{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:40:52Z","timestamp":1786995652682,"version":"build-2736575974"},"reference-count":46,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiology & Behavior"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.physbeh.2010.02.023","type":"journal-article","created":{"date-parts":[[2010,3,4]],"date-time":"2010-03-04T09:41:28Z","timestamp":1267695688000},"page":"187-195","source":"Crossref","is-referenced-by-count":50,"title":["Multi-hormonal weight loss combinations in diet-induced obese rats: Therapeutic potential of cholecystokinin?"],"prefix":"10.1016","volume":"100","author":[{"given":"James L.","family":"Trevaskis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria F.","family":"Turek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter S.","family":"Griffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie","family":"Wittmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Parkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.physbeh.2010.02.023_bib1","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1037\/h0034870","article-title":"Cholecystokinin decreases food intake in rats","volume":"84","author":"Gibbs","year":"1973","journal-title":"J Comp Physiol Psychol"},{"issue":"4950","key":"10.1016\/j.physbeh.2010.02.023_bib2","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1126\/science.2321020","article-title":"Endogenous cholecystokinin reduces feeding in young rats","volume":"247","author":"Weller","year":"1990","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.physbeh.2010.02.023_bib3","doi-asserted-by":"crossref","first-page":"R331","DOI":"10.1152\/ajpregu.2001.280.2.R331","article-title":"Diminished satiation in rats exposed to elevated levels of endogenous or exogenous cholecystokinin","volume":"280","author":"Covasa","year":"2001","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"5910","key":"10.1016\/j.physbeh.2010.02.023_bib4","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/302703a0","article-title":"Rapid development of tolerance to the behavioural actions of cholecystokinin","volume":"302","author":"Crawley","year":"1983","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.physbeh.2010.02.023_bib5","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/sj.clpt.6100272","article-title":"Stimulation of cholecystokinin-A receptors with GI181771X does not cause weight loss in overweight or obese patients","volume":"83","author":"Jordan","year":"2008","journal-title":"Clin Pharmacol Ther"},{"issue":"2","key":"10.1016\/j.physbeh.2010.02.023_bib6","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0196-9781(97)00261-1","article-title":"Long-term effects of CCK-agonist and-antagonist on food intake and body weight in Zucker lean and obese rats","volume":"19","author":"Meereis-Schwanke","year":"1998","journal-title":"Peptides"},{"issue":"5 Pt 2","key":"10.1016\/j.physbeh.2010.02.023_bib7","first-page":"R776","article-title":"Cholecystokinin persistently suppresses meal size but not food intake in free-feeding rats","volume":"246","author":"West","year":"1984","journal-title":"Am J Physiol"},{"issue":"19","key":"10.1016\/j.physbeh.2010.02.023_bib8","doi-asserted-by":"crossref","first-page":"10455","DOI":"10.1073\/pnas.94.19.10455","article-title":"Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice","volume":"94","author":"Barrachina","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.physbeh.2010.02.023_bib9","doi-asserted-by":"crossref","first-page":"R882","DOI":"10.1152\/ajpregu.2000.278.4.R882","article-title":"Cholecystokinin and leptin act synergistically to reduce body weight","volume":"278","author":"Matson","year":"2000","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"5","key":"10.1016\/j.physbeh.2010.02.023_bib10","doi-asserted-by":"crossref","first-page":"R1368","DOI":"10.1152\/ajpregu.00080.2001","article-title":"Daily CCK injection enhances reduction of body weight by chronic intracerebroventricular leptin infusion","volume":"282","author":"Matson","year":"2002","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"1\u20133","key":"10.1016\/j.physbeh.2010.02.023_bib11","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0167-0115(00)00153-1","article-title":"Synergistic interaction between CCK and leptin to regulate food intake","volume":"92","author":"Wang","year":"2000","journal-title":"Regul Pept"},{"issue":"4","key":"10.1016\/j.physbeh.2010.02.023_bib12","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0031-9384(98)00110-3","article-title":"Synergy between amylin and cholecystokinin for inhibition of food intake in mice","volume":"64","author":"Bhavsar","year":"1998","journal-title":"Physiol Behav"},{"issue":"1\u20133","key":"10.1016\/j.physbeh.2010.02.023_bib13","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.regpep.2005.09.025","article-title":"Effects of amylin on feeding of goldfish: interactions with CCK","volume":"133","author":"Thavanathan","year":"2006","journal-title":"Regul Pept"},{"issue":"suppl 1","key":"10.1016\/j.physbeh.2010.02.023_bib14","first-page":"A72","article-title":"Responsiveness to leptin restored by amylin in diet induced obese (DIO) rats: magnitude and mechanisms of synergy","volume":"56","author":"Roth","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.physbeh.2010.02.023_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/oby.2009.478","article-title":"Enhanced