{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:52:17Z","timestamp":1791294737012,"version":"4.1.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIH","award":["DK 17844"],"award-info":[{"award-number":["DK 17844"]}]},{"name":"NIH","award":["DK 54890"],"award-info":[{"award-number":["DK 54890"]}]},{"name":"NIH","award":["DK 54080"],"award-info":[{"award-number":["DK 54080"]}]},{"name":"NIH","award":["DK 54504"],"award-info":[{"award-number":["DK 54504"]}]},{"name":"NIH","award":["DK 56910"],"award-info":[{"award-number":["DK 56910"]}]},{"name":"NIH","award":["DK 54263"],"award-info":[{"award-number":["DK 54263"]}]},{"name":"NIH","award":["DK 56863"],"award-info":[{"award-number":["DK 56863"]}]},{"name":"NIH","award":["DK 061857"],"award-info":[{"award-number":["DK 061857"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiology &amp; Behavior"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1016\/j.physbeh.2011.01.010","type":"journal-article","created":{"date-parts":[[2011,1,18]],"date-time":"2011-01-18T09:13:22Z","timestamp":1295342002000},"page":"10-16","source":"Crossref","is-referenced-by-count":174,"title":["Consumption of a high-fat diet induces central insulin resistance independent of adiposity"],"prefix":"10.1016","volume":"103","author":[{"given":"Deborah J.","family":"Clegg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koro","family":"Gotoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Kemp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Wortman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"Benoit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda M.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"D'Alessio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Tso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy J.","family":"Seeley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"Woods","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2011.01.010_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0091-3022(02)00105-X","article-title":"Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities","volume":"24","author":"Niswender","year":"2003","journal-title":"Front Neuroendocrinol"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0010","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.2337\/diabetes.54.5.1264","article-title":"Insulin signaling in the central nervous system: a critical role in metabolic homeostasis and disease from C. elegans to humans","volume":"54","author":"Porte","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0015","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/35007534","article-title":"Central nervous system control of food intake","volume":"404","author":"Schwartz","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0020","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1126\/science.1104344","article-title":"Diabetes, obesity, and the brain","volume":"307","author":"Schwartz","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0025","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1126\/science.280.5368.1378","article-title":"Signals that regulate food intake and energy homeostasis","volume":"280","author":"Woods","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0030","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.tem.2005.01.008","article-title":"The role of insulin receptor signaling in the brain","volume":"16","author":"Plum","year":"2005","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0035","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1172\/JCI105646","article-title":"The significance of basal insulin levels in the evaluation of the insulin response to glucose in diabetic and nondiabetic subjects","volume":"46","author":"Bagdade","year":"1967","journal-title":"J Clin Invest"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0040","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1172\/JCI113339","article-title":"Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects","volume":"81","author":"Polonsky","year":"1988","journal-title":"J Clin Investig"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0045","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1172\/JCI116773","article-title":"Saturable transport of insulin from plasma into the central nervous system of dogs in vivo: a mechanism for regulated insulin delivery to the brain","volume":"92","author":"Baura","year":"1993","journal-title":"J Clin Investig"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0050","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1172\/JCI115431","article-title":"Evidence for uptake of plasma insulin into cerebrospinal fluid through an intermediate compartment in dogs","volume":"88","author":"Schwartz","year":"1991","journal-title":"J Clin Invest"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0055","doi-asserted-by":"crossref","first-page":"795","DOI":"10.2174\/1381612033455323","article-title":"Insulin and the blood\u2013brain barrier","volume":"9","author":"Woods","year":"2003","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0060","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0026-0495(74)90098-5","article-title":"Comparative measurements of glucose, beta-hydroxybutyrate, acetoacetate, and insulin in blood and cerebrospinal fluid during starvation","volume":"23","author":"Owen","year":"1974","journal-title":"Metabolism"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0065","first-page":"387","article-title":"Insulin in the brain: a hormonal regulator of energy balance","volume":"13","author":"Schwartz","year":"1992","journal-title":"Endocr Rev"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0070","first-page":"53","article-title":"Insulin and the brain: a mutual dependency","volume":"16","author":"Woods","year":"1996","journal-title":"Prog Psychobiol Physiol Psychol"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0075","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.physbeh.2006.08.008","article-title":"Intraventricular insulin and leptin reduce food intake and body weight in C57BL\/6J mice","volume":"89","author":"Brown","year":"2006","journal-title":"Physiol Behav"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0080","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1037\/0735-7044.109.3.528","article-title":"Intraventricular insulin and the level of maintained body weight in rats","volume":"109","author":"Chavez","year":"1995","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0085","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/282503a0","article-title":"Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons","volume":"282","author":"Woods","year":"1979","journal-title":"Nature"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0090","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/0031-9384(92)90112-F","article-title":"Chronic intrahyphothalamic infusions of insulin or insulin antibodies alter body weight and food intake in the rat","volume":"51","author":"McGowan","year":"1992","journal-title":"Physiol Behav"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0095","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0031-9384(77)90343-2","article-title":"Increased