863_bib0049","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/s41401-020-00534-y","article-title":"Ursolic acid reduces hepatocellular apoptosis and alleviates alcohol-induced liver injury via irreversible inhibition of CASP3 in vivo","volume":"42","author":"Ma","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2026.158863_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122343","article-title":"Research progress on rodent models and its mechanisms of liver injury","volume":"337","author":"Mao","year":"2024","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2026.158863_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114569","article-title":"Ursolic acid suppresses ferroptosis by modulating Th17\/treg balance and gut dysbiosis in experimental autoimmune thyroiditis rats","volume":"155","author":"Mou","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"12","key":"10.1016\/j.phymed.2026.158863_bib0052","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.3390\/antiox12122040","article-title":"Extracellular superoxide dismutase attenuates hepatic oxidative stress in nonalcoholic fatty liver disease through the adenosine monophosphate-activated protein kinase activation","volume":"12","author":"Nam","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2026.158863_bib0053","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153439","article-title":"Ursolic acid ameliorates stress and reactive oxygen species in C. elegans knockout mutants by the dopamine Dop1 and Dop3 receptors","volume":"81","author":"Na\u00df","year":"2021","journal-title":"Phytomedicine"},{"issue":"8","key":"10.1016\/j.phymed.2026.158863_bib0054","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.3390\/antiox10081161","article-title":"Ursolic acid and related analogues: triterpenoids with broad health benefits","volume":"10","author":"Nguyen","year":"2021","journal-title":"Antioxidants"},{"issue":"1","key":"10.1016\/j.phymed.2026.158863_bib0055","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.1972746","article-title":"Ursolic acid reverses liver fibrosis by inhibiting NOX4\/NLRP3 inflammasome pathways and bacterial dysbiosis","volume":"13","author":"Nie","year":"2021","journal-title":"Gut. Microbes."},{"issue":"1","key":"10.1016\/j.phymed.2026.158863_bib0056","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1186\/s12889-023-15749-x","article-title":"Global prevalence, incidence, and outcomes of alcohol related liver diseases: a systematic review and meta-analysis","volume":"23","author":"Niu","year":"2023","journal-title":"BMC. Public Health"},{"key":"10.1016\/j.phymed.2026.158863_bib0057","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jclinepi.2021.03.001","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"134","author":"Page","year":"2021","journal-title":"J. Clin. Epidemiol."},{"issue":"10","key":"10.1016\/j.phymed.2026.158863_bib0058","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.3390\/antiox14101210","article-title":"6-O-trans-feruloyl Catalpol, a natural antioxidant from the stem bark of Catalpa ovata, accelerates liver regeneration In vivo via activation of hepatocyte proliferation signaling pathways","volume":"14","author":"Park","year":"2025","journal-title":"Antioxidants"},{"issue":"10","key":"10.1016\/j.phymed.2026.158863_bib0059","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S2468-1253(23)00197-8","article-title":"Global prevalence, cascade of care, and prophylaxis coverage of hepatitis B in 2022: a modelling study","volume":"8","author":"Razavi-Shearer","year":"2023","journal-title":"Lancet Gastroenterol. Hepatol."},{"issue":"3","key":"10.1016\/j.phymed.2026.158863_bib0060","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J."},{"issue":"9","key":"10.1016\/j.phymed.2026.158863_bib0061","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S2468-1253(22)00165-0","article-title":"The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis","volume":"7","author":"Riazi","year":"2022","journal-title":"Lancet Gastroenterol. Hepatol."},{"issue":"23","key":"10.1016\/j.phymed.2026.158863_bib0062","doi-asserted-by":"crossref","first-page":"8985","DOI":"10.3390\/ijms21238985","article-title":"Obesity-related changes in high-density lipoprotein metabolism and function","volume":"21","author":"Stadler","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.phymed.2026.158863_bib0063","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.cgh.2025.03.025","article-title":"Global Epidemiology of primary biliary cholangitis: an updated systematic review and meta-analysis","volume":"24","author":"Tan","year":"2026","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"4","key":"10.1016\/j.phymed.2026.158863_bib0064","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1021\/acs.jproteome.5c01049","article-title":"Route-dependent proteomic landscape in mouse models of carbon tetrachloride-induced hepatic fibrosis","volume":"25","author":"Tao","year":"2026","journal-title":"J. Proteome Res."},{"issue":"12","key":"10.1016\/j.phymed.2026.158863_bib0065","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.3390\/antiox10121859","article-title":"Bioactive compounds in oxidative stress-mediated diseases: targeting the NRF2\/ARE signaling pathway and epigenetic regulation","volume":"10","author":"Thiruvengadam","year":"2021","journal-title":"Antioxidants"},{"issue":"11","key":"10.1016\/j.phymed.2026.158863_bib0066","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/j.cmet.2022.09.017","article-title":"Gut-liver axis: pathophysiological concepts and clinical implications","volume":"34","author":"Tilg","year":"2022","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.phymed.2026.158863_bib0067","doi-asserted-by":"crossref","first-page":"5785","DOI":"10.1038\/s41467-020-19558-3","article-title":"Functional compensation precedes recovery of tissue mass following acute liver