weight loss following coadministration of pramlintide with sibutramine or phentermine in a multi-center trial","author":"Aronne","year":"2010","journal-title":"Obesity"},{"issue":"20","key":"10.1016\/j.physbeh.2010.02.023_bib16","doi-asserted-by":"crossref","first-page":"7257","DOI":"10.1073\/pnas.0706473105","article-title":"Leptin responsiveness restored by amylin agonism in diet-induced obesity: evidence from nonclinical and clinical studies","volume":"105","author":"Roth","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.physbeh.2010.02.023_bib17","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/oby.2009.187","article-title":"Interaction of leptin and amylin in the long-term maintenance of weight loss in diet-induced obese rats","volume":"18","author":"Trevaskis","year":"2010","journal-title":"Obesity"},{"issue":"11","key":"10.1016\/j.physbeh.2010.02.023_bib18","doi-asserted-by":"crossref","first-page":"5679","DOI":"10.1210\/en.2008-0770","article-title":"Amylin-mediated restoration of leptin responsiveness in diet-induced obesity: magnitude and mechanisms","volume":"149","author":"Trevaskis","year":"2008","journal-title":"Endocrinology"},{"issue":"12","key":"10.1016\/j.physbeh.2010.02.023_bib19","doi-asserted-by":"crossref","first-page":"5855","DOI":"10.1210\/en.2006-0393","article-title":"Anti-obesity effects of the \u03b2-cell hormone amylin in diet induced obese rats: effects on food intake, body weight, composition, energy expenditure and gene expression","volume":"147","author":"Roth","year":"2006","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.physbeh.2010.02.023_bib20","doi-asserted-by":"crossref","first-page":"R114","DOI":"10.1152\/ajpregu.00333.2003","article-title":"The anorectic hormone amylin contributes to feeding-related changes of neuronal activity in key structures of the gut-brain axis","volume":"286","author":"Riediger","year":"2004","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"1\u2013-2","key":"10.1016\/j.physbeh.2010.02.023_bib21","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0006-8993(98)01348-1","article-title":"Area postrema and the anorectic actions of dexfenfluramine and amylin","volume":"820","author":"Rowland","year":"1999","journal-title":"Brain Res"},{"issue":"5 Pt 2","key":"10.1016\/j.physbeh.2010.02.023_bib22","first-page":"R1545","article-title":"Central leptin modulates behavioral and neural responsivity to CCK","volume":"276","author":"Emond","year":"1999","journal-title":"Am J Physiol"},{"issue":"3","key":"10.1016\/j.physbeh.2010.02.023_bib23","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0167-0115(94)90003-5","article-title":"Cholecystokinin-and dexfenfluramine-induced anorexia compared using devazepide and c-fos expression in the rat brain","volume":"50","author":"Li","year":"1994","journal-title":"Regul Pept"},{"issue":"3","key":"10.1016\/j.physbeh.2010.02.023_bib24","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0167-0115(97)01034-3","article-title":"Comparison of Fos induced in rat brain by GLP-1 and amylin","volume":"71","author":"Rowland","year":"1997","journal-title":"Regul Pept"},{"issue":"1","key":"10.1016\/j.physbeh.2010.02.023_bib25","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1210\/en.2009-0546","article-title":"Mechanisms of amylin\/leptin synergy in rodent models","volume":"151","author":"Turek","year":"2010","journal-title":"Endocrinology"},{"issue":"8","key":"10.1016\/j.physbeh.2010.02.023_bib26","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1038\/ijo.2008.91","article-title":"Amylin in combination with phentermine, sibutramine or rimonabant elicited additive reductions in food intake and body weight in diet-induced obese rats","volume":"32","author":"Roth","year":"2008","journal-title":"Int J Obes"},{"issue":"1","key":"10.1016\/j.physbeh.2010.02.023_bib27","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1097\/00006676-200107000-00014","article-title":"The method of administration of cholecystokinin determines the effects evoked in the pancreas","volume":"23","author":"Ohlsson","year":"2001","journal-title":"Pancreas"},{"issue":"3","key":"10.1016\/j.physbeh.2010.02.023_bib28","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1172\/JCI200522081","article-title":"Leptin action in the forebrain regulates the hindbrain response to satiety signals","volume":"115","author":"Morton","year":"2005","journal-title":"J Clin Invest"},{"issue":"Suppl 5","key":"10.1016\/j.physbeh.2010.02.023_bib29","doi-asserted-by":"crossref","first-page":"216S","DOI":"10.1038\/oby.2006.312","article-title":"Distributed neural control of energy balance: contributions from hindbrain and hypothalamus","volume":"14","author":"Grill","year":"2006","journal-title":"Obesity (Silver Spring)"},{"issue":"1","key":"10.1016\/j.physbeh.2010.02.023_bib30","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0006-8993(90)90253-8","article-title":"Central and peripheral vagal transport of cholecystokinin binding sites occurs in afferent fibers","volume":"526","author":"Moran","year":"1990","journal-title":"Brain Res"},{"issue":"6","key":"10.1016\/j.physbeh.2010.02.023_bib31","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/0361-9230(95)00045-G","article-title":"Effects of vagotomy on cholecystokinin- and dexfenfluramine-induced Fos-like immunoreactivity in the rat brain","volume":"37","author":"Li","year":"1995","journal-title":"Brain