{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T09:39:44Z","timestamp":1762249184445,"version":"3.33.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiology & Behavior"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1016\/j.physbeh.2007.07.015","type":"journal-article","created":{"date-parts":[[2007,8,9]],"date-time":"2007-08-09T11:38:50Z","timestamp":1186659530000},"page":"1002-1009","source":"Crossref","is-referenced-by-count":14,"title":["Weaver mutant mice exhibit long-term learning deficits under several measures of instrumental behavior"],"prefix":"10.1016","volume":"92","author":[{"given":"Adam","family":"Derenne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew L.","family":"Arsenault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David P.","family":"Austin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey N.","family":"Weatherly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2007.07.015_bib1","series-title":"Parkinson's disease","first-page":"537","article-title":"Weaver mutant mouse in progression of neurodegeneration in Parkinson's disease","author":"Ebadi","year":"2004"},{"key":"10.1016\/j.physbeh.2007.07.015_bib2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0301-0082(00)00061-7","article-title":"The weaver mutant mouse: a model to study the ontogeny of dopamine transmission systems and their role in drug addiction","volume":"64","author":"Maharajan","year":"2001","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.physbeh.2007.07.015_bib3","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1523\/JNEUROSCI.06-11-03319.1986","article-title":"Expression of the weaver gene in dopamine-containing neural systems is dose-dependent and affects both striatal and nonstriatal regions","volume":"6","author":"Roffler-Tarlov","year":"1986","journal-title":"J Neurosci"},{"key":"10.1016\/j.physbeh.2007.07.015_bib4","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/BF00248351","article-title":"Mesencephalic dopamine cell deficit involves areas A8, A9 and A10 in weaver mutant mice","volume":"70","author":"Triarhou","year":"1988","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.physbeh.2007.07.015_bib5","doi-asserted-by":"crossref","first-page":"6901","DOI":"10.1523\/JNEUROSCI.14-11-06901.1994","article-title":"Correlated quantitative studies of the neostriatum, nucleus accumbens, substantia nigra, and ventral tegmental area in normal and weaver mutant mice","volume":"14","author":"Bayer","year":"1994","journal-title":"J Neurosci"},{"key":"10.1016\/j.physbeh.2007.07.015_bib6","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/ng1095-126","article-title":"A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation","volume":"11","author":"Patil","year":"1995","journal-title":"Nat Genet"},{"key":"10.1016\/j.physbeh.2007.07.015_bib7","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/S0896-6273(00)80133-6","article-title":"Identification of the weaver mouse mutation: the end of the beginning","volume":"16","author":"Hess","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.physbeh.2007.07.015_bib8","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1471-4159.1977.tb09629.x","article-title":"Contents of serotonin, norepinephrine and dopamine in the cerebrum of the \u201cstaggerer,\u201d \u201cweaver,\u201d \u201cnervous\u201d neurologically mutant mice","volume":"29","author":"Lane","year":"1977","journal-title":"J Neurochem"},{"key":"10.1016\/j.physbeh.2007.07.015_bib9","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1146\/annurev.physiol.62.1.779","article-title":"Insights from mouse models into the molecular basis of neurodegeneration","volume":"62","author":"Heintz","year":"2000","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.physbeh.2007.07.015_bib10","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0031-6997(24)01469-8","article-title":"Potassium channels: molecular defects, diseases, and therapeutic opportunities","volume":"52","author":"Shieh","year":"2000","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.physbeh.2007.07.015_bib11","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0031-6997(24)01385-1","article-title":"G protein regulation of potassium channels","volume":"50","author":"Yamada","year":"1998","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.physbeh.2007.07.015_bib12","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1523\/JNEUROSCI.02-03-00376.1982","article-title":"Dopamine deficiency in the weaver mutant mouse","volume":"2","author":"Schmidt","year":"1982","journal-title":"J Neurosci"},{"year":"1965","series-title":"Catalog of the neurological mutants of the mouse","author":"Sidman","key":"10.1016\/j.physbeh.2007.07.015_bib13"},{"key":"10.1016\/j.physbeh.2007.07.015_bib14","series-title":"Cerebellar degenerations: Clinical Neurobiology","first-page":"159","article-title":"The Purkinje cell degeneration mutant: a model to study the consequences of neuronal degeneration","author":"Ghetti","year":"1992"},{"key":"10.1016\/j.physbeh.2007.07.015_bib15","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/BF01068144","article-title":"Neurological dysfunction expressed in the grooming behavior of developing weaver mutant mice","volume":"23","author":"Coscia","year":"1993","journal-title":"Behav Genet"},{"key":"10.1016\/j.physbeh.2007.07.015_bib16","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/BF00248807","article-title":"Motor abnormalities in staggerer mutant