{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:38:04Z","timestamp":1791513484844,"version":"4.3.4"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology &amp; Behavior"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.physbeh.2013.10.027","type":"journal-article","created":{"date-parts":[[2013,10,30]],"date-time":"2013-10-30T19:49:50Z","timestamp":1383162590000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"special_numbering":"C","title":["Fluoride exposure during development affects both cognition and emotion in mice"],"prefix":"10.1016","volume":"124","author":[{"given":"Fei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Ping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Hui","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2013.10.027_bb0005","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.fct.2009.01.038","article-title":"Relationship between fluoride intake in Serbian children living in two areas with different natural levels of fluorides and occurrence of dental fluorosis","volume":"47","author":"Mandinic","year":"2009","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0010","first-page":"26","article-title":"Role of free radicals in fluoride-induced toxicity in liver and kidney of mice and its reversal","volume":"31","author":"Sharma","year":"1998","journal-title":"Fluoride"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0015","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/00004850-199400920-00002","article-title":"Psychopharmacology of fluoride: a review","volume":"9","author":"Spittle","year":"1994","journal-title":"Int Clin Psychopharmacol"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0020","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S1382-6689(00)00063-6","article-title":"Calcium preventing locomotor behavioral and dental toxicities of fluoride by decreasing serum fluoride level in rats","volume":"9","author":"Ekambaram","year":"2001","journal-title":"Environ Toxicol Pharmacol"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0025","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ejphar.2007.10.019","article-title":"Subchronic fluoride intake induces impairment in habituation and active avoidance tasks in rats","volume":"579","author":"Chioca","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0030","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0892-0362(00)00123-9","article-title":"Vitamin D ameliorates fluoride-induced embryotoxicity in pregnant rats","volume":"23","author":"Guna Sherlin","year":"2001","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0035","first-page":"201","article-title":"Effects of high fluoride and low iodine on biochemical indexes of the brain and learning-memory of offspring rats","volume":"37","author":"Wang","year":"2004","journal-title":"Fluoride"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0040","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1289\/ehp.9270","article-title":"Arsenic and fluoride exposure in drinking water: children\u2019s IQ and growth in Shanyin county, Shanxi province, China","volume":"115","author":"Wang","year":"2007","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0045","doi-asserted-by":"crossref","first-page":"S153","DOI":"10.1097\/00001648-200007000-00417","article-title":"Influence of fluoride exposure on reaction time and visuospatial organization in children","volume":"11","author":"Calderon","year":"2000","journal-title":"Epidemiology"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0050","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/ajim.4700030215","article-title":"Occupational fluorosis through 50years: clinical and epidemiological experiences","volume":"3","author":"Grandjean","year":"1982","journal-title":"Am J Ind Med"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0926-6917(94)90074-4","article-title":"The neurobehavioural toxicity of endosulfan in rats: a serotonergic involvement in learning impairment","volume":"270","author":"Paul","year":"1994","journal-title":"Eur J Pharmacol Environ Toxicol Pharmacol"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0060","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1101\/lm.461407","article-title":"Dopamine D1 receptors regulate protein synthesis-dependent long-term recognition memory via extracellular signal-regulated kinase 1\/2 in the prefrontal cortex","volume":"14","author":"Nagai","year":"2007","journal-title":"Learn Mem"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0065","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nprot.2006.116","article-title":"Morris water maze: procedures for assessing spatial and related forms of learning and memory","volume":"1","author":"Vorhees","year":"2006","journal-title":"Nat Protoc"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0070","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/BF00177912","article-title":"The use of a plus-maze to measure anxiety in the mouse","volume":"92","author":"Lister","year":"1987","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0075","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0080","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","article-title":"Depression: a new animal model sensitive to antidepressant treatments","volume":"266","author":"Porsolt","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0085","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/0278-6915(95)00066-B","article-title":"Developmental toxicity of sodium fluoride in rats","volume":"33","author":"Collins","year":"1995","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0090","first-page":"264","article-title":"Effects of high fluoride and low iodine on oxidative stress and antioxidant defense of the brain in offspring rats","volume":"37","author":"Wang","year":"2004","journal-title":"Fluoride"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0095","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S1382-6689(98)00033-7","article-title":"Effects of sodium fluoride on locomotor behavior and a few biochemical parameters in rats","volume":"6","author":"Paul","year":"1998","journal-title":"Environ Toxicol Pharmacol"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0100","first-page":"189","article-title":"Effect of vitamin D on chronic behavioral and dental toxicities of sodium fluoride in rats","volume":"36","author":"Ekambaram","year":"2003","journal-title":"Fluoride"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0105","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0892-0362(94)00070-T","article-title":"Neurotoxicity of sodium fluoride in