Res Bull"},{"issue":"5 Pt 2","key":"10.1016\/j.physbeh.2010.02.023_bib32","first-page":"R971","article-title":"Dorsomedial hindbrain participation in cholecystokinin-induced satiety","volume":"251","author":"Edwards","year":"1986","journal-title":"Am J Physiol"},{"issue":"3","key":"10.1016\/j.physbeh.2010.02.023_bib33","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0196-9781(94)00203-I","article-title":"Subdiaphragmatic vagotomy does not influence the anorectic effect of amylin","volume":"16","author":"Lutz","year":"1995","journal-title":"Peptides"},{"issue":"6 Pt 2","key":"10.1016\/j.physbeh.2010.02.023_bib34","first-page":"R1777","article-title":"Anorectic effect of amylin is not transmitted by capsaicin-sensitive nerve fibers","volume":"274","author":"Lutz","year":"1998","journal-title":"Am J Physiol"},{"issue":"1","key":"10.1016\/j.physbeh.2010.02.023_bib35","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0196-9781(02)00280-2","article-title":"Endogenous amylin contributes to the anorectic effects of cholecystokinin and bombesin","volume":"24","author":"Mollet","year":"2003","journal-title":"Peptides"},{"issue":"5","key":"10.1016\/j.physbeh.2010.02.023_bib36","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0031-9384(00)00302-4","article-title":"Attenuation of the anorectic effects of cholecystokinin and bombesin by the specific amylin antagonist AC 253","volume":"70","author":"Lutz","year":"2000","journal-title":"Physiol Behav"},{"issue":"1\u20132","key":"10.1016\/j.physbeh.2010.02.023_bib37","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0006-8993(97)00865-2","article-title":"Peripheral administration of cholecystokinin activates c-fos expression in the locus coeruleus\/subcoeruleus nucleus, dorsal vagal complex and paraventricular nucleus via capsaicin-sensitive vagal afferents and CCK-A receptors in the rat","volume":"770","author":"Monnikes","year":"1997","journal-title":"Brain Res"},{"key":"10.1016\/j.physbeh.2010.02.023_bib38","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.brainres.2007.06.016","article-title":"Lesion of the lateral parabrachial nucleus attenuates the anorectic effect of peripheral amylin and CCK","volume":"1162","author":"Becskei","year":"2007","journal-title":"Brain Res"},{"issue":"4 Pt 2","key":"10.1016\/j.physbeh.2010.02.023_bib39","first-page":"H1359","article-title":"Effects of area postrema stimulation on neurons of the nucleus of the solitary tract","volume":"260","author":"Hay","year":"1991","journal-title":"Am J Physiol"},{"issue":"6","key":"10.1016\/j.physbeh.2010.02.023_bib40","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/j.1365-2826.2008.01734.x","article-title":"Measurement of immediate-early gene activation- c-fos and beyond","volume":"20","author":"Kovacs","year":"2008","journal-title":"J Neuroendocrinol"},{"issue":"31","key":"10.1016\/j.physbeh.2010.02.023_bib41","doi-asserted-by":"crossref","first-page":"10084","DOI":"10.1523\/JNEUROSCI.23-31-10084.2003","article-title":"Hindbrain noradrenergic lesions attenuate anorexia and alter central cFos expression in rats after gastric viscerosensory stimulation","volume":"23","author":"Rinaman","year":"2003","journal-title":"J Neurosci"},{"issue":"8","key":"10.1016\/j.physbeh.2010.02.023_bib42","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1038\/ijo.2008.91","article-title":"Antiobesity effects of the beta-cell hormone amylin in combination with phentermine or sibutramine in diet-induced obese rats","volume":"32","author":"Roth","year":"2008","journal-title":"Int J Obes (Lond)"},{"issue":"1","key":"10.1016\/j.physbeh.2010.02.023_bib43","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0196-9781(95)02046-2","article-title":"Attenuation of the anorectic effects of glucagon, cholecystokinin, and bombesin by the amylin receptor antagonist CGRP(8\u201337)","volume":"17","author":"Lutz","year":"1996","journal-title":"Peptides"},{"issue":"4","key":"10.1016\/j.physbeh.2010.02.023_bib44","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1210\/en.2007-1286","article-title":"Leptin-mediated hypothalamic pathway of cholecystokinin (CCK-8) to regulate body weight in free-feeding rats","volume":"149","author":"Merino","year":"2008","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.physbeh.2010.02.023_bib45","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/bjp.2008.149","article-title":"A cholecystokinin-1 receptor agonist (CCK-8) mediates increased permeability of brain barriers to leptin","volume":"154","author":"Cano","year":"2008","journal-title":"Br J Pharmacol"},{"issue":"1 Pt 2","key":"10.1016\/j.physbeh.2010.02.023_bib46","first-page":"R17","article-title":"Effect of continuous infusions of CCK-8 on food intake and body and pancreatic weights in rats","volume":"254","author":"Lukaszewski","year":"1988","journal-title":"Am J Physiol"}],"container-title":["Physiology & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938410001009?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938410001009?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,26]],"date-time":"2019-05-26T12:34:20Z","timestamp":1558874060000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938410001009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S0031938410001009"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2010.02.023","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}