mice","volume":"68","author":"Lalonde","year":"1987","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.physbeh.2007.07.015_bib17","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/0306-4522(96)00091-7","article-title":"The human homologue of the weaver mouse gene in familial and sporadic Parkinson's disease","volume":"72","author":"Bandmann","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2007.07.015_bib18","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/cne.901520202","article-title":"Sequence of developmental abnormalities leading to granule cell deficit in cerebellar cortex of weaver mutant mice","volume":"152","author":"Rakic","year":"1973","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.physbeh.2007.07.015_bib19","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/cne.901520203","article-title":"Organization of cerebellar cortex secondary to deficit of granule cells in weaver mutant mice","volume":"152","author":"Rakic","year":"1973","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.physbeh.2007.07.015_bib20","doi-asserted-by":"crossref","first-page":"11191","DOI":"10.1073\/pnas.93.20.11191","article-title":"The weaver mutation of GIRK2 results in a loss of inwardly rectifying K+ current in cerebellar granule cells","volume":"93","author":"Surmeier","year":"1996","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.physbeh.2007.07.015_bib21","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/0006-8993(95)00974-U","article-title":"Morphological abnormalities in the hippocampus of the weaver mutant mouse","volume":"696","author":"Sekiguchi","year":"1995","journal-title":"Brain Res"},{"key":"10.1016\/j.physbeh.2007.07.015_bib28","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0166-4328(02)00282-6","article-title":"Motivational views of reinforcement: implications for understanding the behavioral functions of nucleus accumbens dopamine","volume":"137","author":"Salamone","year":"2002","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.physbeh.2007.07.015_bib22","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0165-0173(98)00019-8","article-title":"What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?","volume":"28","author":"Berridge","year":"1998","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.physbeh.2007.07.015_bib23","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0166-2236(03)00233-9","article-title":"Parsing reward","volume":"26","author":"Berridge","year":"2003","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.physbeh.2007.07.015_bib24","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.physbeh.2004.02.004","article-title":"Motivation concepts in behavioral neuroscience","volume":"81","author":"Berridge","year":"2004","journal-title":"Physiol Behav"},{"key":"10.1016\/j.physbeh.2007.07.015_bib25","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.physbeh.2004.04.020","article-title":"Is dopamine required for natural reward?","volume":"81","author":"Cannon","year":"2004","journal-title":"Physiol Behav"},{"key":"10.1016\/j.physbeh.2007.07.015_bib26","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/nrn1406","article-title":"Dopamine, learning and motivation","volume":"5","author":"Wise","year":"2004","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.physbeh.2007.07.015_bib27","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/cne.20689","article-title":"Forebrain substrates of reward and motivation","volume":"493","author":"Wise","year":"2005","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.physbeh.2007.07.015_bib29","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0091-3057(98)00112-9","article-title":"Effects of dopamine antagonists and accumbens dopamine depletions on time-constrained progressive-ratio performance","volume":"61","author":"Aberman","year":"1998","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.physbeh.2007.07.015_bib30","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.bbr.2003.08.007","article-title":"Accumbens dopamine and the regulation of effort in food-seeking behavior: modulation of work output by different ratio or force requirements","volume":"151","author":"Ishiwari","year":"2004","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.physbeh.2007.07.015_bib31","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0166-4328(96)02240-1","article-title":"Rats with partial striatal dopamine depletions exhibit robust and long-lasting behavioral deficits in a simple fixed-ratio bar-pressing task","volume":"86","author":"Lindner","year":"1997","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.physbeh.2007.07.015_bib32","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1111\/j.1460-9568.2005.03972.x","article-title":"Ratio and time requirements on operant schedules: effort-related effects of nucleus accumbens dopamine depletions","volume":"21","author":"Mingote","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.physbeh.2007.07.015_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/jpet.102.035063","article-title":"Nucleus accumbens dopamine and the regulation of effort in food seeking behavior: implications for studies of natural motivation, psychiatry, and drug abuse","volume":"305","author":"Salamone","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.physbeh.2007.07.015_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/jn.1998.80.1.1","article-title":"Predictive reward signal of dopamine neurons","volume":"80","author":"Schultz","year":"1998","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.physbeh.2007.07.015_bib35","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0896-6273(02)00967-4","article-title":"Getting