{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T03:11:44Z","timestamp":1772161904202,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiology &amp; Behavior"],"published-print":{"date-parts":[[2007,9]]},"DOI":"10.1016\/j.physbeh.2007.05.061","type":"journal-article","created":{"date-parts":[[2007,5,26]],"date-time":"2007-05-26T11:11:02Z","timestamp":1180177862000},"page":"245-249","source":"Crossref","is-referenced-by-count":36,"title":["Nature and nurture in suicidal behavior, the role of genetics: some novel findings concerning personality traits and neural conduction"],"prefix":"10.1016","volume":"92","author":[{"given":"Danuta","family":"Wasserman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Geijer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Sokolowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vsevolod","family":"Rozanov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerzy","family":"Wasserman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2007.05.061_bib1","series-title":"Suicide: an unnecessary death","first-page":"111","article-title":"Negative life events (losses, changes, traumas and narcissistic injury) and suicide","author":"Wasserman","year":"2001"},{"key":"10.1016\/j.physbeh.2007.05.061_bib2","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/archpsyc.59.9.801","article-title":"Familial pathways to early-onset suicide attempt: risk for suicidal behavior in offspring of mood-disordered suicide attempters","volume":"59","author":"Brent","year":"2002","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.physbeh.2007.05.061_bib3","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1600-0447.1998.tb09957.x","article-title":"The familial aggregation of adolescent suicide attempts","volume":"97","author":"Johnson","year":"1998","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.physbeh.2007.05.061_bib4","doi-asserted-by":"crossref","unstructured":"Wasserman D. Suicide \u2014 an unnecessary death. London: Martin Dunitz Publishers, Taylor & Francis Group; 2001.","DOI":"10.1201\/b14713"},{"key":"10.1016\/j.physbeh.2007.05.061_bib5","series-title":"Origin, prevention and treatment of affective disorders","first-page":"277","article-title":"A family study of suicide","author":"Schulsinger","year":"1979"},{"key":"10.1016\/j.physbeh.2007.05.061_bib6","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0165-0327(00)00275-5","article-title":"Suicidal behavior in twins: a replication","volume":"66","author":"Roy","year":"2001","journal-title":"J Affect Disord"},{"key":"10.1016\/j.physbeh.2007.05.061_bib7","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1017\/S0033291798006916","article-title":"Suicidal behavior: an epidemiologic and genetic study","volume":"28","author":"Statham","year":"1998","journal-title":"Psychol Med"},{"key":"10.1016\/j.physbeh.2007.05.061_bib8","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0006-3223(96)00217-X","article-title":"Cerebrospinal fluid amines and higher lethality suicide attempts in depressed inpatients","volume":"41","author":"Mann","year":"1997","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.physbeh.2007.05.061_bib9","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1176\/ajp.143.12.1539","article-title":"Reduced CSF concentrations of homovanillic acid to 5-hydroxyindoleacetic acid ratios in depressed patients: relationship to suicidal behavior and dexamethasone nonsuppression","volume":"143","author":"Roy","year":"1986","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.physbeh.2007.05.061_bib10","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1001\/archpsyc.1976.01770100055005","article-title":"5-H1AA in the cerebrospinal fluid: a biochemical suicide predictor?","volume":"33","author":"\u00c5sberg","year":"1976","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.physbeh.2007.05.061_bib11","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1001\/archpsyc.1994.03950010034005","article-title":"Suicidality and 5-hydroxyindoleacetic acid concentration associated with a tryptophan hydroxylase polymorphism","volume":"51","author":"Nielsen","year":"1994","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.physbeh.2007.05.061_bib12","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/sj.mp.4000846","article-title":"Suicide attempts and the tryptophan hydroxylase gene","volume":"6","author":"Abbar","year":"2001","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.physbeh.2007.05.061_bib13","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1176\/ajp.154.10.1451","article-title":"Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients","volume":"154","author":"Mann","year":"1997","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.physbeh.2007.05.061_bib14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/00041444-200010010-00003","article-title":"Tryptophan hydroxylase polymorphisms in suicide victims","volume":"10","author":"Bennett","year":"2000","journal-title":"Psychiatr Genet"},{"key":"10.1016\/j.physbeh.2007.05.061_bib15","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00041444-200010010-00004","article-title":"Search for association between suicide attempt and serotonergic polymorphisms","volume":"10","author":"Geijer","year":"2000","journal-title":"Psychiatr Genet"},{"key":"10.1016\/j.physbeh.2007.05.061_bib16","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1001\/archpsyc.56.1.98","article-title":"Tryptophan hydroxylase gene and manic-depressive illness","volume":"56","author":"Kirov","year":"1999","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.physbeh.2007.05.061_bib17","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1126\/science.1078197","article-title":"Synthesis of serotonin by a second tryptophan hydroxylase isoform","volume":"299","author":"Walther","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.physbeh.2007.05.061_bib18","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.biopsych.2004.07.015","article-title":"Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims","volume":"56","author":"Zill","year":"2004","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.physbeh.2007.05.061_bib19","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.biopsych.2004.02.006","article-title":"Association