feeding in response to bilateral injection of insulin antibodies in the VMH","volume":"19","author":"Strubbe","year":"1977","journal-title":"Physiol Behav"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0100","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1126\/science.289.5487.2122","article-title":"Role of brain insulin receptor in control of body weight and reproduction","volume":"289","author":"Br\u00fcning","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0105","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nn0602-861","article-title":"Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats","volume":"5","author":"Obici","year":"2002","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0110","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1172\/JCI27123","article-title":"Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity","volume":"116","author":"Plum","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0115","doi-asserted-by":"crossref","first-page":"R981","DOI":"10.1152\/ajpregu.00675.2004","article-title":"Reduced anorexic effects of insulin in obesity-prone rats fed a moderate-fat diet","volume":"288","author":"Clegg","year":"2005","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0120","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1210\/en.2006-1126","article-title":"Altered hypothalamic leptin, insulin, and melanocortin binding associated with moderate-fat diet and predisposition to obesity","volume":"148","author":"Irani","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0125","doi-asserted-by":"crossref","first-page":"9048","DOI":"10.1523\/JNEUROSCI.22-20-09048.2002","article-title":"The catabolic action of insulin in the brain is mediated by melanocortins","volume":"22","author":"Benoit","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0130","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1093\/ajcn\/59.2.350","article-title":"Obesity as an adaptation to a high-fat diet: evidence from a cross-sectional study","volume":"59","author":"Astrup","year":"1994","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0135","first-page":"79","article-title":"Dietary fat and obesity: evidence from epidemiology","volume":"49","author":"Lissner","year":"1995","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0140","first-page":"505","article-title":"High and low fat consumers, their macronutrient intake and body mass index: further analysis from the National Diet and Nutrition Survey of British Adults","volume":"50","author":"Macdiarmid","year":"1996","journal-title":"Br J Clin Nutr"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0145","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1111\/j.1753-4887.1998.tb01730.x","article-title":"Physiology of fat replacement and fat reduction: effects of dietary fat and fat substitutes on energy regulation","volume":"56","author":"Roberts","year":"1998","journal-title":"Nutr Rev"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0150","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1093\/jn\/133.4.1081","article-title":"A controlled high-fat diet induces an obese syndrome in rats","volume":"133","author":"Woods","year":"2003","journal-title":"J Nutr"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0155","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/BF00418533","article-title":"Dietary fats and insulin action","volume":"39","author":"Storlien","year":"1996","journal-title":"Diabetologia"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0160","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1152\/physrev.00024.2006","article-title":"Disordered lipid metabolism and the pathogenesis of insulin resistance","volume":"87","author":"Savage","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0165","first-page":"E797","article-title":"High-fat hypocaloric diet modifies carbohydrate utilization of obese rats during weight loss","volume":"280","author":"Cha","year":"2001","journal-title":"Am J Physiol"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0170","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1093\/jn\/122.9.1811","article-title":"Insulin insensitivity is rapidly reversed in rats by reducing dietary fat from 40 to 30% of energy","volume":"122","author":"Harris","year":"1992","journal-title":"J Nutr"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0175","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1053\/meta.2002.32725","article-title":"A low-fat diet has a higher potential than energy restriction to improve high-fat diet-induced insulin resistance in mice","volume":"51","author":"Muurling","year":"2002","journal-title":"Metabolism"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0180","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0195-6663(86)80006-X","article-title":"Intraventricular insulin reduces food intake and body weight of lean but not obese Zucker rats","volume":"7","author":"Ikeda","year":"1986","journal-title":"Appetite"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0185","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1007\/s00125-003-1246-x","article-title":"Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats","volume":"46","author":"Carvalheira","year":"2003","journal-title":"Diabetologia"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0190","first-page":"R974","article-title":"Intracerebroventricular infusions of 3-OHB and insulin in a rat model of dietary obesity","volume":"255","author":"Arase","year":"1988","journal-title":"Am J Physiol"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0195","first-page":"R727","article-title":"Central insulin and macronutrient intake in the rat","volume":"271","author":"Chavez","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0200","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/jn\/123.11.1939","article-title":"AIN-93 purified diets of laboratory rodents: final report of the American Institute of Nutrition Ad Hoc Writing Committee on the Reformulation of the AIN-76 Rodent Diet","volume":"123","author":"Reeves","year":"1993","journal-title":"J Nutr"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0205","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.physbeh.2004.07.026","article-title":"Consumption of a high-fat diet alters the homeostatic regulation of energy balance","volume":"83","author":"Woods","year":"2004","journal-title":"Physiol Behav"},{"issue":"supplement 1","key":"10.1016\/j.physbeh.2011.01.010_bb0210","article-title":"Estrogen mediates body fat distribution and brain sensitivity to adiposity signals","volume":"52","author":"Clegg","year":"2003","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.physbeh.2011.01.010_bb0215","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.2337\/db06-0015","article-title":"Estradiol-dependent decrease in the orexigenic potency of ghrelin in female rats","volume":"Apr;56","author":"Clegg","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0220","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3181\/00379727-163-40720","article-title":"Intraventricular