formal with dopamine and reward","volume":"36","author":"Schultz","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.physbeh.2007.07.015_bib36","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1177\/107385840100700406","article-title":"Reward signaling by dopamine neurons","volume":"7","author":"Schultz","year":"2001","journal-title":"Neuroscientist"},{"key":"10.1016\/j.physbeh.2007.07.015_bib37","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.tins.2004.10.001","article-title":"Dopamine: the salient issue","volume":"27","author":"Ungless","year":"2004","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.physbeh.2007.07.015_bib38","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/35083500","article-title":"Dopamine responses comply with basic assumptions of formal learning theory","volume":"412","author":"Waelti","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.physbeh.2007.07.015_bib39","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.conb.2004.03.017","article-title":"Neural coding of basic reward terms of animal learning theory, game theory, microeconomics and behavioural ecology","volume":"14","author":"Schultz","year":"2004","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.physbeh.2007.07.015_bib40","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/0006-8993(96)80777-3","article-title":"FR discrimination training reverses 6-hydroxydopamine-induced striatal dopamine depletion in a rat model of Lesch\u2013Nyhan syndrome","volume":"713","author":"Stodgell","year":"1996","journal-title":"Brain Res"},{"key":"10.1016\/j.physbeh.2007.07.015_bib41","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0006-8993(97)01184-0","article-title":"Fixed-ratio discrimination training as replacement therapy in Parkinson's disease: studies in a 6-hydroxydopamine-treated rat model","volume":"780","author":"Van Keuren","year":"1998","journal-title":"Brain Res"},{"key":"10.1016\/j.physbeh.2007.07.015_bib42","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0306-4522(03)00096-4","article-title":"Exercise induces behavioral recovery and attenuates neurochemical deficits in rodent models of Parkinson's disease","volume":"119","author":"Tillerson","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2007.07.015_bib43","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0091-3057(02)00950-4","article-title":"Fixed ratio discrimination training increases in vivo striatal dopamine in neonatal 6-OHDA-lesioned rats","volume":"74","author":"Loupe","year":"2002","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.physbeh.2007.07.015_bib44","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/BF00240955","article-title":"Time of neuron origin and gradients of neurogenesis in midbrain dopaminergic neurons in the mouse","volume":"105","author":"Bayer","year":"1995","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.physbeh.2007.07.015_bib45","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1073\/pnas.94.3.923","article-title":"Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2","volume":"94","author":"Signorini","year":"1997","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.physbeh.2007.07.015_bib46","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/0304-3940(89)90052-9","article-title":"Tonic\/clonic seizures in a mouse carrying the weaver gene","volume":"96","author":"Eisenberg","year":"1989","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.physbeh.2007.07.015_bib47","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1901\/jeab.1965.8-19","article-title":"Some properties of spaced responding in pigeons","volume":"8","author":"Staddon","year":"1965","journal-title":"J Exp Anal Behav"},{"key":"10.1016\/j.physbeh.2007.07.015_bib48","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1901\/jeab.1962.5-497","article-title":"Spaced responding in multiple DRL schedules","volume":"5","author":"Zimmerman","year":"1962","journal-title":"J Exp Anal Behav"},{"key":"10.1016\/j.physbeh.2007.07.015_bib49","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1901\/jeab.1983.39-327","article-title":"The microanalysis of fixed-interval responding","volume":"39","author":"Gentry","year":"1983","journal-title":"J Exp Anal Behav"},{"key":"10.1016\/j.physbeh.2007.07.015_bib50","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1901\/jeab.1994.61-11","article-title":"Molecular and molar analyses of fixed-interval performance","volume":"61","author":"Baron","year":"1994","journal-title":"J Exp Anal Behav"},{"key":"10.1016\/j.physbeh.2007.07.015_bib51","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/s00213-006-0339-x","article-title":"Evidence for a role of D1 dopamine receptors in d-amphetamine's effect of timing behavior in the free-operant psychophysical procedure","volume":"185","author":"Cheung","year":"2006","journal-title":"Psychopharmacol"}],"container-title":["Physiology & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938407002880?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938407002880?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T06:27:00Z","timestamp":1737354420000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938407002880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["S0031938407002880"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2007.07.015","relation":{},"ISSN":["0031-9384"],"issn-type":[{"type":"print","value":"0031-9384"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}