{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:23:35Z","timestamp":1788870215866,"version":"build-2803163510"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Natural Sciences and Engineering Research Council (NSERC) of Canada","award":["OGP-0138878"],"award-info":[{"award-number":["OGP-0138878"]}]},{"name":"Fonds de recherche du Qu\u00e9bec \u2014 Sant\u00e9 (FRSQ Groupe de recherche)"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology & Behavior"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.physbeh.2013.09.008","type":"journal-article","created":{"date-parts":[[2013,9,21]],"date-time":"2013-09-21T12:44:01Z","timestamp":1379767441000},"page":"140-146","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Infusions of ascorbic acid into the medial preoptic area facilitate appetitive sexual behavior in the female rat"],"prefix":"10.1016","volume":"122","author":[{"given":"M. Dean","family":"Graham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G.","family":"Pfaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2013.09.008_bb0005","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/978-94-007-2199-9_6","article-title":"Vitamin C, transport and its role in the central nervous system","volume":"56","author":"May","year":"2012","journal-title":"Subcell Biochem"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0010","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/0301-0082(94)90052-3","article-title":"A vitamin as neuromodulator: ascorbate release into the extracellular fluid of the brain regulates dopaminergic and glutamatergic transmission","volume":"43","author":"Rebec","year":"1994","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0015","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0006-8993(81)90056-1","article-title":"Regional distribution of ascorbate in human brain","volume":"212","author":"Mefford","year":"1981","journal-title":"Brain Res"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0020","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0304-3940(82)90147-1","article-title":"Detailed mapping of ascorbate distribution in rat brain","volume":"28","author":"Milby","year":"1982","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0025","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/0306-4522(82)90009-4","article-title":"Linear sweep voltammetry with carbon paste electrodes in the rat striatum","volume":"7","author":"O'Neill","year":"1982","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0030","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0306-4522(89)90349-7","article-title":"Rapid changes in striatal ascorbate in response to tail-pinch monitored by constant potential voltammetry","volume":"30","author":"Boutelle","year":"1989","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0035","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1097\/00001756-199405000-00002","article-title":"Ascorbic acid increases synaptosomal potassium-induced dopamine release","volume":"5","author":"Girbe","year":"1994","journal-title":"Neuroreport"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0040","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1016\/j.neuropharm.2012.08.007","article-title":"Striatal interaction among dopamine, glutamate and ascorbate","volume":"63","author":"Morales","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0045","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1523\/JNEUROSCI.21-02-00668.2001","article-title":"Behavioral activation in rats requires endogenous ascorbate release in striatum","volume":"21","author":"Rebec","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0050","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/0024-3205(92)90400-J","article-title":"Stereospecific effects of ascorbic acid and analogues on D1 and D2 agonist binding","volume":"51","author":"Tolbert","year":"1992","journal-title":"Life Sci"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0055","first-page":"409","article-title":"Differential inhibitory effects of ascorbic acid on the binding of dopamine agonists and antagonists to neostriatal membrane preparations: correlations with behavioral effects","volume":"34","author":"Heikkila","year":"1981","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0060","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1111\/j.1471-4159.1982.tb05341.x","article-title":"Inhibitory effects of ascorbic acid on the binding of [3H]dopamine antagonists to neostriatal membrane preparations: relationship to lipid peroxidation","volume":"38","author":"Heikkila","year":"1982","journal-title":"J Neurochem"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0065","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1016\/0024-3205(79)90091-2","article-title":"Effect of ascorbic acid on neurochemical, behavioral, and physiological systems mediated by catecholamines","volume":"25","author":"Tolbert","year":"1979","journal-title":"Life Sci"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0070","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0361-9230(79)90056-X","article-title":"Ascorbate blocks amphetamine-induced turning behavior in rats with unilateral nigro-striatal lesions","volume":"4","author":"Tolbert","year":"1979","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0075","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/0031-6989(87)90083-X","article-title":"Neurochemical and behavioural changes induced by ascorbic acid and d-amphetamine in the rat","volume":"19","author":"Desole","year":"1987","journal-title":"Pharmacol Res Commun"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0080","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/BF00176860","article-title":"Ascorbate antagonizes the behavioral effects of amphetamine by a central mechanism","volume":"94","author":"White","year":"1988","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0085","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0091-3057(90)90245-D","article-title":"Intrastriatal infusions of ascorbate antagonize the behavioral response to amphetamine","volume":"36","author":"White","year":"1990","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0090","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0006-8993(95)00494-B","article-title":"Ascorbate potentiates amphetamine-induced conditioned place preference