angiotensin elicits drinking in the baboon","volume":"163","author":"Lotter","year":"1980","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0225","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2337\/diabetes.52.2.227","article-title":"Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia","volume":"52","author":"Niswender","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0230","doi-asserted-by":"crossref","first-page":"978","DOI":"10.2337\/diabetes.55.04.06.db05-1339","article-title":"Gonadal hormones determine sensitivity to central leptin and insulin","volume":"55","author":"Clegg","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0235","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0091-3057(01)00780-8","article-title":"Acute third ventricular administration of insulin decreases food intake in two paradigms","volume":"72","author":"Air","year":"2002","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0240","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1210\/endo.143.6.8948","article-title":"Insulin and leptin combine additively to reduce food intake and body weight in rats","volume":"143","author":"Air","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0245","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0014-5793(01)02591-1","article-title":"Insulin modulates insulin-induced STAT3 activation in rat hypothalamus","volume":"500","author":"Carvalheira","year":"2001","journal-title":"FEBS Lett"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0250","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/0361-9230(84)90174-6","article-title":"Reduction of food intake and body weight by chronic intraventricular insulin infusion","volume":"12","author":"Brief","year":"1984","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0255","doi-asserted-by":"crossref","first-page":"682","DOI":"10.2337\/diabetes.52.3.682","article-title":"Differential sensitivity to central leptin and insulin in male and female rats","volume":"52","author":"Clegg","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0260","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/0031-9384(86)90177-0","article-title":"Dependence of food intake on acute and chronic ventricular administration of insulin","volume":"37","author":"Plata-Salaman","year":"1986","journal-title":"Physiol Behav"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0265","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/0031-9384(86)90178-2","article-title":"Effect of intra-third ventricular administration of insulin on food intake after food deprivation","volume":"37","author":"Plata-Salaman","year":"1986","journal-title":"Physiol Behav"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0270","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/0031-9384(95)00108-U","article-title":"Central insulin enhances sensitivity to cholecystokinin","volume":"58","author":"Riedy","year":"1995","journal-title":"Physiol Behav"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0275","doi-asserted-by":"crossref","first-page":"31139","DOI":"10.1074\/jbc.M400458200","article-title":"Hypothalamic responses to long-chain fatty acids are nutritionally regulated","volume":"279","author":"Morgan","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0280","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/nm1201","article-title":"Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis","volume":"11","author":"Lam","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0285","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2337\/diabetes.51.2.271","article-title":"Central administration of oleic acid inhibits glucose production and food intake","volume":"51","author":"Obici","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0290","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1038\/nm1202-798","article-title":"Hypothalamic insulin signaling is required for inhibition of glucose production","volume":"8","author":"Obici","year":"2002","journal-title":"Nat Med"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0295","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1093\/ajcn\/73.3.554","article-title":"Dietary fat content alters insulin-mediated glucose metabolism in healthy men","volume":"73","author":"Bisschop","year":"2001","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0300","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/S0026-0495(98)90080-4","article-title":"Effect of a controlled high-fat versus low-fat diet on insulin sensitivity and leptin levels in African-American and Caucasian women","volume":"47","author":"Lovejoy","year":"1998","journal-title":"Metabolism"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0305","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1210\/endo.134.4.7511094","article-title":"Insulin receptor substrate-1 (IRS-1) expression in rat brain","volume":"134","author":"Baskin","year":"1994","journal-title":"Endocrinology"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0310","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0304-3940(86)90430-1","article-title":"Localization of 125I-insulin binding sites in the rat hypothalamus by quantitative autoradiography","volume":"70","author":"Corp","year":"1986","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0315","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0196-9781(86)90062-8","article-title":"Brain insulin binding is decreased in Wistar Kyoto rats carrying the \u201cfa\u201d gene","volume":"7","author":"Figlewicz","year":"1986","journal-title":"Peptides"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0320","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/272827a0","article-title":"Insulin receptors are widely distributed in the central nervous system of the rat","volume":"272","author":"Havrankova","year":"1978","journal-title":"Nature"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0325","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1177\/002215549904700309","article-title":"Leptin receptor long form splice variant protein expression in neuron cell bodies of the brain and colocalization with neuropeptide Y mRNA in the arcuate nucleus","volume":"47","author":"Baskin","year":"1999","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.physbeh.2011.01.010_bb0330","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/oby.2005.7","article-title":"Cross-talk between the insulin and leptin signaling systems in rat hypothalamus","volume":"13","author":"Carvalheira","year":"2005","journal-title":"Obes Res"}],"container-title":["Physiology &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938411000254?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938411000254?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T23:09:16Z","timestamp":1559948956000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938411000254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":66,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S0031938411000254"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2011.01.010","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]}}}