injury","volume":"11","author":"Walesky","year":"2020","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.phymed.2026.158863_bib0068","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.jhep.2010.10.040","article-title":"Ursolic acid ameliorates hepatic fibrosis in the rat by specific induction of apoptosis in hepatic stellate cells","volume":"55","author":"Wang","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2026.158863_bib0069","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156796","article-title":"Precision strike strategy for liver diseases trilogy with Xiao-Chai-Hu decoction: a meta-analysis with machine learning","volume":"142","author":"Wang","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158863_bib0070","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ijbiomac.2020.05.187","article-title":"Cyclocarya paliurus polysaccharide alleviates liver inflammation in mice via beneficial regulation of gut microbiota and TLR4\/MAPK signaling pathways","volume":"160","author":"Wu","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2026.158863_bib0071","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev-pathmechdis-031521-030435","article-title":"Recent advances in understanding of pathogenesis of alcohol-associated liver disease","volume":"18","author":"Wu","year":"2023","journal-title":"Ann. Rev. Pathol.-Mechan. Dis."},{"key":"10.1016\/j.phymed.2026.158863_bib0072","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2026.107215","article-title":"Preclinical evidence construction for resveratrol against pulmonary fibrosis: a meta-analysis and machine learning study","volume":"140","author":"Wu","year":"2026","journal-title":"J. Funct. Foods."},{"issue":"1","key":"10.1016\/j.phymed.2026.158863_bib0073","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s40104-025-01351-1","article-title":"Rosemary-derived triterpene acids improve growth and lipid metabolism in juvenile grass carp (Ctenopharyngodon idella) through the gut-liver axis by tissue-specifically regulating the farnesoid X receptor","volume":"17","author":"Wu","year":"2026","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.phymed.2026.158863_bib0074","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156942","article-title":"Single-cell transcriptomic atlas reveals the underlying mechanism of indole-3-acetic acid in protecting against acute cholestatic liver injury","volume":"144","author":"Xue","year":"2025","journal-title":"Phytomedicine"},{"issue":"25","key":"10.1016\/j.phymed.2026.158863_bib0075","doi-asserted-by":"crossref","first-page":"7074","DOI":"10.1021\/acs.jafc.1c02362","article-title":"Dietary ursolic acid prevents alcohol-induced liver injury via gut-liver axis homeostasis modulation: the key role of microbiome manipulation","volume":"69","author":"Yan","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2026.158863_bib0076","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2022.105016","article-title":"Advanced methods and implementations for the meta-analyses of animal models: current practices and future recommendations","volume":"146","author":"Yang","year":"2023","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"1","key":"10.1016\/j.phymed.2026.158863_bib0077","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s13578-023-01035-1","article-title":"Bile acid-mediated signaling in cholestatic liver diseases","volume":"13","author":"Zeng","year":"2023","journal-title":"Cell Biosci."},{"key":"10.1016\/j.phymed.2026.158863_bib0078","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2025.111612","article-title":"Ursolic acid alleviates liver fibrosis by regulating hepatic stellate cell activation via the Notch3\/NOX4 pathway","volume":"418","author":"Zhang","year":"2025","journal-title":"Chem. Biol. Interact."},{"issue":"1","key":"10.1016\/j.phymed.2026.158863_bib0079","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1038\/s41467-024-46135-9","article-title":"Deficiency of ASGR1 promotes liver injury by increasing GP73-mediated hepatic endoplasmic reticulum stress","volume":"15","author":"Zhang","year":"2024","journal-title":"Nat. Commun."},{"issue":"26","key":"10.1016\/j.phymed.2026.158863_bib0080","doi-asserted-by":"crossref","first-page":"16317","DOI":"10.1021\/acs.jafc.5c00220","article-title":"Ursolic acid alleviates DSS-induced colitis and associated liver damage by restoring treg\/Th17 balance and modulating gut microbiota and its histidine metabolism","volume":"73","author":"Zhao","year":"2025","journal-title":"J. Agric. Food Chem."},{"issue":"38","key":"10.1016\/j.phymed.2026.158863_bib0081","doi-asserted-by":"crossref","first-page":"21181","DOI":"10.1021\/acs.jafc.4c04762","article-title":"Ursolic acid ameliorates alcoholic liver injury through attenuating oxidative stress-mediated ferroptosis and modulating gut microbiota","volume":"72","author":"Zhou","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2026.158863_bib0082","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105388","article-title":"Regulation of the NLRP3 inflammasome with natural products against chemical-induced liver injury","volume":"164","author":"Zou","year":"2021","journal-title":"Pharmacol. Res."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326010925?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326010925?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:24:07Z","timestamp":1791995047000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326010925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":82,"alternative-id":["S0944711326010925"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158863","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic efficacy and dosing regimen evidence synthesis of Ursolic Acid for liver injury: A preclinical systematic review with machine learning","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158863","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158863"}}