between serotonin transporter gene promoter polymorphism and suicide: results of a meta-analysis","volume":"55","author":"Lin","year":"2004","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.physbeh.2007.05.061_bib20","doi-asserted-by":"crossref","first-page":"8788","DOI":"10.1523\/JNEUROSCI.23-25-08788.2003","article-title":"Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide","volume":"23","author":"Lemonde","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.physbeh.2007.05.061_bib21","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.euroneuro.2006.08.006","article-title":"Association of the serotonin transporter promotor polymorphism with suicide attempters with a high medical damage","volume":"17","author":"Wasserman","year":"2007","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.physbeh.2007.05.061_bib22","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1744-9081-2-14","article-title":"The serotonin 1A receptor C(-1019)G polymorphism in relation to suicide attempt","volume":"2","author":"Wasserman","year":"2006","journal-title":"Behav Brain Funct"},{"key":"10.1016\/j.physbeh.2007.05.061_bib23","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/nm0198-025","article-title":"The neurobiology of suicide","volume":"4","author":"Mann","year":"1998","journal-title":"Nat Med"},{"key":"10.1016\/j.physbeh.2007.05.061_bib24","series-title":"A stress-vulnerability model and the development of the suicidal process","first-page":"13","author":"Wasserman","year":"2001"},{"key":"10.1016\/j.physbeh.2007.05.061_bib25","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/(SICI)1098-2396(199605)23:1<28::AID-SYN4>3.0.CO;2-J","article-title":"Noradrenergic mechanisms in stress and anxiety: I. Preclinical studies","volume":"23","author":"Bremner","year":"1996","journal-title":"Synapse"},{"key":"10.1016\/j.physbeh.2007.05.061_bib26","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0165-1781(97)00068-1","article-title":"Tyrosine hydroxylase allelic distribution in suicide attempters","volume":"72","author":"Persson","year":"1997","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.physbeh.2007.05.061_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-1781(00)00160-8","article-title":"Search for influence of the tyrosine hydroxylase (TCAT)n repeat polymorphism on personality traits","volume":"95","author":"Persson","year":"2000","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.physbeh.2007.05.061_bib28","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/0006-3223(95)00581-1","article-title":"Dopamine-related genes and their relationships to monoamine metabolites in CSF","volume":"40","author":"J\u00f6nsson","year":"1996","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.physbeh.2007.05.061_bib29","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0006-3223(98)00375-8","article-title":"Aggression and anger-related traits associated with a polymorphism of the tryptophan hydroxylase gene","volume":"45","author":"Manuck","year":"1999","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.physbeh.2007.05.061_bib30","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/sj.mp.4001128","article-title":"Association of anger-related traits with SNPs in the TPH gene","volume":"7","author":"Rujescu","year":"2002","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.physbeh.2007.05.061_bib31","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1601-183X.2006.00259.x","article-title":"Genetic variation in the hypothalamic pituitary adrenocortical (HPA) axis regulatory factor, T-box19, and the angry\/hostility personality trait","volume":"6","author":"Wasserman","year":"2007","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.physbeh.2007.05.061_bib32","unstructured":"Wasserman D, Sokolowski M, Rozanov V, Wasserman J. The CRHR1 gene: a marker for suicidality in depressed males exposed to low stress. Genes Brain Behav in press."},{"key":"10.1016\/j.physbeh.2007.05.061_bib33","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/ajmg.b.30128","article-title":"Suicide attempt and basic mechanisms in neural conduction: Relationships to the SCN8A and VAMP4 genes","volume":"133B","author":"Wasserman","year":"2005","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.physbeh.2007.05.061_bib34","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1093\/hmg\/11.22.2765","article-title":"Molecular and pathological effects of a modifier gene on deficiency of the sodium channel Scn8a (Na(v)1.6)","volume":"11","author":"Kearney","year":"2002","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.physbeh.2007.05.061_bib35","series-title":"The neuropsychiatry of limbic and subcortical disorders","year":"1997"},{"key":"10.1016\/j.physbeh.2007.05.061_bib36","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1126\/science.287.5457.1433","article-title":"Mammalian neural stem cells","volume":"287","author":"Gage","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.physbeh.2007.05.061_bib37","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1006\/excr.1999.4678","article-title":"Neural stem cells in the adult human brain","volume":"253","author":"Johansson","year":"1999","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.physbeh.2007.05.061_bib38","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1126\/science.1083968","article-title":"Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene","volume":"301","author":"Caspi","year":"2003","journal-title":"Science"}],"container-title":["Physiology &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938407002338?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938407002338?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,28]],"date-time":"2019-04-28T10:55:03Z","timestamp":1556448903000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938407002338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":38,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["S0031938407002338"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2007.05.061","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2007,9]]}}}