rats","volume":"17","author":"Mullenix","year":"1995","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0110","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0149-7634(85)90030-2","article-title":"Exploratory behavior models of anxiety in mice","volume":"9","author":"Crawley","year":"1985","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0115","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0166-4328(88)90157-X","article-title":"A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data","volume":"31","author":"Ennaceur","year":"1988","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0120","first-page":"211","article-title":"Neurofunctional effects of developmental sodium fluoride exposure in rats","volume":"11","author":"Bera","year":"2007","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0125","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s12640-009-9139-5","article-title":"Memory impairment induced by sodium fluoride is associated with changes in brain monoamine levels","volume":"19","author":"Pereira","year":"2011","journal-title":"Neurotox Res"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0130","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1523\/JNEUROSCI.21-07-02442.2001","article-title":"Behavioral and anatomical correlates of chronic episodic hypoxia during sleep in the rat","volume":"21","author":"Gozal","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0135","first-page":"277","article-title":"Decreased learning and memory ability in rats with fluorosis: increased oxidative stress and reduced cholinesterase activity in the brain","volume":"42","author":"Gao","year":"2009","journal-title":"Fluoride"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0140","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0091-3057(95)02126-4","article-title":"A review of the validity and variability of the elevated plus-maze as an animal model of anxiety","volume":"54","author":"Hogg","year":"1996","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0145","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0091-3057(01)00599-8","article-title":"Intra-and interstrain differences in models of \u201cbehavioral despair\u201d","volume":"70","author":"Bai","year":"2001","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0150","first-page":"12","article-title":"Histological changes in the brain of young fluoride-intoxicated rats","volume":"35","author":"Shivarajashankara","year":"2002","journal-title":"Fluoride"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0155","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/0163-1047(92)90847-W","article-title":"Neurotransmitter receptors involved in post-training memory processing by the amygdala, medial septum, and hippocampus of the rat","volume":"58","author":"Izquierdo","year":"1992","journal-title":"Behav Neural Biol"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0160","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/S0306-4522(98)00030-X","article-title":"Hippocampal acetylcholine and habituation learning","volume":"85","author":"Thiel","year":"1998","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0165","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/0024-3205(91)90530-O","article-title":"Nifedipine and verapamil block the memory-facilitating effect of corticotropin-releasing factor in rats","volume":"48","author":"Lee","year":"1991","journal-title":"Life Sci"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0170","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0892-0362(02)00273-8","article-title":"Chronic fluoride toxicity decreases the number of nicotinic acetylcholine receptors in rat brain","volume":"24","author":"Long","year":"2002","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0175","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neulet.2006.11.023","article-title":"Habituation to an open field alters ecto-nucleotidase activities in rat hippocampal synaptosomes","volume":"413","author":"Pedrazza","year":"2007","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0180","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/ana.10338","article-title":"The structural consequences of newly diagnosed seizures","volume":"52","author":"Liu","year":"2002","journal-title":"Ann Neurol"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0185","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0920-1211(02)00253-X","article-title":"Quantitative magnetic resonance imaging of the amygdala in temporal lobe epilepsy\u2014clinico-pathological correlations (a pilot study)","volume":"53","author":"Lambert","year":"2003","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0190","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/ana.10424","article-title":"Assessing the onset of structural change in familial Alzheimer's disease","volume":"53","author":"Schott","year":"2003","journal-title":"Ann Neurol"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0195","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/jbt.20407","article-title":"Buffalo (Bubalus bubalis) epiphyseal proteins give protection from arsenic and fluoride-induced adverse changes in acetylcholinesterase activity in rats","volume":"26","author":"Bharti","year":"2012","journal-title":"J Biochem Mol Toxicol"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0200","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0006-8993(02)02965-7","article-title":"Dorsal and ventral hippocampal cholinergic systems modulate anxiety in the plus-maze and shock-probe tests","volume":"949","author":"Degroot","year":"2002","journal-title":"Brain Res"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0205","first-page":"74","article-title":"Effect of high-fluoride water on intelligence in children","volume":"33","author":"Lu","year":"2000","journal-title":"Fluoride"},{"key":"10.1016\/j.physbeh.2013.10.027_bb0210","first-page":"84","article-title":"Effect of fluoride in drinking water on children's intelligence","volume":"36","author":"Xiang","year":"2003","journal-title":"Fluoride"}],"container-title":["Physiology &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938413003557?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938413003557?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T14:19:55Z","timestamp":1564582795000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938413003557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":42,"alternative-id":["S0031938413003557"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2013.10.027","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fluoride exposure during development affects both cognition and emotion in mice","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2013.10.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}