and forebrain dopamine release in rats","volume":"688","author":"Pierce","year":"1995","journal-title":"Brain Res"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0095","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/BF00310622","article-title":"Some behavioural and EEG effects of ascorbic acid in rats","volume":"89","author":"Wambebe","year":"1986","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0100","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0006-8993(86)91106-6","article-title":"Dopaminergic control of male sex behavior in rats: effects of an intracerebrally-infused agonist","volume":"370","author":"Hull","year":"1986","journal-title":"Brain Res"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0105","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/0091-3057(94)90547-9","article-title":"Effects of copulation on apomorphine-induced erection in rats","volume":"48","author":"Sachs","year":"1994","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0110","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1523\/JNEUROSCI.21-01-00349.2001","article-title":"Regulation by the medial amygdala of copulation and medial preoptic dopamine release","volume":"21","author":"Dominguez","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0115","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0006-8993(88)91599-5","article-title":"Microinjection of cis-flupenthixol, a dopamine antagonist, into the medial preoptic area impairs sexual behavior of male rats","volume":"443","author":"Pehek","year":"1988","journal-title":"Brain Res"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0120","first-page":"422","article-title":"D2\/D1 ratio in the medial preoptic area affects copulation of male rats","volume":"251","author":"Hull","year":"1989","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0125","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/0091-3057(94)90147-3","article-title":"A D1 agonist in the MPOA facilitates copulation in male rats","volume":"47","author":"Markowski","year":"1994","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0130","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/0091-3057(94)00437-N","article-title":"Dopaminergic drugs in the medial preoptic area and nucleus accumbens: effects on motor activity, sexual motivation, and sexual performance","volume":"51","author":"Moses","year":"1995","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0135","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0166-4328(94)90160-0","article-title":"Axon-sparing lesion of the preoptic area enhances receptivity and diminishes proceptivity among components of female rat sexual behavior","volume":"61","author":"Hoshina","year":"1994","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0140","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.pbb.2010.08.012","article-title":"Differential regulation of female sexual behaviour by dopamine agonists in the medial preoptic area","volume":"97","author":"Graham","year":"2010","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0145","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.pbb.2012.06.020","article-title":"Differential effects of dopamine antagonists infused to the medial preoptic area on the sexual behavior of female rats primed with estrogen and progesterone","volume":"102","author":"Graham","year":"2012","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0155","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1111\/j.1743-6109.2009.01309.x","article-title":"Pathways of sexual desire","volume":"6","author":"Pfaus","year":"2009","journal-title":"J Sex Med"},{"issue":"Suppl. 4","key":"10.1016\/j.physbeh.2013.09.008_bb0160","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1743-6109.2007.00610.x","article-title":"Bremelanotide: an overview of preclinical CNS effects on female sexual function","volume":"4","author":"Pfaus","year":"2007","journal-title":"J Sex Med"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0165","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1006\/hbeh.1999.1516","article-title":"Appetitive and consummatory sexual behaviors of female rats in bilevel chambers. I. A correlational and factor analysis and the effects of ovarian hormones","volume":"35","author":"Pfaus","year":"1999","journal-title":"Horm Behav"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0170","series-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0175","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0006-8993(92)90741-Q","article-title":"Dopamine-, NMDA- and sigma-receptor antagonists exert differential effects on basal and amphetamine-induced changes in neostriatal ascorbate and DOPAC in awake, behaving rats","volume":"579","author":"Pierce","year":"1992","journal-title":"Brain Res"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0180","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0006-8993(00)02345-3","article-title":"Opposite effects of sulpiride and SCH 23390 on ethanol-induced striatal ascorbic acid release in intact and 6-hydroxydopamine lesioned rats","volume":"869","author":"Liu","year":"2000","journal-title":"Brain Res"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0185","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/0024-3205(90)90195-W","article-title":"Effect of direct and indirect dopamine agonists on brain extracellular ascorbate levels in the striatum and nucleus accumbens of awake rats","volume":"47","author":"Phebus","year":"1990","journal-title":"Life Sci"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0190","series-title":"Voltammetry in the neurosciences, principles, methods, and applications","article-title":"Introduction to in vivo voltammetry","author":"Justice","year":"1987"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0195","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0301-0082(90)90014-8","article-title":"In vivo electrochemical measurements in the CNS","volume":"35","author":"Adams","year":"1990","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0200","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/j.1471-4159.1977.tb10440.x","article-title":"Inhibition of dopamine sensitive adenylate cyclase from rat brain striatal homogenates by ascorbic acid","volume":"28","author":"Thomas","year":"1977","journal-title":"J Neurochem"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0304-3940(96)12594-5","article-title":"Stimulation of the medial preoptic area of the hypothalamus in the rat elicits increases in intracavernous pressure","volume":"209","author":"Giuliano","year":"1996","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0210","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1523\/JNEUROSCI.4176-05.2006","article-title":"Preoptic glutamate facilitates male sexual behavior","volume":"26","author":"Dominguez","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0215","series-title":"Hormones, brain and behavior","article-title":"Male sexual behavior","author":"Hull","year":"2009"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0220","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1037\/a0026460","article-title":"An NMDA antagonist in the MPOA impairs copulation and stimulus sensitization in male rats","volume":"126","author":"Vigdorchik","year":"2012","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0225","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.neuroscience.2004.01.022","article-title":"Nitric oxide mediates glutamate-evoked dopamine release in the medial preoptic area","volume":"125","author":"Dominguez","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0230","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/0304-3940(91)90380-C","article-title":"Excitatory amino acid modulation of lordosis in the rat","volume":"126","author":"McCarthy","year":"1991","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0235","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/0006-8993(85)91468-4","article-title":"Inhibition of the lordosis reflex in rats by intrahypothalamic infusion of neural excitatory agents: evidence that the hypothalamus contains separate inhibitory and facilitatory elements","volume":"341","author":"Kow","year":"1985","journal-title":"Brain Res"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0240","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.pbb.2006.02.016","article-title":"Role of glutamate receptors in the ventromedial hypothalamus in the regulation of female rat sexual behaviors I. Behavioral effects of glutamate and its selective receptor agonists AMPA, NMDA and kainate","volume":"83","author":"Georgescu","year":"2006","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0245","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.pbb.2006.02.019","article-title":"Role of glutamate receptors in the ventromedial hypothalamus in the regulation of female rat sexual behaviors. II. Behavioral effects of selective glutamate receptor antagonists AP-5, CNQX, and DNQX","volume":"83","author":"Georgescu","year":"2006","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0250","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.pbb.2007.01.005","article-title":"MK-801 infusions to the ventral tegmental area and ventromedial hypothalamus produce opposite effects on lordosis of hormone-primed rats","volume":"86","author":"Petralia","year":"2007","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0255","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1677\/joe.0.1180287","article-title":"Ascorbic acid potentiates the inhibitory effect of dopamine on prolactin release in primary cultured rat pituitary cells","volume":"118","author":"Shin","year":"1988","journal-title":"J Endocrinol"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0260","first-page":"151","article-title":"Ascorbic acid potentiates the inhibitory effect of dopamine on prolactin release: a putative supplementary agent for PIF","volume":"24","author":"Shin","year":"1990","journal-title":"Endocrinol Exp"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0265","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1126\/science.6828874","article-title":"Midbrain microinfusions of prolactin increase the estrogen-dependent behavior lordosis","volume":"219","author":"Harlan","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0270","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0014-2999(00)00678-6","article-title":"The \u2018low-dose\u2019 concept and the paradoxical effects of prolactin on grooming and sexual behavior","volume":"405","author":"Drago","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0275","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1210\/endo-110-2-677","article-title":"Inhibition of lordosis behavior in the female rats by intraventricular infusion of prolactin and by chronic hyperprolactinaemia","volume":"110","author":"Dudley","year":"1982","journal-title":"Endocrinology"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0280","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/jnr.490230110","article-title":"Sodium-independent transport of noradrenaline in mouse and rat astrocytes in primary culture","volume":"23","author":"Paterson","year":"1989","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0285","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0006-8993(93)90238-I","article-title":"Effect of ascorbate on Na(+)-independent and Na(+)-dependent uptake of [3H]norepinephrine by rat primary astrocyte cultures from neonatal rat cerebral cortex","volume":"602","author":"Kimelberg","year":"1993","journal-title":"Brain Res"},{"key":"10.1016\/j.physbeh.2013.09.008_bb0290","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0006-3223(02)01329-X","article-title":"High-dose ascorbic acid increases intercourse frequency and improves mood: a randomized controlled clinical trial","volume":"52","author":"Brody","year":"2002","journal-title":"Biol Psychiatry"}],"container-title":["Physiology & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938413003053?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938413003053?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T07:37:48Z","timestamp":1563953868000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938413003053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":57,"alternative-id":["S0031938413003053"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2013.09.008","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Infusions of ascorbic acid into the medial preoptic area facilitate appetitive sexual behavior in the female rat","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2013.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}